scholarly journals GJB2 GENE

2015 ◽  
Vol 22 (02) ◽  
pp. 149-152
Author(s):  
Sana Ullah ◽  
Khaista Rahman ◽  
Muhammad Tariq ◽  
Tauseef Ahmad

This article reviews the most prevalent sensory illness of mammals especiallyhumans – Genetic Deafness or hearing loss (HL). For genetic hearing loss more than 100candidate genes have been discovered. The most common candidate gene of these all that isfound all around the world is GJB2 gene. Different types of mutations are found in GJB2 gene.Some of these mutations are non-sense while some are sense mutations. This study is focus onmutation in GJB2 gene and its prevalence in different region of the world.

2020 ◽  
Vol 19 (4) ◽  
pp. 272-278
Author(s):  
Aleksandr V. Pashkov ◽  
Leyla S. Namazova-Baranova ◽  
Elena A. Vishneva ◽  
Irina V. Naumova ◽  
Irina V. Zelenkova

There are about 466 million people (6.1% of global population) with hearing impairment registered in the world according to the data from WHO experts. Their number exceeds 13 million in Russian Federation, and more than 1 million are children. The results of the universal audiological screening program for newborns has shown that 1 child per 1000 newborns is born deaf, another 2–3 children grow deaf during the first years of life. The number of people with hearing impairment will reach 900 million people by 2050 according to the WHO forecasts. Prevention and early diagnosis of hearing loss and rehabilitation of children with such disorders are necessary for avoiding problems with social integration. This review presents the analysis of cognitive abilities development in children and adolescents with different types and degrees of hearing loss with regard to different approaches in their management and rehabilitation.


Author(s):  
Y. Arockia Suganthi ◽  
Chitra K. ◽  
J. Magelin Mary

Dengue fever is a painful mosquito-borne infection caused by different types of virus in various localities of the world. There is no particular medicine or vaccine to treat person suffering from dengue fever. Dengue viruses are transmitted by the bite of female Aedes (Ae) mosquitoes. Dengue fever viruses are mainly transmitted by Aedes which can be active in tropical or subtropical climates. Aedes Aegypti is the key step to avoid infection transmission to save millions of people in all over the world. This paper provides a standard guideline in the planning of dengue prevention and control measures. At the same time gives the priorities including clinical management and hospitalized dengue patients have to address essentially.


2020 ◽  
pp. 50-64
Author(s):  
Anton Zhuravlev

The article presents an overview of factors that contribute to the development of sensorineural hearing loss, and approaches to solving this problem. Considering that we receive a significant part of information about the world through sound signals — and a healthy person is able to recognize over 400,000 different sounds —preservation and restoration of the patient’s hearing is of particular importance for maintaining social activity in modern, informational conditions of the society development.


Author(s):  
T. M. Robinson

This article argues the following five claims: 1. Plato’s description of the origins of cosmos in the Timaeus is not a myth, nor something unlikely: when he called it an eikos mythos or eikos logos, he meant a likely or trustworthy account on this very subject. 2. Among the details in this account, the following are prominent and surprising: a) the world was fashioned in time, in that precise point that was the beginning of time; b) several kinds of duration can be distinguished in cosmology (mainly eternity, sempiternity, perpetuity and time); and c) space is an entity characterized by movement and tension. 3. In the Statesman, Plato repeats much the same thing, adding this time the strange notion that the universe’s circular movement is periodically reversed. 4. In spite of the important differences in detail, there is a striking similarity between Plato’s account of the origins of the world and the explanation adopted by much of modern cosmology. 5. What Plato shares with so many instances of recent thought is here termed “cosmological imaginativity”. A first section of the paper deals exclusively with the Timaeus. Claims 1 and 2a are supported by a revision of the meanings of mythos and logos, followed by brief reference and discussion of the argument at Timaeus 27d, leading to the conclusion that Plato affirms that the ever-changing world has indeed had a beginning in time. Claim 2b describes five different types of duration, corresponding to Forms, the Demiurge, Space, the [empirical] world and its contents, physical objects. The second section is concerned with the myth in the Statesman, discussing it as a parallel and describing its peculiar turn to the Timaeus’ cosmology and cosmogony, a complex spheric and dynamic model. After digressing into some important ideas in modern cosmology, touching especially on affinities of some of Einstein’s ideas with of Plato’s own, the paper closes with a discussion of cosmological imaginativity, oriented to recover and recognize fully Plato’s greatness as a cosmologist.


The effective altruism movement consists of a growing global community of people who organize significant parts of their lives around two key ideas, represented in its name. Altruism: If we use a significant portion of the resources in our possession—whether money, time, or talents—with a view to helping others, we can improve the world considerably. Effectiveness: When we do put such resources to altruistic use, it is crucial to focus on how much good this or that intervention is reasonably expected to do per unit of resource expended (for example, per dollar donated). While global poverty is a widely used case study in introducing and motivating effective altruism, if the ultimate aim is to do the most good one can with the resources expended, it is far from obvious that global poverty alleviation is highest priority cause area. In addition to ranking possible poverty-alleviation interventions against one another, we can also try to rank interventions aimed at very different types of outcome against one another. This includes, for example, interventions focusing on animal welfare or future generations. The scale and organization of the effective altruism movement encourage careful dialogue on questions that have perhaps long been there, throwing them into new and sharper relief, and giving rise to previously unnoticed questions. In the present volume, the first of its kind, a group of internationally recognized philosophers, economists, and political theorists contribute in-depth explorations of issues that arise once one takes seriously the twin ideas of altruistic commitment and effectiveness.


2021 ◽  
pp. 193896552110335
Author(s):  
John W. O’Neill ◽  
Jihwan Yeon

In recent years, short-term rental platforms in the lodging sector, including Airbnb, VRBO, and HomeAway, have received extensive attention and emerged as potentially alternative suppliers of services traditionally provided by established commercial accommodation providers, that is, hotels. Short-term rentals have dramatically increased the available supply of rooms for visitors to multiple international destinations, potentially siphoning demand away from hotels to short-term rental businesses. In a competitive market, an increase in supply with constant demand would negatively influence incumbent service providers. In this article, we examine the substitution effects of short-term rental supply on hotel performance in different cities around the world. Specifically, we comprehensively investigate the substitution effects of short-term rental supply on hotel performance based on hotel class, location type, and region. Furthermore, we segment the short-term rental supply based on its types of accommodations, that is, shared rooms, private rooms, and entire homes, and both examine and quantify the differential effects of these types of short-term rentals on different types of hotels. This study offers a comprehensive analysis regarding the impact of multiple short-term rental platforms on hotel performance and offers both conceptual and practical insights regarding the nature and extent of the effects that were identified.


Forests ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 524
Author(s):  
Junhua Xu ◽  
Shuangbao Zhang ◽  
Guofang Wu ◽  
Yingchun Gong ◽  
Haiqing Ren

With the increasing popularity of cross-laminated timber (CLT) constructions around the world, there have been attempts to produce CLT using local wood species in different countries, such as Japanese larch (Larix kaempferi (Lamb.) Carr.) in China. Thus, the need to investigate the connection performance also increases to support the design and construction of CLT buildings using local wood species. In this study, the withdrawal properties of three different types of self-tapping screws (STS), with a diameter of 6 mm, 8 mm, and 11 mm, were tested with Japanese larch CLT. The results revealed that the withdrawal strength of STS increased with increasing density and effective length, but decreased with an increasing diameter. With a density increment of 0.05 g/cm3, the withdrawal strength increased by an average of 9.4%. With an effective length increment of 24 mm, the withdrawal strength increased by an average of 1.4%. An empirical regression model was adopted to predict the withdrawal strength of Japanese larch CLT based on the results, which can be used for potential engineering design of CLT connections using STS.


Author(s):  
Ling Qiu ◽  
Qujing Chen ◽  
Tian Gao

The world is facing the challenge of aging populations. Urban natural environments, including green spaces and blue spaces, have been demonstrated to have great benefits to the mental restoration of the elderly. However, the study of the specific characteristics of urban environments that are popular and the most restorative for the elderly is still lacking. Photo elicitation as visual stimuli was utilized to explore the differences in preference and psychological restoration of the elderly through the perception of the eight perceived sensory dimensions (PSDs) in different types of urban environments. The results showed that: (1) The respondents had different perceptions of the eight PSDs in the different urban natural environments. Blue space and partly-closed green space were more preferred by the elderly, and also had more psychological restorative effects on the elderly. (2) There was no significant correlation between the number of highly perceived PSDs and preference, as well as between the number of highly perceived PSDs and psychological restoration. However, there was a significant correlation between preference and psychological restoration. (3) Partly-closed green space with more Serene and Refuge qualities, and blue space with more Serene, Refuge and Prospect properties were optimal characteristics for psychological restoration of the elderly. In addition, open green space with more Prospect, Serene and Social qualities, and closed green space with more Space, Refuge and less Nature properties could also increase psychological restoration of older adults. These findings can provide useful guidelines for restorative environmental design for the elderly in the future.


Sign in / Sign up

Export Citation Format

Share Document