scholarly journals Evaluation of an immunity status against measles of health workers in Kharkiv city

2019 ◽  
Keyword(s):  
Blood Serum ◽  
Measles Virus ◽  
Health Workers ◽  
Risk Group ◽  
Age Groups ◽  
Age Group ◽  
Protective Level ◽  
Minimum Number

Objectives. The purpose of this article was to determine the intensity of immunity against measles among health workers in Kharkov to identify and vaccinate susceptible individuals. Materials and methods. ELISA levels of specific measles IgG in blood serum of health workers were studied. Results. It was shown that the largest number of measles-susceptible individuals is observed in the age group of 18 to 27 years (9 % do not have a protective level of antibodies (AT); 7.7 % have a dubious level of protection). In the age groups from 28 to 37 years old and from 38 to 47 years old, a rather large number of measles-sensitive health workers was also detected (6.9 % and 6.1 % - with the absence of a protective level of AT and 6.9 % and 5.1 % - with a dubious level of protection, respectively). The minimum number of measles unprotected health workers was determined in the group aged 48 to 57 years (0.9 % of negative and doubtful results), and among physicians older than 57 years, there were no individuals with a lack of protective levels of antibodies to measles virus. Conclusions. Possible reasons for the prevalence of measles-unprotected health workers in the age groups from 18 to 47 years and the absence of unprotected people in the group of people over 57 are discussed. Doctors are a professional risk group for contracting infections (including measles). The article argues that there is no need for vaccination against measles for medical workers over 57 years old and vaccination of representatives of other age groups is recommended only after determining the strength of measles immunity, since more than 90 % of medical workers have protective levels of IgG.

Biologic Features and Clinical Outcomes According to Age Groups In Myelodysplastic Syndrome

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4963-4963
Author(s):  
Seungbum Lee ◽  
Je-Hwan Lee ◽  
Jung-Hee Lee ◽  
Dae-Young Kim ◽  
Sung-Doo Kim ◽  
...  
Keyword(s):  
High Risk ◽  
Prognostic Factor ◽  
Myelodysplastic Syndrome ◽  
Clinical Outcomes ◽  
Survival Data ◽  
Risk Group ◽  
Age Groups ◽  
Intensive Treatment ◽  
Age Group ◽  
Younger Age

Abstract Abstract 4963 Myelodysplastic syndrome (MDS) is a disease of the elderly, but can also affect younger people. Age is known to be an important prognostic factor in MDS but age variable is not included in most prognostic scoring systems because it is not thought as a disease-related variable. Many reports have showed that MDS is seen one to two decades earlier in Far Eastern countries than Western countries. We retrospectively investigated the differences in biologic features and clinical outcomes according to different age groups in Korean patients with MDS. Primary end points of our study were overall survival (OS) and progression-free survival (PFS). PFS was defined as time from diagnosis to AML progression or death. About one third of the patients received intensive treatment including chemotherapy, hypomethylating treatment or hematopoietic cell transplantation. Therefore, all survival data were censored at the start of intensive treatment to eliminate the influence of the treatments on clinical outcomes. A total of 403 patients, 248 males and 155 females, were included in this study. Median age was 54 years. We divided the patients into three age groups: ≤50 years (n=181), 51 to 60 (n=81), and over 60 (n=141). Baseline biologic features were significantly different according to three age groups: with increasing age, more male preponderance (P=0.009), more BM blast percentage (P<0.001), more advanced WHO subtype (P<0.001), higher proportion of high risk cytogenetic features (P=0.052; ≤60 vs. >60, P=0.011), poorer ECOG performance status (P=0.004), higher IPSS risk group (P=0.019). Five-year survival probabilities were significantly different according to age groups (≤ 50 vs. 51–60 vs. > 60; OS, 66.8% vs. 28.5% vs. 12.2%, P<0001; PFS, 58.5% vs. 37.9% vs. 12.3%, P<0.001). Survivals were also significantly different according to age groups in both IPSS Low/INT-1 (P<0.001 for OS, P=0.001 for PFS) and IPSS INT-2/High risk group (P=0.026 for OS, P=0.069 for PFS). Cox proportional hazards models also demonstrated that age group was an independent prognostic factor for survivals: ≤ 50 vs. 51–60 and > 60; OS, RR 2.3 (P=0.037) and RR 4.6 (P<0.001); PFS, RR 1.3 (P=0.449) and RR 2.0 (P=0.012). Conclusion: Biologic features and clinical outcomes were significantly different among age groups in MDS. Clinical outcomes were better in younger age group independently of biologic features. Survivals (OS & PFS) were better in younger age group and survival differences by age groups were observed in both lower and higher risk MDS, suggesting that age stratification should be considered in treatment decision and clinical trial design. Disclosures: No relevant conflicts of interest to declare.

scholarly journals A herd immunity to measles and rubella viruses in the population of the Republic of Serbia

2021 ◽  
Vol 11 (1) ◽  
pp. 171-176
Author(s):  
M. A. Bichurina ◽  
S. Filipovic-Vignjevic ◽  
A. Yu. Antipova ◽  
M. Bancevic ◽  
I. N. Lavrentieva
Keyword(s):  
Measles Virus ◽  
Herd Immunity ◽  
Age Groups ◽  
Age Group ◽  
Igg Antibodies ◽  
Mmr Vaccine ◽  
Igg Antibody ◽  
Group I ◽  
Study Results ◽  
The Republic

According to the WHO Strategic Plan, measles should be eradicated in 2020 in the five WHO Regions including European Region. However, large measles outbreaks are being periodically registered in diverse European countries. In the Republic of Serbia (SRB), 5,076 measles cases were detected in 2018, among which 15 cases were fatal.Aim of the study was to examine herd immunity to measles and rubella viruses in the population of the Republic of Serbia.Materials and methods. Blood serum samples obtained in 2018 and 2019 from conditionally healthy residents of the Republic of Serbia were tested for the presence of IgG antibodies to measles and rubella viruses in five age groups: I — children from 2 to 6 years old, II — children from 8 to 14 years old, III — 15 to 24 years old, IV — 25 to 49 years old and V — over 50 years old. A total of 1000 samples were obtained, 200 sera in each group. Enzygnost® Anti-Measles virus/IgG and Enzygnost® Anti-Rubella virus/IgG ELISA test systems (Siemens Healthcare Diagnostics Products GmbH, Germany) were used according to the manufacturer's instructions.Results. Overall, around 23.0% and 33.7% of the surveyed persons had no or low level of anti-measles IgG antibody (≥ 275.0 — ≤ 1000.0 IU/1). In age group I, 60% children contained no or “low” anti-measles antibodies titer (29.5% and 30.5%, respectively). In addition, low antibody titer level was mainly detected in individuals from age group II and III (p < 0.05). A third of children under 8—14 contained high IgG-antibodies titer against measles (> 3000.0 IU/l) that might serve as an evidence that such subjects recently recovered after measles. Similar results were obtained for IgG antibodies to rubella in the same age groups.Discussion. The study results evidence about altered routine immunization against measles and rubella in children aged 12—15 months (first vaccination) and those at age of 6—7 years (revaccination) with MMR vaccine. The data obtained correlate with official data on coverage with measles and rubella vaccines in the Republic of Serbia.

scholarly journals A survey of examining herd measles immunity in adults over 35 years old

2020 ◽  
Vol 10 (2) ◽  
pp. 381-386 ◽  
Author(s):  
L. V. Rubis
Keyword(s):  
Measles Virus ◽  
High Titer ◽  
Herd Immunity ◽  
Age Groups ◽  
High Risk Group ◽  
Protective Level ◽  
Protective Antibody ◽  
The Republic ◽  
High Level ◽  
Post Infectious

A high measles incidence rate has been registered in Russia in recent years, with adults being actively involved in the epidemic process (about 40% of patients), thereby underlying relevance of assessing herd immunity in different  age groups to measure its risk. The data on examining serum antibodies to measles virus in 402 residents of Petrozavodsk are shown: 164 and 238 subjects were born in 1948–1968 (51–71 years) and 1970–1983 (36–50 years), respectively. It was found that the second group had significantly higher percentage not only of seropositive persons (94.1±1.5 vs. 77.4±3.3%, respectively), but also frequency of detected high IgG level (5 and more IU/l) reaching 39.7±3.5 vs. 15.4±5.8%, respectively. Analysis of vaccination history showed that of 351 people with protective antibody levels, 20.9% were vaccinated once or twice, 14 of them in childhood and 63 within the 15 years prior to the study. Of the 51 people with no measles antibodies or below protective level, 13.7% were vaccinated: five in childhood, and two within the last 15 years. Among those who was born in 1948–1968, 87.1±2.2% provided no information about previous vaccinations and probably were not vaccinated. In this group, percentage of those examined with a protective antibody level was significantly higher than in the 36–50 years group — 87.1±2.2 and 62.2±4.3%, respectively. In addition, 23 subjects confirmed that they recovered after measles in childhood. Of these, antibodies were detected in 21 subjects, including 9 having serum titer at level of 5 or more IU/ml. Until 1969, the Republic of Karelia registered a high level of measles morbidity (477–2176,0 per 100 thousand). The predominance in the group born before 1969, individuals seropositive to measles mainly at high titer, indicates that intense post-infectious immunity was preserved. The lack of protective level of antibodies to measles virus in 22.6% of persons aged 36–50 years (1969–1983 year of birth), due to the low level of post-infectious and insufficient durability of post-vaccination immunity allowing to definer them as a high risk group for measles infection.

Preantral follicle density in ovarian biopsy fragments and effects of mare age

2017 ◽  
Vol 29 (5) ◽  
pp. 867 ◽  
Author(s):  
K. A. Alves ◽  
B. G. Alves ◽  
G. D. A. Gastal ◽  
K. T. Haag ◽  
M. O. Gastal ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Monte Carlo ◽  
Age Groups ◽  
Experimental Designs ◽  
Age Group ◽  
Preantral Follicle ◽  
Preantral Follicles ◽  
Histological Sections ◽  
Minimum Number

The aims of the present study were to: (1) evaluate preantral follicle density in ovarian biopsy fragments within and among mares; (2) assess the effects of mare age on the density and quality of preantral follicles; and (3) determine the minimum number of ovarian fragments and histological sections needed to estimate equine follicle density using a mathematical model. The ovarian biopsy pick-up method was used in three groups of mares separated according to age (5–6, 7–10 and 11–16 years). Overall, 336 preantral follicles were recorded with a mean follicle density of 3.7 follicles per cm2. Follicle density differed (P < 0.05) among animals, ovarian fragments from the same animal, histological sections and age groups. More (P < 0.05) normal follicles were observed in the 5–6 years (97%) than the 11–16 years (84%) age group. Monte Carlo simulations showed a higher probability (90%; P < 0.05) of detecting follicle density using two experimental designs with 65 histological sections and three to four ovarian fragments. In summary, equine follicle density differed among animals and within ovarian fragments from the same animal, and follicle density and morphology were negatively affected by aging. Moreover, three to four ovarian fragments with 65 histological sections were required to accurately estimate follicle density in equine ovarian biopsy fragments.

scholarly journals Measles immunity in different population groups

2020 ◽  
Vol 12 (1) ◽  
pp. 80-84
Author(s):  
M. A. Belopolskaya ◽  
T. D. Grigoryeva ◽  
V. Yu. Avrutin ◽  
D. V. Potanina ◽  
A. V. Dmitriev ◽  
...  
Keyword(s):  
Age Groups ◽  
Enzyme Linked Immunosorbent Assay ◽  
Age Group ◽  
Young Population ◽  
Protective Level ◽  
Passive Haemagglutination ◽  
Diagnostic Center ◽  
Measles Antibodies ◽  
Measles Outbreaks ◽  
Igg Level

Objective: to examine the state of the immunity to measles in different age groups.Materials and methods: In 2018, 4444 people were examined at the Diagnostic Center (virological). Among them, 3783 people were examined using the passive haemagglutination test for measles (manufactured by Pasteur Research Institute of Epidemiology and Microbiology, Russia). In the remaining 661 cases, the IgG to measles were detected using the enzyme-linked immunosorbent assay (ELISA) by VektoMeaseles IgG test (manufactured by Vector-Best, Russia). The correlation between the measles IgG level (ELISA) and the age was examined in 518 patients. Results: In this study, the immunity to measles was shown to be insufficient in all groups of observed people. Even among medical staff, nearly 10% had no protective level of measles antibodies. We have shown that the correlation between the measles IgG level and the age is statistically significant, so that the number of seronegative persons in different age groups differs significantly. Conclusion: The highest ratio of seronegative individuals was found in the age group between 18 and 25 years (52,33%), which can lead to serious measles outbreaks. Hence, this study confirms a strong need for additional immunization in all groups and especially in young population.

scholarly journals Micrometry of Liver of Non-descript Goats of Jammu Region in Different Age Groups

2021 ◽  
Vol 12 (5) ◽  
pp. 485-489
Author(s):  
Lovish Sethi ◽  
◽  
Shalini Suri ◽  
Kamal Sarma ◽  
Jasvinder Singh Sasan ◽  
...  
Keyword(s):  
Age Groups ◽  
Young Group ◽  
Central Vein ◽  
Age Group ◽  
Mean Values ◽  
Adult Age ◽  
Maximum Thickness ◽  
General Number ◽  
Minimum Number ◽  
The Mean

The present study was conducted on the liver of non-descript goats of Jammu region during 2019. The samples were divided into young (below 1 year), adult (2–3 years) and senile (4 years and above) age groups as per the dentition. Six samples from each age group were collected. The capsule showed maximum thickness in adult age group. Maximum thickness of capsule was seen at upper part of main lobe (UPOML) in the liver of young, adult and senile age group. The diameter of central vein showed highest values in adult, followed senile group probably due to increased liver functions in adult. Inter-central vein distance was maximum in adult age group followed by young and senile groups. The mean values of length of hepatocytes ranged between 13.50 to 22.50 µm in all regions of liver of irrespective of age groups. The mean values showed higher values in adult and senile age groups. The nuclear diameter of the hepatocytes ranged between 9.00 to 13.50 µm with mean values varying between 9.75±0.50 to 10.50±0.64 µm in all the three age groups. Number of liver lobules per field was maximum at MPOML in senile group (14.16±0.61) whereas minimum number was observed at CL in young (4.41±0.22). Maximum number of portal triads per field was seen at VPOML in senile group (5.16±0.32) whereas minimum number was observed at VPOML in young group (3.08±0.19). In general, number of liver lobules and portal triads per field was highest in senile group followed by adult and young.

scholarly journals Indicators of vitamin D in case of Coronavirus infection COVID-19 in children

2021 ◽  
pp. 34-39
Author(s):  
A.G. Hasanov ◽  
◽  
I.E. Huseinova ◽  
Keyword(s):  
Vitamin D ◽  
Blood Serum ◽  
Age Groups ◽  
Serum Vitamin ◽  
Main Group ◽  
Control Group ◽  
Healthy Children ◽  
Age Group ◽  
Subgroup Ii ◽  
Vitamin D Levels

Purpose — to determine and compare vitamin D levels in children diagnosed with COVID-19-associated pneumonia and healthy children. Materials and methods. The study involved 90 children. The main group consisted of 75 inpatient children with a diagnosis of COVID-19-associated pneumonia (positive PCR — polymerase chain reaction with reverse transcription). Patients in the main group were divided into 2 subgroups: subgroup I consisted of 49 patients with a pneumonia of moderate course, and subgroup II — 26 patients with a pneumonia of severe course. The control group consisted of 15 practically healthy children. The scheme of examination of sick children included anamnestic data, the use of clinical, instrumental and laboratory, immunological examination methods. The concentration of vitamin D in the blood serum of sick and healthy children was determined by the method of enzyme3linked immunosorbent assay (ELISA). The indicators were measured on a Stat Fax 4700 device using a Pishqaman reactive kit (made in Germany). Results. The concentration of vitamin D in blood serum was 1.8 times lower in subgroup I and 2.0 times in subgroup II, compared with the control group. The average values of vitamin D in blood serum compared with the control group were <1.1 times lower in the age group <1 year, 1.1 times lower in the age group 1–3 years, and 2.3 times lower in the age group >3 years. Conclusions. Based on our research, it can be concluded that there is a relationship between vitamin D deficiency and COVID-19. Thus, the average level of vitamin D was lower in children with COVID-19-associated pneumonia, and varied depending on the severity of the disease (more pronounced changes were observed in severe pneumonia). There are also differences in vitamin D levels in the age groups of children with COVID-19-associated pneumonia: in children from age groups under 1 year and 1–3 years old the decrease in serum vitamin D level is less pronounced than in the age group over 3 years old. The main mechanisms of vitamin D involvement in the immune modulation process in COVID-19 require further study. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local ethics committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: children, COVID-19, vitamin D.

scholarly journals Comparative Analysis of the Measles Antibody Levels in Healthy Medical Personnel of Maternity Ward and Women in Labor

2021 ◽  
Vol 12 ◽  
Author(s):  
Mikhail Petrovich Kostinov ◽  
Pavel Ivanovich Zhuravlev ◽  
Lylia Solomonovna Gladkova ◽  
Kirill Vadimovich Mashilov ◽  
Valentina Borisovna Polishchuk ◽  
...  
Keyword(s):  
Blood Serum ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Measles Virus ◽  
Age Group ◽  
Igg Antibodies ◽  
Maternity Ward ◽  
Serum Samples ◽  
Ward Personnel

It has been proven that post-vaccination immunity to measles virus after two doses of vaccine is not able to persistently protect against infection throughout life. The goal of this research was to determine the immune layer to the measles virus among women in labor and maternity ward personnel in the same medical institution. The levels of IgG antibodies to measles virus in the umbilical cord blood of 594 women in labor and 88 workers of the maternity ward were studied by ELISA. It was revealed that 22.7% of umbilical cord blood serum samples from parturient women and 21.4% of blood serum samples from maternity ward personnel were seronegative (&lt;0.18 IU/ml). Levels of IgG antibodies to measles virus in low values (&lt;1.0 IU/ml) were detected in 67% of blood serum samples among women in labor and 68.9% among employees of the maternity ward. Among women in labor, women under 35 years of age are at the highest risk of contracting measles; the proportion of women with low levels of protective antibodies in this age group was almost 70%, and the proportion of women without protective levels of antibodies was 23%. Compared with the age group 36–43, the age of women in labor under 35 was associated with a higher chance of not having immune protection against infection with measles virus OR [95% CI] = 2.2 [1.1–4.5] (p = 0.02) or had a low level of protection OR [95% CI] = 1.9 [1.2–3.0] (p = 0.001). It was also found that among women over 35 years of age, the proportion of persons with a high level of antibodies in women in labor was statistically significantly higher than among members of the maternity ward staff (13 and 0%, respectively, p = 0.007). Thus, maternity ward employees and women in labor constitute a risk group for measles due to the presence of a high proportion of seronegative persons among women of childbearing age (both maternity ward employees and women in labor). These conditions create the need to revise current approaches to present vaccination procedures, especially in the current epidemiological situation with COVID-19.

scholarly journals Measles Cases by Age Group during the Elimination of Infection

2017 ◽  
Vol 16 (3) ◽  
pp. 18-25 ◽  
Author(s):  
O. V. Tsvirkun ◽  
A. G. Gerasimova ◽  
N. T. Tikhonova ◽  
E. B. Ezhlova ◽  
A. A. Melnikova ◽  
...  
Keyword(s):  
Measles Virus ◽  
Adult Population ◽  
Age Groups ◽  
First Year ◽  
Age Group ◽  
Epidemic Process ◽  
Leading Role ◽  
Measles Elimination ◽  
Children First ◽  
First Year Of Life

Objective. With the increase in vaccination coverage of the child population began the process of ousting children determining the incidence of measles in the country and by 2004, the children ceased to play a leading role in maintaining the epidemic process of measles. The definition of significance in the epidemic process of measles individuals of different age, including children in the first year of life, was the purpose of the work. Material and methods. Measles cases in different age groups were analyzed for the period 2003 - 2015 in the Russian Federation. 1799 cases of measles in children under 1 year were investigated. The ELISA method were examined the sera of children up to 1 year in 2002 - 22 sampls, 2016 - 31 sampls. Results. Analysis of the incidence of measles in different age groups conducted since the beginning of the program of measles elimination in Russia to date (2003 - 2015), showed that with the increase in the level of the immune stratum, the incidence of measles inculcated among the population declined markedly and even in the boom years (2012 - 2014) intensive morbidity rates of children aged 3 - 6 years, adolescents and adults averages ranged from 3.0 to 4.0 per 100 thousand of the appropriate age. The exception was children first year of life and children aged 1 - 2 years, of intense the incidence of which was several times higher (in average, respectively, was 22.0 and 19.0). If the vast majority of affected children aged 1 - 2 years had been vaccinated against measles, for various reasons, the children of the first year of life, according to the immunization calendar, the vaccination could not be. Conclusion. Detailed analysis showed that the incidence of measles in the country determined by the adult population. Comparison of incidence and state of specific immunity to measles virus in children the first year of life suggests that their involvement in the epidemic process of measles is not determinative. Changing the proportion of affected children of this age are directly linked with fluctuations in the long-term dynamics of the overall incidence of measles in the country, and high, compared with other age groups, the intensive indicator of disease is not due to a large numerical composition of this age group.

scholarly journals Antibody Responses In Bangladeshi Children Following Measles Vaccination.

2017 ◽  
Vol 10 (1) ◽  
pp. 13-17
Author(s):  
Sharmin Sultana ◽  
Shahina Tabassum ◽  
Afzalun Nessa ◽  
Munira Jahan
Keyword(s):  
Immune Response ◽  
Antibody Titer ◽  
Measles Virus ◽  
Age Groups ◽  
Antibody Responses ◽  
Enzyme Linked Immunosorbent Assay ◽  
Antibody Concentration ◽  
Age Group ◽  
Measles Vaccination ◽  
The Mean

Measles is a highly contagious vaccine preventable viral disease which mainly affects children. Infection with wild measles virus induces an immune response that provides life long protection. Measles has been targeted for global eradication. In Bangladesh, there is insufficient data about the antibody responses in children following measles vaccination. In the present study, the antibody response of a single dose of measles vaccine was investigated among 77 children of different age groups. The humoral immune response immunoglobin IgG (IgG) was detected by a commercial Enzyme-linked Immunosorbent Assay (ELISA). Among the study population, detectable antibody titer was observed in 75.3% children while 24.7% showed detectable titers. The mean antibody concentration was highest (2.75 ± 1.10 IU/ml) in the 13-24 months age group, decreased gradually with age, and was lowest (0.77 ± 0.13 IU/ml) in the 85-96 months age group. Thereafter, the mean antibody concentration gradually increased again in the 97-108 months (1.20 ± 0.13 IU/ml) and in the 109-120 months (1.45 ± 0.13 IU/ml) age groups. The mean antibody titer was statistically significant in relation to age (p<0.01) but not to gender (p<0.95). This study showed that around 25% children remained antibody negative indicating challenges ahead for eradication of measles from Bangladesh.Bangladesh J Med Microbiol 2016; 10 (1): 13-17

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