scholarly journals Investigation of healing effects of Afyonkarahisar Region thermal spring water on experimentally-induced nephritis in mice

2021 ◽  
pp. 313-321
Author(s):  
Bülent Elitok ◽  
Agilonu Yasin ◽  
Yavuz Ulusoy ◽  
Bahadır Kilinç
Keyword(s):  
Treatment Period ◽  
Hot Spring ◽  
Tap Water ◽  
Day Treatment ◽  
Thermal Spring ◽  
Spring Water ◽  
Control Group ◽  
Study Group ◽  
Blood Biochemical ◽  
Thermal Spring Water

The aim of this study was to determine the efficacy of Afyokarahisar termomineral water in the treatment of nephritis. For this purpose, 40 Albino mouse at the same daily age were used. Nephritis was induced by adding adenine to their feed at a rate of 0.2% for 6 weeks. After nephritis was induced, a 21-day treatment period was started, and the mice were equally divided into two groups as control and study. While control group mice were received tap water daily and bathing in tap water, study group animals were given fresh Süreyya I hot spring water daily and bathing in this water. Clinical, hematological, blood biochemical and histopathological examinations were performed before the study, after nephritis formation, and on days of 1st, 7th, 14th and 21st of treatment period. Results of this study showed that WBC, NEUT and MCV levels increased significantly (p < 0.05) following nephritis formation, while RBC, HB, HCT, LYM, MCH and MCHC levels decreased significantly (p < 0.05). It was also determined that AST, GGT, GLU, BUN and IgG levels of blood biochemical parameters were significantly increased (p < 0.05) and TP, ALB levels decreased significantly (p < 0.05) after nephritis formation. At the end of the study, it was seen that all the measured parameters turned to the normal range in the study group animals, whereas problems still continuing with control group animals. Consequently, it was concluded that Süreyya I hot spring water was very successful in the treatment of nephritis and considered as an option in the treatment of nephritis.

scholarly journals Investigation of Healing Effects of Afyon Region Thermal Spring Water on Experimentally-Induced Gastritis in Mice

2020 ◽  
Vol 11 (Vol.11, no.3) ◽  
pp. 236-243
Author(s):  
Constantin Munteanu ◽  
Yavuz ULUSOY ◽  
Bahadir KİLİC
Keyword(s):  
Hot Spring ◽  
Tap Water ◽  
Blood Gases ◽  
Thermal Spring ◽  
Spring Water ◽  
Control Group ◽  
Study Group ◽  
Blood Biochemical ◽  
Thermal Spring Water ◽  
Significant Difference

In this study, 40 Albino mice were induced with ethyl alcohol to form of gastritis. In the treatment stage, control group mice were given tap water, while study group mice were given fresh water of Süreyya I hot spring. Clinical, hematological, biochemical, blood gases measurements and histopathological examinations of the gastric tissue were performed on the 1st, 7th, 14th and 21th days after the initiation of the treatment. At the end of the study, no significant difference was found between the groups in terms of body temperature (p> 0.05), whereas heart and respiratory frequencies were significantly higher in the study group animals (p <0.05). Although mean WBC, NOTR, MON, EOS and MCV decreased significantly in both groups (p <0.05), it was found that the mean of these parameters were more significant in SG at all measurement times (p <0.05). It was determined that TP, ALB and GLU levels increased in SG contrast to CG, and statistically significant decreases in AST, ALT, CK, ALP, LDH, UREA, CREA and IgG levels after the treatment. Additionally, pH, partial CO2 pressure, base deficit, bicarbonate, Ca and K levels decreased after gastritis procedure, whereas lactate, Na and Cl levels increased. Consequently, the clinical, hematological, blood biochemical parameters, blood gases and histopathological findings were evaluated as a whole, it was concluded that Süreyya I hot spring water was very successful in the treatment of gastritis.

scholarly journals Investigation of the Healing Effects of Afyonkarahisar Region Hot Spring Waters' Inhalation on Experimentally Induced Asthma in Mice

2020 ◽  
Vol 11 (Vol.11, no.3) ◽  
pp. 261-268
Author(s):  
Bülent ELITOK ◽  
Yavuz ULUSOY ◽  
KİLİC Bahadir
Keyword(s):  
Hot Spring ◽  
Tap Water ◽  
Day Treatment ◽  
Study Groups ◽  
Chronic Inflammatory Disease ◽  
Spring Water ◽  
Control Group ◽  
Albino Rats ◽  
Study Group ◽  
Blood Biochemical

Asthma is a chronic inflammatory disease of the airways observed exclusively in humans and sometimes animals. In this study, 40 Albino rats of the same age were used. After 6 weeks of ovalbumin-induced asthma in all animals, 40 rats were randomly divided into two groups as control and study groups for a 21-day treatment period. At the treatment stage, the control group animals were treated with normal tap water, while the study group animals were treated with hot spring water. Clinical, hematological, blood biochemical and histopathological examinations were performed before starting the study, after asthma formation, and on days of 1st, 7th, 14th and 21st after treatment. Total leukocyte, neutrophil, monocyte, AST, ALT, GGT, total cholesterol, triglyceride levels were significantly decreased (p <0.05) in the study group animals which treated with hot spring water. These normalization changes were confirmed by histopathological findings. Consequently, it was concluded that hot spring water of Afyonkarahisar Region provide a very successful treatment in asthma, and it should be considered as a supportive option for the treatment of asthma.

Investigation of Therapeutic Effects of Thermal Waters of Afyonkarahisar Region in Stress-Induced Mice

2020 ◽  
Author(s):  
Bülent Elitok
Keyword(s):  
Hot Spring ◽  
Tap Water ◽  
Day Treatment ◽  
Study Groups ◽  
Spring Water ◽  
Thermal Waters ◽  
Control Group ◽  
Therapeutic Effects ◽  
Glucose Levels ◽  
Blood Biochemical

In this study, 20 Albino mice of the same daily age were used. All the animals were restrained in well-ventilated 50 ml tubes (plus 3 or 4 cm long middle tubes), which were slipped over the tail to restrict movement even more and left undisturbed under an opaque duration of the stress (30 min). After stress procedure was applied in all animals, 20 mice which have same alive weight average and constitute the study material were divided into two groups as control group (CG) (n=10) and study groups (SG) (n=10) for a 21-day treatment period equally and randomly. Normal tap water was added to the CG mice’ drinkers, while the hot spring water that was brought from the source each day as fresh added to SG mice’ drinkers and they were allowed to reach ad libitum. Clinical, hematological and blood biochemical parameters were measures on 1, 7, 14 and 21 days after treatment in all the animals. The results of this study showed that cortisol and glucose levels decreased in stressed mice treated with Süreyya I Hot Spring Water, while ALB, TP, T3 and T4 levels increased and these changes were statistically significant plessthan0.06) when compared to the control group.

scholarly journals Investigation of the Therapeutic Effects of Hot Springs Waters Sourced from Afyonkarahisar Region on Experimentally-induced Myocardial infarctus in Rats

2020 ◽  
Vol 11 (Vol.11, no.3) ◽  
pp. 244-251
Author(s):  
Constantin Munteanu ◽  
Mehmet Ali EMEKSIZ ◽  
Yavuz ULUSOY ◽  
Bahadir KİLİC
Keyword(s):  
Myocardial Infarction ◽  
Hot Springs ◽  
Hot Spring ◽  
Tap Water ◽  
Public Health Problem ◽  
Study Groups ◽  
Control Group ◽  
Therapeutic Effects ◽  
Study Group ◽  
Blood Biochemical

Myocardial infarction is an important public health problem in human and animals. In this study, myocardial infarction was induced by intraperitoneally injected isoproterenol hydrochloride in saline solution at a dose of 85 mg/kg body weight for 2 days. After myocardial infarction formation, three animals were exed to collect blood and histopathological specimens. The remaining 32 rats were divided into control and study groups for treatment. In the treatment stage; the control group animals were treated with tap water, while the study group animals were received Süreyya I hot spring mineral water. Clinical, hematological, blood biochemical and histopathological examinations was performed in all the animals before study, after myocardial infarction, and on 1st, 7th, 14th and 21st days after treatment. In terms of T, P and R, there were significant differences (p <0.05) with respect to time periods between control and study groups (p <0.05). WBC, NOTR, MON MCH, HCT ve MCV levels decreased, while RBC, HG, HCT, LENF, MCH and MCHC levels increased following treatmen in both groups. These changes were significant in study group comaper to control. It was also seen that ALT, AST, CK and CRP levels of blood biochemical parameters were significantly increased (p <0.05) after myocardial infarction formation. By begining treatment, TP, ALB and GLU levels increased, whereas ALT, AST, CK and CRP levels decreased, especially on the 21st day of the study in the SG. It was concluded that in the correct temperature and time to use Süreyya I hot spring water as drinking and bathing was very successful in the treatment of myocardial infarction, either itself or along with other medical treatments.

STUDY ON THE EFFECT OF THE CATGUT-EMBEDDING METHOD COMBINING WITH HERBAL MEDICINE ON THE TREATMENT OF SCIATICA BY WIND-COLD-DAMP ARTHRALGIA

2014 ◽  
pp. 206-215
Author(s):  
Huu Tham Nguyen ◽  
Thi Tan Nguyen
Keyword(s):  
Herbal Medicine ◽  
Traditional Medicine ◽  
Clinical Characteristics ◽  
Day Treatment ◽  
Patient Treatment ◽  
Control Group ◽  
Controlled Trials ◽  
Study Group ◽  
Moderate Pain ◽  
Embedding Method

Objectives: To investigate clinical characteristics of patients with sciatica in Traditional Medicine Hospital in Thua Thien Hue province; To evaluate the effectiveness of the catgut-embedding method combining with herbal medicine on the treatment of sciatica by wind-cold-damp arthralgia. Subjects and Methods: Patients diagnosed with sciatica by wind-cold-damp arthralgia in-patient treatment in Traditional Medicine Hospital in Thua Thien Hue province. Methods: Clinical and controlled trials, a survey of 72 patients, which were divided into 2 groups: The study group: 36 patients: receiving treatment by catgut-embedding and herbal medicine; The control group: 36 patients: only use herbal medicine. 28-day treatment period. Patients were assessed at admission (T0), after 14 days (T14), after 28 days of treatment (T28). Results: After 28 days of treatment: no severity both 2 groups. The study group fell to 8.3% moderate pain, mostly mild pain (91.7%); the control group was 44.4% moderate pain, mild 55.6%.The catgut-embedding method does not cause any side effects. Key words: catgut-embedding method, sciatica by wind-cold-damp arthralgia

scholarly journals Characteristics associated with clinical response to Comano thermal spring water balneotherapy in pediatric patients with atopic dermatitis

2021 ◽  
Vol 47 (1) ◽  
Author(s):  
Davide Geat ◽  
Mattia Giovannini ◽  
Ezio Gabriele Barlocco ◽  
Riccardo Pertile ◽  
Stefania Farina ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Clinical Response ◽  
Disease Severity ◽  
Early Onset ◽  
Pediatric Patients ◽  
Thermal Spring ◽  
Spring Water ◽  
Food Allergies ◽  
Thermal Spring Water

Abstract Background Several studies have investigated the efficacy of balneotherapy in atopic dermatitis (AD), including a pediatric open randomized clinical trial conducted at the Comano thermal spring water center, which showed a significant reduction in AD severity and an improvement of the quality of life. However, so far many studies on balneotherapy in pediatric AD have included relatively small populations without identifying patients’ characteristics associated with their response. The aim of the present study was to identify any features associated with the clinical response to the Comano thermal spring water balneotherapy in a large cohort of pediatric AD patients. Methods An observational study was conducted on 867 children aged ≤16 years (females 50.5%, mean patient’s age 5.9 years, standard deviation ±3.6 years) with mild to severe AD who underwent balneotherapy at the Comano thermal spring water center (Comano, Trentino, Italy) from April to October 2014. Patients were stratified according to their disease severity, which was evaluated using five SCORing Atopic Dermatitis (SCORAD) categories before and immediately after a thermal spring water balneotherapy course. Potential characteristics associated with the patients’ clinical response to Comano thermal spring water balneotherapy were investigated. Results A statistically significant improvement in AD severity was observed after Comano thermal spring water balneotherapy (p < 0.0001). A significantly higher percentage of patients achieving improvement in AD severity was reported among children ≤4 years old (p < 0.0001) with early-onset AD (p < 0.0001), severe AD (p < 0.0001) or coexistent reported food allergies (p < 0.01). The therapy was well tolerated, and no relevant adverse effects were reported during the treatment course. Conclusions Comano thermal spring water balneotherapy is a safe complementary treatment for pediatric patients with AD, as it was able to reduce the disease severity, especially in children ≤4 years old, with early onset AD, severe AD or concomitant food allergies.

Avène Thermal Spring Water: an active component with specific properties

2010 ◽  
Vol 25 ◽  
pp. 2-5 ◽  
Author(s):  
C Merial-Kieny ◽  
N Castex-Rizzi ◽  
B Selas ◽  
S Mery ◽  
D Guerrero
Keyword(s):  
Active Component ◽  
Thermal Spring ◽  
Spring Water ◽  
Thermal Spring Water

scholarly journals Effect of bathing in a 0.1% aqueous solution of ethacridine lactate on selected physiological parameters of Cornu aspersum Müller edible snails

2020 ◽  
Vol 64 (2) ◽  
pp. 313-318
Author(s):  
Jerzy Ziętek ◽  
Beata Dzięgiel ◽  
Alicja Wójcik ◽  
Anna Wilczyńska ◽  
Łukasz Adaszek ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Bacterial Infections ◽  
Tap Water ◽  
Antibiotic Use ◽  
Physiological Parameters ◽  
Control Group ◽  
Study Group ◽  
Ethacridine Lactate ◽  
Cornu Aspersum ◽  
Lactate Solution

AbstractIntroductionThe prohibition of antibiotic use in edible snails obligates breeders to treat bacterial infections by different means, of which a common one is a bath in Gram-positive– and partially Gram-negative–bactericidal ethacridine lactate solution. The aim of the study was to determine the effect of bathing Cornu aspersum Müller snails in a 0.1% aqueous solution of ethacridine lactate on selected physiological parameters of haemolymph.Material and MethodsThe study included 80 snails, divided into two equal groups (study and control). The study group was subjected to bathing in ethacridine lactate and the control group to bathing in tap water. Both groups were treated daily for seven days. The number of haemocytes in the haemolymph, the activity of alanine (ALT) and aspartate (AST) aminotransferases, and the concentration of urea were determined.ResultsIn the study group, after exposure to ethacridine lactate solution an increase in ALT activity, changes in the De Ritis ratio, an increase in the amount of haemocytes, and a decrease in body weight were found. No such changes were detected in the control group snails or in animals after the first bath.ConclusionMultiple applications of a 0.1% ethacridine lactate bath may adversely affect Cornu aspersum Müller snails.

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