scholarly journals Association of Serum Ferritin Level with Acute Coronary Syndrome

2018 ◽  
Vol 32 (2) ◽  
pp. 89-93
Author(s):  
Abu Thaher Mohammad Mahfuzul Hoque ◽  
HI Lutfur Rahman Khan ◽  
Abdul Wadud Chowdhury ◽  
Md Mohshin Ahmed ◽  
Khandker Md Nurus Sabah ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Control Group ◽  
Case Group ◽  
Newly Diagnosed ◽  
College Hospital ◽  
Medical College ◽  
Coronary Syndrome

Background: A substantial number of patients get admitted in different hospitals of Bangladesh with the diagnosis of acute coronary syndrome (ACS). No underlying conventional risk factors can be identified in significant number of these patients. Therefore new emerging risk factors are likely to be involved in these patients. As many authors reported that high serum ferritin levels are associated with diabetes mellitus (DM) and hypertension (HTN), it may have role in the pathogenesis of ACS.So we designed this study to test the relation between hyperferritinemia and newly diagnosed acute coronary syndrome patients of Bangladesh.Methods: The study was an observational case control study done in Department of Cardiology, Dhaka Medical College Hospital, from January 2013 to December 2013. Newly diagnosed patients with acute coronary syndrome (ACS) in the age group of 30- 70 years, admitted in the coronary care unit (CCU) of Dhaka Medical College Hospital, Dhaka, within the study period were taken as cases and age& sex matched healthy subject with no history of ischemic heart disease (IHD) and with normal ECG were taken as control by purposive sampling. In our study, the number of cases and controls were 65 each. So, total number of subject was 130.Results: According to the serum ferritin level both cases and controls were divided into two sub groups: subjects with normal ferritin level and with hyperferritinaemia. Normal ferritin level was found in 35(53.8%) subjects of case group and 62(95.4%) subjects of control groups. Hyperferritinaemia was found in 30(46.2%) subjects of case group and 3(4.6%) subjects of control group. Hyperferritinaemia was found to be significantly higher in case group than in control group (p<0.001).Conclusion: The study concludes that the serum ferritin level of patients with ACS was significantly higher than the control group.Bangladesh Heart Journal 2017; 32(2) : 89-93

A STUDY OF HYPERURICACIDEMIA AND THE PRESENCE AND SEVERITY OF ACUTE CORONARY SYNDROME IN INDEX MEDICAL COLLEGE, HOSPITAL AND RESEARCH CENTER, INDORE ( M.P.)

2021 ◽  
Vol 5 (7) ◽  
Author(s):  
B. Khanam ◽  
M. Imran Khan ◽  
Ajay Kumar Singh ◽  
Sumit Solanki ◽  
S.M. Holkar
Keyword(s):  
Acute Coronary Syndrome ◽  
Control Group ◽  
Case Group ◽  
College Hospital ◽  
Medical College ◽  
Coronary Syndrome ◽  
Luminal Stenosis ◽  
Angiographic Evidence ◽  
The Mean ◽  
High Uric Acid

Background: Few studies have assessed the relation of hyperuricacidemia with the acute coronary syndrome (ACS). This study investigated the association between high uric acid levels with the presence and severity of ACS.  Methods: Three hundred and seventy patients having angiographic evidence of atherosclerosis (CAD + case group) compared to 170 patients with no luminal stenosis (n=110) or with <50% luminal stenosis (n=60) at coronary angiography (CAD – control group). Results: The mean age of the patients was 60 ± 10 years (317 men, 58.7%). Hyperuricacidemia was more likely associated with a trend toward higher vessel scores, indicating a more severe CAD (adjusted OR=1.51, 95% CI=1.09-2.09; P=0.005) in the whole population. A comparison of sex-specific values showed a significant association existed only in men. Conclusions: Asymptomatic hyperuricacidemia may be associated with the presence and severity of ACS. Keywords: Hyperuricacidemia, Severity & Acute Coronary Syndrome.

scholarly journals Serum Ferritin Status in Microcytic Hypochromic Anaemic Medical Students

2014 ◽  
Vol 28 (1-2) ◽  
pp. 23-28
Author(s):  
Hafiza Akhter ◽  
Nasim Jahan ◽  
Nayma Sultana ◽  
Tabassum Ferdous ◽  
Hasina Akhter ◽  
...  
Keyword(s):  
Young Adults ◽  
Medical Students ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Control Group ◽  
Medical College ◽  
Microcytic Hypochromic Anaemia ◽  
Hypochromic Anaemia ◽  
Significant Difference

Background: Microcytic hypochromic anaemia is common in young adults , specially in females. It is important to know the serum ferritin status of the medical students who will be involved, in future, with the health care delivery system and to prevent anaemia among them. Objective: To observe the serum ferritin status in microcytic hypochromic anaemic medical students. Methods: This cross sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka from July 2009 to June 2010. A total number of 516 apparently healthy young adults of both sexes, age ranged from 18 to 22 years , were selected for the study from two medical college in Dhaka city. Of them, 276 were nonanaemic (control group A) and 240 were anaemic (study group B). Again , anaemic (B) subjects are divided into anaemic female (B1) and anaemic male (B2) . Among the anaemic (B) subjects, 170 had normocytic normochromic , 68 had microcytic hypochromic and 2 had macrocytic hypochromic anaemia. Serum ferritin was estimated by Micro-particle Enzyme Immunoassay in subjects (68 in number) who were suffering from microcytic hypochromic anaemia. The statistical analysis was done by using unpaired ‘t’ test , Pearson’s correlation coefficient test as applicable. Result: The mean serum ferritin level was almost similar and showed no statistically significant difference between group B1 and B2. Again, a significant positive correlation of serum ferritin level with haemoglobin was observed in both female and male in microcytic hypochromic anaemic group. Conclusion: This study reveals that serum ferritin level is one of the most sensitive and accurate indicator indicating iron status and thus microcytic hypochrmic anaemia. DOI: http://dx.doi.org/10.3329/bjpp.v28i1-2.20077 Bangladesh J Physiol Pharmacol 2012; 28(1&2):23-28

PREDICTIVE SIGNIFICANCE OF HIGH SERUM FERRITIN LEVELS IN THE DEBUT OF MALIGNANT LYMPHOMA

2020 ◽  
pp. 74-81
Author(s):  
Babaeva T.N. ◽  
Seregina O.B. ◽  
Pospelova T.I.
Keyword(s):  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Prognostic Significance ◽  
Average Concentration ◽  
High Serum ◽  
Control Group ◽  
Malignant Neoplasms ◽  
Significant Prognostic Factor ◽  
Malignant Lymphomas

At present, the serum ferritin level is not included in the list of prognostic factors; however, it is known that its increased serum level in patients with malignant neoplasms relates with the tumor burden, the degree of disease activity and correlates with a worse prognosis in patients with hematologic malignancies.The normalization of serum ferritin level during remission period confirms the involving of hyperferritinemia in mechanisms of tumor progression and may testify for clinical importance of measurement of serum ferritin level in patients, including those with malignant lymphomas. Objective:The aim of this study was to assess of the prognostic significance of high ferritin levels at the onset of the disease in patients with malignant lymphomas. Materials and methods:98 patients with malignant lymphomaswere enrolled in this study, including 72 patients (73.5%) with non-Hodgkins lymphomas (NHL) and 26 patients (26.5%) with Hodgkin’s lymphoma (HL). The increased serum ferritin level (more than 350 ng/ml) was found in 53 (54.2%) patients with malignant lymphomas at the onset of disease and its average concentration was 587,62±131,6 ng/ml (8.3 times higher values of control group, p<0.001).Also the positive statistical correlationsbetween increased ferritin level and increased level of LDH (r=0.47, p<0.001, n=98) and C-reactive protein (r=0.41, p<0.001, n=98) as well as the presence of B-symptomswere found. The median OS was significantly shorter in the group of patients with increased ferritin level (more than 350 ng/ml) at the onset of disease in comparison with group of patients with normal ferritin level, where the median OS was not reach during the observation period. Patients with increased ferritin level before starting chemotherapy also showed worse results of overall survival and increased mortality risk (OR 8.122; 95% CI, 1.764-37.396;р<0.05) compare with a group of patients with ferritin level ˂350 hg/ml at the onset of disease. Conclusion:These results make it possible to include lymphomas’s patients with increased ferritin level at the onset of disease in the group with poor prognosis and lower OS, while the increased ferritin level in patients without previous blood transfusions should be considered as a significant prognostic factor.

Smartphone-based tele-electrocardiography support for primary care physicians reduces the pain-to-treatment time in acute coronary syndrome

2017 ◽  
Vol 24 (8) ◽  
pp. 540-546 ◽  
Author(s):  
Vivek Chauhan ◽  
Prakash C Negi ◽  
Sujeet Raina ◽  
Sunil Raina ◽  
Mukul Bhatnagar ◽  
...  
Keyword(s):  
Primary Care ◽  
Acute Coronary Syndrome ◽  
Primary Care Physician ◽  
Primary Care Physicians ◽  
Intervention Group ◽  
Care Physician ◽  
Medical College Hospital ◽  
College Hospital ◽  
Medical College ◽  
Coronary Syndrome

Background The Himachal Pradesh state acute coronary syndrome registry recorded a median delay of 13 h between the time of onset of pain to the time of making the diagnosis and giving treatment for acute coronary syndrome. We conducted a pilot study on providing 24-h tele-electrocardiography (Tele-ECG) services in the district Kangra of Himachal Pradesh, with the aim to reduce the time taken for diagnosis of acute coronary syndrome. Methods The intervention group for the study included eight rural community health centres, each with one to three primary care physicians, who were all unskilled in electrocardiogram interpretation. We provided them with 24-h Tele-ECG support. The primary care physicians used their smartphones to transmit the electrocardiogram image to the command centre, which was then read by the skilled specialist physicians in our medical college hospital and the report sent back within five minutes of having received the electrocardiogram. Antiplatelets were given by the primary care physician to patients diagnosed with acute coronary syndrome, who was then transported to the medical college hospital. The urban sub-divisional hospitals ( n = 6) formed the control group for the study. These hospitals had five to fifteen unskilled primary care physicians and one to two skilled specialist physicians; no intervention was done in this group. A pilot was run from February 2015–January 2016. Results We received 819 Tele-ECG consultations within the intervention group; 157 cases of acute coronary syndrome were confirmed and transferred to our medical college hospital facility. Similarly, we admitted 177 cases of acute coronary syndrome at the medical college hospital, who were first attended to by the primary care physician in the control group. Aspirin was administered to 91% and 58% of patients with acute coronary syndrome in the intervention and the control groups, respectively ( p < 0.0001). The median hospital-to-aspirin time (h) in the intervention and the control groups was 0.7 ± 1.45 h and 3.5 ± 10 h, respectively ( p < 0.0001). In the intervention group, 72% of the ST elevation myocardial infarction patients were diagnosed within 12 h by the primary care physician using Tele-ECG support. Interpretation and conclusions Smartphone-based Tele-ECG support for primary care physicians reduced the hospital-to-aspirin time in acute coronary syndrome significantly ( p < 0.0001). This is an effective low cost strategy and is easily replicable anywhere in the world.

scholarly journals Assessment of serum Ferritin level and its correlation with HbA1c in Diabetic Nephropathy

2020 ◽  
Vol 11 (2) ◽  
pp. 46-51
Author(s):  
Madhura Navule Siddappa ◽  
Kowsalya Ramprasad
Keyword(s):  
Diabetic Nephropathy ◽  
Glycemic Control ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Pearson Correlation ◽  
The Body ◽  
Control Group ◽  
Type Ii

Background: Serum ferritin levels reflecting the body iron stores, is known to be elevated in type 2 Diabetes Mellitus. However its association with diabetic complications including Diabetic nephropathy (DN), and overall glycemic control needs to be validated. Aims and Objectives: The aim of this study was to find the Serum Ferritin level abnormalities in DM patients with nephropathy in comparison with DM patients without nephropathy and to find correlation of Serum Ferritin (SF) levels with levels of Glycated Hemoglobin (HbA1c) in patients with diabetic nephropathy. Materials and Methods: This is a retrospective study, which included eighty five registered patients with Type 2 DM (44 Type II DM without nephropathy cases and 41 cases of Type II DM with nephropathy). SF and HbA1c was estimated in all cases across both the groups and were compared with age and sex matched controls and analysed. Results: Serum Ferritin levels were higher in diabetics with nephropathy compared to diabetics without nephropathy (p<0.0001). SF levels were higher in diabetic groups compared to control group (p <0.001).The correlation between HbA1c and SF was assessed among all cases of DM with nephropathy group using pearson correlation test and it showed a significantly positive correlation (r=0.431) with a SF (mean = 938±148) and HbA1c (mean = 9.2±2.02). Conclusion: Serum ferritin levels positively correlate with HbA1c levels in Type II DM cases with nephropathy, which suggests that serum Ferritin levels can be used as a surrogate marker of glycemic control in Type II DM with nephropathy.

scholarly journals Outcome of Premature Rupture of Membranes – A Study of 120 Cases in Dhaka Medical College Hospital

2017 ◽  
Vol 25 (2) ◽  
pp. 82-86
Author(s):  
Afrina Begum ◽  
Tabassum Ghani ◽  
Subinoy Krishna Paul ◽  
Taufiqua Hussain ◽  
Noorjahan ◽  
...  
Keyword(s):  
Medical College Hospital ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Hypertensive Disorder ◽  
Premature Rupture ◽  
Maternal Complications ◽  
College Hospital ◽  
Medical College ◽  
Group A

Introduction: Premature rupture of membrane or PROM means when membrane ruptures before the onset of labour at a gestational age less than 37 completed weeks. In Bangladesh, every year, around 28,000 women die due to complications of pregnancy and childbirth. Nonscientific intervention in PROM made at various levels intensify the pregnancy complications several times, thereby leading many more deaths of foetus and newborn. Aetiology of PROM is largely unknown. The possible causes are either reduction of membrane strength or an increase in intrauterine pressure or both. Proper diagnostic facilities, proper monitoring and standard protocol in the management can improve the maternal and fetal outcome.Aim and objective: The aim of the study was to observe the incidence, type and maternal and fetal outcome of PROM.Materials and Method: A prospective case control analytical study was carried out at Dhaka Medical College Hospital, Dhaka from May ‘2000 to December‘2000. Total 120 patients were selected for this study among them 60 patients as case (Group A) and 60 patients were taken as control (Group B). Both primi and multigravida with Pregnancy more than 28 weeks with intact membrane as control and spontaneous rupture of membrane taken as case. High- risk patients such as hypertensive disorder of pregnancy, APH, cardiac disease, previous H/O caesarean section were excluded from the study. After taking proper history, speculum examination, some diagnostic investigations were carried out. Findings were recorded in predesigned questionnaire and statistical analysis were done using computerized software SPSS for Windows. A P value < 0.05 was taken as significant.Results: In our study maternal complications were significantly higher in Group A patients (Chi-square test: X2 = 6.263, df= 1, P< 0.05). Number of premature babies in PROM patients (25%) was significantly higher than control group. Perinatal morbidity was found higher in PROM (36.66%) compared to control group (31.66%). Most common morbidity was neonatal jaundice in PROM patients (13.33%) compared to babies of control group (8.33%).Conclusion: This study focused on certain risk factors in relation to PROM which can be preventable and reduce incidence and improvement of maternal and fetal outcome.J Dhaka Medical College, Vol. 25, No.2, October, 2016, Page 82-86

scholarly journals Efficacy of Hematological and Coagulation Parameters in the Diagnosis and Prognosis of Patients with Acute Coronary Syndrome

2018 ◽  
Author(s):  
Arsalan Majeed Adam ◽  
Muhammad Armughan Ali ◽  
Arshad Ali Shah ◽  
Ather Hasan Rizvi ◽  
Aiman Rehan ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Blood Cell ◽  
Cox Regression ◽  
Control Group ◽  
Case Group ◽  
Coagulation Parameters ◽  
Coronary Syndrome ◽  
Diagnosis And Prognosis ◽  
Wbc Count

Background: The diagnosis and management of acute coronary syndrome (ACS) have improved significantly over the past few decades; however, the recognition of myocardial ischemia still proves to be a dilemma for cardiologists. The aim of this study was to determine the role of hematological and coagulation parameters in the diagnosis and prognosis of patients with ACS. Methods: This prospective study recruited 250 patients with ACS and 250 healthy controls. The diagnostic role of hematological and coagulation parameters was assessed by comparing the patients with ACS with the control group. The relationships between these parameters and mortality were determined by dividing the patients into 2 groups: Group A (discharged) and Group B (patients who died within 30 days of follow-up). Multivariate Cox regression analysis was performed to calculate the hazard ratio (HR). Results: The mean age of the patients was 55.14±10.71 years, and 65.2% of them were male.  Prothrombin time (P<0.001), activated partial thromboplastin time (P<0.001), mean platelet volume (MPV) (P<0.001), white blood cell (WBC) count (P<0.001), and red blood cell distribution width (RDW) (P<0.001) were significantly higher in the case group than in the control group. WBC count (P<0.001), RDW (P<0.001), and MPV (P<0.001) were significantly higher in the controls than in the case group. The Cox regression model showed that RDW above 16.55% (HR=6.8), MPV greater than 11.25 fL (HR=2.6), and WBC higher than 10.55×103/μL (HR=6.3) were the independent predictors of mortality. Conclusion: In addition to being the independent predictors of short-term mortality, RDW, WBC, and MPV when used together with the coagulation profile may aid in the diagnosis of ACS in patients presenting with chest pain.

scholarly journals A COMPARATIVE STUDY OF THE ASSOCIATION OF SERUM FERRITIN LEVEL WITH GESTATIONAL DIABETES MELLITUS IN THE DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY AT SMS MEDICAL COLLEGE & ATTACHED GROUP OF HOSPITALS, JAIPUR

2021 ◽  
Vol 5 (11) ◽  
Author(s):  
Priyanka Inaniya ◽  
B S Meena ◽  
Manju Sharma ◽  
Mohan Lal Meena ◽  
Rashma Gera ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Pregnant Female ◽  
Antenatal Visit ◽  
Medical College ◽  
Obstetrics And Gynaecology

Background: The present study aimed to study the association of Serum Ferritin level with gestational diabetes mellitus Methods: All Pregnant Females in Gestational age of 16 to 32 weeks presenting to the Ante natal clinic of Department of Obstetrics and Gynaecology, SMS Medical College, Jaipur.  Based on Oral Glucose tolerance test, study participants were divided into two groups, Pregnant female with Gestational Diabetes (GDM group) and Pregnant female without Gestational Diabetes (Controls) Results: Mean ferritin level was significantly higher in GDM group (33.51 ng/ml)) as compared to control group (24.97 ng/ml). This difference in mean ferritin level among the two groups was found to be statistically significant (p<0.001). This indicates that higher ferritin level is significantly associated with risk of GDM. Conclusion: Serum ferritin in this study had a significant correlation with development of GDM. High ferritin range was found in females with GDM. Routine use of monitoring of serum ferritin levels, during the antenatal visit in the mid trimester should be carried out, for early prediction of developing GDM. Keywords: GDM, Serum ferrtin, Metabolic conditions.

scholarly journals Demographic proles of epileptic patients and their awareness towards epilepsy with the inuence on compliance

2016 ◽  
Vol 45 (1) ◽  
pp. 20-24
Author(s):  
Md Ferdous Mian ◽  
Mohammad Jobayer ◽  
Zeenat Afroz ◽  
Ahmed Hossain Chowdhury ◽  
Rajib Nayan Chowdhury ◽  
...  
Keyword(s):  
Low Income ◽  
Educational Status ◽  
Income Group ◽  
Control Group ◽  
Case Group ◽  
College Hospital ◽  
Medical College ◽  
Epileptic Patients ◽  
Almost All ◽  
And Control

There are about 2 million epilepsy patients in Bangladesh. The aim of this study was to correlate the demographic parameter of epilepsy patients with their knowledge about the disease and also with the compliance of antiepileptic drugs. This retrospective study was carried out in the Department of Neurology at Dhaka Medical College Hospital, Bangladesh from July 2010 to June 2012. A total of 100 epilepsy patients of any age and sex attending the epilepsy clinic were enrolled of which 50 patients who had experienced one or more seizures over last six months were designated as uncontrolled epileptic patients were in case group and 50 patients who were seizure-free for six months were designated as controlled epileptic patients were in control group. Mean age of case and control groups were 21.84 ±8.70 and 23.94 ±10.28 years respectively. Most of the epilepsy patients were between the age of 11 to 30 years that was 88% in case group and 76% in control group. Male was predominant than female in both group. Among study population 70% and 58% had educational status below Primary level in case and control group respectively. Seventy percent of uncontrolled epilepsy patients were from low income group and 62% of them were unemployed. Maximum (68% in case and 44% in control group) patients were from rural area. Almost all controlled epilepsy patients took drugs regularly, whereas 52% patients with uncontrolled epilepsy did not took drugs regularly and 64% of them had history of missing anti-epileptic drugs. Knowledge about the disease, treatment and prognosis of epilepsy was better in control group than in case group of epilepsy patients. It may be concluded that lower socioeconomical condition, less education and lack of awareness about epilepsy and non-affordability, limited availability of drugs, lack of counseling have contributed to the non-compliance of antiepileptic drugs.Bangladesh Med J. 2016 Jan; 45 (1): 20-24

scholarly journals Association Between Intraventricular Conduction Disorders and Intrahospital Prognosis in Patients with Acute Coronary Syndrome

2018 ◽  
Vol 3 (1) ◽  
pp. 32
Author(s):  
Mehdi Latif ◽  
Mohammad Salehi ◽  
Nazanin Janfada ◽  
Leila Foroutan ◽  
MohammadMoein Ashrafi
Keyword(s):  
Risk Factors ◽  
Acute Coronary Syndrome ◽  
Ejection Fraction ◽  
Significant Relationship ◽  
Control Group ◽  
Case Group ◽  
Intraventricular Conduction ◽  
Coronary Syndrome ◽  
Conduction Disorders ◽  
The Mean

Background: Acute coronary syndrome (ACS) is one of the most common heart diseases. Interventricular conduction disorders are complications of acute myocardial infarctions and have different types, such as left and right bundle branch blocks and left anterior and posterior hemiblocks. The prognosis of this disease can affect therapeutic methods, duration of hospitalization, and timely intervention decisions. Therefore, in this study, we evaluated the relationship between interventricular conduction disorders and the prognosis of patients with ACS.Methods: Using the convenience sampling method, this analytical case-control study was conducted on 140 patients with ACS (61 patients in the case group and 79 patients in the control group) who were treated from March to August 2013. The underlying variables of the risk factors for ACS were evaluated, along with prognostic evaluation factors, in two groups: a case group (patients with interventricular conduction disorders) and a control group (patients without interventricular conduction disorders). Data were analyzed with SPSS v. 17 software using the chi-squared test, the analysis of variance test, Student’s t-test, and Fisher’s exact test. Results: The mean age of patients was 64.1 ± 5.8 years in the case group and 62.9 ± 8.8 years in the control group. No significant relationship was observed between ACS risk factors, such as hyperlipidemia, diabetes, hypertension, previous myocardial infarction, and smoking, and the prognosis of patients with ACS. The mean ejection fraction was 39.7 in the case group and 45.1 in the control group, so a significant relationship existed between the two groups (P<0.05). In addition, systolic heart failure was more common in the case group than in the control group.Conclusion: We found that the presence of auscultation (rales sound) and shortness of breath on the first day of hospital admission in the case group was significantly different from the control group (P<0.05). Furthermore, the ejection fraction in the case group was lower than in the control group, and the frequency of mitral regurgitation in the case group was higher than in the control group. These factors can effectively predict the prognosis of patients with ACS. Finally, we found that interventricular conduction disorders weakened the prognosis of patients with ACS.

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