scholarly journals INTRAOCULAR PRESSURE

2016 ◽  
Vol 23 (03) ◽  
pp. 317-323
Author(s):  
Muhammad Shahid Faruqi Faruqi ◽  
Abdul Rehman Khokhar ◽  
Abdul Ghaffar Khan ◽  
Tanvir Ali Shirwany
Keyword(s):  
Intraocular Pressure ◽  
P Value ◽  
Intra Ocular Pressure ◽  
Applanation Tonometer ◽  
Healthy Control ◽  
Ocular Pressure ◽  
Study Methodology ◽  
Student’S T ◽  
Age And Sex ◽  
Student’S T Test

Objectives: To evaluate the intraocular pressure in diabeto-hypertensivesubjects and age and sex matched normal healthy adults. Study Design: Cross-sectionalanalytic study. Methodology: 50 subjects visiting the out-patient department (OPD) ofOphthalmology in Lahore General Hospital, Lahore, were examined. 25 were newly diagnoseddiabeto-hypertensive, and 25 normal healthy were selected from the relatives of these patients.IOP was checked by Goldman Applanation Tonometer. Blood pressure was checked bymercury sphygmomanometer. Blood glucose level checked by glucometer. Results: The IOPwas raised in both eyes of diabeto-hypertensive patients and there was a significant differencein intraocular pressure of normal healthy control and diabeto-hypertensive subjects. Thedifferences between two groups was analyzed by paired Student’s t-test. The P-value was<0.001. Conclusion: Intra-ocular pressure can be raised in all diabeto-hypertensive subjects,which shows that co-existence of diabetes and hypertension were important risk factor forraised intraocular pressure.

Early Post-Operative Effect of Phacoemulsification on Anterior Chamber Depth and Intraocular Pressure in Patients with Cataract

2021 ◽  
Vol 37 (2) ◽  
Author(s):  
Mashal Tayyab ◽  
Awaid Abid
Keyword(s):  
Intraocular Pressure ◽  
Anterior Chamber ◽  
Anterior Chamber Depth ◽  
Pressure Change ◽  
P Value ◽  
Iol Implantation ◽  
Intra Ocular Pressure ◽  
Significant Difference ◽  
Ocular Pressure ◽  
The Mean

Purpose:  To determine the Anterior Chamber depth and Intraocular pressure change following uncomplicated phacoemulsification. Study Design:  Quasi experimental study. Place and Duration of Study:  Layyton Rehmatullah Benevolent Trust Free Eye and Cancer Hospital, Lahore from 16/12/2017 to 15/06/2018. Methods:  One hundred and thirty nine patients who came to Layyton Rehmatullah Benevolent Trust Free Eye for phacoemulsification and IOL implantation were included in the study. Anterior Chamber depth was measured with IOL Master and intraocular pressure was determined using Goldmann Applanation Tonometer one day before and one month after surgery. Data was recorded on a self-designed proforma. Comparison between pre- and post-operative data with respect to change was analyzed by chi-square test. P-value ≤ 0.05 was considered significant. Results:  The mean intra-ocular pressure dropped from 14.36 ± 4.19 mmHg to 12.14 ± 4.26 mmHg 1 month after surgery with a mean drop of 2.21 ± 0.65 mmHg while the mean anterior chamber depth increased from 2.31 ± 0.08 mm to 3.59 ± 0.37 mm with a mean increase of 1.29 ± 0.36 mm. There was no statistically significant difference in the mean change of intra-ocular pressure and anterior chamber depth across various subgroups based on patient’s age, gender and duration of cataract. Conclusion:  Phacoemulsification and IOL implantation not only improves the visual acuity by removing the cataract but also deepens the anterior chamber and decreases intra-ocular pressure, which can have a beneficial effect in glaucoma patients. Key Words:  Phacoemulsification, Cataract, Intraocular pressure, Lens, Anterior chamber depth.

scholarly journals INTRA OCULAR PRESSURE

2018 ◽  
Vol 25 (12) ◽  
pp. 1833-1839
Author(s):  
Arsalan Ahmed Rajput ◽  
Azfar Ahmed Mirza ◽  
Ghazi Khan Maree ◽  
Adil Ali Shaikh
Keyword(s):  
Intraocular Pressure ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
P Value ◽  
Strong Positive Correlation ◽  
Positive Correlation ◽  
Intra Ocular Pressure ◽  
Department Of Ophthalmology ◽  
Ocular Pressure ◽  
The Mean

Introduction: The ideal optical properties of the eye requires support of state of the eye-ball which is normally regulated by the intraocular pressure (IOP). There is variation in the measurements of IOP with Goldmann applanation tonometry if the thickness of the central cornea is not uniform, the IOP is high when cornea is thicker and vice versa. Therefore, the central corneal thickness (CCT) is thought to affect the IOP readings, however, as shown, the evidence available remains controversial. The aim of the study was to determine correlation between CCT and IOP. Objectives: To determine the correlation between the Central Corneal Thickness (CCT) and Intra Ocular Pressure (IOP). Study Design: A cross-sectional study. Placeand Duration: Department of Ophthalmology, Aga Khan University Hospital, Karachi from July to December, 2014. Methodology: During the study period of six months total 431 participants were purposively sampled according to the set criteria. Variables included were age, gender, CCT, and IOP. Correlation between IOP and CCT was assessed by using Pearson correlation test, P value of < 0.05 was considered significant. Results: Out of 431 participants, 239 (55.5%) males and 192 (44.5%) females. The mean age was 34.9 ranging from 20 to 50 years. The mean central corneal thickness of right eye was 529 μm with SD ± 39.5 and range of 473-591 μm. The mean intraocular pressure of right eye was 14.7 μm, SD ± 3.1 with a range of 9-21 mmHg. The left eye mean central corneal thickness was 533, SD ± 29.6 with range of 481-589 μm. The mean intraocular pressure of left eye was 15.6, SD ± 3.1 with a range of 10-21 mmHg. Strong positive correlation was found (P-value < 0.001) between central corneal thickness andintra ocular pressure for both eyes. Conclusion: There is positive correlation between CCT and IOP. Therefore, along with the routine ophthalmic examination for intraocular pressure measurements pachymetry should also be considered for accurate interpretation of the results.

scholarly journals Mean Change in Intra-Ocular Pressure in patients undergoing Trabeculectomy with Mitomycin C

2021 ◽  
Vol 15 (5) ◽  
pp. 1044-1046
Author(s):  
Munib Ur Rehman ◽  
Shahid Mahmood Dayal ◽  
Ali Zain Ul Abidin
Keyword(s):  
Intraocular Pressure ◽  
Mitomycin C ◽  
Congenital Glaucoma ◽  
P Value ◽  
Cross Sectional ◽  
Primary Congenital Glaucoma ◽  
Intra Ocular Pressure ◽  
Department Of Ophthalmology ◽  
Significant Difference ◽  
Ocular Pressure

Aim: To examine the outcomes of trabeculectomy followed by mitomycin C in term of mean change in intra-ocular pressure in patients presented with primary congenital glaucoma. Study design: Cross-sectional/observational Place and duration of study: Department of Ophthalmology, Khawaja Muhammad Safdar Medical College, Allama Iqbal Memorial Teaching Hospital, Sialkot from 7th July 2020 to 6thJanuary 2021. Methods: Fortypatients of both genders with ages up to 5 years presented with primary congenital glaucoma were enrolled in this study. Patients demographics were recorded after taking written consent from parents/guardians. All the patients were receivedtrabeculectomy with 0.4mg/ml Mitomycin C was applied below the flap for 2 to 3 minutes. Intraocular pressure was examined preoperatively and at 12th day after surgery. Results:Twenty-four (60%) were males while 16 (40%) were females. 30 (75%) patients were ages <2yearsand 10 (25%) patients had ages >2 years. A significant difference was observed regarding mean change in intra-ocular pressure (pre-operatively 30.48±3.62 versus post-operatively 16.35±2.86) with p-value <0.001. Conclusion: Trabeculectomy with Mitomycin C is very effective for reducing intraocular pressure. A significant decrease in intra-ocular pressure was observed post-operatively. Keywords: Primary congenital glaucoma, Intra-ocular pressure, Trabeculectomy, Mitomycin C

scholarly journals Effect of ondansetron on spinal induced hypotension in caesarean deliveries

2020 ◽  
Vol 8 (4) ◽  
pp. 193-199
Author(s):  
Pujan Balla ◽  
Anil Shrestha ◽  
Ninadini Shrestha ◽  
Navindra Bista ◽  
Moda Nath Marhatta
Keyword(s):  
Spinal Anesthesia ◽  
Elective Caesarean Section ◽  
P Value ◽  
Chi Square ◽  
Induced Hypotension ◽  
Intergroup Comparison ◽  
Chi Square Test ◽  
The Mean ◽  
Student’S T ◽  
Student’S T Test

Background: Spinal anesthesia is the preferred technique of anesthesia employed for caesarean sections. However, it is very often complicated by hypotension. Different drugs and techniques have been used to prevent the hypotension induced by spinal anesthesia. In this study, the effect of ondansetron on the prevention of hypotension after spinal anesthesia was evaluated. Objectives: To determine the effect of prophylactic ondansetron on prevention of spinal induced hypotension in elective caesarean section. Methodology: Eighty-six parturients planned for elective caesarean deliveries were randomized into two groups of 43 each. Group O received Ondansetron 4 mg (4 ml) and Group S received Normal Saline (4 ml) intravenously 10 minutes prior to spinal anesthesia. Blood pressure, heart rate, phenylephrine requirements, occurrence of nausea and vomiting and APGAR scores of neonates were compared between the groups. Hemodynamic data was analyzed using Student’s t-test for intergroup comparison and ANOVA was used for intragroup comparison. Categorical data was analyzed using Pearson Chi-Square test. For all determinants, p-value <0.05 was considered significant. Results: Occurrence of hypotension in Group O (20.9 %) was significantly lower than in Group S (72.1%) (p < 0.05). The mean arterial pressure was significantly higher in Group O at 2, 6, 8, 12 and 14 minutes (p < 0.05). The use of phenylephrine (37.21 mcg vs. 146.51 mcg, p < 0.05) and occurrence of nausea (11.6%, vs. 41.9% p < 0.002) was significantly lower in ondansetron group. Conclusion: Ondansetron is effective in preventing spinal induced hypotension in elective caesarean sections.

scholarly journals CLINICAL BIOCHEMISTRY DATABASE ANALYSIS: A RESTRICTED DIALYSIS COHORT /

2013 ◽  
Vol 33 (2) ◽  
pp. 162-168
Author(s):  
Martina Bellini ◽  
Paolo Paparella
Keyword(s):  
Retrospective Study ◽  
Clinical Biochemistry ◽  
Clinical Chemistry ◽  
P Value ◽  
Dialysis Patients ◽  
Database Analysis ◽  
Iron Storage ◽  
Inflammatory Profile ◽  
Student’S T ◽  
Student’S T Test

Summary Background: A retrospective study was undertaken to inves- tigate the biochemistry data of a restricted cohort of dialysis- related arthropathy patients. The aim of our study was to characterize this specific cohort of dialysis patients using a clinical chemistry database analysis. Methods: An elaboration of more than 160,000 items of biochemical data, collected from 2001 to 20|11, was made of 50 patients, 25 with dialysis-related arthropathy and 25 patients asymptomatic for arthropathy. A Student's t-test was applied, considering a P-value less than 0.05 as statistically significant. Results: Significant and relevant unexpected biochemical dif- ferences were found between the two groups of patients. The serum level of p2-microglobulin was similar, while fer- ritin values were significantly higher in symptomatic patients. We excluded the possibility that the ferritin difference between the two groups was due to different iron storage and to an inflammatory profile. Conclusions: The correct use of a biochemical database could permit to identify significant values which must be cor- related with clinical data, but which could be the first step to a wider research.

CD34+ Selection before Autologous Peripheral Blood Stem Cell Transplantation: Comparison of the Nexell Isolex 300i® and Miltenyi Biotec CliniMACS® Systems.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 1070-1070
Author(s):  
Simon Mantha ◽  
David G. Savage ◽  
Gwen L. Nichols ◽  
Donna Skerrett ◽  
Charles S. Hesdorffer
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Stem Cell ◽  
Peripheral Blood ◽  
Plasma Cell Dyscrasia ◽  
P Value ◽  
Student’S T ◽  
Cd34 Selection ◽  
Number Of Cells ◽  
Student’S T Test

Abstract Autologous stem cell transplant has been used with variable success rates in the treatment of different malignancies. One of the potential causes of relapse is contamination of the stem cell collection by neoplastic cells. Purging the stem cells by CD34+ selection has been used to reduce such contamination. In this study two different devices were compared in their efficiency to achieve CD34+ selection of peripheral blood stem cells collected in individuals undergoing autologous transplant for breast cancer, neuroblastoma, plasma cell dyscrasia, lymphoma (both Hodgkin and non Hodgkin), rhabdomyosarcoma and amyloidosis. A total of 28 patients were randomized to CD34 selection on the Nexell Isolex 300i® system (NIS) or the Miltenyi Biotec CliniMACS® (MCMS) system. The prevalence of plasma cell dyscrasia was higher in the MCMS group (57%) than in the NIS group (22%). On the other hand, there were 2 cases of Hodgkin lymphoma and 2 cases of breast cancer in the NIS group, in comparison to none in the MCMS group. Average values for parameters of selection efficacy for the 19 patients transplanted are shown in table 1 (recovery = number of cells post / number of cells pre-selection X 100, viability measured with the trypan blue exclusion test). Transplant was done as per local protocols according to the type of malignancy. CD34+ cell dose was determined by institutional guidelines. Average values for engraftment are shown in table 2 (two patients who died before engraftment in the MCMS group were excluded from calculation of the mean values). One patient died of graft failure in the MCMS group in contrast to none in the NIS group. Although the numbers of patients are relatively low, this is the first randomized study in which the selection efficiency of the NIS and MCMS devices have been compared in patients receiving CD34-selected autografts. CFU-GM recovery and cell viability were lower, while neutrophil engraftment was slower in the MCMS group, but these differences were not statistically significant. Our data do not show any clinically significant advantage for either the NIS or MCMS selection device. Table 1 Device CD34+ recovery (%,range) CFU-GEMM recovery (%,range) CFU-GM recovery (%,range) Viability pre (%,range) Viability post (%,range) P-value calculated with Student’s t-Test. NIS 52 (16–76) 5 (1–14) 9 (0–42) 95 (91–99) 95 (90–99) MCMS 66 (48–75) 4 (1–5) 5 (0–9) 94 (80–99) 88 (60–100) P 0.17 0.71 0.57 0.69 0.16 Table 2 Device CD34+ infused (X 106/kg, range) Time to ANC ≥500 (days, range) Time to plt ≥20 (days, range) # Units plt P-value calculated with Student’s t-Test. NIS 3.6 (2.0–5.2) 12.2 (9–20) 15.9 (11–38) 19.4 (0–30) MCMS 3.6 (1.5–5.1) 15.1 (11- ∞) 16.8 (9-∞) 40.2 (6–150) P - 0.22 0.79 0.23

scholarly journals Immediate Effect of Intravitreal Bevacizumab Injection on Intraocular Pressure

2020 ◽  
Vol 36 (4) ◽  
Author(s):  
Rabeeah Zafar ◽  
Amna Rizwan ◽  
Badar-ud-din Ather Naeem ◽  
Asfandyar Asghar ◽  
Naila Obaid
Keyword(s):  
Intraocular Pressure ◽  
Case Series ◽  
Intravitreal Bevacizumab ◽  
P Value ◽  
Diabetic Patients ◽  
Vascular Endothelial ◽  
Post Injection ◽  
Intravitreal Bevacizumab Injection ◽  
Applanation Tonometer ◽  
Endothelial Growth Factor

Purpose:  To determine the immediate effect of intravitreal Bevacizumab on intraocular pressure (IOP) in eyes with retinal vascular disorders. Study Design:  Interventional case series. Place and Duration of Study:  Ophthalmology Department, Fauji Foundation Hospital, Rawalpindi, from January 2019to July 2019. Methods:  One hundred and thirty one patients were included in this study using non probability consecutive sampling. IOP was measured before intravitreal injection (baseline) and at 5 and 30 minutes post-injection. Descriptive statistics were obtained using SPSS version 21.0. Results:  One hundred and thirty one eyes of 131 patients were observed for IOP change after intra vitreal injection of Bevacizumab. Among them 23 (18%) were males and 108 (82.4%) were females. Mean age was 57.57 ± 13.09 years. Mean IOP at baseline was 16.16 ± 2.52 mmHg. At 5 minutes after injection, 108 eyes (82.4%) had raised IOP, maximum IOP recorded was 44 mmHg. There was a statistically significant correlation between IOP at baseline and 5 minutes with p = 0.005 (≤0.05). At 30 minutes, 94 eyes (71.7%) had IOP fallen back to normal. Statistically, an insignificant correlation was present between IOP at baseline and 30 minutes (p = 0.081) post-injection. IOP rise was not significantly correlated to gender, age, hypertension and asthma at any interval (p value > 0.05). However, IOP rise was significantly correlated in diabetic patients at 30 minutes. Conclusion:  IOP elevation has been observed after intravitreal bevacizumab in immediate post-injection period which warrants the monitoring of IOP in this critical period to avoid serious blinding complications. Key Words:  Bevacizumab, Vascular endothelial growth factor, Intraocular pressure, Goldmann applanation tonometer.

scholarly journals ACUTE APPENDICITIS

2015 ◽  
Vol 22 (09) ◽  
pp. 1212-1216
Author(s):  
Abdul Salam Memon ◽  
Shahida Khatoon ◽  
Riaz Ahmed Memon ◽  
Afzal Junejo
Keyword(s):  
Acute Appendicitis ◽  
Mean Platelet Volume ◽  
P Value ◽  
Platelet Volume ◽  
Chi Square ◽  
Chi Square Test ◽  
The Difference ◽  
Student’S T ◽  
Control Study ◽  
Student’S T Test

Objectives: To study mean platelet volume (MPV) in acute appendicitis andits correlation with leukocyte count. Study Design: Case control study Place and Duration:Department of Surgery, Liaquat University of Medical and Health Sciences Jamshoro/Hyderabadfrom January 2013 to February 2014. Subjects and Methods: Subjects with clinical suspicionof acute appendicitis were selected according inclusion and exclusion criteria. A sample of 49acute appendicitis patients and 37 controls were studied. The Blood samples were collected insodium citrate vacutainers and processed on Sysmex KX 21 analyzers. The main analysis wasthe comparison of the difference of MPV between acute appendicitis and controls. Data wasanalyzed on SPSS version 21.0 by student’s t-test, Chi-square test and Pearson’s correlation (r)was used to evaluate association of MPV with platelet counts and leukocytes. A p-value of ≤0.05was taken significant. Results: The mean platelet volume and leukocytes were significantlyelevated in patients with acute appendicitis. MPV and leukocytosis in controls and cases werenoted as 7.93±2.1 vs. 9.10±2.9fl (p=0.0001) and 6980±120 vs. 13980±340 μL-1 respectively.MPV was positively correlated with leukocytosis (r=0.419) (p=0.0001), while Platelets showeda negative correlation. Conclusion: Elevated MPV and leukocytosis are observed in acuteappendicitis. MPV may be exploited for clinical diagnosis of acute appendicitis but in a properclinical context along with leukocytosis.

scholarly journals Biaya dan Outcome Hemodialisis di Rumah Sakit Kelas B dan C

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Firda Tania ◽  
Hasbullah Thabrany
Keyword(s):  
Weight Loss ◽  
T Test ◽  
P Value ◽  
Intermediate Outcome ◽  
Student’S T ◽  
Base Group ◽  
Eq Vas ◽  
Student’S T Test

 Gagal Ginjal Kronis (GGK) merupakan kondisi yang semakin meningkat kejadiannya di Indone­sia, menghabiskan banyak dana publik Jaminan Kesehatan Nasional (JKN). Dalam program JKN, hemodi­alisis (HD) untuk penanganan GGK dijamin tetapi perleu keseimbangan antara biaya dan outcome. Sejak 2014, BPJS menanggung hampir seluruh biaya HD di Indonesia dengan besaran tarif Casemix Base Group (CBG) yang berbeda menurut kelas Rumah Sakit (RS). Tujaun dari penelitian ini adalah untuk mengetahui perbedaan biaya Hemodialisis pada Rumah Sakit Kelas B dan Kelas C.Studi evaluasi ekonomi ini dilakukan di dua RS dengan kelas berbeda: kelas B (RS B) dan kelas C (RS C) dengan perbedaan kepemilikan. Kepemilikan RS B adalah pemerintah daerah sedangkan RS C dimiliki oleh yayasan swasta. Outcome HD diukur dengan suatu survey ke pasien HD. Analisis outcome dilakukan dengan penilaian kualitas hidup (instrumen EQ-5D) dengan Indeks EQ, EQ VAS, intermediate outcome berupa rerata Intra Dialytic Weight Loss (IDWL), dan rerata Hb. Perbedaan rerata nilai hasil diuji dengan Student’s t-test. Responden dipilih dari pasien GGK yang menjalani HD di kedua RS selama Feb­ruari-April 2016. Analisis biaya menurut perspektif pasien, meliputi biaya langsung medis, biaya langsung non medis, dan biaya tidak langsung. Biaya sebenarnya yang dikeluarkan oleh RS dikumpulkan dari doku­men RS. Studi kualitatif tambahan dilakukan dengan wawancara mendalam kepada informan kunci di RS yang bertanggung jawab atas unit HD. Pada penelitian ini, total responden sebanyak adalah 100 orang (di RS B 76 orang & di RS C 24 orang). Menurut perspektif pasien, biaya langsung medis HD selama sebulan di RS B Rp 5.215.331 dan di RS C Rp 7.781.744. Besaran tarif CBG untuk RS kelas B adalah Rp 962.800 dan kelas C adalah Rp 893.300. Menurut perspektif RS, tidak terdapat perbedaan biaya operasional HD antar kelas RS. Biaya langsung non medis HD selama sebulan di RS B Rp 566.260 dan di RS C Rp 334.500. Biaya tidak langsung HD selama sebulan di RS B Rp 165.530 dan di RS C Rp 45.830. Rerata total biaya HD selama sebulan di RS B Rp 6.149.285 dan di RS C Rp 8.162.077. Pada intermediate outcome didapatkan bahwa rerata Hb pada RS B sebesar 10,26 g% berbeda secara signifikan dengan RS C (8,21 g%), p= 0,000. Rerata IDWL pada RS B (0,0403) tidak berbeda secara signifikan dengan RS C (0,0438), p= 0.188. Rerata EQ Indeks sebesar 0,7178 dan EQ VAS sebesar 64,74 di RS B tidak berbeda secara signifikan dengan rerata EQ Indeks sebesar 0,7208 dan EQ VAS sebesar 64,79 di RS C, dengan p value secara berurutan p=0,94 dan p= 0,986

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