Background: Study was conducted on 60 patients of both sexes taken for various surgical procedures taking from 30 to 90 minutes at Index Medical College Hospital & Research Centre, Indore, from Jan 2012 to Dec 2012.
Result: More of the children in the control group (25%) were anxious on reversal of residual paralysis than in the 0.5 mg/kg dose group and the 0.75 mg/kg dose group (5%, 0%, resp.)
The number of children who were drowsy but arousable was the highest in the 0.75mg/kg dose group (50%) followed by the 0.5 mg/kg dose group (20%) and the control group (10%). The differences observed between the 0.75mg/kg dose group and the control group were statistically significant. Also, the percentage of children who were calm were significantly higher in the
0.5 mg/kg dose group (75%) compared to the control group (25%).
Most of the children in the three groups recovered spontaneous ventilation and could be extubated within 5 minutes.
However, 2 children in each of the 3 groups were extubated within 5–10 minutes of reversal. Recovery of spontaneous ventilation and extubation was delayed by over 15 minutes in 2 children in the 0.75 mg/kg dose group. Midazolam dose did not impact the overall recovery times for children in any of the 3 groups, as the average time interval from premedication to full recovery was similar for all 3 groups.
Conclusion: Observation were made in terms of pulse rate, respiratory rate,Spo2, patient's acceptance of the medication, reaction to separation from parents, sedation scores, and recovery conditions. No side effects reported with Midazolam syrup like nausea, vomiting, hiccoughing, apnoea and laryngospasm.
Keywords: Adverse, Midazolam, Premedication & Paediatrics.