3D Bioprinting: The Imminent Future of Maxillofacial Rehabilitation

2021 ◽  
Vol 13 (3) ◽  
pp. 220-226
Author(s):  
P Roshan Kumar ◽  
N Kalavathy ◽  
Mitha M Shetty ◽  
Archana K Sanketh ◽  
Rutuja Tidke
Keyword(s):  
3D Printing ◽  
Reconstructive Surgery ◽  
Donor Site ◽  
Three Dimensional ◽  
Donor Site Morbidity ◽  
Biologically Active ◽  
Organ Shortage ◽  
3D Bioprinting ◽  
Future Prospects ◽  
Maxillofacial Prosthesis

Three dimensional (3D) printing is the most widely used technology in reconstructive surgery to fabricate complex maxillofacial prosthesis. 3D Bioprinting, a combination of 3D printing and tissue engineering is a rapidly expanding technology in the field of regenerative medicine for autograft production. It is an additive manufacturing process in which there is computer-aided deposition of living cells with extracellular matrix (ECM) components with a biomaterial in particular combinations, for the fabrication of 3D biologically active tissue. In this review, we introduced the techniques, principles, limitations and future prospects of 3D bioprinting, a method that can open up new avenues in reconstructive surgery, by solving the problem of organ shortage and decreasing the donor site morbidity.

scholarly journals Recent Applications of Three Dimensional Printing in Cardiovascular Medicine

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 742 ◽  
Author(s):  
Chiara Gardin ◽  
Letizia Ferroni ◽  
Christian Latremouille ◽  
Juan Carlos Chachques ◽  
Dinko Mitrečić ◽  
...  
Keyword(s):  
3D Printing ◽  
Heart Valves ◽  
Rapid Development ◽  
Three Dimensional ◽  
3D Models ◽  
Heart Tissue ◽  
Organ Shortage ◽  
3D Bioprinting ◽  
Cardiovascular Medicine

Three dimensional (3D) printing, which consists in the conversion of digital images into a 3D physical model, is a promising and versatile field that, over the last decade, has experienced a rapid development in medicine. Cardiovascular medicine, in particular, is one of the fastest growing area for medical 3D printing. In this review, we firstly describe the major steps and the most common technologies used in the 3D printing process, then we present current applications of 3D printing with relevance to the cardiovascular field. The technology is more frequently used for the creation of anatomical 3D models useful for teaching, training, and procedural planning of complex surgical cases, as well as for facilitating communication with patients and their families. However, the most attractive and novel application of 3D printing in the last years is bioprinting, which holds the great potential to solve the ever-increasing crisis of organ shortage. In this review, we then present some of the 3D bioprinting strategies used for fabricating fully functional cardiovascular tissues, including myocardium, heart tissue patches, and heart valves. The implications of 3D bioprinting in drug discovery, development, and delivery systems are also briefly discussed, in terms of in vitro cardiovascular drug toxicity. Finally, we describe some applications of 3D printing in the development and testing of cardiovascular medical devices, and the current regulatory frameworks that apply to manufacturing and commercialization of 3D printed products.

scholarly journals Discovering new 3D bioprinting applications: Analyzing the case of optical tissue phantoms

2018 ◽  
Vol 5 (1) ◽  
Author(s):  
Marisela Rodriguez-Salvador
Keyword(s):  
Optical Properties ◽  
3D Printing ◽  
Clinical Training ◽  
Three Dimensional ◽  
Biological Tissues ◽  
3D Bioprinting ◽  
Technology Intelligence ◽  
Biomedical Device ◽  
Tissue Phantoms ◽  
Scientific Papers

Optical tissue phantoms enable to mimic the optical properties of biological tissues for biomedical device calibration, new equipment validation, and clinical training for the detection, and treatment of diseases. Unfortunately, current methods for their development present some problems, such as a lack of repeatability in their optical properties. Where the use of three-dimensional (3D) printing or 3D bioprinting could address these issues. This paper aims to evaluate the use of this technology in the development of optical tissue phantoms. A competitive technology intelligence methodology was applied by analyzing Scopus, Web of Science, and patents from January 1, 2000, to July 31, 2018. The main trends regarding methods, materials, and uses, as well as predominant countries, institutions, and journals, were determined. The results revealed that, while 3D printing is already employed (in total, 108 scientific papers and 18 patent families were identified), 3D bioprinting is not yet applied for optical tissue phantoms. Nevertheless, it is expected to have significant growth. This research gives biomedical scientists a new window of opportunity for exploring the use of 3D bioprinting in a new area that may support testing of new equipment and development of techniques for the diagnosis and treatment of diseases.

scholarly journals Bio-inks for 3D bioprinting: recent advances and future prospects

2017 ◽  
Vol 8 (31) ◽  
pp. 4451-4471 ◽  
Author(s):  
Ilze Donderwinkel ◽  
Jan C. M. van Hest ◽  
Neil R. Cameron
Keyword(s):  
Extracellular Matrix ◽  
Three Dimensional ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Cell Aggregates ◽  
3D Bioprinting ◽  
Future Prospects ◽  
Printing Inks ◽  
Polymer Bead ◽  
Polymeric Hydrogels

In the last decade, interest in the field of three-dimensional (3D) bioprinting has increased enormously. This review describes all the currently used bio-printing inks, including polymeric hydrogels, polymer bead microcarriers, cell aggregates and extracellular matrix proteins.

scholarly journals Fabrication of 3D Printing Scaffold with Porcine Skin Decellularized Bio-Ink for Soft Tissue Engineering

Materials ◽  
2020 ◽  
Vol 13 (16) ◽  
pp. 3522
Author(s):  
Su Jeong Lee ◽  
Jun Hee Lee ◽  
Jisun Park ◽  
Wan Doo Kim ◽  
Su A Park
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
3D Printing ◽  
Three Dimensional ◽  
3D Bioprinting ◽  
Research Groups ◽  
Porcine Skin ◽  
Alginate Hydrogel ◽  
Chemical Treatments ◽  
Soft Tissue Engineering

Recently, many research groups have investigated three-dimensional (3D) bioprinting techniques for tissue engineering and regenerative medicine. The bio-ink used in 3D bioprinting is typically a combination of synthetic and natural materials. In this study, we prepared bio-ink containing porcine skin powder (PSP) to determine rheological properties, biocompatibility, and extracellular matrix (ECM) formation in cells in PSP-ink after 3D printing. PSP was extracted without cells by mechanical, enzymatic, and chemical treatments of porcine dermis tissue. Our developed PSP-containing bio-ink showed enhanced printability and biocompatibility. To identify whether the bio-ink was printable, the viscosity of bio-ink and alginate hydrogel was analyzed with different concentration of PSP. As the PSP concentration increased, viscosity also increased. To assess the biocompatibility of the PSP-containing bio-ink, cells mixed with bio-ink printed structures were measured using a live/dead assay and WST-1 assay. Nearly no dead cells were observed in the structure containing 10 mg/mL PSP-ink, indicating that the amounts of PSP-ink used were nontoxic. In conclusion, the proposed skin dermis decellularized bio-ink is a candidate for 3D bioprinting.

scholarly journals 4D Printing: A Review on Recent Progresses

Micromachines ◽  
2020 ◽  
Vol 11 (9) ◽  
pp. 796 ◽  
Author(s):  
Honghui Chu ◽  
Wenguang Yang ◽  
Lujing Sun ◽  
Shuxiang Cai ◽  
Rendi Yang ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Three Dimensional ◽  
Complex Structures ◽  
Future Prospects ◽  
4D Printing ◽  
Stimulation Method ◽  
Shape Property ◽  
External Stimuli

Since the late 1980s, additive manufacturing (AM), commonly known as three-dimensional (3D) printing, has been gradually popularized. However, the microstructures fabricated using 3D printing is static. To overcome this challenge, four-dimensional (4D) printing which defined as fabricating a complex spontaneous structure that changes with time respond in an intended manner to external stimuli. 4D printing originates in 3D printing, but beyond 3D printing. Although 4D printing is mainly based on 3D printing and become an branch of additive manufacturing, the fabricated objects are no longer static and can be transformed into complex structures by changing the size, shape, property and functionality under external stimuli, which makes 3D printing alive. Herein, recent major progresses in 4D printing are reviewed, including AM technologies for 4D printing, stimulation method, materials and applications. In addition, the current challenges and future prospects of 4D printing were highlighted.

scholarly journals Three-Dimensional Technology Applications in Maxillofacial Reconstructive Surgery: Current Surgical Implications

Nanomaterials ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 2523
Author(s):  
Yasmin Ghantous ◽  
Aysar Nashef ◽  
Aladdin Mohanna ◽  
Imad Abu-El-naaj
Keyword(s):  
3D Printing ◽  
Head And Neck ◽  
Donor Site ◽  
Maxillofacial Surgery ◽  
Three Dimensional ◽  
Oral And Maxillofacial Surgery ◽  
3D Technology ◽  
Printing Technology ◽  
Reconstructive Procedures ◽  
3D Printing Technology

Defects in the oral and maxillofacial (OMF) complex may lead to functional and esthetic impairment, aspiration, speech difficulty, and reduced quality of life. Reconstruction of such defects is considered one of the most challenging procedures in head and neck surgery. Transfer of different auto-grafts is still considered as the “gold standard” of regenerative and reconstructive procedures for OMF defects. However, harvesting of these grafts can lead to many complications including donor-site morbidity, extending of surgical time, incomplete healing of the donor site and others. Three-dimensional (3D) printing technology is an innovative technique that allows the fabrication of personalized implants and scaffolds that fit the precise anatomy of an individual’s defect and, therefore, has attracted significant attention during the last few decades, especially among head and neck surgeons. Here we discuss the most relevant applications of the 3D printing technology in the oral and maxillofacial surgery field. We further show different clinical examples of patients who were treated at our institute using the 3D technology and discuss the indications, different technologies, complications, and their clinical outcomes. We demonstrate that 3D technology may provide a powerful tool used for reconstruction of various OMF defects, enabling optimal clinical results in the suitable cases.

scholarly journals Three-Dimensional Printing: Custom-Made Implants for Craniomaxillofacial Reconstructive Surgery

2017 ◽  
Vol 10 (2) ◽  
pp. 089-098 ◽  
Author(s):  
Mariana Matias ◽  
Horácio Zenha ◽  
Horácio Costa
Keyword(s):  
3D Printing ◽  
Reconstructive Surgery ◽  
Three Dimensional ◽  
Tactile Feedback ◽  
Current Status ◽  
Printing Technology ◽  
Three Dimensional Printing ◽  
3D Printing Technology ◽  
Custom Made ◽  
The Aesthetic

Craniomaxillofacial reconstructive surgery is a challenging field. First it aims to restore primary functions and second to preserve craniofacial anatomical features like symmetry and harmony. Three-dimensional (3D) printed biomodels have been widely adopted in medical fields by providing tactile feedback and a superior appreciation of visuospatial relationship between anatomical structures. Craniomaxillofacial reconstructive surgery was one of the first areas to implement 3D printing technology in their practice. Biomodeling has been used in craniofacial reconstruction of traumatic injuries, congenital disorders, tumor removal, iatrogenic injuries (e.g., decompressive craniectomies), orthognathic surgery, and implantology. 3D printing has proven to improve and enable an optimization of preoperative planning, develop intraoperative guidance tools, reduce operative time, and significantly improve the biofunctional and the aesthetic outcome. This technology has also shown great potential in enriching the teaching of medical students and surgical residents. The aim of this review is to present the current status of 3D printing technology and its practical and innovative applications, specifically in craniomaxillofacial reconstructive surgery, illustrated with two clinical cases where the 3D printing technology was successfully used.

3D-BIOPRINTING (Application of 3D printer for Organ Fabrication)

2015 ◽  
Vol 3 (5) ◽  
pp. 346
Author(s):  
Y. Aishwarya ◽  
B. Gourangi ◽  
K. Abhijeet
Keyword(s):  
Organ Transplant ◽  
Three Dimensional ◽  
Organ Shortage ◽  
3D Printer ◽  
Layer By Layer ◽  
3D Bioprinting ◽  
Successive Layer ◽  
Major Development ◽  
High Level ◽  
Advanced Computer

Chronic shortage of human organs for transplantation has become more problematic in spite of major development in transplant technologies. In 2009, only 27,996 (18%) of 154,324 patients received organs and 8,863 (25 per day) died while on the waiting list. As of early 2014, approximately 120,000 people in the U.S. were awaiting an organ transplant. The solution to this problem is 3D bio-printing. This technology may provide a unique and new opportunity where we can print 3D organs. It incorporates two technologies, tissue engineering and 3D printing. 3D bioprinting involves dispensing cells onto a biocompatible scaffold using a successive layer-by-layer approach to generate tissue-like three-dimensional structures. It uses instruction in the CAD file for formation of the object, high level computer programming and ability to build highly advanced computer systems, it offers hope for bridging the gap between organ shortage and transplantation needs.

scholarly journals Current research in development of polycaprolactone filament for 3D bioprinting: a review

2021 ◽  
Vol 926 (1) ◽  
pp. 012080
Author(s):  
C Amni ◽  
Marwan ◽  
S Aprilia ◽  
E Indarti
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Development Stage ◽  
Biological Properties ◽  
Fabrication Process ◽  
3D Bioprinting ◽  
Three Dimensional Printing ◽  
Further Development ◽  
Dimensional Printing ◽  
The Ideal

Abstract Three-dimensional printing (3DP) provides a fast and easy fabrication process without demanding post-processing. 3D-bioprinting is a special class in 3DP. Bio-printing is the process of accurately 3DP structural design using filament. 3D bio-printing technology is still in the development stage, its application in various engineering continues to increase, such as in tissue engineering. As a forming material in 3D printing, many types of commercial filaments have been developed. Filaments can be produced from either natural or synthetic biomaterials alone, or a combination of the two as a hybrid material. The ideal filament must have precise mechanical, rheological and biological properties. Polycaprolactone (PCL) is specifically developed and optimized for bio-printing of 3D structures. PCL is a strategy in 3D printing to better control interconnectivity and porosity spatially. Structural stability and less sensitive properties environmental conditions, such as temperature, humidity, etc make PCL as an ideal material for the FDM fabrication process. In this review, we provide an in-depth discussion of current research on PCL as a filament currently used for 3D bio-printing and outline some future perspectives in their further development.

scholarly journals 3D PRINTING AND 3D BIOPRINTING TO USE FOR MEDICAL APPLICATIONS

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Milan Šljivić ◽  
Dragoljub Mirjanić ◽  
Nataša Šljivić ◽  
Cristiano Fragassa ◽  
Ana Pavlović
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
3D Models ◽  
Physical Models ◽  
Layer By Layer ◽  
3D Bioprinting ◽  
Solid Objects ◽  
Modern Methods ◽  
Digital File

The Additive manufacturing 3D printing is a process of creating a three dimensional solid objects or rapid prototyping of 3D models from a digital file, which builds layer by layer. The 3D bioprinting is a form sophisticated of 3D printing technology involving cells and tissues for the production of tissue for regenerative medicine, which is also built layer by layer into the area of human tissue or organ. This paper defines the modern methods and materials of the AM, which are used for the development of physical models and individually adjusted implants for 3D printing for medical purposes. The main classification of 3D printing and 3D bioprinting technologies are also defined by typical materials and a field of application. It is proven that 3D printing and 3D bioprinting techniques have a huge potential and a possibility to revolutionize the field of medicine.

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