Side-effects of supplementation of vitamin D in a patient with sarcoidosis – a case study

Vitamin D and calcium are considered crucial for the treatment of bone diseases. Both vitamin D and calcium contribute to bone homeostasis but also preserve muscle health by reducing the risk of falls and fractures. Low vitamin D concentrations result in secondary hyperparathyroidism and contribute to bone loss, although the development of secondary hyperparathyroidism varies, even in patients with severe vitamin D deficiency. Findings from observational studies have shown controversial results regarding the association between bone mineral density and vitamin D/calcium status, thus sparking a debate regarding optimum concentrations of 25-hydroxyvitamin D and calcium for the best possible skeletal health. Although most of the intervention studies reported a positive effect of supplementation with calcium and vitamin D on bone in patients with osteoporosis, this therapeutic approach has been a matter of debate regarding potential side effects on the cardiovascular (CV) system. Thus, the aim of this review is to consider the current evidence on the physiological role of vitamin D and calcium on bone and muscle health. Moreover, we provide an overview on observational and interventional studies that investigate the effect of vitamin D and calcium supplementation on bone health, also taking into account the possible CV side-effects. We also provide molecular insights on the effect of calcium plus vitamin D on the CV system.

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Vitamin D supplementation helps to struggle musculoskeletal pain in Parkinson's disease - Clinical case study

Parkinsonism & Related Disorders ◽

10.1016/j.parkreldis.2020.06.245 ◽

2020 ◽

Vol 79 ◽

pp. e66-e67

Author(s):

G. Sahakyan ◽

H. Manvelyan

Keyword(s):

Parkinson’S Disease ◽

Vitamin D ◽

Parkinson's Disease ◽

Musculoskeletal Pain ◽

Clinical Case ◽

Vitamin D Supplementation ◽

Clinical Case Study

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Fibrous dysplasia of bone with Vitamin D resistant rickets: A case study

Metabolism ◽

10.1016/0026-0495(68)90004-8 ◽

1968 ◽

Vol 17 (11) ◽

pp. 988-998 ◽

Cited By ~ 28

Author(s):

Will G. Ryan ◽

Albert F. Nibbe ◽

Theodore B. Schwartz ◽

Robert D. Ray

Keyword(s):

Vitamin D ◽

Fibrous Dysplasia ◽

Fibrous Dysplasia Of Bone ◽

Vitamin D Resistant Rickets ◽

Resistant Rickets

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Family Planning Radio Messages Directed at Men and Women in a Developing Society: A Case Study

Current Issues of Mass Communication ◽

10.17721/2312-5160.2020.27.31-40 ◽

2020 ◽

pp. 31-40

Author(s):

Alex Eloho Umuerri ◽

Ngozi Bibian Okeibunor

Keyword(s):

Content Analysis ◽

Family Planning ◽

Side Effects ◽

Research Method ◽

Sampling Technique ◽

Men And Women ◽

Contraceptive Pill ◽

Family Planning Programs ◽

Developing Society

The study examined radio family planning messages with particular reference to the nature of the audience influence on communication content by using a chat program on radio in a developing society. The study adopted content analysis research method with a purposive sampling technique and used a radio script having six items for analyses. Results showed that there were more family planning segments for women than for men and, there were more family planning for drugs/pills and materials/implantation than for injection. In addition, there were side effects in the use of family planning just as there were quite a number of frequently asked questions except for condoms-fiesta/kiss. This paper concludes that radio scripts/messages for family planning programs should accommodate more topics/segments of family planning for men and women, specifically, natural methods should be included. Furthermore, radio family planning messages should focus more on the benefits of family planning and specifically the benefits of contraceptive pill and post pill emergency should be examined. Other formats of programs should be employed in the campaign for family planning messages on radio, and development communicators and content developers of radio family planning scripts should explore more areas to make radio messages more robust.

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Non-Healing Ulcer, managed through Unani Formulation along with Leech Therapy: A Case Study

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v9i6-s.3750 ◽

2019 ◽

Vol 9 (6-s) ◽

pp. 211-215

Author(s):

Minhaj Ahmad ◽

Zehra Zaidi ◽

Abdul Nasir

Keyword(s):

Side Effects ◽

Male Patient ◽

Severe Pain ◽

New Delhi ◽

Healing Ulcer ◽

Unani Medicine ◽

Leech Therapy ◽

The Right ◽

Local Examination

A male patient aged 43yrs. came to surgery OPD Majeedia Unani Hospital Jamia Hamdard New Delhi, in September 2018 with the complain of ulcer in the right foot posteriorly along the necrosis of Tendon Achilles. He was unable to walk a distance of about 100 meter due severe pain in the ulcer and calf muscle. limping on movement was very prominent. After required investigations and local examination of wounds, patient was planned and treated by local application, and combination of Unani Medicines formulations along with leech therapy as described in texts of Unani System of Medicine. With this Unani treatment non healing ulcer completely healed without any locomotor disturbances. The condition of leg totally resolved without any complications and side effects. Keywords: Non healing ulcer, Unani medicine, leech therapy.

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Vitamin D-enhanced pork meat consumers’ purchase intention: an exploratory case study in Spain

BRAZILIAN JOURNAL OF FOOD TECHNOLOGY ◽

10.1590/1981-6723.10520 ◽

2021 ◽

Vol 24 ◽

Author(s):

Begoña Panea ◽

Guillermo Ripoll

Keyword(s):

Vitamin D ◽

Purchase Intention ◽

Uv Light ◽

Population Data ◽

Age Group ◽

Pork Meat ◽

Willingness To Buy ◽

Gender And Age ◽

Consumption Habit

Abstract: This paper investigated if Spanish consumers would be willing to consume vitamin D-enhanced pork meat from animals fed on mushrooms treated with ultraviolet (UV) light. The questionnaire briefly explained the context of the study (vitamin D deficiency) and asked the consumers to choose answers with which they were most in agreement (non-enriched meat, enriched meat with synthetic vitamin D or enriched meat with vitamin D from UV-irradiated mushrooms). A survey was conducted to 400 non-vegan nor vegetarian consumers in Aragón (Spain) by direct invitation. Sampling was carried out in a random and stratified manner, by province, gender and age group using the Aragón population data for 2017 (INE). Some sociodemographic, health and consumption habit data were requested. Most consumers preferred non-enriched meat. Treatment with UV-irradiated mushrooms was rejected by most consumers, and the consumers who presented any willingness to buy meat enriched with UV-irradiated mushrooms were in the youngest age group.

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Can Iron and Folic Acid-IFA and Ca & Vitamin D Supplementation in Pregnancy be Fitted into Habitual Pattern of Three Meals A Day?

The Indian Journal of Nutrition and Dietetics ◽

10.21048/ijnd.2019.56.4.23960 ◽

2019 ◽

Vol 56 (4) ◽

pp. 341

Author(s):

Prema Ramachandran ◽

Amrita Pramanik ◽

K. Kalaivani

Keyword(s):

Vitamin D ◽

Folic Acid ◽

Side Effects ◽

Pregnant Women ◽

Ferrous Sulphate ◽

Vitamin D Supplementation ◽

Meal Pattern ◽

Iron And Folic Acid ◽

Habitual Pattern ◽

In Pregnancy

In India prevalence of anaemia and vitamin D deficiency in pregnancy are widespread. National programmes recommend that two tablets of iron and folic acid (IFA) and two tablets of calcium and vitamin D (Ca & Vit D) to be given every day from second trimester till delivery. To minimize the side effects and increase compliance, it is advised that each tablet should be taken after a meal. Most households follow a three meal pattern. A study was taken up to find out how IFA and Ca & Vit D supplementations can be fitted into the habitual three meal pattern. A short term crossover supplementation study was carried out on 38 pregnant women to assess side effects following consumption after lunch of one or two tablets containing 500mg elemental calcium (as calcium carbonate) and 250 IU vitamin D or 60 mg of elemental iron as ferrous sulphate. Prevalence of side effects was higher in women who received iron supplements as compared to Ca & Vit D supplements. Taking two tablets of Ca & Vit D together after meal was associated with significantly higher prevalence of side effects as compared to taking one tablet after meal. Taking two tablets of iron together after meal was not associated with any significant increase in prevalence of side effects as compared to one tablet. Giving two tablets of iron together after one meal and giving one tablet of calcium and vitamin after two meals is feasible option for providing two tablets each of iron and Ca & Vit D to pregnant women who habitually follow a three meal pattern.

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Literature based discovery of alternative TCM medicine for adverse reactions to depression drugs

BMC Bioinformatics ◽

10.1186/s12859-020-03735-8 ◽

2020 ◽

Vol 21 (S5) ◽

Author(s):

Qing Xie ◽

Kyoung Min Yang ◽

Go Eun Heo ◽

Min Song

Keyword(s):

Side Effects ◽

Herbal Medicines ◽

Interaction Network ◽

Enrichment Analysis ◽

New Drugs ◽

Protein Protein Interaction ◽

Target Drug ◽

Target Disease ◽

Literature Based Discovery

Abstract Background In recent years, Traditional Chinese Medicine (TCM) and alternative medicine have been widely used along with western drugs as a complementary form of treatment. In this study, we first use the scientific literature to identify western drugs with obvious side effects. Then, we find TCM alternatives for these western drugs to ameliorate their side effects. Results We used depression as a case study. To evaluate our method, we showed the relation between herb-ingredients-target-disease for representative alternative herbs of western drugs. Further, a protein-protein interaction network of western drugs and alternative herbs was produced, and we performed enrichment analysis of the targets of the active ingredients of the herbs and examined the enrichment of Gene Ontology terms for Biological Process, Cellular Component, and Molecular Function and KEGG Pathway levels, to show how these targets affect different levels of gene expression. Conclusion Our proposed method is able to select herbs that are highly relevant to the target indication (depression) and are able to treat the side effects caused by the target drug. The compounds from our selected alternative herbal medicines can therefore be complementary to the western drugs and ameliorate their side effects, which may help in the development of new drugs.

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