THE PULMONARY CIRCULATION PECULIARITIES IN MEN UNDER 60 YEARS OLD WITH PULMONARY HYPERTENSION, DEVELOPED DURING MYOCARDIAL INFARCTION

2020 ◽  
pp. 31-35
Author(s):  
Men’shikova A.N. ◽  
Goncharov S.A. ◽  
Gordienko A.V.
Keyword(s):  
Myocardial Infarction ◽  
Pulmonary Hypertension ◽  
Normal Level ◽  
Pulmonary Circulation ◽  
Comparative Assessment ◽  
Pulmonary Resistance ◽  
Group Iii ◽  
The Third ◽  
Group Ii ◽  
Observation Period

Relevance. Formation of pulmonary hypertension (PH) in myocardial infarction (MI) remains poorly understood. Aim. To evaluate changes in pulmonary circulation indicators (PCI) in men under 60 years old (y.o) with PH that is developing in subacute MI period to improve understanding of developmental options and prevention. Material and methods. The study included men aged 19-60 y.o. with MI and various dynamics of mean pulmonary ar-tery pressure (MPAP), determined by echocardiography (A. Kitabatake) in the first 48 hours (1) and completion of third week (2) of MI. Patients were divided into four groups: studied (I) included 84 patients (mean age 50.4±7.1 y.o) with PH (MPAP2 25 and more mm Hg) and normal level of MPAP1. Group II included patients with a normal level of MPAP in both phases of the study (88 men, 52.1±6.6 y.o); group III – with elevated levels of MPAP at both points of study (184 men, 51.2±5.5 y.o) and IV – with increased levels of MPAP1 and normal levels of MPAP2 (94 men, 50.5±6.8 y.o). A comparative assessment of PCI in selected groups was performed. Results. In first 48 hours of MI, the minimum values of MPAP (I: 21.9±3.3; II: 20.3±2.5; III: 39.0±11.2 (mm Hg)) and total pulmonary resistance (TPR) ) (I: 380.0±171.0; II: 306.8±136.3; III: 616.0±279.8 (dyn×sec×cm-5)) were noted in group II, and the maximum - in III (p˂0.0001). When considering their dynamics at the end of the third week of MI, MPAP increased in I (39.5%; p˂0.0001), decreased in III (16.0%; p˂0.0001) and IV groups (42.9%; p˂0.0001). TPR decreased in II (12.1%), III (28.6%) and IV (54.2%) groups (p ˂0.0001). Conclusions. The study group is distinguished by unfavorable changes in PCI during observation period, in contrast to other groups, which confirms expediency of assessing dynamics of these parameters as possible marker of negative prognosis for PH.

THE PULMONARY CIRCULATION IN MEN UNDER 60 YEARS OLD WITH MYOCARDIAL INFARCTION AND CHRONIC INFLAMMATORY PULMONARY DISEASE

2021 ◽  
pp. 34-39
Author(s):  
Men’shikova A.N. ◽  
Gordienko A.V. ◽  
Nhan Trinh Van
Keyword(s):  
Myocardial Infarction ◽  
Pulmonary Circulation ◽  
Comparative Assessment ◽  
Pulmonary Diseases ◽  
Study Group ◽  
Type I ◽  
Pulmonary Resistance ◽  
The Third ◽  
Mean Pressure ◽  
The Mean

Relevance. Formation of pulmonary hypertension (PH) in myocardial infarction (MI) and chronic inflammatory pulmonary diseases (CIPD) remains poorly understood. Aim. To evaluate changes in pulmonary circulation indicators (PCI) in men under 60 years old (y.o) with CIPD that in acute and subacute MI periods to improve understanding of developmental options and prevention. Material and methods. The study included men aged 19-60 years old with type I myocardial infarction. Patients are divided into two age-comparable groups: I - the study group, with CIPD - 142 patients; II - control, without it - 424 patients. A comparative assessment of PCI in the first 48 hours and the end of the subacute period of MI in these groups was performed. Results. In the first hours of MI, higher values of total pulmonary resistance (TPR) (I: 572.4 ± 276.0; II: 505.3 ± 286.6 (dyn×sec×cm-5)) were noted in the study group. When considering their dynamics at the end of the third week of MI, the mean pressure in the pulmonary artery decreased in both groups (I: 18.3%; p˂0.0001; II: 11.2%; p˂0.0001). TPR decreased in both groups (I: 36.1%; II: 24.4%) and heart rate also decreased (I: 11.0%; II: 5.3%; p˂0,0001 for all indicators). Conclusions. The study group is distinguished by more pronounced disorders of pulmonary circulation in the first hours of MI, which confirms the feasibility of their assessment and study of indicators of the severity of CIPD as additional markers of a negative prognosis of PH.

THE PULMONARY CIRCULATION PECULIARITIES IN YOUNG AND MIDDLE-AGED MEN WITH MYOCARDIAL INFARCTION AND RECURRENT EPISODES OF ISCHEMIA

2021 ◽  
pp. 60-65
Author(s):  
Gordienko A.V. ◽  
Epifanov S.Yu. ◽  
Nosovich D.V.
Keyword(s):  
Myocardial Infarction ◽  
Pulmonary Circulation ◽  
Comparative Assessment ◽  
Study Group ◽  
Type I ◽  
Pulmonary Resistance ◽  
The Third ◽  
Group I ◽  
Circulation Parameters ◽  
Ischemic Events

Relevance. The pulmonary hypertension (PH) and heart failure (HF) development during myocardial infarction (MI) in men with recurrent ischemic events (RIE) has not been adequately studied. Aim. To evaluate changes in pulmonary circulation parameters (PCP) in men under 60 years old (y.o.) in acute and subacute MI periods with RIS to improve understanding of PH and HF developmental options and to search for possible ways to improve prevention. Material and methods. The study included men aged 19-60 years old with type I of MI. Patients are divided into two age-comparable groups: I - the study group, with RIS - 110 patients; II - control, without it - 555 patients. A comparative assessment of PCP in the first 48 hours and the end of the subacute period of MI in these groups was performed. Results. In the first hours of MI the higher values of total pulmonary resistance (TPR) and mean pulmonary artery pressure (MPAP) were noted in the study group. When considering their dynamics at the end of the third MI week the MPAP decreased in both groups (I: by 8.7%; p˂0.0001; II: by 15.0%; p˂0.0001). TPR decreased in both groups (I: by 30.6%; II: by 29.6%; p˂0.0001) too. The heart rate - I: by 6.2%; p=0.03; II: 8.4%; p˂0.0001). At the end of the third MI week, MPAP remained elevated in the study group (I: 30.6 ± 12.7; II: 27.2 ± 7.7; p = 0.03).

THE CLINICAL COURSE OF MYOCARDIAL INFARCTION PECULIARITIES IN MEN UNDER 60 YEARS OLD WITH PULMONARY HYPERTENSION

2020 ◽  
pp. 64-68
Author(s):  
Gordienko A.V. ◽  
Men’shikova A.N. ◽  
Sotnikov A.V.
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Pulmonary Hypertension ◽  
Clinical Course ◽  
Comparative Assessment ◽  
Study Group ◽  
Routine Examination ◽  
Group Iii ◽  
Appropriate Treatment ◽  
Level Group

Relevance. Pulmonary hypertension (PH) negatively affects the prognosis of myocardial infarction (MI). Aim. To evaluate MI clinical features (CF) in men under 60 years old (y.o.) with PH, arising during MI to improve pre-vention and outcomes. Material and methods. The study included men 19-60 y.o. with MI and various dynamics of mean pulmonary artery pressure (MPAP), determined by echocardiography (A. Kitabatake) in first 48 hours (1) and completion of third week (2). Patients were divided into four groups: studied (I) included 67 patients (mean age 50.4±7.1 y.o) with PH (MPAP2 25 and more mm Hg) and normal of MPAP1 level. Group II included patients with a normal MPAP in both phases of study (70; 52.1±6.6 y.o); group III – with elevated MPAP at both study points (149; 51.2±5.5 y.o) and IV – with in-creased MPAP1 and normal MPAP2 (61, 50.5±6.8 y.o). A comparative assessment of the MI CF frequency in selected groups were performed. Results. The study group occupied intermediate place frequency in medical history presence: coronary heart disease (I: 59.5; II: 61.4; III: 63.6 and IV: 48.9%; p = 0.04), chronic heart failure (CHF) (35.7 ; 34.1; 51.1 and 24.5%, respec-tively; p=0.001), repeated (45.2; 42.0; 47.3 and 29.8%) and early recurrent (3.6; 3.4 ; 6.0 and 3.2%; pIII-IV=0.006) MI, Q-MI (44.0; 35.2; 58.7 and 56.4; p=0.001), anginal MI phenotype (75.0; 74.7; 54.3 and 77.7%; p˂0.0001) and acute HF (ACF) (45,2; 36,8; 50,5 и 48,9%; р=0,002). No pulmonary edema was detected in it (p˂0.0001). Conclusions. Men under 60 y.o. with PH resulting from MI occupy an intermediate place in frequency of complica-tions, ACF and CHF in first 56 days of MI during routine examination compared with other MPAP dynamics patients. This confirms the need for additional verification of PH genesis for the appropriate treatment.

scholarly journals Detection and Characterization of Prevotella Intermedia and Its In Vitro Susceptibility to Selected Antimicrobial Agents in Chronic Periodontitis and Acute Myocardial Infarction

2019 ◽  
Vol 3 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Deepa Anumala ◽  
Mohan Kumar Pasupuleti ◽  
Ravindra Reddy Nagireddy
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Chronic Periodontitis ◽  
Antimicrobial Agents ◽  
Prevotella Intermedia ◽  
Causative Role ◽  
In Vitro Susceptibility ◽  
Group Iii ◽  
Group I ◽  
Group Ii

Background: Periodontal disease has been reported to play a causative role in acute myocardial infarction (AMI), which may add to the various risk factors associated with coronary heart disease. The objective of the present study was to investigate the presence of Prevotella intermedia – an established periodontal pathogen – in subgingival plaque samples of chronic periodontitis and AMI patients in order to identify a possible association, and to evaluate the susceptibility of Prevotella intermedia to nine antimicrobial agents. Methods: After undergoing screening for eligibility, a total of 50 subjects were included in the present study. Twenty patients were diagnosed with AMI and generalized chronic periodontitis (Group I), 20 patients were diagnosed with only AMI (Group II), and 10 subjects were healthy controls (Group III). The isolated Prevotella intermedia strains were tested for susceptibility to bacitracin, chloramphenicol, penicillin G, polymyxin, gentamycin, neomycin, tetracycline, cefotaxime, and cefoxitin using an antibiotic zonescale to determine minimum inhibitory concentrations (MICs). Results: Periodontal pathogens were identified by phenotypic and enzymatic methods. The mean bacterial load of Prevotella intermedia species was higher in Group I compared to Group II and Group III. It was also found that pencillin G, gentamycin, neomycin, tetracycline, cefotaxime, and cefoxitin inhibited 90% of Prevotella intermedia, whereas bacitracin, chloramphenicol, and polymyxin inhibited 80% of Prevotella intermedia. Thus, only 10% of Prevotella intermedia were resistant to these antibiotics. Conclusion: The present study confirms that Prevotella intermedia is associated with chronic periodontitis and AMI.

scholarly journals Prediction of the Site of Coronary Artery Lesion in Acute Inferior Myocardial Infarction with Right Sided Precordial Lead (V4r)

1970 ◽  
Vol 4 (1) ◽  
pp. 46-52
Author(s):  
MS Alam ◽  
M Ullah ◽  
SU Ulabbi ◽  
MM Haque ◽  
R Uddin ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Wave Group ◽  
Precordial Lead ◽  
Inferior Myocardial Infarction ◽  
Group Iii ◽  
T Wave ◽  
Group I ◽  
St Segment ◽  
Group Ii ◽  
Acute Inferior Myocardial Infarction

Background: The patient with inferior wall AMI, site of culprit lesions is an important determinant of outcome. Patient with RV infarction have a poor prognosis whereas those with occlusion of LCX have a good prognosis. Early diagnosis and treatment substantially reduce cardiac events particularly in high-risk patients. V4R can be used as to locate the site of obstruction. Materials and methods: 81 patients with acute inferior myocardial infarction admitted to the coronary care unit (CCU) within 12 hours after the onset of chest pain who underwent coronary angiogram were included in the study. Standard 12-lead ECG with right precordial lead V4R was recorded. Patients were categorized into within 3 groups according to early changes of V4R-Group- I - ST-segment elevation > 1 mm and positive T- wave, Group-II- ST-segment iso-electric and positive T-wave, Group-III- ST-segment depression >1 mm and negative T -wave. Results: In group I patients, highest percentage of the patients had lesion in proximal RCA (97.2%); whereas in group II patients, highest percentage in the distal RCA (89.7%) followed by LCX (41.4%) and in group III patients, highest percentage also in LCX (100.0%) followed by LAD (56.3%). Based on analysis of sensitivity and specificity, it was revealed that in group I patients of ECG finding suggested 100.0% sensitivity, 97.8% specificity and 98.8% accuracy. In group II patients, 92.9% sensitivity, 94.3% specificity and 93.8% had accuracy. In case of group III patients, 93.8% sensitivity, 98.5% specificity and 97.5% accuracy. Conclusion: The configuration of the ST-T segment in lead V4R is a sensitive and specific tool to recognize the occluded vessel in acute inferior MI whether it is proximal RCA, distal RCA or LCX. Since it is an inexpensive method, it can be readily used to locate the site of occlusion in AMI - Inferior. Keywords: Coronary artery disease; Myocardial infarction;, Lead V4r. DOI: http://dx.doi.org/10.3329/cardio.v4i1.9389 Cardiovasc. J. 2011; 4(1): 46-52

Androgen secretion in women with threatened miscarriage

2020 ◽  
Vol 19 (5) ◽  
pp. 22-28
Author(s):  
М.М. Amiraslanova ◽  
◽  
I.V. Kuznetsova ◽  
E.P. Gitel ◽  
◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
First Trimester ◽  
Total Testosterone ◽  
Third Trimester ◽  
Group Iii ◽  
The Third ◽  
Threatened Miscarriage ◽  
Group I ◽  
Androgen Secretion ◽  
Group Ii

Objective. To assess androgen secretion and its possible effect on pregnancy in women with threatened miscarriage in the first trimester. Patients and methods. This prospective observational study included 120 pregnant women divided into four groups. Group I comprised 32 patients with threatened miscarriage and hyperandrogenism who received corticosteroids; Group II was composed of 28 patients with threatened miscarriage and hyperandrogenism who did not receive corticosteroids; Group III included 30 patients with threatened miscarriage and no hyperandrogenism; and Group IV comprised 30 women with normal pregnancy. Serum levels of dehydroepiandrosterone sulfate (DHEA-S), 17-hydroxyprogesterone (17-OHP), and total testosterone were measured on the following weeks of gestation: 5–8, 9–12, 13–18, 19–24, and 25–32. We also evaluated clinical outcomes of pregnancy. Results. We observed no significant differences in 17-ОНР and DHEA-S secretion between women from Group III and controls. Patients from Group II demonstrated higher hormone levels than controls; however, their dynamics of 17-ОНР and testosterone secretion was similar to that in women without hyperandrogenism, so their DHEA-S levels decreased and reached control values by the third trimester. Corticosteroids reduced 17-ONR secretion in the second and third trimesters and DHEA-S secretion in the third trimester. Women receiving corticosteroids demonstrated the poorest clinical pregnancy outcomes. Conclusion. Hyperandrogenism should be considered as one of the risk factors for poor pregnancy outcomes. Administration of corticosteroids to reduce androgen levels impairs normal dynamics of their secretion, does not improve pregnancy outcomes, and is potentially harmful; therefore, these drugs should not be used for such purposes. Key words: pregnancy, hyperandrogenism, corticosteroid therapy, pregnancy outcomes, pregnancy loss, androgen secretion, threatened miscarriage

scholarly journals THE INFLUENCE OF THE INTENSITY OF BREEDING OF HEIFERS OF UKRAINIAN BLACK-AND-WHITE DAIRY BREED IN DIFFERENT AGE PERIODS ON THE FUTURE DAIRY PRODUCTIVITY

2020 ◽  
Vol 59 ◽  
pp. 17-25
Author(s):  
S. F. Antonenko
Keyword(s):  
Live Weight ◽  
State Enterprise ◽  
Milk Productivity ◽  
Group Iii ◽  
Black And White ◽  
The Third ◽  
Group I ◽  
Animal Number ◽  
Group Ii ◽  
The Difference

The scientific experiment was carried out in two stages at State enterprise pilot farm “Hontarivka”, Vovchansk district, Kharkiv region. First stage. In a retrospective analysis of the rearing calf intensity from 3 to 6 months revealed that the highest live weight at 6-month age had animals of group III, .which is probably 47.0 kg or 34.6% and 23.0 kg or 14.4% (P < 0.001 in both comparison cases) outperformed peers I and II groups. A similar trend was observed in the analysis of live weight of heifers at 9 and 12-month age. Live weight at insemination in the higher growth group also had better rates of 4.0 and 3.7%, respectively, in animals of groups I and II (P < 0.001–0.05). It should be noted that the required live weight for insemination at heifers at growth rates of up to 500 g was reached in only 20.3 months, however, in the other two groups, the insemination age decreased by 1.5 and 1.7 months. Firstcalf heifers from group III also had the highest milk expectancy of 170.0 and 123.0 kg, or 3.1 and 2.3%, respectively, then animals in groups I and II. In the age period from 6 to 9 months it was found that at 9-month age heifers of group III had a higher live weight against animals of I and II groups respectively by 39.0 and 16.0 kg or 18.8 and 7.0% (P < 0.001 in both comparison cases). Intergroup differences by this indicator at 12-month age hiefers decreased to 35.0 and 8.0 kg, respectively, or 13.0 and 2.7% (P < 0.001 in both cases of comparison), which provided an advantage for the live weight of group III over I and II groups during the first fruitful insemination. Whereas the age of first fruitfull insemination, on the contrary, was lower at heifers of group III at 49 and 34 days than at groups I and II heifers. The highest milk productivity was also found at firstcalf heifers of group III at 634 kg or 12.3% (P < 0.001) and at 137 kg or 2.5% against animal I and II groups. The heifer live weight at the period from 9 to 12 months corresponded to the established differences at other age periods generally. And 12-month age calves of group III also significantly exceeded the analogues of group I by 38.0 kg or 14.0% (P < 0.001) and peers of group II – by 23.0 kg or 8.0% (P < 0.001). The live weight at fruitfull insemination of group III heifers was the largest and the difference compared with animals of group I was 21.0 kg or 5.3% (P < 0.01) and group II – 19.0 kg or 4.8% (P < 0.001). Group III animals also had the highest milk productivity, which is likely to be higher than group I peers by 751 kg or 14.5% (P < 0.001) and group II animals by 552 kg or 10.3% (P < 0.001). Second stage. It was found that during the experiment, live weight of free-stall keeping heifers were outnumbered by peers. In particular, the live weight of group I animals at the first month of the experiment was less by 8.0 kg or 2.9%, the second by 15.0 kg or 4.7% (P < 0.05) and the third by 19.0 kg or 5.4% against peers of group II. A similar pattern was observed in the estimation of intensive growth of these animals. However, at the end of the experiment, the heifers of the experimental group were 7.0 cm or 5.9% (P < 0.001) higher in the withers, 7.0 cm or 5.6% (P < 0.001) in the back, and the sacrum – 6.0 cm or 4.7% (P < 0.001). They showed deeper breasts by 3.0 cm or 4.9% (P < 0.01), larger breast widths – by 2.0 cm or 5.4% (P < 0.01), width in macaques – by 2.0 cm or 4.9% (P < 0.01), oblique torso length – 8.0 cm or 5.8% (P < 0.001), chest circumference 9.0 cm or 5.6% (P < 0.001) and girth – 1.0 cm or 6.1% (P < 0.01). It should be noted that from the second month of the research the animal number the free-stall keeping animal number, which ready for insemination, was more at 2.3 times or 5 goals than stall keeping heifers, and their live weight was more at 8 kg or 3.0%. With age, the differences between the groups gradually increased and by the third month reached 8 goals or 2.6 times and 19.0 kg or 5.7%.

scholarly journals THE PREVALENCE OF DENTOALVEOLAR ANOMALIES AND DEFORMITIES IN PATIENTS WITH DENTAL DEFECTS.

2018 ◽  
pp. 20-25
Author(s):  
B.M. Mirchuk ◽  
Y.V. Maksymov
Keyword(s):  
Age Groups ◽  
Group Iv ◽  
Adult Patients ◽  
Dental Anomalies ◽  
Group Iii ◽  
Functional Changes ◽  
The Third ◽  
Group I ◽  
Mandibular Position ◽  
Group Ii

As result of the presence of defects in the dentition, a range of morphological, aesthetic and functional changes arises, which considerably complicates the process of diagnosis and treatment of this pathology. Defects in the dentition, in combination with a variety of anomalies and deformations, often impede the implementation of rational prosthetics, and occasionally make it, impracticable at all one to this reason, one of the urgent problems in modern dentistry, which requires further, is the study of adverse factors that arise in the prosthetics of dental defects in adult patients with dentoalveolar anomalies and deformations of different etiologies. The aim is to investigate the prevalence of dental anomalies and deformities in adult patients’ prosthetic treatment. Materials and methods. 83 patients aged 20-60 and older were involved in prosthetic treatment. The diagnosis was based on classification have been of surveyed on Kennedy and D.A. Calveliss. Patients were divided into 4 age groups: Group I included 49 patients aged 20 to 30 years; Group II included 10 patients aged 31 to 40 years; Group III included 13 patients aged 41 to 50 years; IV group contained 11 patients aged 51 to 60 years and older. Results. In the 1st group, with coverage of 49 persons aged 20 to 30 years 12,5% of women suffered from defects of dentition which was under half the size of that of men (29,4%).All patients with dental defects needed prosthetic treatment. The prevailing majority of the surveyed-96,9% of females and 100% of males were diagnosed with dental anomalies. In group II, with 10 patients being examined in the 31-40 aged bracket, a significant increase in the number of persons with dental defects was observed: in women by 5.7 times up to 71,4% and in men-by 2.7 times up to 66,7% in comparing with those in Group I. Each of the examined patients with dental defects needed protection and orthodontic treatment. All patients in the third group (41-50 years) and the in IV group ( 51-60 years and older) of defects of dentitions were 50.0% women and 57.1% men of the third group and 71,4% of women and 75,0% of men of the IV group needed prosthetics of secondary dentition of teeth. Al l women of both subgroups have been diagnosed with dental anomalies, whereas in men. Orthodontic pathology was detected in 85,7% of individuals of group III and 75,0% of individuals group IV. Conclusions. Prosthetic treatment with restoration of the integrity of the dentition is one of the reasons for the significant growth of secondary deformations and the formation of dentoalveolar anomalies. According to our observations, patients 30 years of age or older who seek orthopedic help have defects in the dentition. Most often, these patients are diagnosed with included dentition defects in the lateral areas (from 35.3% to 63.6%), which are complicated by secondary deformations of the dentition (from 33.3% to 100%). The results of the studies confirm the need for further study of the state of the dentoalveolar system in patients with dentition defects, namely: the formation of secondary deformations, occlusion disorders, changes in the shape and size of the dentition, decrease in occlusion height, temporomandibular joint dysfunction, blockage or forced mandibular position etc.

TRANSIENT BONE LOSS OF DISTAL RADIUS AND ULNA FOLLOWING CLEAN-CUT TENDON INJURIES, REPAIR AND PASSIVE MOBILISATION

2007 ◽  
Vol 32 (3) ◽  
pp. 320-325 ◽  
Author(s):  
E. KEKILLI ◽  
K. ERTEM ◽  
C. YAGMUR ◽  
A. ATASEVER ◽  
N. ELMALI ◽  
...  
Keyword(s):  
Bone Loss ◽  
Distal Region ◽  
Tendon Injuries ◽  
Mineral Density ◽  
Group Iii ◽  
The Third ◽  
Group I ◽  
Forearm Bones ◽  
Group Ii ◽  
Early Passive

The aim of this study was to investigate whether there is any significant bone loss of the ulna and radius following acute tendon-artery-nerve clean-cut injuries at the wrist level which were repaired and rehabilitated by early passive mobilisation. Fifty-eight patients who underwent such operation were enrolled in this study. Patients in Group I ( n = 28) had primary tendon repairs alone, in Group II ( n = 15) primary tendon and nerve repairs and in Group III ( n = 15) primary tendon, nerve and artery repairs. Bone mineral density (BMD) measurements of the ulna and radius were obtained during the first week, the sixth week, the third month and the 12th month after operation. The results demonstrated that BMD decrease in the ulna was more common than in the radius. When compared with the first week BMD measurements, the highest reduction was seen in the sixth week in Group I and during the third month, when bone loss of both the radius and ulna was considerable in Group II. The bone loss in all groups and subgroups were found to have recovered at the 12th month measurements, except in the distal region of the ulna in Group I. This study suggests that passive immobilisation is deleterious in respect of demineralisation of the forearm bones.

Experience of using solutions for tumescent anesthesia with endovenous radiofrequency obliteration: a comparative study

2020 ◽  
Vol 21 (3) ◽  
pp. 59-64
Author(s):  
L. N. Komarova ◽  
◽  
Keyword(s):  
Comparative Study ◽  
Endocrine System ◽  
Venous Disease ◽  
Tumescent Anesthesia ◽  
Group Iii ◽  
The Third ◽  
Group I ◽  
Radiofrequency Obliteration ◽  
Group Ii ◽  
Descriptive Scale

The incidence of varicose disease of the lower extremities throughout the world remains at a fairly high level. Given its socio-economic significance, low-impact surgical treatment methods continue to improve, as well as methods of anesthesia for them. In most cases, the mixtures used for infiltration anesthesia during endovenous surgery include lidocaine and adrenaline. The active substance of adrenaline, epinephrine hydrochloride, has a direct stimulating effect on α- and β-adrenergic receptors, and can cause serious disturbances in the cardiovascular system. It is not recommended for patients with CVD and endocrine system pathologies. Aim. minimize pain when performing tumescent anesthesia during endovenous radiofrequency obliteration of veins. Material and Methods. A comparative study was performed in which 192 patients with clinical forms of chronic C2-C6 venous disease took part. All patients using the envelope method were divided into three groups: patients of the first group (I) planned to perform RFO and miniphlebectomy using Klein mixture for tumescent anesthesia, the pH of which was 6.6, lidocaine concentration 0.04%. Patients of the second group (II) planned anesthesia using a solution, the pH of which was 7.3, the concentration of lidocaine was 0.02%. In patients of the third group (III), a solution with a pH of 7.4 was used, the concentration of lidocaine was 0.08%. The level of pain during the administration of the anesthetic was evaluated using two scales – the verbal descriptive scale of pain assessment (VASOB) and the visual analogue scale (VAS). Results. Patient groups were comparable in age, sex, clinical form of the disease. When assessing pain on a verbal descriptive scale, 50% of patients (27) in group II noted a complete absence of pain during tumescent anesthesia, in group III – 54.5% (48). Very severe pain (8 points) was noted by 4 patients from Group I, who were anesthetized by administering a Klein mixture, which constituted 8%; unbearable pain (10 points) also noted two patients from this group (4%). According to YOUR, the average pain in the first group was 3.02 ± 1.07, in the second – 1.13 ± 0.23, in the third – 0.93 ± 0.27 (p = 0.05). Pronounced pain (more than 5 cm according to YOUR) was noted only in the first group in 12 patients (24%). Conclusion. None of the test solutions completely removed pain during tumescent paravasal anesthesia. But the use of a solution with a pH of 7.3-7.4 is less painful when administered and significantly reduces pain during tumescent anesthesia, which was used in patients of groups II and III.

Sign in / Sign up

Export Citation Format

Share Document