The Expression of Serum Ferritin and Its Clinical Predictive Value in Patients With Hemorrhagic Fever With Renal Syndrome

Abstract As a natural focus disease characterized by systemic immunopathological injury, there is a considerable diversity and heterogeneity in clinical course and prognosis of the patients with hemorrhagic fever with renal syndrome (HFRS). Therefore, the importance of early prediction and prognostic evaluation of severe patients in reducing mortality is self-evident. In this study, we detected the expression of serum ferritin and investigated its role on disease severity assessment and prognosis prediction in HFRS patients. The levels of serum ferritin in acute phase were higher than that of healthy controls and in convalescent phase of the same type, and gradually increased with the aggravation of the disease, which showed highest expression in the critical-type patients. Serum ferritin demonstrated significant correlations with conventional laboratory parameters (WBC, PLT, AST, ALB, APTT, Fib) and the length of hospital stay. High levels of ferritin were significantly associated with the death of HFRS, with a hazard ratio of 4.12. Serum ferritin showed a comparable predictive efficacy for the prognosis (death) of HFRS with that of conventional laboratory parameters, which with the AUC of 0.860 (95%CI: 0.782 ~ 0.938, P < 0.001). These results indicated that the detection of serum ferritin might be beneficial to early prediction and prognosis evaluation in severe HFRS patients and which is worthy of clinical application.

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Influence of microbiological diagnosis on the clinical course of spondylodiscitis

Infection ◽

10.1007/s15010-021-01642-5 ◽

2021 ◽

Author(s):

Martin Stangenberg ◽

Klaus Christian Mende ◽

Malte Mohme ◽

Theresa Krätzig ◽

Lennart Viezens ◽

...

Keyword(s):

Blood Culture ◽

Species Differences ◽

Clinical Course ◽

Diagnostic Yield ◽

Bacterial Species ◽

Bacterial Pathogen ◽

Length Of Hospital Stay ◽

Bacterial Detection ◽

Laboratory Parameters ◽

Overall Mortality

Abstract Purpose This study sought to recognize differences in clinical disease manifestations of spondylodiscitis depending on the causative bacterial species. Methods We performed an evaluation of all spondylodiscitis cases in our clinic from 2013–2018. 211 patients were included, in whom a causative bacterial pathogen was identified in 80.6% (170/211). We collected the following data; disease complications, comorbidities, laboratory parameters, abscess occurrence, localization of the infection (cervical, thoracic, lumbar, disseminated), length of hospital stay and 30-day mortality rates depending on the causative bacterial species. Differences between bacterial detection in blood culture and intraoperative samples were also recorded. Results The detection rate of bacterial pathogens through intraoperative sampling was 66.3% and could be increased by the results of the blood cultures to a total of 80.6% (n = 170/211). S. aureus was the most frequently detected pathogen in blood culture and intraoperative specimens and and was isolated in a higher percentage cervically than in other locations of the spine. Bacteremic S. aureus infections were associated with an increased mortality (31.4% vs. overall mortality of 13.7%, p = 0.001), more frequently developing complications, such as shock, pneumonia, and myocardial infarction. Comorbidities, abscesses, length of stay, sex, and laboratory parameters all showed no differences depending on the bacterial species. Conclusion Blood culture significantly improved the diagnostic yield, thus underscoring the need for a structured diagnostic approach. MSSA spondylodiscitis was associated with increased mortality and a higher incidence of complications.

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8806 Russian patients demonstrate T cell count as better marker of COVID-19 clinical course severity than SARS-CoV-2 viral load

Scientific Reports ◽

10.1038/s41598-021-88714-6 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Konstantin S. Sharov

Keyword(s):

Viral Load ◽

Comparative Analysis ◽

T Cell ◽

Cell Count ◽

T Lymphocyte ◽

Clinical Course ◽

Time Interval ◽

Early Prediction ◽

Disease Prognosis ◽

Respiratory Index

AbstractThe article presents a comparative analysis of SARS-CoV-2 viral load (VL), T lymphocyte count and respiratory index PaO2:FiO2 ratio as prospective markers of COVID-19 course severity and prognosis. 8806 patients and asymptomatic carriers were investigated in time interval 15 March–19 December 2020. T cell count demonstrated better applicability as a marker of aggravating COVID-19 clinical course and unfavourable disease prognosis than SARS-CoV-2 VL or PaO2:FiO2 ratio taken alone. Using T cell count in clinical practice may provide an opportunity of early prediction of deteriorating a patient’s state.

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Handwriting in Alzheimer’s Disease

Journal of Alzheimer s Disease ◽

10.3233/jad-210279 ◽

2021 ◽

pp. 1-9

Author(s):

Margarete Delazer ◽

Laura Zamarian ◽

Atbin Djamshidian

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Course ◽

Typical Feature ◽

Healthy Controls ◽

Spearman Correlation ◽

Writing Difficulties ◽

Motor Programs ◽

Processing Level ◽

Diagnostic Values

Background: Agraphia is a typical feature in the clinical course of Alzheimer’s disease (AD). Objective: Assess the differences between AD and normal aging as regards kinematographic features of handwriting and elucidate writing deficits in AD. Methods: The study included 23 patients with AD (78.09 years/SD = 7.12; MMSE 21.39/SD = 3.61) and 34 healthy controls (75.56 years/SD = 5.85; MMSE 29.06/SD = 0.78). Both groups performed alphabetical and non-alphabetical writing tasks. The kinematographic assessment included the average number of inversions per stroke (NIV; number of peaks in the velocity profile in a single up or down stroke), percentage of automated segments, frequency (average number of strokes per second), writing pressure, and writing velocity on paper. Results: A total of 14 patients showed overt writing difficulties reflected by omissions or substitutions of letters. AD patients showed less automated movements (as measured by NIV), lower writing velocity, and lower frequency of up-and-down strokes in non-alphabetical as well as in alphabetical writing. In the patient group, Spearman correlation analysis between overt writing performance and NIV was significant. That means patients who had less errors in writing a sentence showed a higher automaticity in handwriting. The correctness of alphabetical writing and some kinematographic measures in writing non-alphabetical material reached excellent diagnostic values in ROC analyses. There was no difference in the application of pressure on the pen between patients and controls. Conclusion: Writing disorders are multi-componential in AD and not strictly limited to one processing level. The slow and poorly automated execution of motor programs is not bound to alphabetical material.

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Can 2-Aticyto Complex be an Effective Agent for Recovery of The Symptoms and Enhancing Laboratory Parameters in COVID-19 Patients?

European Journal of Medical and Health Sciences ◽

10.24018/ejmed.2021.3.2.745 ◽

2021 ◽

Vol 3 (2) ◽

pp. 35-39

Author(s):

Ferhan Kerget ◽

Buğra Kerget ◽

Alperen Aksakal ◽

Abdullah Osman Koçak

Keyword(s):

Clinical Symptoms ◽

Clinical Course ◽

Symptomatic Treatment ◽

Clinical Situation ◽

National Guideline ◽

Control Group ◽

Effective Agent ◽

Laboratory Parameters ◽

Taste And Smell ◽

D Dimer

Background: SARS-CoV-2 (Covid-19) pandemic which was firstly identified in Wuhan/China in December 2019.There still exists no precise treatment for this pandemic yet despite many agents are tried in prophylaxis and treatment for Covid-19. In this study, we aimed to investigate the efficacy of 2-aticyto complex in clinical course in these patients. Materials and Methods: 150 patients who applied to the Infection Diseases Polyclinics between dates September 2020-November 2020 having diagnosed with Covid-19 were included in our study. The patients were randomized into 2 groups (75 in each group) of which the first group only had the treatment of National Guideline and the second group had Viruthol® including 2-aticyto complex (at the dose of 27000 mcg/day) in addition to the treatment of the National Guideline. The laboratory parameters, clinical outcomes and the first day on which PCR result turned into negative of the patients were compared. Results: In Viruthol® group, LDH, CRP, D-Dimer and ferritin levels were significantly decreased compared to the control group, while lymphocyte levels were higher. (p=0.02, p=0.001, p=0.01, p=0.02, p=0,001 respectively). In addition to that, clinical symptoms such as fever, headache, weakness, loss of taste and smell and muscle-joint pain recovered more rapidly in contrast with the control group (p=0.001, p=0.05, p=0.001, p=0.001, p=0.001, respectively). PCR results of the Viruthol® group turned negative in a statistically significant shorter period of time with respect to the control group (p=0.001). Conclusion: Viruthol® containing 2-aticyto complex may be an agent that can be used both symptomatic treatment and improving the clinical situation and recovery of the patients followed up for Covid-19.

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Efficacy of α-tocopherol administration in community-acquired pneumonia

Russian Pulmonology ◽

10.18093/0869-0189-2007-0-3-99-102 ◽

2007 ◽

pp. 99-102

Author(s):

F. R. Farkhutdinov

Keyword(s):

Reactive Oxygen Species ◽

Whole Blood ◽

Blood Concentration ◽

Conventional Treatment ◽

Clinical Course ◽

Reactive Oxygen ◽

Redox Status ◽

Community Acquired Pneumonia ◽

Oxygen Species ◽

Laboratory Parameters

We studied effect of α tocopherol on clinical course and production of reactive oxygen species (ROS) in the whole blood in patients with community acquired pneumonia (CAP). The trial involved 70 patients with CAP. Generation of ROS was studied using the luminol dependent chemilumines cence (LDCL) method. Conventional treatment was given to all the patients. Besides this, 35 patients received α tocopherol. LDCL intensity of the blood was enhanced in all the patients. Treatment with α-tocopherol decreased ROS blood concentration and resulted in positive dynamics of clini cal and laboratory parameters. By contrast, patients on the conventional treatment maintained high LDCL intensity and there was slowly resolved course of inflammation in many cases. So, α tocopherol improved redox status in patients with CAP and increased efficiency of the treatment.

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Abstract TP170: Persistently Elevated Factor VIII In Acute Ischemic Stroke Is Associated With Higher CRP, Lower Baseline NIHSS, And Longer Length Of Hospital Stay

Stroke ◽

10.1161/str.44.suppl_1.atp170 ◽

2013 ◽

Vol 44 (suppl_1) ◽

Author(s):

Adrianne M Dorsey ◽

Amelia K Boehme ◽

Laurie Schluter ◽

Karen C Albright ◽

Tiffany R Chang ◽

...

Keyword(s):

Ischemic Stroke ◽

Factor Viii ◽

Hospital Stay ◽

Acute Ischemic Stroke ◽

Acute Phase ◽

Clinical Course ◽

Length Of Hospital Stay ◽

Lower Baseline ◽

Persistent Elevation

Objective: We sought to determine the proportion of patients with elevated factor VIII (FVIII) levels whose FVIII levels remain elevated after the acute phase of stroke, and the patient characteristics that predict sustained elevation of FVIII levels. Background: Factor VIII plays a major role in the fluid phase of blood coagulation. Elevated FVIII has been shown to increase risk of venous and arterial thrombosis. The importance of screening for elevated FVIII after a first thrombotic event especially acute ischemic stroke (AIS) has not been adequately investigated. Design/Methods: We reviewed FVIII levels taken at baseline and follow-up in patients with AIS treated at our stroke center from July 2008 to June 2012. Elevated FVIII was defined as >150%. Baseline demographics, laboratory data, clinical course, outcomes, and time to follow-up were collected in patients with elevated FVIII at baseline and data was compared in patients who had normalized FVIII with patients whose FVIII remained elevated at least 7 days later. Results: Repeat FVIII levels were available for 34/111 patients with elevated FVIII level with AIS. FVIII remained elevated in 68% after a median interval of 110 days. Factors associated with persistent elevation included higher baseline FVIII level (239 vs 185%, p=0.015), elevated CRP (73.3 vs 12.5%, p=0.008), lower baseline NIHSS (4 vs 8, p=0.046), and longer length of hospital stay (8 vs. 3, p=0.0063). Normalization of FVIII was associated with tPA use (54.5% vs 13%, p=0.016). No relationship was found between persistently elevated FVIII and baseline demographics, clinical course and outcomes. Conclusion: Persistently elevated FVIII after AIS may be predicted by higher baseline levels and elevations in CRP. Despite worse baseline stroke severity, patient with normalization of FVIII had similar outcomes as those with persistent elevation, which may be explained by the higher use of tPA in the normalized group. The relevance of elevated FVIII in stroke is not well understood. Our preliminary results suggest elevations persist in the majority and may not merely represent an acute phase reactant.

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Adverse Drug Reaction (ADR) as a Cause of Hospitalization at a Government Hospital in Saudi Arabia: A Prospective Observational Study

Current Drug Safety ◽

10.2174/1574886314666190520105330 ◽

2019 ◽

Vol 14 (3) ◽

pp. 192-198 ◽

Cited By ~ 1

Author(s):

Nouf Alayed ◽

Bushra Alkhalifah ◽

Munirah Alharbi ◽

Naief Alwohaibi ◽

Maryam Farooqui

Keyword(s):

Saudi Arabia ◽

Observational Study ◽

Prospective Observational Study ◽

Hospital Admissions ◽

Financial Burden ◽

Length Of Hospital Stay ◽

Morbidity And Mortality ◽

Severity Assessment ◽

Hospitalization Rates ◽

Naranjo Algorithm

Background: ADRs represent a substantial burden on health care resources worldwide and are considered as one of the leading causes of morbidity and mortality which significantly affects hospitalization rates. However, ADR related hospital admissions are not well explored in Saudi Arabia. Objectives: The current study aims to evaluate ADR-related admissions at King Saud Hospital, Unaizah, Qassim, Saudi Arabia. Method: A prospective, observational study was conducted at King Saud Hospital Unaizah. Over a period of 6 months, patients above 12 years of age who visited the Emergency Department (ED) with an ADR were included in this study. The investigators collected patient data by reviewing the patient's medical records and the ED records for admission. The Naranjo algorithm was used to assess the causality of the suspected ADR, and Hartwig’s Severity Assessment Scale was used to assess the severity of the ADR. Results: Out of 4739 admissions to the wards, 38 (0.801%) were related to an ADR. The majority of patients were male (52.6%), with a mean age of ± 49.08 years. The total length of hospital stay was 565 days with a mean of ± 14.87 days. The causality assessment shows that 35 (92.1%) cases were probable ADRs, whereas 3 (7.9%) cases were possible ADRs. Moreover, the severity assessment showed that 6 (15.1%) cases were mild, and 27 (71.1%) and 5 (13.2%) cases were moderate and severe, respectively. In regard to the outcome of patients, most patients recovered after the ADR, and 2 ADRs resulted in the death of the patient. Conclusion: Our study shows that ADRs as a cause of hospitalization in Qassim population is considerably low. However, ADRs may contribute to morbidity and mortality and result in a considerable financial burden.

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Apoptosis and its relation with clinical course in patients with Crimean‐Congo hemorrhagic fever

Journal of Medical Virology ◽

10.1002/jmv.25467 ◽

2019 ◽

Vol 91 (8) ◽

pp. 1385-1393 ◽

Cited By ~ 1

Author(s):

Aynur Engin ◽

Huseyin Aydin ◽

Ziynet Cinar ◽

Seyit Ali Buyuktuna ◽

Mehmet Bakir

Keyword(s):

Clinical Course ◽

Hemorrhagic Fever ◽

Crimean Congo Hemorrhagic Fever

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High Levels of Serum Angiopoietin 2 and Angiopoietin 2/1 Ratio at the Critical Stage of Dengue Hemorrhagic Fever in Patients and Association with Clinical and Biochemical Parameters

Journal of Clinical Microbiology ◽

10.1128/jcm.00436-19 ◽

2020 ◽

Vol 58 (4) ◽

Cited By ~ 4

Author(s):

Maheshi Mapalagamage ◽

Shiroma M. Handunnetti ◽

Ananda Rajitha Wickremasinghe ◽

Gayani Premawansa ◽

Sharmila Thillainathan ◽

...

Keyword(s):

Dengue Hemorrhagic Fever ◽

Biochemical Parameters ◽

Hemorrhagic Fever ◽

Severe Dengue ◽

Healthy Controls ◽

Critical Stage ◽

Positive Correlations ◽

Angiopoietin 2 ◽

Disease Stages ◽

Angiopoietin 1

ABSTRACT Longitudinal changes of serum angiopoietin 1 (Ang-1) and angiopoietin 2 (Ang-2) associated with endothelial stability in dengue patients with different disease stages were studied. Serum Ang-1 and Ang-2 levels were measured in confirmed dengue fever (DF) patients on admission (DFA, n = 40) and discharge (DFD, n = 20); in dengue hemorrhagic fever (DHF) patients on admission (DHFA, n = 40), at critical stage (DHFC, n = 36), and on discharge (DHFD, n = 20); and in healthy controls (HC, n = 25). DHFC had the highest serum Ang-2 and lowest Ang-1 levels compared to DFA, DHFA, and HC (P < 0.050). The ratio of serum Ang-2/Ang-1 in DHFC was the highest among all study categories tested (P < 0.001). Significant positive correlations were observed between serum Ang-1 and platelet count in DHFA (Pearson r = 0.653, P < 0.001) and between Ang-1 and pulse pressure in DHFC (r = 0.636, P = 0.001). Using a cutoff value of 1.01 for the Ang-2/Ang-1 ratio for DHFC, a sensitivity of 83.2% and a specificity of 81.2% discerning DF from DHF were obtained. Therefore, serum Ang-2/Ang-1 could be used as a biomarker for endothelial dysfunction in severe dengue at the critical stage.

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Quantitative NS1 antigen and the severity of dengue virus infections

Paediatrica Indonesiana ◽

10.14238/pi55.2.2015.87-90 ◽

2015 ◽

Vol 55 (2) ◽

pp. 87

Author(s):

Ni Made Adi Purnami ◽

Mohammad Juffrie ◽

Made Gde Dwi Lingga Utama

Keyword(s):

Clinical Course ◽

Nonstructural Protein ◽

Dengue Infection ◽

Hemorrhagic Fever ◽

Cross Sectional Study ◽

Severe Dengue ◽

Virus Infections ◽

Cross Sectional ◽

Nonstructural Protein 1 ◽

Spearman Test

Background Dengue infection is one of the main cause ofmorbidity and mortality in children in Indonesia. Since it is knownthat earlier treatment and supportive therapies can decreased casefatality rate from dengue hemorrhagic fever (DHF), identificationof children who have risks to develop to DHF must be quicklyidentified, mainly in areas of endemic.Objective To find a correlation between increased quantitativesecreted nonstructural protein-1 (sNS1) with clinical course ofsevere dengue infections.Methods This was a cross-sectional study conducted on childrenwith dengue infections in Tropical Infections Division of ChildHealth Department, Sanglah Hospital, Denpasar. Detection ofthe dengue antigen was made by examining sNS1 quantitativeimmuno-assay. Analysis correlation of Spearman test was used tolook the relationship between increased quantitative sNS1 withclinical course of severe dengue infections.Results There was a positive relationship between quantitativesNS1 and clinical course of severe dengue infections with a valueof r = 0.903, P=0.001. Increased sNS1 level had a positivecorrelation with more severe dengue infections.Conclusions Quantitative sNS1 titer has a strong positivecorrelation with clinical course of severe dengue infections.

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