scholarly journals Healing effects of Ziziphus jujuba hydroalcoholic extract with exercise training on histopathological changes of male wistar rats testicular tissue in response to Boldenone steroid administration

2018 ◽  
Vol 6 (1) ◽  
pp. 12-21
Author(s):  
Behrooz Yahyaei ◽  
Mahnaz Nouri ◽  
Hamid Matmir ◽  
◽  
◽  
...  
Keyword(s):  
Exercise Training ◽  
Wistar Rats ◽  
Testicular Tissue ◽  
Histopathological Changes ◽  
Hydroalcoholic Extract ◽  
Steroid Administration ◽  
Male Wistar Rats ◽  
Ziziphus Jujuba

PARKINSONIA ACULEATA AS A POTENTIAL PHYTOTHERAPIC FACTOR IN THE INFLAMMATORY AND DYSLIPIDEMIC CONTROL OF WISTAR RATS

2021 ◽  
pp. 8
Author(s):  
◽  
◽  
◽  
Keyword(s):  
Inflammatory Cytokines ◽  
Wistar Rats ◽  
Serum Triglycerides ◽  
Hydroalcoholic Extract ◽  
Parkinsonia Aculeata ◽  
Commercial Diet ◽  
Aerial Parts ◽  
Westernized Diet ◽  
Male Wistar Rats ◽  
Pro Inflammatory Cytokines

Objective: The study evaluated the hypolipidemic and anti-inflammatory potential of the hydroalcoholic extract of P. Aculeata (HEPa/EtOAC) in Wistar rats fed with Westernized diet. Methods: The experiment was approved by the Ethics Committee (Federal University of Pernambuco-23076.027165 / 2010-21). The hydroalcoholic extract (HEPa/EtOAc) was obtained from the aerial parts of P. Aculeata and portioned by acetate/ethanol in different concentrations. 36 male Wistar rats were initially divided into two groups: Control (C, n = 6), fed a commercial diet (26g / 100g of protein; 63g / 100g of carbohydrates; 11g / 100g of lipids) and Westernized (W; n = 30) – fed an experimental diet (15g / 100g of protein; 51g / 100g of carbohydrates; 34 g/100g of lipids) receving water ad libitum. After 4 months of diet, W group was arbitrarily redistributed into six subgroups according to water supplementation, or different extracts concentrations: (n = 6 animals/group): W- distilled water (1mL/kg; po); WG – genfibrozil (140 mg/kg; p.o.); W35- 35 mg/kg; W70 – 70 mg /kg; p.o. and W140- 140 mg/kg; p.o for 30 days. The lipid profile and pro-inflammatory cytokines were analyzed. Results: The westernized diet caused dyslipidemia and the treatment with HEPa-EtOAc (140mg / kg), promoted a significant reduction in the concentration of pro-inflammatory cytokines, in total cholesterol, in the LDLc and serum triglycerides. Conclusion: The reduction of dyslipidemia and pro-inflammatory cytokines from the of P. Aculeata extract corroborate the ethnopharmacological potential of the plant, already used by the population for hypoglycemic purposes.

scholarly journals Antioxidant and Hepatoprotective Effect of Cajanus cajan in N-Nitrosodiethylamine-Induced Liver Damage

2019 ◽  
Vol 87 (3) ◽  
pp. 24 ◽  
Author(s):  
Emeka Eze Joshua Iweala ◽  
Winifred Osa Evbakhavbokun ◽  
Emmanuel Ndubisi Maduagwu
Keyword(s):  
Tobacco Smoke ◽  
Cajanus Cajan ◽  
Wistar Rats ◽  
Reduced Glutathione ◽  
Liver Weight ◽  
Treated Group ◽  
Hepatoprotective Effect ◽  
Histopathological Changes ◽  
Glutathione S Transferase ◽  
Male Wistar Rats

N-Nitrosodiethylamine (NDEA) is a nitrosamine derivative with carcinogenic and mutagenic properties which can be found in tobacco smoke, meat and various food products. This study examined the antioxidant and hepatoprotective potential of Cajanus cajan (C. cajan) with respect to hepatotoxicity in male Wistar rats. Administration of NDEA induced hepatotoxicity at 200 mg/kg while C. cajan was administered (200, 400 and 800 mg/kg) for 28 days. NDEA-induced hepatotoxicity significantly (p ≤ 0.05) increased alanine aminotransferase (ALT), aspartate aminotransferase (AST) and malondialdehyde (MDA) and significantly (p ≤ 0.05) decreased reduced glutathione (GSH), albumin (ALB), glutathione S-transferase (GST), catalase (CAT) and superoxide dismutase (SOD). C. cajan-treated groups were seen to have significantly (p ≤ 0.05) decreased ALT and AST and significantly (p < 0.05) increased ALB, GST, GSH, SOD and CAT. The NDEA-treated group also showed a marginal increase in body weight and a significant (p ≤ 0.05) increase in liver weight. The C. cajan treated groups showed a significant (p ≤ 0.05) increase and decrease respectively in body and liver weights. Histopathological changes also substantiated NDEA-induced hepatotoxicity and the hepatoprotective effect of C. cajan on the liver. The results indicate that C. cajan has the potential to ameliorate NDEA-induced hepatotoxicity.

scholarly journals Protective Effect of Terminalia arjuna Against DBTC Induced Pancreatic Cancer in Male Wistar Rats

2021 ◽  
pp. 248-256
Author(s):  
Kadiyala Harshitha ◽  
Uma Sankar Gorla
Keyword(s):  
Pancreatic Cancer ◽  
Body Weight ◽  
Protective Effect ◽  
Wistar Rats ◽  
Negative Control ◽  
Terminalia Arjuna ◽  
Hydroalcoholic Extract ◽  
Group I ◽  
Male Wistar Rats ◽  
Per Oral

Aims: To study the protective effect of hydroalcoholic bark extract of Terminalia arjuna against DBTC induced pancreatic cancer in male wistar rats. Study design: Healthy male Wistar Albino rats weighing 150-200 g were segregated into four groups (n=6). Group I was considered as normal control, received normal saline (0.9%w/v, 1 ml/kg body weight, orally). Group II rats were treated with DBTC (6 mg/kg body weight, i.p.) which served as negative control. Group III and IV received Terminalia arjuna Linn bark hydroalcoholic extract at doses of 250 mg/kg body weight, per oral and 500 mg/kg body weight, per oral respectively. Place and Duration of Study: University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India, between May 2020 and July 2020. Methodology: The experimental animals were segregated into four groups of six rats each. According to acute toxicity data, 250 mg/kg as low dose and 500 mg/kg as high dose of the test compound have been chosen for administration. All the drugs were given for 28 consecutive days to all the respective groups with standard pellet diet and water ad libitum. The assessment of serum parameters such as α-Amylase, Lipase and blood glucose levels were carried out on 1st day, 14th day and 28th day to the respective groups. Results: Pretreated groups of Terminalia arjuna Linn bark hydroalcoholic extract (250 mg/kg and 500 mg/kg body weight, orally) showed significant (‘#’p<0.001) decrease in the levels of α-Amylase, Lipase and glucose in the blood when compared to DBTC (6 mg/kg body weight, i.p.) induced group which served as negative control. Conclusion: This study suggests that Terminalia arjuna may have a protective role against DBTC induced pancreatic cancer in male wistar rats and further investigation may be required to confirm its therapeutic potentials clinically.

scholarly journals Effect of Continuous Exercise Training on Protein Levels of SIRT3 and OGG1 in the Liver Tissue of Male Wistar Rats

2019 ◽  
Vol 27 (5) ◽  
pp. 97-107
Author(s):  
Zufa Zanjirian ◽  
Mohammad Esmaeil Afzal pour ◽  
Hadi Sarir ◽  
Mohsen Mohammadnia Ahmadi ◽  
◽  
...  
Keyword(s):  
Exercise Training ◽  
Liver Tissue ◽  
Wistar Rats ◽  
Continuous Exercise ◽  
Protein Levels ◽  
Male Wistar Rats

scholarly journals Effect of Hydroalcoholic Extract ofCydonia oblongaMiller (Quince) on Sexual Behaviour of Wistar Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Muhammad Aslam ◽  
Ali Akbar Sial
Keyword(s):  
Body Weight ◽  
Single Dose ◽  
Sexual Behaviour ◽  
Wistar Rats ◽  
Sexually Active ◽  
Cydonia Oblonga ◽  
Hydroalcoholic Extract ◽  
Male Wistar Rats ◽  
Mating Performance ◽  
Remarkable Manner

Cydonia oblongaMiller (quince) is regarded as a potent libido invigorator in Tib-e-Nabvi and Unani System of Medicine. This study was carried out to evaluate the aphrodisiac activity of the hydroalcoholic extract of the fruits ofCydonia oblongaMiller (quince) in Wistar rats. The extract was administered orally by gavage in the dose of 500 mg/kg and 800 mg/kg body weight per day as a single dose for 28 days. The observed parameters were mounting frequency, assessment of mating performance, and orientation activities towards females, towards the environment, and towards self. The results showed that after administration of the extract mounting frequency and the mating performance of the rats increased highly significantlyP<0.01. The extract also influenced the behaviour of treated animals in comparison to nontreated rats in a remarkable manner, making them more attracted to females. These effects were observed in sexually active male Wistar rats.

scholarly journals Effects of Exercise Training Intensity on Plasma Levels of Creatinine Kinas After a Myocardial Infarction in Male Wistar Rats

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Abdolhamid Zokaei ◽  
Mehran Ghahramani
Keyword(s):  
Myocardial Infarction ◽  
Exercise Training ◽  
Plasma Levels ◽  
Wistar Rats ◽  
Interval Training ◽  
Cardiac Cells ◽  
Repeated Measure ◽  
Control Group ◽  
Male Wistar Rats ◽  
Intensity Of Exercise

Background: The creatine phosphokinase-MB (CPK-MB) isoenzyme level is useful in determining the myocardial infarction (MI) extent and time. Evidence indicates the possible effect of exercise training on reducing the amount of CPK-MB, but the proper intensity of exercise is still unclear. Objectives: In this study the effect of intensity of exercise training on creatinine kinas after a myocardial infarction in plasma levels of male Wistar rats was comparing. Methods: Thirty two male Wistar rats at 10 weeks of age were divided in to four groups [low (N = 8), moderate (N = 8), and high (N = 8) intensity interval training and a control (N = 8) group (no exercise)]. Six weeks later, rats became MI patients through surgery. CPK-MB plasma levels were investigated before training, immediately after training for six weeks as well as 12 hours after MI. The data were analyzed by ANOVA with repeated measure and Tukey (α ≥ 0.05). Results: The results showed that changes in CK enzyme at 12 hours after MI in LIIT (113.88 ± 19.25), MIIT (135.88 ± 35.58) and HIIT (105.75 ± 19.05) were statistically significant compared to the control group (124.62 ± 23.41) only in 12 hours after MI and this reduction in the low-intensity interval training group was significant than the other two groups (P = 0.0001). Conclusions: In this study, six weeks of interval training with each intensity was likely to make cardiac cells resistant to necrosis resulting in low levels of the CPK-MB enzyme compared to the control group after the myocardial infarction event.

scholarly journals Effect of Silymarin Supplementation in Lung and Liver Histological Modifications during Exercise Training in a Rodent Model

2021 ◽  
Vol 6 (3) ◽  
pp. 72
Author(s):  
Nancy Vargas-Mendoza ◽  
Marcelo Angeles-Valencia ◽  
Ángel Morales-González ◽  
Mauricio Morales-Martínez ◽  
Eduardo Madrigal-Bujaidar ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Exercise Training ◽  
Lipid Content ◽  
Wistar Rats ◽  
Muscle Size ◽  
Cell Recovery ◽  
Pulmonary Tissue ◽  
Histological Changes ◽  
Male Wistar Rats ◽  
Intrahepatic Lipid

Background: Exercise training induces adaptive physiological and morphological modifications in the entire organism; however, excessive loads of training may increase damage in tissues. The purpose of this study was to evaluate the effect of silymarin in lung and liver histological changes in rats subjected to exercise training (ET). Methods: Male Wistar rats were subjected to an 8-week ET treadmill program 5 days per week, 60 min/session, and were previously administered 100 mg ascorbic acid or 100 mg of silymarin. Results: Silymarin increased alveolar and bronchial muscle size, improve vascularization, and reduced tissue inflammation. In liver, silymarin promoted the reduction of lipid content. Conclusion: Silymarin supplementation may improve inflammation in pulmonary tissue after 8 weeks of the ET treadmill program, improve cell recovery, and reduce intrahepatic lipid content.

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