scholarly journals FEATURES OF CLINICAL AND LABORATORY PARAMETERS AND CLINICAL COURSE OF PSORIASIS IN PATIENTS WITH CONCOMITANT ALIMENTARY OBESITY

2021 ◽  
Vol 1 (1) ◽  
pp. 53
Author(s):  
Ya. O. Yemchenko ◽  
K. Ye. Ischeikin ◽  
I. P. Kaidashev
Keyword(s):  
Clinical Course ◽  
Laboratory Parameters ◽  
Alimentary Obesity

scholarly journals Can 2-Aticyto Complex be an Effective Agent for Recovery of The Symptoms and Enhancing Laboratory Parameters in COVID-19 Patients?

2021 ◽  
Vol 3 (2) ◽  
pp. 35-39
Author(s):  
Ferhan Kerget ◽  
Buğra Kerget ◽  
Alperen Aksakal ◽  
Abdullah Osman Koçak
Keyword(s):  
Clinical Symptoms ◽  
Clinical Course ◽  
Symptomatic Treatment ◽  
Clinical Situation ◽  
National Guideline ◽  
Control Group ◽  
Effective Agent ◽  
Laboratory Parameters ◽  
Taste And Smell ◽  
D Dimer

Background: SARS-CoV-2 (Covid-19) pandemic which was firstly identified in Wuhan/China in December 2019.There still exists no precise treatment for this pandemic yet despite many agents are tried in prophylaxis and treatment for Covid-19. In this study, we aimed to investigate the efficacy of 2-aticyto complex in clinical course in these patients. Materials and Methods: 150 patients who applied to the Infection Diseases Polyclinics between dates September 2020-November 2020 having diagnosed with Covid-19 were included in our study. The patients were randomized into 2 groups (75 in each group) of which the first group only had the treatment of National Guideline and the second group had Viruthol® including 2-aticyto complex (at the dose of 27000 mcg/day) in addition to the treatment of the National Guideline. The laboratory parameters, clinical outcomes and the first day on which PCR result turned into negative of the patients were compared. Results: In Viruthol® group, LDH, CRP, D-Dimer and ferritin levels were significantly decreased compared to the control group, while lymphocyte levels were higher. (p=0.02, p=0.001, p=0.01, p=0.02, p=0,001 respectively).  In addition to that, clinical symptoms such as fever, headache, weakness, loss of taste and smell and muscle-joint pain recovered more rapidly in contrast with the control group (p=0.001, p=0.05, p=0.001, p=0.001, p=0.001, respectively). PCR results of the Viruthol® group turned negative in a statistically significant shorter period of time with respect to the control group (p=0.001). Conclusion: Viruthol® containing 2-aticyto complex may be an agent that can be used both symptomatic treatment and improving the clinical situation and recovery of the patients followed up for Covid-19.

scholarly journals Efficacy of α-tocopherol administration in community-acquired pneumonia

2007 ◽  
pp. 99-102
Author(s):  
F. R. Farkhutdinov
Keyword(s):  
Reactive Oxygen Species ◽  
Whole Blood ◽  
Blood Concentration ◽  
Conventional Treatment ◽  
Clinical Course ◽  
Reactive Oxygen ◽  
Redox Status ◽  
Community Acquired Pneumonia ◽  
Oxygen Species ◽  
Laboratory Parameters

We studied effect of α tocopherol on clinical course and production of reactive oxygen species (ROS) in the whole blood in patients with community acquired pneumonia (CAP). The trial involved 70 patients with CAP. Generation of ROS was studied using the luminol dependent chemilumines cence (LDCL) method. Conventional treatment was given to all the patients. Besides this, 35 patients received α tocopherol. LDCL intensity of the blood was enhanced in all the patients. Treatment with α-tocopherol decreased ROS blood concentration and resulted in positive dynamics of clini cal and laboratory parameters. By contrast, patients on the conventional treatment maintained high LDCL intensity and there was slowly resolved course of inflammation in many cases. So, α tocopherol improved redox status in patients with CAP and increased efficiency of the treatment.

scholarly journals Clinical Picture and Risk Factors of Severe Respiratory Symptoms in COVID-19 in Children

Viruses ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2366
Author(s):  
Anna Mania ◽  
Kamil Faltin ◽  
Katarzyna Mazur-Melewska ◽  
Paweł Małecki ◽  
Katarzyna Jończyk-Potoczna ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care ◽  
Odds Ratio ◽  
Respiratory Symptoms ◽  
Oxygen Therapy ◽  
Clinical Course ◽  
Area Under The Curve ◽  
Clinical Findings ◽  
Laboratory Parameters ◽  
Tract Involvement

Children with COVID-19 develop moderate symptoms in most cases. Thus, a proportion of children requires hospital admission. The study aimed to assess the history, clinical and laboratory parameters in children with COVID-19 concerning the severity of respiratory symptoms. The study included 332 children (median age 57 months) with COVID-19. History data, clinical findings, laboratory parameters, treatment, and outcome, were evaluated. Children were compared in the groups that varied in the severity of symptoms of respiratory tract involvement. Children who required oxygen therapy represented 8.73%, and intensive care 1.5% of the whole cohort. Comorbidities were present in 126 patients (37.95%). Factors increasing the risk of oxygen therapy included comorbidities (odds ratio (OR) = 92.39; 95% confidence interval (95% CI) = (4.19; 2036.90); p < 0.00001), dyspnea (OR = 45.81; 95% CI (4.05; 518.21); p < 0.00001), auscultation abnormalities (OR = 34.33; 95% CI (2.59; 454.64); p < 0.00001). Lactate dehydrogenase (LDH) > 280 IU/L and creatinine kinase > 192 IU/L were parameters with a good area under the curve (0.804-LDH) and a positive predictive value (42.9%-CK). The clinical course of COVID-19 was mild to moderate in most patients. Children with comorbidities, dyspnea, or abnormalities on auscultation are at risk of oxygen therapy. Laboratory parameters potentially useful in patients evaluated for the severe course are LDH > 200 IU/L and CK > 192 IU/L.

scholarly journals The Expression of Serum Ferritin and Its Clinical Predictive Value in Patients With Hemorrhagic Fever With Renal Syndrome

2021 ◽  
Author(s):  
Haifeng Hu ◽  
Pingzhong Wang ◽  
Jianqi Lian ◽  
Xiaoyan Wang ◽  
Jing Li ◽  
...  
Keyword(s):  
Serum Ferritin ◽  
Clinical Course ◽  
Length Of Hospital Stay ◽  
Hemorrhagic Fever ◽  
Early Prediction ◽  
Severity Assessment ◽  
Healthy Controls ◽  
Natural Focus ◽  
Laboratory Parameters ◽  
Critical Type

Abstract As a natural focus disease characterized by systemic immunopathological injury, there is a considerable diversity and heterogeneity in clinical course and prognosis of the patients with hemorrhagic fever with renal syndrome (HFRS). Therefore, the importance of early prediction and prognostic evaluation of severe patients in reducing mortality is self-evident. In this study, we detected the expression of serum ferritin and investigated its role on disease severity assessment and prognosis prediction in HFRS patients. The levels of serum ferritin in acute phase were higher than that of healthy controls and in convalescent phase of the same type, and gradually increased with the aggravation of the disease, which showed highest expression in the critical-type patients. Serum ferritin demonstrated significant correlations with conventional laboratory parameters (WBC, PLT, AST, ALB, APTT, Fib) and the length of hospital stay. High levels of ferritin were significantly associated with the death of HFRS, with a hazard ratio of 4.12. Serum ferritin showed a comparable predictive efficacy for the prognosis (death) of HFRS with that of conventional laboratory parameters, which with the AUC of 0.860 (95%CI: 0.782 ~ 0.938, P < 0.001). These results indicated that the detection of serum ferritin might be beneficial to early prediction and prognosis evaluation in severe HFRS patients and which is worthy of clinical application.

Clinical course and laboratory parameters of the first Dobrava-Belgrade hantavirus infection imported to Germany

2008 ◽  
Vol 42 (1) ◽  
pp. 91-93 ◽  
Author(s):  
Jonas Schmidt-Chanasit ◽  
Helga Meisel ◽  
Jörg Hofmann ◽  
Andreas Rang ◽  
Evelyn Lambrecht ◽  
...  
Keyword(s):  
Clinical Course ◽  
Hantavirus Infection ◽  
Laboratory Parameters

scholarly journals Modern approaches to the treatment of postpartum purulent-septic diseases

2019 ◽  
pp. 58-69 ◽  
Author(s):  
N. Yu. Ivannikov ◽  
A. E. Mitichkin ◽  
V. I. Dimitrova ◽  
O. A. Slyusareva ◽  
S. A. Khlynova ◽  
...  
Keyword(s):  
Postoperative Complications ◽  
Antibiotic Therapy ◽  
Comparative Study ◽  
Anticoagulant Therapy ◽  
Clinical Picture ◽  
Clinical Course ◽  
Reproductive Function ◽  
Laboratory Parameters ◽  
Early Postoperative Complications ◽  
Prospective Comparative Study

The cohort prospective comparative study showed improvement of the management of patients with various forms of purulentseptic diseases (PSD). The study included 276 women with PSD admitted to the gynecological hospital from January 1, 2014 to December 31, 2016. The patients were divided into two cohorts depending on the clinical course, management, and outcomes, which corresponded to the clinical forms of PSD: uncomplicated and complicated. The parameters that were evaluated in patients in both groups included complaints, pregnancy course and childbirth, duration of manifestations of the disease, the clinical picture, laboratory parameters. The study resulted in the development of an algorithm for management of patients with PSD including lavage of the site of infection, adequate antibiotic therapy depending on the type of pathogen, infusion and anticoagulant therapy, and treatment of vaginitis. The developed algorithm for management of patients with various forms of postpartum PSD allowed all 276 (100%) participants to preserve reproductive function and avoid early postoperative complications.

scholarly journals Influence of microbiological diagnosis on the clinical course of spondylodiscitis

Infection ◽  
2021 ◽  
Author(s):  
Martin Stangenberg ◽  
Klaus Christian Mende ◽  
Malte Mohme ◽  
Theresa Krätzig ◽  
Lennart Viezens ◽  
...  
Keyword(s):  
Blood Culture ◽  
Species Differences ◽  
Clinical Course ◽  
Diagnostic Yield ◽  
Bacterial Species ◽  
Bacterial Pathogen ◽  
Length Of Hospital Stay ◽  
Bacterial Detection ◽  
Laboratory Parameters ◽  
Overall Mortality

Abstract Purpose This study sought to recognize differences in clinical disease manifestations of spondylodiscitis depending on the causative bacterial species. Methods We performed an evaluation of all spondylodiscitis cases in our clinic from 2013–2018. 211 patients were included, in whom a causative bacterial pathogen was identified in 80.6% (170/211). We collected the following data; disease complications, comorbidities, laboratory parameters, abscess occurrence, localization of the infection (cervical, thoracic, lumbar, disseminated), length of hospital stay and 30-day mortality rates depending on the causative bacterial species. Differences between bacterial detection in blood culture and intraoperative samples were also recorded. Results The detection rate of bacterial pathogens through intraoperative sampling was 66.3% and could be increased by the results of the blood cultures to a total of 80.6% (n = 170/211). S. aureus was the most frequently detected pathogen in blood culture and intraoperative specimens and and was isolated in a higher percentage cervically than in other locations of the spine. Bacteremic S. aureus infections were associated with an increased mortality (31.4% vs. overall mortality of 13.7%, p = 0.001), more frequently developing complications, such as shock, pneumonia, and myocardial infarction. Comorbidities, abscesses, length of stay, sex, and laboratory parameters all showed no differences depending on the bacterial species. Conclusion Blood culture significantly improved the diagnostic yield, thus underscoring the need for a structured diagnostic approach. MSSA spondylodiscitis was associated with increased mortality and a higher incidence of complications.

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