scholarly journals Urinary C-peptide Creatinine Ratio and Its Correlation with Parameters of Metabolic Syndrome

2021 ◽  
Vol 3 (2) ◽  
pp. 1
Author(s):  
Manoj Gedam ◽  
Dipti Sarma ◽  
Bipul Choudhury
Keyword(s):  
Metabolic Syndrome ◽  
Biochemical Parameters ◽  
Prospective Observational Study ◽  
Serum Insulin ◽  
Fasting Insulin ◽  
Creatinine Ratio ◽  
Fasting Serum ◽  
C Peptide ◽  
Non Invasive ◽  
Simple Tool

To assess the correlation between urinary C peptide creatinine ratio with serum C peptide, serum insulin and its correlation with clinical and biochemical parameters of metabolic syndrome. A total of 100 subjects more than 18 years of age with metabolic syndrome according to ATP III criteria with 100 controls were included in a prospective observational study for a period of 1.5 years. Individual parameters of metabolic syndrome was higher in females with hypertriglyceridemia was most common and hyperglycaemia least common parameter of metabolic syndrome. Fasting urinary C peptide creatinine ratio and Stimulated urinary C peptide correlate significantly with fasting serum C peptide (p<0.01),stimulated serum C peptide (p<0.01), serum fasting insulin (p<0.01) and HOMA IR (p<0.01). A fasting urinary C peptide creatinine ratio of more than 1.8 nmol/mmol, stimulated urinary C peptide creatinine ratio more than 2.8 nmol/mmol and HOMA IR >2.7 can be used as a parameter to distinguish individual with and without metabolic syndrome. Urinary C peptide creatinine ratio correlate with serum C peptide and parameters of metabolic syndrome and can be used as a non-invasive simple tool to assess insulin resistance and also to distinguish patients with and without metabolic syndrome.

scholarly journals Urinary C-Peptide Creatinine Ratio as a Non-Invasive Tool for Identifying Latent Autoimmune Diabetes in Adults (LADA)

2019 ◽  
Vol Volume 12 ◽  
pp. 2531-2537 ◽  
Author(s):  
Wei Liu ◽  
Xingquan Huang ◽  
Xiuying Zhang ◽  
Xiaoling Cai ◽  
Xueyao Han ◽  
...  
Keyword(s):  
Autoimmune Diabetes ◽  
Creatinine Ratio ◽  
C Peptide ◽  
Non Invasive ◽  
Latent Autoimmune Diabetes

scholarly journals The Glycemic Effects of Pomegranate Juice

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 486-486
Author(s):  
Jing Wang ◽  
Sijia Wang ◽  
Jieping Yang ◽  
Ru-Po Li ◽  
Xinyi Ye ◽  
...  
Keyword(s):  
Single Dose ◽  
Water Intake ◽  
Healthy Subjects ◽  
Serum Insulin ◽  
Serum Glucose ◽  
Pomegranate Juice ◽  
Fasting Serum ◽  
Sugar Water ◽  
C Peptide ◽  
Lower Glucose

Abstract Objectives We recently showed that a single dose of pomegranate juice (PomJ) intake reduced fasting glucose and increased insulin in young healthy subjects. Our study aims to determine the responses of blood glucose as well as principle hormones involved in glucose homeostasis (insulin, C-peptide, glucagon and gastric inhibitory polypeptide (GIP)) after consuming a single dose of 8 oz PomJ, glucose/fructose dissolved in water compared to water in healthy subjects. Methods 21 Healthy, normal weight individuals (BMI of &gt;18 to 26.9 kg/m2, fasting serum glucose &lt; 100 mg/dL) were recruited. Volunteers were randomly assigned to take a single dose of 8 oz of water, PomJ, or water with 18.6 g of glucose + 18.3 g of fructose to match PomJ sugar content, followed by 1-week wash out, and crossover to other interventions in a random order. Fasting blood was collected before, and at 15, 30, 60, 90, 120, 150 and 180 minutes (min) after the drink. Serum glucose was measured enzymatically (Cayman) and insulin, C-peptide, glucagon, and GIP were analyzed using the multiplex human cytokine panel (Millipore). Results 21 healthy volunteers were divided in to 2 groups according to the fasting serum insulin levels: healthy subjects with low fasting serum insulin ≤995 pg/mL (LFSI, n = 12) and healthy subjects with high fasting serum insulin &gt;995 pg/mL (HFSI, n = 9). In all subjects, water intake did not change the levels of glucose and hormonal markers. In LFSI subjects, significant lower glucose at 15 min and GIP at both 15 min and 30 min were observed after PomJ compared to sugar water intake. The area under the curve of serum GIP from LFSI volunteers consuming PomJ was lower compared to sugar water. The levels of insulin, C-peptides and glucagon in response to PomJ and sugar water intake were similar. In HFSI subjects, levels of glucose, C-peptide and glucagon in response to PomJ and sugar water intake were similar. Significant higher insulin at 15 and 30 min, and lower GIP at both 15, 30 and 60 min were observed after PomJ compared to sugar water intake. Conclusions Compared to identical amount of sugar in water, lower glucose response was observed after Pom J in LFSI subjects while higher insulin level and decreased GIP level in HFSI subjects without any difference in glucose. Our data suggest that components in PomJ likely regulate individuals’ glucose metabolism. Funding Sources Center for Human Nutrition.

Fasting serum insulin in relation to components of the metabolic syndrome in European healthy men: The European fat distribution study

Metabolism ◽  
1995 ◽  
Vol 44 (1) ◽  
pp. 35-40 ◽  
Author(s):  
M. Cigolini ◽  
J.C. Seidell ◽  
G. Targher ◽  
J.P. Deslypere ◽  
B.M. Ellsinger ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Serum Insulin ◽  
Fat Distribution ◽  
Fasting Serum ◽  
Healthy Men ◽  
Distribution Study ◽  
The Metabolic Syndrome

scholarly journals Homeostasis model assessment, serum insulin and their relation to body fat in cats

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Emma M. Strage ◽  
Charles J. Ley ◽  
Johannes Forkman ◽  
Malin Öhlund ◽  
Sarah Stadig ◽  
...  
Keyword(s):  
Body Fat ◽  
Body Condition Score ◽  
Serum Insulin ◽  
Reference Interval ◽  
Population Based ◽  
Biological Variation ◽  
Model Assessment ◽  
Fasting Insulin ◽  
Homeostasis Model Assessment ◽  
Fasting Serum

Abstract Background Obesity is associated with insulin resistance (IR) and considered a risk factor for diabetes mellitus (DM) in cats. It has been proposed that homeostasis model assessment (HOMA-IR), which is the product of fasting serum insulin (mU/L) and glucose (mmol/L) divided by 22.5, can be used to indicate IR. The objectives of this study were threefold: (i) to evaluate associations between body fat, fasting insulin, and HOMA-IR, (ii) to determine population-based reference interval of HOMA-IR in healthy lean cats, and (iii) to evaluate biological variation of HOMA-IR and fasting insulin in cats. Results 150 cats were grouped as lean or overweight based on body condition score and in 68 of the cats body fat percentage (BF%) was estimated by computed tomography. Fasting serum insulin and glucose concentrations were analysed. Statistical differences in HOMA-IR and insulin between overweight or lean cats were evaluated using Wilcoxon rank-sum test. Robust method with Box-Cox transformation was used for calculating HOMA-IR reference interval in healthy lean cats. Relations between BF% and HOMA-IR and insulin were evaluated by regression analysis. Restricted maximum likelihood ratio was used to calculate indices of biological variation of HOMA-IR and insulin in seven cats. There were significant differences between groups with overweight cats (n = 77) having higher HOMA-IR (p < 0.0001) and insulin (p = 0.0002) than lean cats (n = 73). Reference interval for HOMA-IR in lean cats was 0.1–3.0. HOMA-IR and fasting insulin concentrations showed similar significant positive association with BF% (p = 0.0010 and p = 0.0017, respectively). Within-animal coefficient of variation of HOMA-IR and insulin was 51% and 49%, respectively. Conclusions HOMA-IR and fasting insulin higher in overweight than lean cats and correlate to BF%. The established population-based reference interval for HOMA-IR as well as the indices of biological variation for HOMA-IR and fasting insulin may be used when interpreting HOMA-IR and fasting insulin in cats. Further studies are needed to evaluate if HOMA-IR or fasting insulin is useful for identifying cats at risk of developing DM.

scholarly journals Relationship of serum fasting insulin with gonadotropins in infertile women

2014 ◽  
Vol 29 (1-2) ◽  
pp. 17-24
Author(s):  
Shamima Bari ◽  
Rokeya Begum ◽  
Qazi Shamima Akter ◽  
Tanvir Alam ◽  
Kadeja Begum
Keyword(s):  
Blood Glucose ◽  
Serum Insulin ◽  
Fasting Blood Glucose ◽  
Insulin Level ◽  
Fasting Insulin ◽  
Serum Insulin Level ◽  
Fasting Serum ◽  
Infertile Women ◽  
Group B ◽  
Fertile Women

Background: Infertility has become a global health problem in the world wide affecting 8-10% of couple. It is also a matter of social injustice and inequality. Increase level of insulin has been implicated as a cause of infertility. Objective: To find out the association of fasting serum insulin level with gonadotropins in infertile women. Methods: This cross sectional study was conducted in the department of Physiology, Dhaka Medical College, Dhaka from July 2010 to June 2011. A total number of 150 female age ranged from 20 – 40 years were included in this study. Out of them100 infertile women were selected as study group (group B). Group B was subdivided into group B1 and B2. Group B1 consisted of 50 primary infertile women and group B2 consisted of 50 secondary infertile women. Rest 50 age matched apparently healthy parous women were considered as base line control group A. All the study subjects were selected from out patient department of infertility unit, BSMMU, Dhaka. The control subjects were selected by personal contact. Serum fasting insulin was measured by enzyme-link-immunosorbend assay. Fasting blood glucose and blood glucose two hours after breakfast were measured by glucose oxidase method. The Data were collected in a prescribed data sheet after taking written consent. Statistical analyses were done by unpaired students “t” tests by SPSS program version 12. The level of significance was calculated and p value <0.05 was accepted as level of significance. Results: In this study, the mean fasting serum insulin level were significantly higher in infertile women than those of fertile women (p<0.001). Within the study group serum fasting insulin was higher in primary infertile women than that of secondary infertile women both were statistically not significant. Again, serum FSH and LH levels were significantly lower (P<.0001) in infertile women than those of fertile women. But serum FSH level was lower and LH level was higher in primary infertile women than that of secondary infertile women. In addition, fasting blood glucose level was almost similar but within normal limits in all groups. Blood glucose 2HABF was significantly higher in secondary infertile women than that of fertile women but within in normal limit. Moreover, fasting serum insulin level was negatively correlated with serum FSH and LH in primary infertility but negatively correlated with serum FSH and positive correlation with serum LH in secondary infertility. Conclusion: From the above study it may be concluded that fasting serum insulin level was higher in infertile women than those of healthy fertile women. These alterations may lead to menstrual irregularities, ovulatory dysfunction and infertility. http://dx.doi.org/10.3329/bjpp.v29i1-2.20063 Bangladesh J Physiol Pharmacol 2013; 29(1&2) : 17-24

scholarly journals Determinant components of newly onset versus improved metabolic syndrome in a population of Iran

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kamran Bagheri Lankarani ◽  
Behnam Honarvar ◽  
Parisa Keshani ◽  
Hadi Raeisi Shahraki
Keyword(s):  
Metabolic Syndrome ◽  
Biochemical Parameters ◽  
The Other ◽  
Second Phase ◽  
Two Phase ◽  
Non Invasive ◽  
Multiple Variable ◽  
Study Participants ◽  
Baseline Category ◽  
Variable Analysis

Abstract This study aimed to determine the risk factors related to regression and progression of metabolic syndrome, in a 4-year cohort study. A total of 540 individuals (≥ 18 years old) participated in both phase of the study. Participants were categorized into 3 categories of regressed, progressed and unchanged metabolic syndrome (MetS). Demographic, anthropometric and biochemical parameters were assessed for each individual in both phase. Variables differences (delta: Δ) between the two phase of study were calculated. Unchanged group was considered as baseline category. Based on IDF, MetS had been regressed and progressed in 42 participants (7.7%) and 112 (20.7%) participants respectively, in the second phase. More than 47% of people, whose MetS regressed, experienced also NAFLD regression. Results of multiple variable analysis revealed that increased age, positive Δ-TG, and Δ-FBS, significantly increased the odds of MetS progression based on IDF and ATP III definitions, while negative Δ-HDL and Δ-neutrophil to lymph ration increased the odds of progression. On the other hand, negative Δ-TG and positive Δ-HDL significantly increased the odds of Mets regression based of both IDF and ATP III. Management of hypertriglyceridemia, hyperglycemia, and HDL is a critical, non-invasive and accessible approach to change the trend of MetS.

scholarly journals Emerging role of C-peptide as an early biomarker of metabolic syndrome

2021 ◽  
Vol 9 (8) ◽  
pp. 2376
Author(s):  
Rana Usmani ◽  
Tariq Masood ◽  
Kanika Kakkar ◽  
Gunjan Mishra ◽  
Adarsh Uniyal ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Serum Insulin ◽  
Insulin Level ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
C Peptide ◽  
Insulin Levels ◽  
General Physical Examination ◽  
Early Biomarker ◽  
General Physical

Background: Metabolic syndrome is a health issue of rising concern as it has a correlation with the occurrence of cardiovascular events. Early identification of this syndrome by evaluating levels of biomarkers such as C peptide can help medical professionals prevent the occurrence of life-threatening cardiovascular diseases.Methods: This cross-sectional study was carried out in 89 subjects who were diagnosed to have metabolic syndrome. General Physical examination was done and fasting C peptide and insulin levels were quantified, followed by statistical analysis and their correlation. The prevalence of defining parameters of Metabolic Syndrome as per IDF 2005 was studied.Results: Out of 89 (100%) subjects, 80 (89.8%) subjects (Mean±SD=6.14±3.47) had C- peptide level >1.89 ng/ml which was statistically highly significant (p<0.001). Also, out of 89 (100%) subjects, 67 (24.71%) subjects had insulin level <25 mIU/L which was statistically significant (p<0.001).Conclusions: It was thereby concluded that serum C peptide levels were raised in patients of Metabolic syndrome and it is superior to serum Insulin levels as an early biomarker of the same.

scholarly journals Urinary C-Peptide Secretion(UCPS): Can It be A New Index to Reflect Insulin Sensitivity and A Predictor in Pregnant Women?

2020 ◽  
Author(s):  
Zhang Wei ◽  
Minmin An ◽  
Qi Fu ◽  
Xiaohua Men ◽  
Yinhui He ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Pregnant Women ◽  
Serum Insulin ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Fasting Serum ◽  
C Peptide ◽  
Matsuda Index ◽  
Peptide Secretion ◽  
Better Than

Abstract Background: In order to assess the correlation between pregnant women's urinary C-peptide secretion(UCPS) and insulin sensitivity, and to examine the predictors of gestational diabetes. Methods: we recruited 166 women between 20 and 28 weeks of gestation. Their height and weight were measured to calculate the body mass index (BMI). 75g OGTT was carried out, so as to detect the serum glucose, serum insulin and C-peptide levels. Besides, the homeostasis model assessment of insulin resistance (HOMA-IR), homeostasis model assessment of β cell function (HOMA-β), Matsuda index, and area under the serum C-peptide curve (CPauc) were calculated. Additionally, the fasting urine specimen and all urine samples within 2 hours after OGTT were collected to determine the urinary C-peptide and urine volume to calculate UCPS. Results: We found that Fasting serum insulin (Fins), Fasting serum C-peptide (FCP), BMI, OGTT 2h UCPS(UCPS120), CPauc, Matsuda index and HOMA-IR of GDM group were higher than NGT group. FCP was correlated with UCPS0 (r=0.234, p=0.002) and HOMA-β(r=0.251, p=0.001). UCPS120 was correlated with CPauc(r=0.176 p<0.001), Matsuda index(r=-0.362, p<0.001) and HOMA-IR(r=0.336, p<0.001). The combination of BMI and UCPS120 was better than other index in predicting GDM, with a sensitivity of 72.0% and specificity of 70.7%. Conclusion: UCPS120 had the potential to be a new index to reflect insulin sensitivity in pregnant women. To screening the GDM, the combination of BMI and UCPS120 was better than other index.

EVALUATION OF SERUM C-PEPTIDE AND SERUM INSULIN LEVEL IN INDIVIDUAL WITH HIGH BMI/ SEDENTARY LIFE STYLE; NEWLY DIAGNOSED CASES OF HYPERTENSION/ TYPE2DM; AND OLD CASES OF DIABETES MELLITUS.

2021 ◽  
pp. 19-21
Author(s):  
Shipra Singh ◽  
Dipti Debbarma ◽  
Harishankar Mishra
Keyword(s):  
Diabetes Mellitus ◽  
Serum Insulin ◽  
P Value ◽  
Strong Positive Correlation ◽  
Fasting Insulin ◽  
Newly Diagnosed ◽  
Strong Negative Correlation ◽  
C Peptide ◽  
Sedentary Life ◽  
Sedentary Life Style

Introduction: Diabetes mellitus is the commonest endocrine disorder in population. This clinical syndrome is due to either absolute or relative insulin deciency. Currently number of diabetics worldwide is 422 million. In India the projected increase is from 20 to 62 million, The term diabetes is derived from Greek words Dia meaning “through”, and Bainein meaning “to go”. This disease causes loss of weight as if the body mass is passed through urine. It is a disease known from ancient times. Charaka in his treatise, elaborated this disorder as “Madhumeha” (meaning sweet urine) around 400 BC. Aim & Objective: The level of fasting insulin and serum c-peptide in individual with high BMI /sedentary life style; newly diagnosed cases of hypertension / type2 DM; and old cases of diabetes mellitus. Raised level of serum insulin and c-peptide as a cause of progressive diabetes which can lead to cardiovascular complications and help to prepare patient. Materials And Methods: It is an observational cross sectional study done in the diabetic outpatient clinic of our hospital. 60 diabetic patients were evaluated for fasting plasma glucose level, post prandial glucose level, Glycosalated haemoglobin HbA1c, fasting Insulin and fasting C-peptide level. Results And Analysis: From the above table it was inferred that there is very strong positive correlation of HbA1c with C-PEPTIDE and INSULIN ( r > 0.7 and p value = .000 ). From the table it is inferred that there is a very strong positive correlation of INSULIN with C-PEPTIDE ( r > 0.7 and p value =.000 ). From table it is inferred that C-PEPTIDE has a strong negative correlation with SBPand DBP. (r value > 0.7 and p = .000 ). From table it is inferred that INSULIN has a strong negative correlation with SBPand DBP. ( r value > 0.7 and p =.000). Summary & Conclusion: The level of serum insulin and c-peptide is found to be higher in “newly diagnosed” cases than that of “old diagnosed” cases and this can be explained by the fact that treatment modies the course of disease and slows its progression. With passage of duration, hypertension starts to build up in established cases of diabetes. C-peptide and serum insulin testing should be done in patients with poor blood glucose control to decide treatment modalities and to create awareness about lifestyle modications and education to Prevent progression of prediabetic stage to diabetic and further to its complicated stage.

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