The Influence of Kenikir (Cosmos caudatus Kunth) Ethanol Extract Concentrations on Peel off Gel Formula and its Anti-Aging Effect

2021 ◽  
Vol 5 (7) ◽  
pp. 1196-1200
Keyword(s):  
Ethanol Extract ◽  
Aging Effect ◽  
Cosmos Caudatus

scholarly journals Efek Hepatoprotektor Ekstrak Etanol Daun Kenikir (Cosmos caudatus Kunth.) Pada Tikus Yang Diinduksi Doksorubisin

2019 ◽  
Vol 6 (2) ◽  
pp. 33
Author(s):  
Junvidya Heroweti ◽  
Ibrahim Arifin ◽  
Nurul Arlin Hidayati ◽  
Rizki Suciantika
Keyword(s):  
Ethanol Extract ◽  
Male Rats ◽  
Control Group ◽  
Control Group Design ◽  
Group Iii ◽  
Group Design ◽  
Cosmos Caudatus ◽  
Group I ◽  
Level Data ◽  
One Way Anova

ABSTRAK Doksorubisin adalah agen kemoterapi yang mempunyai efek samping hepatotoksik dengan cara pembentukan radikal bebas. Daun kenikir (Cosmos caudatus Kunth.) memiliki potensi untuk mencegah efek hepatotoksik akibat penggunaan doksorubisin. Penelitian bertujian untuk membuktikan potensi Ekstrak Etanol Daun Kenikir (EEDK) sebagai hepatoprotektor pada tikus yang diinduksi doksorubisin. Penelitian ini merupakan penelitian eksperimental menggunakan randomized matched post only control group design. Sebanyak 25 ekor tikus galur wistar dibagi menjadi 5 kelompok secara acak. Kelompok I, control normal diberi asupan aquadest, kelompok II kontrol hepatotoksik diberikan doksorubisin dosis 5 mg/KgBB. Kelompok III, IV dan V merupakan kelompok perlakuan EEDK dengan dosis berturut-turut 250,500, dan 1000 mg/kgBB dengan doksorubisin dosis 5 mg/kgBB. Pemberian doksorubisin dilakukan pada hari ke-1, ke-5,ke-9 dan hari ke-13 secara intraperitonial (ip) dan pemberian EEDK dilakukan 1 kali sehari selama 14 hari secara peroral (po). SEluruh hewan uji diambil darahnya pada hari ke-15. Kadar SGOT dan SGPT dievaluasi untuk melihat adanya kerusakan hati. Data kadar SGOT dianalisis dengan one way anova, sedangkan data kadar SGPT dianalisis menggunakan Kruskall-wallis. Hasil penelitian menunjukkan bahwa doksorubisin dapat menyebabkan hepatotoksik ditandai dengan peningkatan kadar SGOT dan SGPT. Ekstrak etanol daun kenikir mampu memberikan efek hepatoprotektor yang signifikan (p≤0,05) pada tikus yang diinduksi doksorubisin ditunjukkan dengan penurunan kadar SGOT dan SGPT. Kata Kunci: doksorubisin, daun kenikir, hepatoprotektor, SGOT, SGPT  ABSTRACT Doxorubicin is a chemotherapeutic agent has hepatotoxic side effects through the formation of free radicals. Marigold leaves (Cosmos caudatus Kunth.) has the potential to prevent hepatotoxic effects caused by the use of doxorubicin. This study aims to prove the potential of Ethanol Extract of Marigold Leaves (EEDK) as a hepatoprotector in doxorubicin-induced rats. This study was an experimental study with a randomized matched post test only control group design. 25 wistar male rats were divided into 5 groups randomly. Group I as normal control was given aquadest intake, group II as hepatotoxic control was given doxorubicin dose 5 mg/Kg BW, group III, IV and V was EEDK treatment group dose 250, 500 and 1000 mg/Kg BW and doxorubicin dose 5 mg/Kg BW. Doxorubicin was given on day 1, 5, 9 and 13intraperitoneal (i.p) and EEDK was given once a day for 14 days orally (p.o). All blood samples were taken on the 15th day. SGOT and SGPT levels were evaluated to see liver damage. SGOT level data were analyzed statistically by One Way Anova, while SGPT level data were analyzed using Kruskall-Wallis. The results showed that doxorubicin-induced hepatotoxity characterized by increased SGOT and SGPT levels. Ethanol extract of marigold leaves can provide hepatoprotector effect significantly (p≤0.05) in doxorubicin-induced rats indicate by decreased SGOT and SGPT levels. Keywords: doxorubicin, marigold leaves, hepatoprotector, SGOT, SGPT

scholarly journals Anti-aging Activity of Xylaria striata in Drosophila melanogaster

2019 ◽  
pp. 1-7
Author(s):  
Shi-Jun Yuan ◽  
Wei-Yi Li ◽  
Tian-Tian Jian ◽  
Yi Huang
Keyword(s):  
Oxidative Stress ◽  
Drosophila Melanogaster ◽  
Survival Time ◽  
Fruit Body ◽  
Ethanol Extract ◽  
Aging Effect ◽  
Health Food ◽  
Ultrasonic Assisted ◽  
Development And Utilization

Aims: To evaluate the application potential of Xylaria striata Pat. in anti-aging field. Methodology: Extracting the fruit body of X. striata by ultrasonic-assisted extraction method. In this study, Drosophila melanogaster was used as an anti-aging organism material. After feeding with different concentrations of extract, the natural survival time, survival time under oxidative stress and survival time under UV irradiation of D. melanogaster were all measured. In addition, the in vivo activity of SOD、CAT and MAD, protein concentration and body weight were determined to evaluate the anti-aging effect of ethanol extract from X. striata. Results: The results showed that the ethanol extract of X. striata could extend the lifespan of D. melanogaster under both irradiation and oxidative stress condition. And the ethanol extract could enhance the activity of CAT in D. melanogaster, especially at concentration of 50 μM, and the content of MAD in D. melanogaster were decreased significantly. Conclusion: This study clarified the anti-aging activity of X. striata in D. melanogaster and  it would provide some theoretical basis for its further development and utilization in anti-aging drugs and health food.

scholarly journals Physical Evaluation and Anti-Aging Effect of Red Bean Ethanolic Extract (Vigna angularis (Wild.) Ohwi & Ohashi) Peel-Off Gel Mask

2019 ◽  
Vol 7 (22) ◽  
pp. 3907-3910
Author(s):  
Bayu Eko Prasetyo ◽  
Dwi Rafika ◽  
Lia Laila ◽  
Fat Aminah
Keyword(s):  
Pore Size ◽  
Antioxidant Properties ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Aging Effect ◽  
Moisture Level ◽  
Dark Spot ◽  
Homogeneity Test ◽  
Irritation Test ◽  
Red Bean

BACKGROUND: The product development of an anti-aging dosage for human skin is a very interesting issue because every human wants to be looked young as long as possible. A studies and development of plant that contain of antioxidant properties need to be studied further. AIM: The aim of this research was to formulate and evaluate the physical and anti-aging effect of the Peel-Off Gel Mask from Red Bean Ethanol Extract (PGMRB). METHODS: The Extract Ethanol of Red Bean was extracted by maceration methods with ethanol 96%. The Peel-off base was consisted of Polyvinyl alcohol, glycerin and carbomer 940. The gel formulation was made in 3 formulas (F1, F2, and F3) consisted with 1%, 3% and 5% ethanol extract, respectively. The blank formula (F0) was also prepared as a control formula. The evaluation of gel formulation included organoleptic test, pH determination, stability test, homogeneity test, peeling time, irritation test and anti-aging effect test included moisture level, skin pore size, the evenness test and dark spot test by using skin analyzer. RESULTS: All of the formula showed a homogen, pH around 6, peeling time less than 20 minutes, no irritation and stable for 12 weeks storage at room temperature. The treatment with PGMRB demonstrated an improvement on the moisture level, pore size, evenness and the number of black spots with F3 containing 5% extract as the best formula. CONCLUSION: The ethanol extract of red bean can be formulated become a peel-off gel mask and having the anti-aging effect.

scholarly journals Pengaruh Ekstrak Etanol Daun Kenikir (Cosmos caudatus) terhadap Kadar Glutathion Dan Interleukin 6 Serum Tikus Wistar Jantan yang Diberi Pakan Tinggi Kolesterol

2020 ◽  
Vol 11 (1) ◽  
pp. 77
Author(s):  
I Gusti Agung Dewi Sarihati ◽  
I Gusti Ayu Sri Dhyanaputri
Keyword(s):  
Interleukin 6 ◽  
Wistar Rats ◽  
Ethanol Extract ◽  
Serum Levels ◽  
Male Rats ◽  
P Value ◽  
High Cholesterol ◽  
Endothelial Cell Function ◽  
Cosmos Caudatus ◽  
Male Wistar Rats

<p>Chronic dyslipidemia, especially in hypercholesterolemia, can directly disrupt endothelial cell function through increased formation of oxidized LDL which will stimulate an inflammatory response including interleukin 6 (IL-6) release. For this reason, it is necessary to have anti-inflammation that can reduce the effects of hypercholesterolemia on blood vessels. Polyphenols have anti-inflammatory effects and kenikir leaves are vegetables that are rich in polyphenols. This study aims to prove the effect of kenikir leaf (<em>Cosmos caudatus</em>) ethanol extract on IL-6 levels of serum of male Wistar rats fed high cholesterol. The method used is a true experimental study with a Post-test Only Control Group Design. Samples using 24 male rats were divided into 4 groups DS, DTK, Ss, and Cc. DTK, Ss and Cc groups were given high cholesterol feed for 20 weeks. In the 17th to 20th weeks the Ss group was given additional simvastatin and the Cc group was given an additional extract of <em>Cosmos caudatus</em> leaf. Whereas the DS group was only given standard feed for 20 weeks. After 20 weeks all rats in all four groups were examined serum GSH and IL-6 levels. The results showed the highest GSH serum levels average in Cc with p-value=0,016 but not different from Ss. IL-6 serum levels in DTK were higher than those of the other three groups and were significantly different with p-value=0,035. The difference occurs between DTK and DS, Ss and Cc, not different between DS, Ss and Cc. The ethanol extract of kenikir leaf influences the serum IL-6 levels of male Wistar rats fed high cholesterol.</p>

The antimicrobial activity of Usnea barbata ethanol extract

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
M Živković ◽  
J Kukić-Marković ◽  
M Milenković ◽  
G Nikolić ◽  
I Savić ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Ethanol Extract

Use of Syzygium cumini (L.) ethanol extract against bacteria from bovine mastitis

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
AL Magalães ◽  
N Gabriel ◽  
L Rabelo ◽  
I Maciel ◽  
L Silva ◽  
...  
Keyword(s):  
Bovine Mastitis ◽  
Ethanol Extract ◽  
Syzygium Cumini

Protective effects of ethanol extract of a Mexican propolis on indomethacin-induced gastric mucosal damage in mice.

2019 ◽  
Author(s):  
DV Pilar ◽  
VVS Ibran ◽  
RC Mario ◽  
CA Octavio ◽  
MM Canales-Martinez ◽  
...  
Keyword(s):  
Ethanol Extract ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Protective Effects

ISOLATION AND IDENTIFICATION OF 16-OXOOESTRADIOL-17β IN HUMAN PLACENTAE

1959 ◽  
Vol XXXII (II) ◽  
pp. 195-208 ◽  
Author(s):  
E. Diczfalusy ◽  
Anne-Marie v. Münstermann
Keyword(s):  
Ethanol Extract ◽  
Full Term ◽  
Free Form ◽  
Isolation And Identification ◽  
Human Placentae

ABSTRACT From the ethanol extract of 100 full term placentae approximately 200 μg of an α-ketolic Kober chromogen have been isolated in a »free« form. The evidence obtained indicates that this α-ketolic Kober chromogen is identical with 16-oxooestradiol-17β.

Sign in / Sign up

Export Citation Format

Share Document