3D PRINTING AND 3D BIOPRINTING TO USE FOR MEDICAL APPLICATIONS

AbstractFirst patented in 1986, three-dimensional (3D) printing, also known as additive manufacturing or rapid prototyping, now encompasses a variety of distinct technology types where material is deposited, joined, or solidified layer by layer to create a physical object from a digital file. As 3D printing technologies continue to evolve, and as more manuscripts describing these technologies are published in the medical literature, it is imperative that standardized terminology for 3D printing is utilized. The purpose of this manuscript is to provide recommendations for standardized lexicons for 3D printing technologies described in the medical literature. For all 3D printing methods, standard general ISO/ASTM terms for 3D printing should be utilized. Additional, non-standard terms should be included to facilitate communication and reproducibility when the ISO/ASTM terms are insufficient in describing expository details. By aligning to these guidelines, the use of uniform terms for 3D printing and the associated technologies will lead to improved clarity and reproducibility of published work which will ultimately increase the impact of publications, facilitate quality improvement, and promote the dissemination and adoption of 3D printing in the medical community.

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Layer-By-Layer: The Case for 3D Bioprinting Neurons to Create Patient-Specific Epilepsy Models

Materials ◽

10.3390/ma12193218 ◽

2019 ◽

Vol 12 (19) ◽

pp. 3218 ◽

Cited By ~ 5

Author(s):

Natasha Antill-O’Brien ◽

Justin Bourke ◽

Cathal D. O’Connell

Keyword(s):

Three Dimensional ◽

3D Models ◽

Patient Specific ◽

Layer By Layer ◽

3D Bioprinting ◽

3D Structures ◽

Neuronal Populations ◽

Layer Deposition ◽

Epilepsy Models ◽

Ink Formulation

The ability to create three-dimensional (3D) models of brain tissue from patient-derived cells, would open new possibilities in studying the neuropathology of disorders such as epilepsy and schizophrenia. While organoid culture has provided impressive examples of patient-specific models, the generation of organised 3D structures remains a challenge. 3D bioprinting is a rapidly developing technology where living cells, encapsulated in suitable bioink matrices, are printed to form 3D structures. 3D bioprinting may provide the capability to organise neuronal populations in 3D, through layer-by-layer deposition, and thereby recapitulate the complexity of neural tissue. However, printing neuron cells raises particular challenges since the biomaterial environment must be of appropriate softness to allow for the neurite extension, properties which are anathema to building self-supporting 3D structures. Here, we review the topic of 3D bioprinting of neurons, including critical discussions of hardware and bio-ink formulation requirements.

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Surgeon-Based 3D Printing for Microvascular Bone Flaps

Journal of Reconstructive Microsurgery ◽

10.1055/s-0037-1600133 ◽

2017 ◽

Vol 33 (06) ◽

pp. 441-445 ◽

Cited By ~ 5

Author(s):

Erin Taylor ◽

Matthew Iorio

Keyword(s):

3D Printing ◽

Avascular Necrosis ◽

Femoral Condyle ◽

Three Dimensional ◽

3D Models ◽

Physical Models ◽

Innovative Technology ◽

Source Imaging ◽

Femoral Trochlea ◽

Vascularized Bone

Background Three-dimensional (3D) printing has developed as a revolutionary technology with the capacity to design accurate physical models in preoperative planning. We present our experience in surgeon-based design of 3D models, using home 3D software and printing technology for use as an adjunct in vascularized bone transfer. Methods Home 3D printing techniques were used in the design and execution of vascularized bone flap transfers to the upper extremity. Open source imaging software was used to convert preoperative computed tomography scans and create 3D models. These were printed in the surgeon's office as 3D models for the planned reconstruction. Vascularized bone flaps were designed intraoperatively based on the 3D printed models. Results Three-dimensional models were created for intraoperative use in vascularized bone flaps, including (1) medial femoral trochlea (MFT) flap for scaphoid avascular necrosis and nonunion, (2) MFT flap for lunate avascular necrosis and nonunion, (3) medial femoral condyle (MFC) flap for wrist arthrodesis, and (4) free fibula osteocutaneous flap for distal radius septic nonunion. Templates based on the 3D models allowed for the precise and rapid contouring of well-vascularized bone flaps in situ, prior to ligating the donor pedicle. Conclusions Surgeon-based 3D printing is a feasible, innovative technology that allows for the precise and rapid contouring of models that can be created in various configurations for pre- and intraoperative planning. The technology is easy to use, convenient, and highly economical as compared with traditional send-out manufacturing. Surgeon-based 3D printing is a useful adjunct in vascularized bone transfer. Level of Evidence Level IV.

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Where Is the Missing Matter?

3D Printing ◽

10.4018/978-1-5225-1677-4.ch007 ◽

2017 ◽

pp. 145-152

Author(s):

Tihomir Mitev

Keyword(s):

Additive Manufacturing ◽

3D Printing ◽

Industrial Revolution ◽

Raw Materials ◽

New Technology ◽

Three Dimensional ◽

Material Object ◽

Layer By Layer ◽

Solid Objects ◽

Thing In Itself

The additive manufacturing (or the popular 3D printing) is relatively new technology which opens new spaces for entrepreneurial imagination and promises next stage of the industrial revolution. It is creating three dimensional solid objects from a digital file. The printer transforms the file into a material object layer by layer, using different raw materials. Today, the additive manufacturing is successfully used in architecture, medicine and healthcare, light and heavy industries, education, etc. The paper analyses the roles of actors in manufacturing the objects. It starts with the Heideggerian questioning of technology (), searching for the causes of bringing into appearance of the 3D model. According to Heideggerian analysis the technology is represented as an ‘unveiling of the truth'. The paper suggests that the old understanding of matter as a thing-in-itself should be replaced by a new, flexible, fluid, concept of matter, which is more or less manipulable. The matter is no more an occasion for object's taking place. On the other hand, it seems 3D printing technology is reduced to mere means; a simple intermediary, a copier of ideas. From that perspective the paper questioning the problem of action in ANT and search how action and interaction is distributed and how actors constitutes themselves as well as their actor-world.

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Recent Applications of Three Dimensional Printing in Cardiovascular Medicine

Cells ◽

10.3390/cells9030742 ◽

2020 ◽

Vol 9 (3) ◽

pp. 742 ◽

Cited By ~ 5

Author(s):

Chiara Gardin ◽

Letizia Ferroni ◽

Christian Latremouille ◽

Juan Carlos Chachques ◽

Dinko Mitrečić ◽

...

Keyword(s):

3D Printing ◽

Heart Valves ◽

Rapid Development ◽

Three Dimensional ◽

3D Models ◽

Heart Tissue ◽

Organ Shortage ◽

3D Bioprinting ◽

Cardiovascular Medicine

Three dimensional (3D) printing, which consists in the conversion of digital images into a 3D physical model, is a promising and versatile field that, over the last decade, has experienced a rapid development in medicine. Cardiovascular medicine, in particular, is one of the fastest growing area for medical 3D printing. In this review, we firstly describe the major steps and the most common technologies used in the 3D printing process, then we present current applications of 3D printing with relevance to the cardiovascular field. The technology is more frequently used for the creation of anatomical 3D models useful for teaching, training, and procedural planning of complex surgical cases, as well as for facilitating communication with patients and their families. However, the most attractive and novel application of 3D printing in the last years is bioprinting, which holds the great potential to solve the ever-increasing crisis of organ shortage. In this review, we then present some of the 3D bioprinting strategies used for fabricating fully functional cardiovascular tissues, including myocardium, heart tissue patches, and heart valves. The implications of 3D bioprinting in drug discovery, development, and delivery systems are also briefly discussed, in terms of in vitro cardiovascular drug toxicity. Finally, we describe some applications of 3D printing in the development and testing of cardiovascular medical devices, and the current regulatory frameworks that apply to manufacturing and commercialization of 3D printed products.

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Where is the Missing Matter?

International Journal of Actor-Network Theory and Technological Innovation ◽

10.4018/ijantti.2015010102 ◽

2015 ◽

Vol 7 (1) ◽

pp. 10-17 ◽

Cited By ~ 1

Author(s):

Tihomir Mitev

Keyword(s):

Additive Manufacturing ◽

3D Printing ◽

Industrial Revolution ◽

Raw Materials ◽

New Technology ◽

Three Dimensional ◽

Material Object ◽

Layer By Layer ◽

Solid Objects ◽

Thing In Itself

The additive manufacturing (or the popular 3D printing) is relatively new technology which opens new spaces for entrepreneurial imagination and promises next stage of the industrial revolution. It is creating three dimensional solid objects from a digital file. The printer transforms the file into a material object layer by layer, using different raw materials. Today, the additive manufacturing is successfully used in architecture, medicine and healthcare, light and heavy industries, education, etc. The paper analyses the roles of actors in manufacturing the objects. It starts with the Heideggerian questioning of technology (), searching for the causes of bringing into appearance of the 3D model. According to Heideggerian analysis the technology is represented as an ‘unveiling of the truth'. The paper suggests that the old understanding of matter as a thing-in-itself should be replaced by a new, flexible, fluid, concept of matter, which is more or less manipulable. The matter is no more an occasion for object's taking place. On the other hand, it seems 3D printing technology is reduced to mere means; a simple intermediary, a copier of ideas. From that perspective the paper questioning the problem of action in ANT and search how action and interaction is distributed and how actors constitutes themselves as well as their actor-world.

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Three-dimensionally printed polycaprolactone/multicomponent bioactive glass scaffolds for potential application in bone tissue engineering

Biomedical glasses ◽

10.1515/bglass-2020-0006 ◽

2020 ◽

Vol 6 (1) ◽

pp. 57-69

Author(s):

Amirhosein Fathi ◽

Farzad Kermani ◽

Aliasghar Behnamghader ◽

Sara Banijamali ◽

Masoud Mozafari ◽

...

Keyword(s):

Tissue Engineering ◽

3D Printing ◽

Bone Tissue Engineering ◽

Bone Tissue ◽

Three Dimensional ◽

Layer By Layer ◽

Composite Scaffolds ◽

3D Printed ◽

Co Doped

AbstractOver the last years, three-dimensional (3D) printing has been successfully applied to produce suitable substitutes for treating bone defects. In this work, 3D printed composite scaffolds of polycaprolactone (PCL) and strontium (Sr)- and cobalt (Co)-doped multi-component melt-derived bioactive glasses (BGs) were prepared for bone tissue engineering strategies. For this purpose, 30% of as-prepared BG particles (size <38 μm) were incorporated into PCL, and then the obtained composite mix was introduced into a 3D printing machine to fabricate layer-by-layer porous structures with the size of 12 × 12 × 2 mm3.The scaffolds were fully characterized through a series of physico-chemical and biological assays. Adding the BGs to PCL led to an improvement in the compressive strength of the fabricated scaffolds and increased their hydrophilicity. Furthermore, the PCL/BG scaffolds showed apatite-forming ability (i.e., bioactivity behavior) after being immersed in simulated body fluid (SBF). The in vitro cellular examinations revealed the cytocompatibility of the scaffolds and confirmed them as suitable substrates for the adhesion and proliferation of MG-63 osteosarcoma cells. In conclusion, 3D printed composite scaffolds made of PCL and Sr- and Co-doped BGs might be potentially-beneficial bone replacements, and the achieved results motivate further research on these materials.

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Porous PLAs with Controllable Density by FDM 3D Printing and Chemical Foaming Agent

Micromachines ◽

10.3390/mi12080866 ◽

2021 ◽

Vol 12 (8) ◽

pp. 866

Author(s):

A. R. Damanpack ◽

André Sousa ◽

M. Bodaghi

Keyword(s):

3D Printing ◽

Flow Rate ◽

Three Dimensional ◽

Poly Lactic Acid ◽

Layer By Layer ◽

Printing Technology ◽

Material Density ◽

Foaming Agent ◽

3D Printing Technology ◽

Fabrication Parameters

This paper shows how fused decomposition modeling (FDM), as a three-dimensional (3D) printing technology, can engineer lightweight porous foams with controllable density. The tactic is based on the 3D printing of Poly Lactic Acid filaments with a chemical blowing agent, as well as experiments to explore how FDM parameters can control material density. Foam porosity is investigated in terms of fabrication parameters such as printing temperature and flow rate, which affect the size of bubbles produced during the layer-by-layer fabrication process. It is experimentally shown that printing temperature and flow rate have significant effects on the bubbles’ size, micro-scale material connections, stiffness and strength. An analytical equation is introduced to accurately simulate the experimental results on flow rate, density, and mechanical properties in terms of printing temperature. Due to the absence of a similar concept, mathematical model and results in the specialized literature, this paper is likely to advance the state-of-the-art lightweight foams with controllable porosity and density fabricated by FDM 3D printing technology.

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Hydrogel-Based Bioinks for Three-Dimensional Bioprinting: Patent Analysis

Materials Proceedings ◽

10.3390/iocps2021-11239 ◽

2021 ◽

Vol 7 (1) ◽

pp. 3

Author(s):

Ahmed Fatimi

Keyword(s):

Tissue Engineering ◽

Detailed Analysis ◽

State Of The Art ◽

Three Dimensional ◽

Patent Analysis ◽

The State ◽

Driving Factors ◽

3D Bioprinting ◽

Preparation Methods

There are a variety of hydrogel-based bioinks commonly used in three-dimensional bioprinting. In this study, in the form of patent analysis, the state of the art has been reviewed by introducing what has been patented in relation to hydrogel-based bioinks. Furthermore, a detailed analysis of the patentability of the used hydrogels, their preparation methods and their formulations, as well as the 3D bioprinting process using hydrogels, have been provided by determining publication years, jurisdictions, inventors, applicants, owners, and classifications. The classification of patents reveals that most inventions intended for hydrogels used as materials for prostheses or for coating prostheses are characterized by their function or properties Knowledge clusters and expert driving factors show that biomaterials, tissue engineering, and biofabrication research is concentrated in the most patents.

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Bioprinting in ophthalmology: current advances and future pathways

Rapid Prototyping Journal ◽

10.1108/rpj-06-2018-0144 ◽

2019 ◽

Vol 25 (3) ◽

pp. 496-514 ◽

Cited By ~ 19

Author(s):

Nataraj Poomathi ◽

Sunpreet Singh ◽

Chander Prakash ◽

Rajkumar V. Patil ◽

P.T. Perumal ◽

...

Keyword(s):

3D Printing ◽

Cardiac Tissue ◽

Human Life ◽

Three Dimensional ◽

3D Models ◽

Eye Diseases ◽

Biological Research ◽

Content Type ◽

Almost All ◽

Time Of Operation

Purpose Bioprinting is a promising technology, which has gained a recent attention, for application in all aspects of human life and has specific advantages in different areas of medicines, especially in ophthalmology. The three-dimensional (3D) printing tools have been widely used in different applications, from surgical planning procedures to 3D models for certain highly delicate organs (such as: eye and heart). The purpose of this paper is to review the dedicated research efforts that so far have been made to highlight applications of 3D printing in the field of ophthalmology. Design/methodology/approach In this paper, the state-of-the-art review has been summarized for bioprinters, biomaterials and methodologies adopted to cure eye diseases. This paper starts with fundamental discussions and gradually leads toward the summary and future trends by covering almost all the research insights. For better understanding of the readers, various tables and figures have also been incorporated. Findings The usages of bioprinted surgical models have shown to be helpful in shortening the time of operation and decreasing the risk of donor, and hence, it could boost certain surgical effects. This demonstrates the wide use of bioprinting to design more precise biological research models for research in broader range of applications such as in generating blood vessels and cardiac tissue. Although bioprinting has not created a significant impact in ophthalmology, in recent times, these technologies could be helpful in treating several ocular disorders in the near future. Originality/value This review work emphasizes the understanding of 3D printing technologies, in the light of which these can be applied in ophthalmology to achieve successful treatment of eye diseases.

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