scholarly journals Cytokine intoxication as a model of cell apoptosis and predict of schizophrenia - like affective disorders

2021 ◽  
Vol 5 (1) ◽  
pp. 038-040
Author(s):  
Drozdova Elena Viktorovna
Keyword(s):  
Cell Apoptosis ◽  
Affective Disorders ◽  
Schizoaffective Disorders ◽  
Pathophysiological Mechanisms ◽  
Suicidal Attempts ◽  
Long Time

For a long time there was no explanation of a study which had revealed that people with schizoaffective disorders and in particular suicidal attempts rarely get cancer. But now, we can assume that there are diseases that are “mirrored” because they occur with reverse/feedback pathophysiological mechanisms so that they are, in fact, antagonists.

The study of suicidal behavior at patients with anhedonia in schizophrenia

2011 ◽  
Vol 26 (S2) ◽  
pp. 1464-1464
Author(s):  
N. Orlova ◽  
M. Shkliar ◽  
E. Khaustova
Keyword(s):  
Risk Factor ◽  
Suicidal Behavior ◽  
Affective Disorders ◽  
Negative Symptoms ◽  
Paranoid Schizophrenia ◽  
Illness Duration ◽  
The Past ◽  
Suicidal Attempts ◽  
Suicidal Ideas ◽  
Suicide Plan

IntroductionThe suicidal behavior at patients with anhedonia in schizophrenia is one of the burn problems in modern psychiatry.ObjectivesAnhedonia belongs to negative symptoms in schizophrenia. The suicidal activity at patients with it consists from 7% tо 43%. At those patients fixed the suicidal ideas - 40%, suicidal attempts - 23% and complete suicide - 6,4%.AimsStudy the methods of suicidal behavior at those patients.MethodsThe Columbia Suicide severity research scale (C-SSRS).Results157 patients with anhedonia. Selected 49 (31, 21%) patients with suicidal behavior on admission or in the past. 23 women and 26 men with a mean age of 34, 37(±1, 92) and mean illness duration of 7, 72(±1, 42). The anhedonia level was 21, 26(±1, 26). 73,48% were the patients with Schizophrenia among them 44,91% with “postpsychotic depression” (295.60), 28, 57% with paranoid schizophrenia (295.30) and 26,52% - patients with affective disorders (296.3×). All patients wished to die. 79,59% (n = 39) had a suicidal attempts and 20,41% (n = 10) had a suicidal ideas. Active suicidal ideas without the suicide plan had 79, 59% patients. The methods of suicidal attempts were poisoning (38, 52%), cutting (25, 64%), hanging (12, 8%), falls (20, 48%), drowning (2, 56%).ConclusionsAnhedonia in schizophrenia is a risk factor of suicidal behavior. The suicidal behavior declared itself with suicidal attempts much more than suicidal ideas. Suicidal attempts were impulsive and dangerous with risk for life. It point to seriousness and danger results of suicidal behavior.

scholarly journals How much do patients on lithium know about their medication?

1991 ◽  
Vol 15 (3) ◽  
pp. 136-137 ◽  
Author(s):  
Norma Delany
Keyword(s):  
Side Effects ◽  
Affective Disorders ◽  
Acute Mania ◽  
Schizoaffective Disorders ◽  
Treatment Of Depression

Lithium is a drug used extensively in psychiatry for the treatment of depression, acute mania, and the prophylaxis of recurrent affective disorders. Lithium also has a place in the management of schizoaffective disorders and has been suggested for aggression and alcoholism. The side-effects, dangers of toxicity, and need for monitoring are well documented and should be considered before starting anyone on lithium. Likewise patients should be adequately informed of the benefits and hazards of treatment.

scholarly journals Studi Kasus Dinamika Psikologis Pasien dengan Gangguan Mental Psikotik Skizoafektif

PSYCHE 165 ◽  
2020 ◽  
pp. 114-120
Author(s):  
Santi Tri Wintari
Keyword(s):  
Social Support ◽  
Emotional Regulation ◽  
Affective Disorders ◽  
Coping Skills ◽  
Qualitative Case Study ◽  
External Factors ◽  
Internal Factors ◽  
Schizoaffective Disorders ◽  
And Coping

This study aims to describe the psychological dynamics and factors that cause one schizophrenic spectrum disorder that is schizoaffective for the symptoms of schizophrenia and affective disorders that stand out at the same time. This research is a qualitative case study with one participant, Joko who is diagnosed with schizoaffective disorder. The examination used interviews, observation, and several psychological tests. The results show that there are internal factors such as personality, coping skills, genetic vulnerability and external factors such as social support and unfulfilled affection and stressors as triggers that contribute to schizoaffective disorders. The results of the study can be a reference to prevent schizoaffective disorders through psychoeducation to families and help people with schizoaffective disorders by providing interventions to train emotional regulation and coping skills.

scholarly journals Family Role on Schizoaffective Type Patients Treatment

2021 ◽  
Vol 10 (2) ◽  
pp. 79
Author(s):  
Triningsih Setiawati ◽  
Khairina Khairina ◽  
Syarifah Aini
Keyword(s):  
Young Adult ◽  
General Population ◽  
Schizoaffective Disorder ◽  
Mixed Type ◽  
Family Role ◽  
Schizoaffective Disorders ◽  
Biopsychosocial Approach ◽  
Manic Depressive ◽  
Affective Symptoms ◽  
Long Time

              Schizoaffective disorder is a mental disorder accompanied by schizophrenic and affective symptoms that both stand out at one time. Affective symptoms that appear are manic, depressive or both. The prevalence of patients with schizoaffective disorder is about 0.3% of the general population. Women suffer more from schizoaffective disorder and usually suffer from depressive type schizoaffective disorder. The case that will be discussed here is a young adult woman who first suffered from a schizoaffective mixed type disorder. The difficulty faced in handling this case is to provide an understanding of the patient and family about schizoaffective disorders and how patients take medication regularly for a long time. Therefore, a biopsychosocial approach is considered the most suitable to overcome the difficulties in handling this case.

PATHOPHYSIOLOGICAL MECHANISMS OF DAMAGING ACTION OF CYTOMEGALOVIRUS INFECTION IN PREGNANCY

2017 ◽  
Vol 1 (66) ◽  
pp. 98-107 ◽  
Author(s):  
Оксана Кытикова ◽  
Oksana Kytikova ◽  
Татьяна Новгородцева ◽  
Tatyana Novgorodtseva ◽  
Ксения Петрова ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
First Trimester ◽  
Modern Medicine ◽  
Pathophysiological Mechanism ◽  
Negative Consequences ◽  
Childbearing Age ◽  
Pathophysiological Mechanisms ◽  
Long Time ◽  
First Trimester Of Pregnancy ◽  
In Pregnancy

This systematic review was undertaken to define the urgency of studying the problem of cytomegalovirus infection due to the high frequency of detection of specific antibodies among women of childbearing age and the negative consequences of cytomegalovirus for the fetus and newborn. Despite the advances in modern medicine in the study of etiopathogenesis and diagnosis of cytomegalovirus infection during pregnancy, there is currently no trend towards a reduction in the incidence of obstetric pathologies and fetal damage. Physiological features of the functioning of the immune system in pregnancy are discussed; they create the prerequisites for the emergence or activation of long time persistent cytomegalovirus infection and intrauterine fetal damage. Complications in newborns are much more common if the primary cytomegalovirus infection was detected in the first trimester of pregnancy. Cytomegalovirus infection is accompanied by the development of immunodeficiency, but pathophysiological mechanisms of cytomegalovirus infection with the damaging effect in the first trimester of pregnancy need to be detailed. The pathophysiological mechanism of mismatch of immune regulation in pathological pregnancy and in the presence of cytomegalovirus infection is Th-1/Th-2 imbalance which can serve as a target for the development of pathogenetically oriented therapy of pregnant women with cytomegalovirus infection. It is suggested that the specification of these mechanisms will reduce the frequency of obstetric pathologies.

The Study on the Apoptosis of Rat’s Granule Cells Induced by Ethanol

2011 ◽  
Vol 287-290 ◽  
pp. 116-119
Author(s):  
Shu Feng Li ◽  
Li Hao ◽  
Hui Li Tong ◽  
Dan Dan Zhao ◽  
Yun Qin Yan
Keyword(s):  
Cell Apoptosis ◽  
Granule Cells ◽  
Ex Vivo ◽  
Genital System ◽  
Long Time

To drink excessively for long time would damage human genital system seriously, nevertheless there is still less researches on the effect of ethanol to granule cells. Here we adhibit means of TUNEL coloration and flowcytometry examination and treat ex vivo granule cells with ethanol at different chroma and time. The result shows that ex vivo granule cells treated with ethanol at different chroma and time can be observed distinctly the morphologic character of cell apoptosis, and the percentage of apoptosis of ex vivo granule cells induced by ethanol would increase in a certain bound of chroma and time as the increasing of the chroma and time, indicating that ethanol can produce dysgenesia by inducing the apoptosis of granule cells of ovaries. The damage of ethanol for granule cells arouses people to control drinking and nip drinking evil in the bud, which is a world of practical importances for human’s procreate and health.

Morbidity Risks of Schizophrenia and Affective Disorders among First-Degree Relatives of Patients with Schizoaffective Disorders

1991 ◽  
Vol 158 (2) ◽  
pp. 165-170 ◽  
Author(s):  
Ming T. Tsuang
Keyword(s):  
Affective Disorder ◽  
Affective Disorders ◽  
Clinical Characteristics ◽  
Heterogeneous Group ◽  
Family Data ◽  
Schizoaffective Disorders ◽  
First Degree Relatives ◽  
Morbidity Risks ◽  
Research Criteria

Of 510 patients consecutively admitted and diagnosed as schizophrenic, 310 who failed to meet research criteria for schizophrenia were labelled as having ‘atypical psychosis'. This heterogeneous group of patients was then subtyped into more homogeneous subgroupings according to their clinical characteristics, independent of their family data. One subgroup resembled schizophrenia, one resembled affective disorders and a third (n = 57), which did not resemble either schizophrenia or affective disorder, was defined as ‘schizoaffective’. Comparing the morbidity risks for schizophrenic and affective disorders in the relatives of this schizoaffective group with those of the relatives of ‘typical’ groups of schizophrenia and affective disorder, showed that this group was different from those with schizophrenic and affective disorders.

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