scholarly journals Preservatives Stability: Stability Study of Parabens under Different Conditions of Stress Degradation

2020 ◽  
Vol 11 (3) ◽  
pp. 4187-4194
Author(s):  
Ismail Bennani ◽  
Madiha Alami Chentoufi ◽  
Miloud El Karbane ◽  
Ibrahim Sbai El Otmani ◽  
Amine Cheikh ◽  
...  
Keyword(s):  
Extreme Values ◽  
Stability Study ◽  
Wide Field ◽  
Direct Influence ◽  
Light Conditions ◽  
Influence Of Temperature ◽  
Stress Degradation ◽  
Quality Of Products ◽  
The Stability

Preservatives are used in a wide field of application to maintain the quality of products. They are used to deal with the chemical, physical and microbiological problems and the constraints of the development of several formulations. In this work, we tested the stability of antimicrobial preservatives which are the parabens under different stress degradation conditions to evaluate their degree of effectiveness. The tested parabens were incubated in different solutions at different pH, Temperatures, light conditions, and presence or absence of sucrose in solution (create a medium similar of syrups). The HPLC was used for the assay, by a validated method for the parabens assay and the statistical analysis of the data is carried out by JMP software. The results show a direct influence of temperature and pH on the level of parabens, while the influence of light remains negligible. The increase in temperature gives a degree of immunity of parabens levels, especially with the extreme values of pH. This study is one of the first studies of forced decomposition of parabens carried out under the various conditions suggested. The results give an idea of the stability profile of the tested parabens and suggest a model of the conditions of conservation and use of these products in different domains and under different conditions.

scholarly journals Influence of additives of tungsten oxide nanoparticles on the thermophysical and mechanical properties of polymer composite materials

2021 ◽  
Vol 1 (79) ◽  
pp. 55-61
Author(s):  
A. A. Agisheva ◽  
◽  
L. K. Tastanova ◽  
A. Z. Bekeshev ◽  
M. N. Umurzakov ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tungsten Oxide ◽  
Elevated Temperatures ◽  
Industrial Applications ◽  
Thermal And Mechanical Properties ◽  
Functional Additives ◽  
Tungsten Oxide Nanoparticles ◽  
Quality Of Products ◽  
The Stability

Tungsten containing particles as functional additives have high potential for the reinforcement of different materials, such as polymer-based resins. The thermal and mechanical properties of polymer composites with additions of tungsten oxide were investigated. Incorporation of 1% WO3 nanoparticles increases the Young‘s modulus. An increase in the stability of the materials at elevated temperatures and an improvement in the mechanical properties of the resins are observed. Tungsten containing nanoparticles increase the quality of products for industrial applications.

scholarly journals Analytical Modeling of Oscillations of Movable Operating Elements of a Roll-Drum Activator

2018 ◽  
Vol 7 (4.3) ◽  
pp. 58
Author(s):  
Alexander Krot ◽  
Artem Ruchka ◽  
Alexander Savchenko ◽  
Olga Krot ◽  
Dmitry Supryaga
Keyword(s):  
Analytical Modeling ◽  
Free Oscillations ◽  
Optimal Stabilization ◽  
Equipment Operation ◽  
Shock Absorbers ◽  
Activation Efficiency ◽  
Quality Of Products ◽  
The Stability ◽  
Positive Effect

The article investigates the equipment for mechanical activation of building mixtures and the effect of the resulting oscillations on the activation efficiency and on the stability of the equipment operation. The activation of the entire building mixture with filler and wetted by finite amount of water can solve many problems that determine the quality of bricks or materials. Carried out researches of harmful oscillations of working of roll-drum activator (RDA) and their effects on the quality of processing. The own frequency of free oscillations arising in the RDA during its operation was determined experimentally. The possibility to stabilize the machine by installing shock absorbers has been examined. The influence of unwanted oscillations on the quality of products has been examined; the most optimal stabilization of the movement of "lever – roll" by using of additional external oscillations on the system has been defined. The analytical model of law of motion of the system with external oscillations and the parameters of its oscillations has been obtained. The parameters of oscillations of the roll has been determined; it was confirmed that the external oscillations have a positive effect on the efficiency of the activation and product quality.  

Flow and Temperature Analysis of Molten Pool in Twin-Roll Strip Casting Process

2007 ◽  
Vol 340-341 ◽  
pp. 695-700 ◽  
Author(s):  
Xiao Ming Zhang ◽  
Zheng Yi Jiang ◽  
L.M. Yang ◽  
Xiang Hua Liu ◽  
Guo Dong Wang
Keyword(s):  
Molten Pool ◽  
Metal Flow ◽  
Casting Process ◽  
Strip Casting ◽  
Roll Casting ◽  
Quality Of Products ◽  
The Stability ◽  
Experimental Values ◽  
Twin Roll

In twin-roll strip casting process, metal flow and temperature distribution in the molten pool directly affect the stability of the process and the quality of products. In this paper, a 3D coupling temperature-flow finite element simulation during twin-roll strip casting has been carried out, and the influences of the outlet angle and the submerged depth on the temperature and flow fields in the molten pool were investigated for the twin-roll casting of stainless steel. An inverse method was used to determine the boundary conditions between the roll and molten pool. Simulation results are consistent with the experimental values. Numerical simulation is helpful to optimise the twin-roll strip casting process and to improve the quality of products in practice.

scholarly journals IMPURITY PROFILING OF FIRST LINE ANTI-TB DRUG-TERIZIDONE USING CHROMATOGRAPHIC AND RELATED TECHNIQUES

2021 ◽  
pp. 83-95
Author(s):  
PRAGATI J. VANAVI ◽  
SADHANA J. RAJPUT
Keyword(s):  
Formic Acid ◽  
Degradation Products ◽  
Storage Condition ◽  
Stability Study ◽  
Preparative Hplc ◽  
Esi Ms ◽  
Impurity Profiling ◽  
Stress Degradation ◽  
Bulk Drug ◽  
The Stability

Objective: The objective of the present study was to investigate the stability of TRZ against different stressors and to prepare impurity profile for potential impurities and degradation products (DPs) formed under stress degradation of TRZ bulk drug and formulation. Methods: Three analytical methods were developed; the stability-indicating method that was developed using HPLC instrument with 0.01M ammonium acetate buffer (pH 4.0 using glacial acetic acid (GAA)) and acetonitrile in gradient program. The second method was a UPLC/ESI-MS method using 0.1 % Formic acid in Milli Q water (pH= 2.70) and 0.1%Formic acid in Milli Q water: Acetonitrile (10:90) in gradient program for identification of TRZ and DPs while the third, preparative HPLC method was used for isolation of impurities using (A) 0.05% ammonia (NH3) in water and (B) Acetonitrile+20% mobile phase A in gradient sequence. Gradient sequences are described in the main text. Results: The analytical method for stability study was developed and validated using ICH (Q2) R1 guidelines. The result of stability study by stress degradation showed that TRZ was susceptible to degradation in acid (7 DPs), alkaline, neutral (9 DPs) and oxidative conditions (10 DPs); major DPs were identified (where it was possible) and the chemical structure was elucidated by combining the data of ESI/MS, NMR and/or Tandem MS. The Impurity profiling was completed by reporting all the DPs, either major or minor for TRZ bulk drug and formulation. Conclusion: The complete Impurity profiling for TRZ is reported for the first time in literature. The study data would be add-on for formulation storage condition and further development.

scholarly journals PROVIDING OF FINANCIAL STABILITY OF ENTERPRISES OF PASTRY INDUSTRY

2021 ◽  
pp. 62-69
Author(s):  
Volodimir Mishchenko ◽  
Sergii Mekhovych ◽  
Irina Gorobets
Keyword(s):  
Financial Stability ◽  
Capital Investment ◽  
Financial Condition ◽  
Confectionery Products ◽  
European Standards ◽  
The Government ◽  
Quality Of Products ◽  
The Stability ◽  
The Cost

The article identifies the main trends characteristic of the modern confectionery market of Ukraine. The reasons for the slowdown in production growth, the gradual increase in prices for all types of confectionery, changes in the structure of demand for products are considered. Exports of confectionery products require Ukrainian producers to expand their own range, as well as to bring the quality of products to European standards. The recent trend characterizes the increase in demand in the domestic market for complex (combined) confectionery, so the main prerequisite for the development of the industry is to improve production, which requires significant capital investment. The paper analyzes the dynamics of the main indicators of the sample of confectionery enterprises in order to assess the stability of their financial condition. For providing of steady development of industry the Government program, is needed built on balanced to demand with application of state-private partnership. In the conditions of COVID epidemic with the aim of prevention of possible bankruptcy it is expedient to inculcate the cost-oriented management and preventive anti-crisis dynamic management. For their introduction it is necessary to work out branch purposeful events on in-plant training of workers of pastry industry.

EVALUATION OF SHELF LIFE OF BHALLATAKA TAILA (OIL)

INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (06) ◽  
pp. 36-41
Author(s):  
Anu Ruhila ◽  
◽  
Pramod R. Yadav ◽  
Galib R ◽  
Pradeep K. Prajapati
Keyword(s):  
Shelf Life ◽  
Fatty Acid Content ◽  
Stability Study ◽  
Polyunsaturated Fatty Acid Content ◽  
Accelerated Stability ◽  
Physico Chemical ◽  
Current Scenario ◽  
The Government ◽  
The Stability

Bhallataka Taila (Oil) is extracted with the help of Patala Yantra. It is one of the important formulations in Ayurveda pharmaceutics. Shelf life for various dosage forms are described in Ayurveda classics. In the current scenario, the amendment of Rule No. 161-B of the Drugs and Cosmetic Act 1940, specifies the maximum shelf life of Ayurvedic formulations. However, there is a lack of shelf life data for individual for-mulations. Thus, the present study is aimed to evaluate the shelf life of Bhallataka Taila (Oil). Bhallataka Taila (Oil) was extracted following classical guidelines. The sample was subjected to an accelerated stability study maintaining the temperature and humidity 40 +- 2 0C and 75 +- 5 %, respectively. Physico-chemical parameters were analysed at the initiation of the study and at an interval of 1, 3 and 6 months to check the degradation levels in the formulation. Tests for microbial limit and heavy metals were also conducted for the safety and quality of the product. On extrapolating the observations, the shelf life for Bhallataka Taila (Oil) was found to be 4.89 years, which exceeds the shelf life mentioned for Taila (Oil) in official gazettes of the Government of India. This oil preparation does not incorporate any liquid media such as Swarasa (Juice), Kwatha (decoction), etc. as required in any Taila Preparation, resulting in low degradation rate. The oil is rich in PUFA (polyunsaturated fatty acid) content and tocopherols, which may contribute to the stability of the oil.

scholarly journals Evolution of the Stabilis® Database: Creation of a Level of Evidence for Stability Studies

2018 ◽  
Vol 3 (1) ◽  
pp. 3-12 ◽  
Author(s):  
Elise D’Huart ◽  
Pauline Lider ◽  
Jean Vigneron ◽  
Béatrice Demoré
Keyword(s):  
Analytical Method ◽  
Antiviral Drugs ◽  
Stability Study ◽  
Antifungal Drugs ◽  
Quality Level ◽  
Stability Studies ◽  
Level Of Evidence ◽  
Stability Data ◽  
The Stability

AbstractBackgroundStabilis®is an international database on stability and compatibility of drugs. The stability data comes mainly from publications of pharmaceutical journals. As the quality of the published stability studies is not equivalent, the objective of this work was to propose a level of evidence for the physico-chemical stability studies selected for the database.MethodsAt first, we evaluated the main pharmacological class consulted by the users. This work was then divided into 5 steps: (1) updating of the criteria to validate a stability study, (2) creating a grid rating articles, (3) rating of the articles of stability studies for anticancer, antifungal and antiviral drugs by 2 evaluators, (4) creation of new screens in the database to enter rating, to visualize the pictograms and commentaries by the users, (5) creation of a guideline to explain the different levels of evidence.ResultsThe main pharmacological class consulted by Stabilis®users is the anticancer drugs and then antiinfectives. We have selected anticancer, antifungal and antiviral drugs for our study. Two hundred and forty publications were evaluated. The highest level attributed was A for anticancer and antifungal drugs and C for antiviral drugs. This difference can be explained by the fact that the majority of publications about antiviral drugs were older.The most frequent anomalies in the rating of articles were an incomplete or imperfect validation of the analytical method (high value of the coefficient of variation) and a defect in the evaluation of the stability indicating capacity.It must be noted that the level of evidence is not the quality level of the analytical method but the mixture of the quality of the method validation and of the results. This aspect was a choice of the Stabilis®team and seems important because the security of the patient is impacted by both aspects.ConclusionsThis new function contributes to help the Stabilis®users to evaluate the stability data published and to take a decision for their use in daily practice. This function will be progressively extended to other pharmacological classes of injectable drugs and then for non-injectable preparations.

scholarly journals Bio-analytical Approach for Stability Studies of Bendroflumethiazide Materials

2021 ◽  
pp. 195-203
Author(s):  
B. Veeraswami ◽  
V. M. K. Naveen
Keyword(s):  
Stability Study ◽  
Stability Studies ◽  
Dry Extract ◽  
Long Term Stability ◽  
Analytical Stability ◽  
Ich Guidelines ◽  
The Stability ◽  
Efficacy Prediction

In this paper a comprehensive study of stability related, and evidence based best practices of Bio-analytical stability on Bendroflumethiazide drug samples are studied. The proposed approach is very significant and essential for the drugs development process address the specify the acceptancy, purity, efficacy, prediction of strength and quality of the drugs. The stability study constituents several methods like Bench-Top, Auto-sampler, Freeze-Thaw, Dry-extract, Wet-extract, Short-term, long-Term stability studies at relative intervals results the complete stability information about the drug under the proposed and validated method. There ported out comes of this methos shows this drug have good stability according to ICH guidelines.

scholarly journals Stability indicating RP-HPLC method for the simultaneous estimation of Quercetin and Rutin in bulk drug

2020 ◽  
Vol 11 (1) ◽  
pp. 1254-1258
Author(s):  
Gomathy Subramanian ◽  
Narenderan S T ◽  
Meyyanathan S N
Keyword(s):  
Hplc Method ◽  
Stability Study ◽  
Simultaneous Estimation ◽  
Stability Indicating ◽  
Photolytic Degradation ◽  
Ich Guidelines ◽  
Stress Degradation ◽  
Bulk Drug ◽  
The Stability ◽  
Excellent Reproducibility

A stability-indicating HPLC technique has been developed and validated for Quercetin and Rutin under different stability environments of acid, base, neutral, oxidative, and photolytic degradation. The stability study were executed according to the ICH guidelines. The separation was accomplished utilizing Phenomenex Luna C18 (250 x 4.6mm i.d, 5µ) column at a detection wavelength of 259 nm utilizing the mobile phase established of 20mM Ammonium acetate (pH 3.0) and  acetonitrile 60: 40, v/v at the flow rate of 1.0 ml/min and injection volume of 20 µl. The linearity of the developed technique was obtained over the range of 1-5 µg/ml and 0.1-0.5 µg/ml for Quercetin and Rutin, respectively, with a correlation coefficient of more than 0.99. Further, the stress degradation studies were performed for which the results obtained stated that Quercetin and Rutin were more susceptible to acidic and oxidative conditions. The developed method provides good sensitivity and excellent reproducibility and can be further used to study the stability in formulations.

scholarly journals EFFICIENCY OF MARKETING IN SELECTION AND EVALUATION OF THE COMPETENCE OF PERSONNEL OF VETERINARY ENTERPRISES

2020 ◽  
Vol 21 (1) ◽  
pp. 60-64
Author(s):  
A. V. Grymak
Keyword(s):  
Veterinary Medicine ◽  
Professional Competence ◽  
Marketing Research ◽  
Developed Countries ◽  
Production Program ◽  
Organizational Work ◽  
Quality Of Products ◽  
The Stability ◽  
State Of The Environment

Not only animal welfare but also the state of the environment and human health depend on the quality and harmlessness of the products produced by the veterinary medicine enterprises. Practice, foreign and domestic experience confirm that the competence of the personnel of the enterprise, the ability to organize production and qualified, professional decision making are the leading in ensuring the quality of products produced for veterinary medicine. The point is that every employee, regardless of their position, should see the results of their professional contribution to the quality of veterinary medicine products, their competitiveness in the market. This is undoubtedly justified in the use of marketing opportunities, which will help the managers of enterprises to find those decisions in the selection of personnel, evaluation of their professional competence, which will be the most favorable for the enterprise and will guarantee the stability of the personnel, which will ensure the qualitative and effective execution of the production program of the enterprise, regardless of forms of his property. The study of the objective necessity of using marketing in the selection and evaluation of the personnel of the enterprise shows that marketing in solving this problem will be effective under the conditions: understanding of marketing by all employees in the enterprise, its necessity in solving specific tasks, providing management and specialists of the enterprise with the tasks defined by marketing . In such circumstances, marketing studies of the personnel problem will help to obtain objective information about the compliance of the company staff with the positions held, the attitude of the employees to fulfill their duties, the ability of the staff to find priorities in improving the activity of the company as a whole and its authority in the market of veterinary medicine and consumers respectively. The winners are those businesses that use marketing research results in their work. Although, it should be noted that not all domestic veterinary medicine companies use the principles of marketing, while in developed countries, marketing research is a priority, they are catalysts for achieving the desired economic results. Analysis of the activity of veterinary medicine enterprises shows the need to intensify the organizational work on the introduction of marketing at domestic enterprises and provide the necessary methodological assistance as a whole.

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