scholarly journals Personal Hygiene and the Risk of Leprosy: A Meta-Analysis from Case Control Study

2020 ◽  
Author(s):  
Priscilla Jessica Pihahey ◽  
◽  
Bhisma Murti ◽  
Yulia Lanti Retno Dewi ◽  
◽  
...  
Keyword(s):  
Odds Ratio ◽  
English Language ◽  
Case Control Study ◽  
Meta Analysis ◽  
Social Contact ◽  
Case Control ◽  
Personal Hygiene ◽  
Central Java ◽  
The Impact ◽  
Control Study

ABSTRACT Background: Leprosy is caused by Mycobacterium leprae (M. leprae) which is transmitted through nasal and oral fluids. The incubation period for M. leprae ranging from 3 years to 20 years. The impact of leprosy is a disability that reduces the quality of life. Social contact to patients can increase the risk of leprosy. This study aimed to determine the relationship between personal hygienic and the risk of leprosy. Subjects and Method: This was a meta-analysis and systematic review on the Leprosy determinants. This study was conducted by search published articles from PubMed, ProQuest, Science Direct, Scopus, Spinger Link, EBSCO, Google Scholar, Embase, LILACS, Embase, Emerald, PLOS, and Indonesian National Library (Perpusnas) electronic databases. “leprosy OR hansen desease AND risk factor AND Personal hygiene OR sanitation AND odds ratio” keywords were inserted to find related articles. The inclusion criteria were full text, open access article, published from 1949 to 2020, using Indonesian or English language, case control study, and reporting adjusted odds ratio (aOR). The articles were analyzed using PRISMA flow chart and Revman 5.3. Results: 4 articles were met the criteria. A sample of 297 cases and 297 controls was selected for this study. This study reported that poor personal hygiene increased the risk of Leprosy 3.52 times (aOR= 3.52; 95%CI= 2.30 to 5.40; p<0.001). Conclusion: Poor personal hygiene increases the risk of Leprosy. Keywords: personal hygiene, Leprosy, meta-analysis Correspondence: Priscilla Jessica Pihaheys. Masters Program in Public Health. Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: 08114852336. DOI: https://doi.org/10.26911/the7thicph.01.53

scholarly journals Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? A Case-Control Study and Meta-analytic Assessment

2021 ◽  
Vol 11 ◽  
Author(s):  
Bo Fan ◽  
Alradhi Mohammed ◽  
Yuanbin Huang ◽  
Hong Luo ◽  
Hongxian Zhang ◽  
...  
Keyword(s):  
Overall Survival ◽  
Bladder Cancer ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Female Patients ◽  
Kaplan Meier ◽  
History Of ◽  
The Impact ◽  
Control Study

Aspirin, widely used to prevent cardiovascular disease, had been linked to the incidence of bladder cancer (BCa). Existing studies focusing on Chinese populations are relatively rare, especially for Northeast China. Meanwhile, relevant studies on the effects of aspirin on the occurrence or prognosis of BCa are inconsistent or even controversial. First, in the case control study, logistic regression analysis was used to investigate the association between aspirin intake and risk of BCa including 1121 patients with BCa and the 2242 controls. Subsequently, Kaplan-Meier curve and Cox regression analyses were applied to explore the association between aspirin intake and clinicopathological factors which may predict overall survival (OS) and recurrence-free survival (RFS) of BCa patients. Finally, we quantificationally combined the results with those from the published literature evaluating aspirin intake and its effects on the occurrence, outcome of surgery and prognosis of BCa by meta-analysis up to May 1, 2021.Our case-control study demonstrated that the regular use of aspirin was not associated with a reduced incidence of BCa (P=0.175). Stratified analyses of sex showed that aspirin intake did not lead to a lower risk of BCa in female patients (P=0.063). However, the male population who regularly took aspirin had a lower incidence of BCa (OR=0.748, 95% CI= 0.584-0.958, P=0.021). Subgroup analyses stratified by smoking found a significant reduction in the risk of BCa in current smokers with aspirin intake (OR=0.522, 95% CI=0.342-0.797, P=0.002). In terms of prognosis of BCa, patients with a history of aspirin intake did not had a markedly longer OS or RFS than those with no history of aspirin intake by Kaplan-Meier curves. Stratified analysis by sex showed no correlation between aspirin intake and the recurrence or survival of BCa for either male or female patients. However, in people younger than 68, aspirin intake seemed to have prolonged effects for overall survival (HR=3.876; 95% CI=1.326-11.325, P=0.019). Then, we performed a meta-analysis and the combined results from 19 articles and our study involving more than 39524 BCa cases indicated that aspirin intake was not associated with the occurrence of BCa (P=0.671). Subgroup analysis by whether regular use of aspirin, by the mean duration of use of aspirin, by sex, by smoking exposure, by research region and by study type also supported the above results. In terms of the impact of aspirin intake on the prognosis of patients with BCa, 11 articles and our study involving 8825 BCa cases were eligible. The combined results showed that patients with aspirin intake did not have significantly influence on survival, recurrence, progression and metastasis than those without aspirin intake. On the whole, both our retrospective study and literature meta-analysis suggested a lack of a strong relevant association between the use of aspirin and the incidence or prognosis of BCa. Thus, additional long-term follow-up prospective research is warranted to clarify the association of aspirin with BCa incidence and prognosis.

scholarly journals The impact of Alzheimer's disease on the loss of dental elements. Systematic review with meta-analysis of case control study

2019 ◽  
Vol 10 ◽  
Author(s):  
Mario Dioguardi ◽  
Giovanni Di Gioia ◽  
Marco Mascitti ◽  
Andrea Santarelli ◽  
Maurizio Procaccini ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
The Impact ◽  
Control Study

scholarly journals The neutrophil to lymphocyte ratio is an independent predictor for severe COVID-19

2021 ◽  
Author(s):  
Jiangli Cheng ◽  
Aijia Ma ◽  
Jing Yang ◽  
Meiling Dong ◽  
Xuelian Liao ◽  
...  
Keyword(s):  
Odds Ratio ◽  
Case Control Study ◽  
Independent Predictor ◽  
Meta Analysis ◽  
Case Control ◽  
Neutrophil To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Severe Group ◽  
Meta Analyses ◽  
Control Study

Summary Purpose The aim of this study was to determine whether the neutrophil to lymphocyte ratio (NLR) can predict severe Coronavirus disease 2019 (COVID-19). Patients and methods A multicenter case-control study was conducted to investigate whether the NLR can help predict the severity of COVID-19. Patients confirmed to have COVID-19 between 16 January 2020 and 15 March 2020 were enrolled. Furthermore, meta-analyses were conducted based on both previous studies and our case-control study. Results In the case-control study, 213 patients (severe: 81) were included. The results suggested that the NLR was an independent risk factor (odds ratio [OR], 1.155, 95% confidence interval [95% CI]: 1.043–1.279, P = 0.006) and a great predictor (the area under the ROC curve was 0.728, 95% CI: 0.656–0.800) for severe COVID-19. In total, 18 datasets from 16 studies combined with our case-control study (severe: 1211; non-severe: 5838) were included in the meta-analyses and the results showed that the NLR of the severe COVID-19 group was significantly higher than that of the non-severe group (SMD = 1.10, 95% CI: 0.90–1.31, P < 0.001). Based on the 2 × 2 data from 6 studies, the SROC of NLR for predicting severe COVID-19 was 0.802, with a sensitivity of 0.67 (95% CI: 0.61–0.72) and a specificity of 0.75 (95% CI: 0.73–0.78). Conclusion Based on a multicenter case-control study and a meta-analysis, we found that the initial NLR was a great predictor of severe COVID-19.

scholarly journals A Canadian Multicentre Case-Control Study of SporadicEscherichia coli0157:H7 Infection

1999 ◽  
Vol 10 (2) ◽  
pp. 117-121 ◽  
Author(s):  
Donna Holton ◽  
Jeff Wilson ◽  
Andrea Ellis ◽  
David Haldane ◽  
Nicole April ◽  
...  
Keyword(s):  
Risk Factors ◽  
Odds Ratio ◽  
Case Control Study ◽  
Population Attributable Fraction ◽  
Ground Beef ◽  
Case Control ◽  
Attributable Fraction ◽  
Personal Hygiene ◽  
E Coli ◽  
Control Study

OBJECTIVE: To evaluate further risk factors forEscherichia coli0157:H7 infection including consumer preferences related to the consumption of ground beef and the role of person-to-person transmission of this infection.PATIENTS AND METHODS: A case-control study of sporadicE coli0157:H7 infection was undertaken in five Canadian cites from June to December 1991. One hundred cases ofE coli0157:H7 infection were age- and sex-matched to 200 neighbourhood controls. Cases and controls were interviewed face-to-face to obtain information on potential risk factors for infection and health outcomes. Daycare providers of case and control children were interviewed regarding risk factors for infection at the institutional level. Contacts of cases and controls who reported diarrhea in the seven days before the case onset date were also interviewed about their symptoms and risk factors.RESULTS: All cases had diarrhea during the course of their illness and 90 (90%) reported bloody diarrhea. Four (4%) were reported to have developed hemolytic uremic syndrome; however, there were no fatalities. Sixty-one (61%) of patients were hospitalized. Two variables were associated with infection in the final conditional logistic regression model: eating pink hamburger patties (odds ratio = 12.4, P=0.0001, population attributable fraction =40.2%) and contact with a nonhousehold member suffering from diarrhea (odds ratio = 7.0, P=0.0054, population attributable fraction = 10.3%) in the seven days before illness. Forty per cent of cases and controls who indicated that they prefer well done hamburgers said they would eat a ‘pink’ hamburger if served to them rather than ask that the hamburger be cooked longer.CONCLUSIONS: Health care workers should remain vigilant in their efforts to educate the public as to the risks associated with the consumption of ground beef that is inadequately cooked, and the importance of personal hygiene in the prevention of enteric illness.

Association of the UCP polymorphisms with susceptibility to obesity: case-control study and meta-analysis

2014 ◽  
Author(s):  
Bianca Souza ◽  
Leticia Brondani ◽  
Tais Assmann ◽  
Ana Paula Boucas ◽  
Andrea Carla Bauer ◽  
...  
Keyword(s):  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Control Study

Maternal-Fetal Management in Trombophilia Related and Placenta-Mediated Pregnancy Complications

2018 ◽  
Vol 69 (9) ◽  
pp. 2396-2401
Author(s):  
Costin Berceanu ◽  
Elena Loredana Ciurea ◽  
Monica Mihaela Cirstoiu ◽  
Sabina Berceanu ◽  
Anca Maria Ofiteru ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Pregnancy Complications ◽  
Case Control Study ◽  
Case Control ◽  
Placental Insufficiency ◽  
Management Options ◽  
Specific Therapy ◽  
Pregnancy Morbidity ◽  
The Impact ◽  
Control Study

It is widely accepted that thrombophilia in pregnancy greatly increases the risk of venous thromboembolism. Pregnancy complications arise, at least partly, from placental insufficiency. Any change in the functioning of the gestational transient biological system, such as inherited or acquired thrombophilia, might lead to placental insufficiency. In this research we included 64 pregnant women with trombophilia and 70 cases non-trombophilic pregnant women, with or without PMPC, over a two-year period. The purpose of this multicenter case-control study is to analyze the maternal-fetal management options in obstetric thrombophilia, the impact of this pathology on the placental structure and possible correlations with placenta-mediated pregnancy complications. Maternal-fetal management in obstetric thrombophilia means preconceptional or early diagnosis, prevention of pregnancy morbidity, specific therapy as quickly as possible and fetal systematic surveilance to identify the possible occurrence of placenta-mediated pregnancy complications.

scholarly journals A case–control study in France showing that a pro-inflammatory diet is associated with a higher risk of breast cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mariem Hajji-Louati ◽  
Emilie Cordina-Duverger ◽  
Nasser Laouali ◽  
Francesca-Romana Mancini ◽  
Pascal Guénel
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Odds Ratio ◽  
Hormone Receptors ◽  
Case Control Study ◽  
Breast Cancer Subtype ◽  
Case Control ◽  
Tumor Subtype ◽  
Control Study

AbstractDietary regimens promoting inflammatory conditions have been implicated in breast cancer development, but studies on the association between pro-inflammatory diet and breast cancer risk have reported inconsistent results. We investigated the association between the inflammatory potential of diet and breast cancer risk in a case–control study in France including 872 breast cancer cases and 966 population controls. All women completed a food frequency questionnaire that was used to compute a Dietary Inflammatory Index (DII) based on the inflammatory weight of 33 dietary components. The DII ranged from a median of − 3.22 in the lowest quartile (anti-inflammatory) to + 2.96 in the highest quartile (pro-inflammatory). The odds ratio contrasting quartile 4 to quartile 1 was 1.31 (95% CI 1.00, 1.73; p-trend = 0.02). Slightly higher odds ratios were observed in post-menopausal women, particularly those with body mass index > 25 kg/m2 (odds ratio 1.62; 95% CI 0.92, 2.83; p-trend = 0.02), and among ever smokers (odds ratio 1.71; 95% CI 1.11, 2.65; p-trend 0.01). The analyses by breast cancer subtype showed that the DII was associated with breast tumors that expressed either the estrogen (ER) or progesterone (PR) hormone receptors or the Human Epidermal Growth Factor Receptor-2 (HER2), but no association was seen for the triple negative breast tumor subtype. Our results add further evidence that a pro-inflammatory diet is associated with breast cancer risk with possible effect variation according to tumor subtype.

scholarly journals Plasma acylcarnitines and risk of lower-extremity functional impairment in older adults: a nested case–control study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Francisco Félix Caballero ◽  
Ellen A. Struijk ◽  
Alberto Lana ◽  
Antonio Buño ◽  
Fernando Rodríguez-Artalejo ◽  
...  
Keyword(s):  
Older Adults ◽  
Confidence Interval ◽  
Lower Extremity ◽  
Functional Impairment ◽  
Odds Ratio ◽  
Case Control Study ◽  
Case Control ◽  
Community Dwelling ◽  
Control Study ◽  
Long Chain

AbstractElevated concentrations of acylcarnitines have been associated with higher risk of obesity, type 2 diabetes and cardiovascular disease. The aim of the present study was to assess the association between L-carnitine and acylcarnitine profiles, and 2-year risk of incident lower-extremity functional impairment (LEFI). This case–control study is nested in the Seniors-ENRICA cohort of community-dwelling older adults, which included 43 incident cases of LEFI and 86 age- and sex- matched controls. LEFI was assessed with the Short Physical Performance Battery. Plasma L-carnitine and 28 acylcarnitine species were measured. After adjusting for potential confounders, medium-chain acylcarnitines levels were associated with 2-year incidence of LEFI [odds ratio per 1-SD increase: 1.69; 95% confidence interval: 1.08, 2.64; p = 0.02]. Similar results were observed for long-chain acylcarnitines [odds ratio per 1-SD increase: 1.70; 95% confidence interval: 1.03, 2.80; p = 0.04]. Stratified analyses showed a stronger association between medium- and long-chain acylcarnitines and incidence of LEFI among those with body mass index and energy intake below the median value. In conclusion, higher plasma concentrations of medium- and long-chain acylcarnitines were associated with higher risk of LEFI. Given the role of these molecules on mitochondrial transport of fatty acids, our results suggest that bioenergetics dysbalance contributes to LEFI.

scholarly journals Case–Control Study and Meta-Analysis of the Association Between LIPG rs9958947 SNP and Stroke Risk

2021 ◽  
Author(s):  
Kok Yeow Phneh ◽  
Eric Tzyy Jiann Chong ◽  
Syahiskandar Sybil Shah ◽  
Yuen Kang Chia ◽  
Dayang Maryama Bte Awang Daud ◽  
...  
Keyword(s):  
Stroke Risk ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Control Study
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