scholarly journals Tempo życia – tempo biografii. Wstęp do badań nad problematyką czasu w biografiach Brunona Schulza

2021 ◽  
pp. 36-53
Author(s):  
Katarzyna Warska
Keyword(s):  
Clock Time ◽  
Great Ability

A biographer has a great ability to operate with time. He/she lengthens or shortens parts of his/her story, which makes meanings and gives a hierarchy to events. A biographer’s actions have consequences because the time of the biography relates to the time of a character’s life: the clock time and time as it is experienced. One period that is traditionally abridged in a character’s life is childhood. By abridging it, a biographer may renege on a moral pact. The case of Bruno Schulz’s abridged childhood is of particular importance because of his work and declarations.

In silico Defining the Repeat-containing Proteins in the Acinetobacter baumannii Proteome, a Great Reservoir of Templates for Synthetic Biology

2019 ◽  
Vol 13 (2) ◽  
pp. 149-158
Author(s):  
Mohammad Reza Rahbar ◽  
Mahboubeh Zarei ◽  
Navid Nezafat ◽  
Manica Negahdaripour ◽  
Younes Ghasemi
Keyword(s):  
Acinetobacter Baumannii ◽  
Drug Targets ◽  
Closely Related Species ◽  
Great Ability ◽  
Repeat Proteins ◽  
Significant Difference ◽  
Biological Determinants ◽  
Tandem Repeat Proteins ◽  
Diagnostic Approaches ◽  
Novel Therapeutic

Background: Acinetobacter baumannii is an important nosocomial pathogen with great ability to resist antibiotics. Tandem repeat proteins, abundant in prokaryotic proteomes, attract attention due to their role in virulence and various biological processes. Defining repeat- containing proteins may pave the way to find novel therapeutic targets as well as vaccine candidate and give pieces of evidence of mechanisms of evolution and adaptation of organisms to various environmental conditions. Objective: In the present study, we employed bioinformatics tools to define repeatcontaining proteins within A. baumannii proteome for emphasizing the existence of natural sources for synthesizing novel therapeutic and diagnosis material. Results: We defined various kinds of repeat modules in a number of proteins and compared the abundance of these proteins in some closely related species. No significant difference was observed in the count of repeat-containing proteins in different species. But the existence of some important virulence factors is mentionable in our screening. Conclusion: Repeat containing proteins are important biological determinants of A. baumannii and are well worth researching for finding drug targets and vaccine candidates. These proteins can be served as a template for designing and synthesizing peptides for therapeutic and diagnostic approaches.

Impact of Sustainability Reporting on Firm Performance of Companies in India

2015 ◽  
Vol 4 (3) ◽  
Author(s):  
Priyanka Garg
Keyword(s):  
Environmental Sustainability ◽  
Rural Livelihoods ◽  
Sustainability Reporting ◽  
Annual Reports ◽  
Marginal Lands ◽  
Great Ability ◽  
Reporting Practices ◽  
Long Run ◽  
Short Run ◽  
Core Idea

The core idea of sustainability is that current decisions should not impair the prospects for maintaining or improving future living standards (Repetto, 1986). GRI (2006) defined sustainability as meeting the needs of the present without compromising the ability of future generations to meet their needs. The challenges of sustainable development are many and it is widely accepted that organizations have not only a responsibility but also a great ability to exert positive change on the state of the worlds economy, and environmental and social conditions. Further, the issue of environmental sustainability is intertwined with that of poverty and inequity. The causative relationship runs both ways- increased poverty and loss of rural livelihoods accelerates environmental degradation as displaced people put greater pressure on forests, fisheries, and marginal lands. The present study has made an attempt to investigate the relationship between sustainability reporting and financial performance of companies in India. Data have been collected with the help of annual reports of selected companies and Prowess Database. Collected data have been analyzed with the help of SPSS 16.0. The study shows that sustainability reporting practices of companies has improved over the time. Further, research reveals that sustainability reporting practices of a firm impact its performance negatively in short run while positively in long run.

scholarly journals The role of optical coherence tomography guidance in scaffold versus stent optimization

2020 ◽  
Vol 72 (1) ◽  
Author(s):  
Arif A. Al Nooryani ◽  
Nagwa A. Abdelrahman ◽  
Hatem A. Helmy ◽  
Yehia T. Kishk ◽  
Ayman K. M. Hassan
Keyword(s):  
Decision Making ◽  
Optical Coherence Tomography ◽  
Coronary Intervention ◽  
Drug Eluting Stents ◽  
Optical Coherence ◽  
Total Rate ◽  
Great Ability ◽  
Bioresorbable Scaffolds ◽  
Drug Eluting ◽  
The Impact

Abstract Background Optical coherence tomography showed a great ability to identify adverse features during percutaneous coronary intervention with drug-eluting stents and resulted in better clinical outcomes. The study aimed to assess the impact of optical coherence tomography on intraoperative decision-making during implantation of Absorb bioresorbable scaffolds versus everolimus drug-eluting stents. Results We performed an observational study that included 223 consecutive patients post optical coherence tomography-guided implantation of either Absorb bioresorbable scaffolds (162 patients) or everolimus drug-eluting stents (61 patients). We studied the influence of optical coherence tomography on intraoperative decision-making during implantation of bioresorbable scaffolds versus drug-eluting stents by analyzing the total rate of optical coherence tomography-dependent modifications in each device. After satisfactory angiographic results, the total rate of required intervention for optical coherence tomography detected complications was significantly higher in the bioresorbable scaffolds arm compared to drug-eluting stents arm (47.8% versus 32.9%, respectively; p = 0.019). The additional modifications encompassed further optimization in the case of device underexpansion or struts malapposition, and even stenting in the case of strut fractures, or significant edge dissection. Conclusions Compared to drug-eluting stents, Absord scaffold was associated with a significantly higher rate of optical coherence tomography-identified intraprocedural complications necessitating further modifications. The study provides some hints on the reasons of scaffolds failure in current PCI practice; it offers a new insight for the enhancement of BRS safety and presents and adds to the growing literature for successful BRS utilization.

scholarly journals Efficacy of the parasitoid, Trichogrammatoidea bactrae Nagaraja (Hymenoptera: Trichogrammatidae) on the cotton leafworm, Spodoptera littoralis (Boisd.) (Lepidoptera: Noctuidae) egg masses

2021 ◽  
Vol 31 (1) ◽  
Author(s):  
Hend O. Mohamed
Keyword(s):  
Spodoptera Littoralis ◽  
Insect Pests ◽  
Single Layer ◽  
Control Agent ◽  
Physical Characteristics ◽  
Great Ability ◽  
Egg Masses ◽  
Cotton Leafworm ◽  
Lepidoptera Noctuidae ◽  
Trichogrammatoidea Bactrae

Abstract Background The Egyptian cotton leafworm, Spodoptera littoralis (Boisd.) (Lepidoptera: Noctuidae) is one of the major insect pests, causing a significant damage on different cultivated agricultural crops. Developing an alternative non-chemical tool, an effective and environmentally friendly method to suppress pest's infestation is essentially needed. Therefore, biological control by releasing the egg parasitoids could be the most promising tool for integrated pest management. Results This study was designed to evaluate the efficacy of the egg parasitoid, Trichogrammatoidea bactrae Nagaraja (Hymenoptera: Trichogrammatidae) as a bio-control agent against S. littoralis egg masses with different physical characteristics (number of egg layer and degree of scale density) in a no-choice and choice tests, under laboratory conditions. Also, the parasitoids’ fitness in terms of parasitism percentage, developmental period, adults’ emergence percentage, female offspring percentage, and longevity were investigated. The results revealed that T. bactrae wasps had a great ability to parasitize S. littoralis egg masses, but with different rates, related to their layers and scales’ thickness in both tests. The highest parasitism percentage was observed on one-layer eggs, followed by two layers. However, 3-layer eggs were the least preferable one. High numbers of adult emergencies (> 80%) were observed in all tested egg masses, except in the case of 3 layers with high scales. Furthermore, female-biased sex ratios were noticed at all examined eggs, with only the exception of high-scaly eggs with a single layer that recorded the lowest rate (≤ 45%). Besides, the survival of adult female parasitoids was not significantly affected in both tests. Conclusions T. bactrae could be used as a bio-control agent against S. littoralis egg masses with different physical characteristics based on the achieved results.

scholarly journals Monoclonal antibodies and chimeric antigen receptor (CAR) T cells in the treatment of colorectal cancer

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ke-Tao Jin ◽  
Bo Chen ◽  
Yu-Yao Liu ◽  
H uan-Rong Lan ◽  
Jie-Ping Yan
Keyword(s):  
Colorectal Cancer ◽  
T Cells ◽  
Monoclonal Antibodies ◽  
Immune Responses ◽  
Chimeric Antigen Receptor ◽  
Antigen Receptor ◽  
Therapeutic Approaches ◽  
Great Ability ◽  
Car T Cells ◽  
Car T

AbstractColorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer deaths worldwide. Besides common therapeutic approaches, such as surgery, chemotherapy, and radiotherapy, novel therapeutic approaches, including immunotherapy, have been an advent in CRC treatment. The immunotherapy approaches try to elicit patients` immune responses against tumor cells to eradicate the tumor. Monoclonal antibodies (mAbs) and chimeric antigen receptor (CAR) T cells are two branches of cancer immunotherapy. MAbs demonstrate the great ability to completely recognize cancer cell-surface receptors and blockade proliferative or inhibitory pathways. On the other hand, T cell activation by genetically engineered CAR receptor via the TCR/CD3 and costimulatory domains can induce potent immune responses against specific tumor-associated antigens (TAAs). Both of these approaches have beneficial anti-tumor effects on CRC. Herein, we review the different mAbs against various pathways and their applications in clinical trials, the different types of CAR-T cells, various specific CAR-T cells against TAAs, and their clinical use in CRC treatment.

scholarly journals Comparison of Searching Behaviour of Three Evolutionary Algorithms Applied to Water Distribution System Design Optimization

Water ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 695 ◽  
Author(s):  
Weiwei Bi ◽  
Yihui Xu ◽  
Hongyu Wang
Keyword(s):  
Evolutionary Algorithms ◽  
Real Time ◽  
Distribution System ◽  
Optimization Design ◽  
Distribution Systems ◽  
Water Distribution ◽  
Optimal Solutions ◽  
Great Ability ◽  
Searching Behaviour ◽  
Run Time

Over the past few decades, various evolutionary algorithms (EAs) have been applied to the optimization design of water distribution systems (WDSs). An important research area is to compare the performance of these EAs, thereby offering guidance for the selection of the appropriate EAs for practical implementations. Such comparisons are mainly based on the final solution statistics and, hence, are unable to provide knowledge on how different EAs reach the final optimal solutions and why different EAs performed differently in identifying optimal solutions. To this end, this paper aims to compare the real-time searching behaviour of three widely used EAs, which are genetic algorithms (GAs), the differential evolution (DE) algorithm and the ant colony optimization (ACO). These three EAs are applied to five WDS benchmarking case studies with different scales and complexities, and a set of five metrics are used to measure their run-time searching quality and convergence properties. Results show that the run-time metrics can effectively reveal the underlying searching mechanisms associated with each EA, which significantly goes beyond the knowledge from the traditional end-of-run solution statistics. It is observed that the DE is able to identify better solutions if moderate and large computational budgets are allowed due to its great ability in maintaining the balance between the exploration and exploitation. However, if the computational resources are rather limited or the decision has to be made in a very short time (e.g., real-time WDS operation), the GA can be a good choice as it can always identify better solutions than the DE and ACO at the early searching stages. Based on the results, the ACO performs the worst for the five case study considered. The outcome of this study is the offer of guidance for the algorithm selection based on the available computation resources, as well as knowledge into the EA’s underlying searching behaviours.

Working Time on Mars

KronoScope ◽  
2009 ◽  
Vol 8 (2) ◽  
pp. 159-178 ◽  
Author(s):  
Zara Mirmalek
Keyword(s):  
Natural Phenomenon ◽  
Clock Time ◽  
Effective Work ◽  
Work Support ◽  
Organizational Infrastructure ◽  
Industrial Organizations ◽  
Time Work ◽  
Standard Clock ◽  
Temporal Rhythm ◽  
Post Industrial

AbstractThe constancy of clock time as an effective work support technology has made it almost impossible to imagine a modern organization where time, specifically standard clock time, is not a component of the organizational infrastructure. Demonstrating the degree to which clock time has become embedded within the organizational sphere are the ways in which clock time operates as though it were a natural phenomenon, rather than a human-built technology (Adam, 1990; Anderson, 1964; Bluedorn, 2002; de Grazia, 1964; Zerubavel, 1981). The naturalization of clock time within organizations is evidenced by the reified assumption technology of clock time is fixed and cannot be modified to support contextually based temporal rhythms of work. The opportunity to challenge particular notions about the relationship between time and work is found in the organization of NASA's Mars Exploration Rovers mission (MER). In addition to standard clock time, the MER mission employed an extra-terrestrial version of standard clock time, known as “Mars time,” to track the presence and absence of sunlight on Mars. Drawing on empirical data, I foreground the inadequacies of the time support technologies that led me to question the use of standard clock time as a way of ordering the experience of time on Mars. I argue that the naturalization of clock time within post-industrial organizations contributed to this occasion in which the scientific exploration of Mars was conducted according to an agrarian era temporal rhythm but for which work support was organized around an industrial era time/work relationship.

PSIX-5 Diet is more powerful than age in shaping the rumen bacterial community and function of dairy cattle

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 444-444
Author(s):  
YangYi Hao ◽  
Shuai Huang ◽  
Shengli Li
Keyword(s):  
Bacterial Community ◽  
Dairy Cattle ◽  
Rumen Fluid ◽  
Rumen Bacteria ◽  
Great Ability ◽  
Linear Discriminant ◽  
High Fiber ◽  
Fiber Diet ◽  
High Fiber Diet ◽  
And Function

Abstract The objective was to understand the effects of diet and age on the rumen bacterial community and function, 48 dairy cattle were selected. Rumen fluid samples were collected from each animal at 1.5 (1.5M, milk and starter diet, n=8), 6 (6M, starter and oat grass, n=8), 9 (9M, high fiber diet, n=8), 18 (18M, high fiber diet, n=8), 23 (23M, high fiber diet, n=8) and 27 (27M, high grain diet, n=8) months old. The acetate/propionate ratio (A/P) at M9, M18, and M23 were significantly higher than M27 and M1.5 (P < 0.05), while the A/P at M6 was lower than others (P < 0.05). The total volatile fatty acid at M23 and M27 was higher than others (P < 0.05). The urease at M18 was significantly lower than M1.5, M6, and M9 (P < 0.05), and the xylanase at M18 was significantly higher than M1.5, M23, and M27 (P < 0.05). 16S rRNA sequencing data and the Linear discriminant analysis showed that thirty-three bacteria were identified as biomarkers among ages and diets. The age and diet contributed 7.98% and 32.49% to the rumen bacteria community using the variation partitioning approach analysis. The norank_f_p-251-o5 was significantly and positively correlated with age (r = 0.83, P < 0.01), while Eubacterium was significantly and negatively correlated with age (r = -0.84, P < 0.01). Dietary fiber showed a strong correlation (r > 0.80, P < 0.01) with Lachnospiraceae, NK4A214_group, Saccharofermentans, Clostridia, Pseudobutyrivibrio Bacteroidales_UCG-001. These genera also negatively correlated with dietary crude protein and starch (r < - 0.80, P < 0.01). All these bacteria were significantly correlated with A/P, acetate, and urease (r > 0.5, P < 0.05). These findings collectively indicated that diet drives the great ability to shape the rumen bacteria community and function than age.

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