scholarly journals Application of simple head cooling combined with gangliosides in neonatal hypoxic-ischemic encephalopathy

2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Zhen Zhan ◽  
Huanhuan Cheng ◽  
Xianhong Lin ◽  
Yangyang Meng ◽  
Liying Dai ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Adverse Reactions ◽  
Clinical Symptoms ◽  
Clinical Performance ◽  
Hypoxic Ischemic Encephalopathy ◽  
Control Group ◽  
Observation Group ◽  
Head Cooling ◽  
Disturbance Of Consciousness ◽  
Ischemic Encephalopathy

Objective To investigate the effect of simple head cooling combined with ganglioside therapy on neonatal hypoxic-ischemic encephalopathy (HIE) and its clinical efficacy. Methods A total of 100 children with HIE admitted in the neonatal ward of our hospital from August 2018 to October 2020 were selected as the research objects, and were divided into control group and observation group according to the random number table method, with 50 cases in each group. The control group was treated with gangliosides, and the observation group was treated with simple head cooling combined with gangliosides. Observe and compare the clinical performance improvement time, the level of relevant hematological examination indexes before and after treatment, and the neonatal behavioral neurological assessment (NBNA), clinical efficacy, and adverse reactions. Results The improvement time of convulsions, disturbance of consciousness, pupil changes, hypotonia, and gastrointestinal dysfunction in the observation group was significantly lower than that in the control group (all P＜0.001). After treatment, the NSE, IL-6, CK, CK-MB of the two groups of children were significantly lower than before treatment, and the serum calcium and NBNA scores were significantly higher than before treatment, and the decrease or increase in the observation group was significantly higher than that of the control Group (all P＜0.001). The total effective rate of treatment of children in the observation group (82.00%) was higher than that of the control group (62.00%) (P<0.05). There were no obvious adverse reactions in both groups. Conclusion The simple head cooling combined with gangliosides in the treatment of HIE can improve the clinical symptoms, blood test index levels, and NBNA scores. The clinical effect is clear and superior to the single use of gangliosides.

scholarly journals Meta-Analysis of Clinical Efficacy and Safety of Ligustrazine in the Treatment of Idiopathic Pulmonary Fibrosis

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Xiaozheng Wu ◽  
Wen Li ◽  
Zhenliang Luo ◽  
Yunzhi Chen
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Clinical Efficacy ◽  
Adverse Reactions ◽  
Clinical Symptoms ◽  
Gas Analysis ◽  
Control Group ◽  
Efficacy And Safety ◽  
Arterial Blood Gas ◽  
Arterial Blood

Objective. To systematically review the efficacy and safety of Ligustrazine in the treatment of idiopathic pulmonary fibrosis (IPF). Methods. The electronic literature databases (PubMed, EMbase, CNKI, WanFang database, and VIP) were retrieved through a computer to find out the randomized controlled trials (RCT) of Ligustrazine in the treatment of IPF according to the inclusion/exclusion criteria screening test. Cochrane’s bias risk table was also used to evaluate the quality of the study and to extract effective data. RevMan 5.3 was used for statistical analysis. Results. A total of 7 RCTs (a total of 366 patients, including 196 in experimental and 170 in control group). Compared with the control group, Ligustrazine could improve the clinical symptoms ([OR] = 2.20, 95% CI [1.40, 3.46], P = 0.0006 ), lung function (VC % [MD] = 3.92, 95% CI [0.68, 7.17], P = 0.02 ), (TLC% [MD] = 4.94, 95% CI [0.37, 9.52], P = 0.03 ), the pulmonary diffusion function (DLCO % [MD] = 9.12, 95% CI [5.70, 12.55], P < 0.00001 ), and arterial blood gas analysis (PaO2 [MD] = 7.11, 95% CI [1.96, 12.25], P = 0.007 ) (PaCO2 [MD] = −2.42, 95% CI [−4.36, −0.49], P = 0.01 ) of IPF patients, respectively. However, FEV1/FVC % ([MD] = 9.37, 95% CI [−1.23, 19.97], P = 0.08 ) and adverse reactions ([MD] = 0.35, 95% CI [0.02, 5.36], P = 0.45 ) were not significantly improved. Conclusion. Ligustrazine has certain clinical efficacy in the treatment of IPF, but the safety of applying it and the adverse reactions need to be further analyzed and determined. It can be considered as a new alternative and complementary medicine to be promoted and recommended for use in medical units in various countries in the world and it solved the difficult problem of conventional drug treatment of IPF; therefore, more research strength can be put in the treatment of the pathological mechanism of IPF for further exploration. The study was registered under registration number CRD42020193626.

scholarly journals The Efficacy of Tripterygium Glycosides Combined with LMWH in Treatment of HSPN in Children

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Yan Jin ◽  
Yanzheng Wang ◽  
Sai Wang ◽  
Qiongqiong Zhao ◽  
Donghua Zhang ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Clinical Symptoms ◽  
Effective Rate ◽  
Control Group ◽  
Clinical Effects ◽  
Observation Group ◽  
Significant Difference ◽  
Before And After ◽  
Qilu Hospital ◽  
Tripterygium Glycosides

Objective. This study aimed to explore the clinical efficacy and relevant mechanism of Tripterygium glycosides combined with low molecular weight heparin calcium (LMWH) in the treatment of Henoch–Schönlein purpura nephritis (HSPN) in children. Methods. 64 cases of children patients with HSPN treated at Qilu Hospital (Qingdao) from January 2015 to May 2020 were selected and randomly divided into the control group and the observation group and 32 cases in each group. Conventional medical treatment was applied in the two groups, besides which the control group was given LMWH while the observation group was given Tripterygium glycosides based on the control group. The clinical efficacy and the indexes of clinical symptoms of the two groups were compared. Immune globulin level, fibrinogen content (FIB), prothrombin time (PT), platelet level (PLT), and activated partial thromboplastin time (APTT) level of the two groups were compared before and after the treatment. Results. The total effective rate in the observation group was significantly higher than that of the control group, and the recurrence rate in the observation group was lower than that in the control group. After treatment, urine red blood cell count and 24 h urine protein were obviously better than those of the control group. There was no statistically significant difference in PT between the two groups of children before and after treatment. The levels of PLT and FIB in the two groups of patients after treatment were significantly lower than before treatment, and the PLT levels in the observation group were lower than those in the control group. Conclusion. The combination of Tripterygium glycosides and LMWH had good clinical effects in the treatment of children with HSPN, and it could improve the clinical symptoms, the mechanism of which might be related to the increase of PT, a decrease of PLT, and the improvement of coagulation function.

scholarly journals Curative effect of Omeprazole under different treatment courses in treatment of children with PU and HP infection and its influence on inflammatory factors

2020 ◽  
Vol 36 (7) ◽  
Author(s):  
Shaohui Zhang ◽  
Yuan-da Zhang ◽  
Qing-wei Dong ◽  
Fang Gu
Keyword(s):  
Adverse Reactions ◽  
Eradication Rate ◽  
Clinical Symptoms ◽  
Statistical Significance ◽  
Symptom Relief ◽  
Inflammatory Factors ◽  
Controlled Study ◽  
Control Group ◽  
Observation Group ◽  
Curative Effect

Objective: To compare curative effect and safety of omeprazole under different treatment courses in treatment of children with peptic ulcer (PU, diameter ≤1.0cm) and helicobacter pylori (HP) infection and its influence on inflammatory cytokines. Methods: The study was a randomized controlled study and conducted at Baoding children’s hospital from June 2015 to June 2018. In this study 100 PU children with positive HP were chosen and classified into two groups at random. The 58 cases in the observation group were given omeprazole + amoxicillin + clarithromycin, and the antibiotics were not used two weeks later. Then, omeprazole was used to treat for two weeks. 42 cases in the control group were given omeprazole + amoxicillin + clarithromycin for two weeks. Curative effect, HP eradication rate, clinical symptoms, incidence of adverse reactions, level of serum inflammatory cytokine interleukin-6 (IL-6) and level of tumor necrosis factor-a (TNF-a) in two groups were compared. Results: Total effective rate, HP eradication rate and clinical symptom relief of observation group were better than those of control group, and the differences showed statistical significance (P<0.05). The differences of two groups in the incidence of adverse reactions had no statistical significance (P<0.05). Serum IL-6 level and TNF-a level of observation group were significantly lower than those of control group and before the treatment, and the differences had statistical significance (P<0.05). Conclusion: The application of omeprazole in treatment of PU patients with positive HP for four weeks can significantly improve PU cure rate and HP eradication rate, relieve clinical symptoms and reduce inflammatory response, so it deserves to be promoted clinically. doi: https://doi.org/10.12669/pjms.36.7.3048 How to cite this:Zhang S, Zhang Y, Dong Q, Gu F. Curative effect of Omeprazole under different treatment courses in treatment of children with PU and HP infection and its influence on inflammatory factors. Pak J Med Sci. 2020;36(7):---------. doi: https://doi.org/10.12669/pjms.36.7.3048 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Benefits of a Nanosilver Nasal Spray for Postoperative Care of Patients with Chronic Rhinosinusitis

2020 ◽  
Vol 20 (12) ◽  
pp. 7342-7346
Author(s):  
Xia Zhao ◽  
Chenghua Zhao ◽  
Xiaoning Zhang ◽  
Liqun Xing
Keyword(s):  
Chronic Rhinosinusitis ◽  
Adverse Reactions ◽  
Clinical Symptoms ◽  
Metallic Silver ◽  
Control Group ◽  
Observation Group ◽  
Pathogenic Microorganisms ◽  
Post Surgery ◽  
Nanosilver Particles ◽  
Symptoms And Signs

To explore tending to patients with chronic rhinosinusitis using a nanosilver compound. From February 2014 to August 2016, 112 surgical patients with chronic rhinosinusitis were randomly divided into an observation group and a control group. Patients in the observation group were given antibiotics, care to retain hemostasis, and other treatment after surgery. Patients in the observation group were administered treatment with bonbijing nano antibacterial water spray post-surgery. The progress of both groups recorded. Nanosilver is metallic silver of nanometer size. Nanosilver particles in the spray are approximately 25 nm in diameter, strongly inhibit growth of or kill dozens of pathogenic microorganisms, e.g., Escherichia coli. Postoperative pain in patients in the observation group was less than pain in the control group patients (p < 0.05). Symptom and sign scores in observation group patients were lower than scores in control group patients (p < 0.05). Incidence of adverse reactions and complications was also lower in observation group patients (p<0.05). Use of nanosilver for tending to patients with chronic rhinosinusitis after surgery can significantly improve clinical symptoms and signs, and reduce adverse reactions and complications.

Analysis of Clinical Efficacy of Nano-Albumin Paclitaxel Treatment for Advanced Cell Lung Cancer

2020 ◽  
Vol 20 (10) ◽  
pp. 6019-6025
Author(s):  
Xiaoxue Li ◽  
Yi Zhang ◽  
Xiuyi Zhi ◽  
Yuanbo Li ◽  
Kun Qian
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Clinical Efficacy ◽  
Cell Lung Cancer ◽  
Adverse Reactions ◽  
Small Cell ◽  
Control Group ◽  
Observation Group ◽  
Small Cell Lung ◽  
Platinum Chemotherapy

To compare the clinical efficacy and adverse reactions associated with nano-albumin paclitaxel combined with cisplatin and traditional paclitaxel combined with cisplatin for the treatment of non-small cell lung cancer. From December 2016 to August 2019, 78 patients with non-small cell lung cancer in our hospital were randomly allocated into either the observation group (n = 39) or the control group (n = 39). The observation group was treated with nano-albumin combined with cisplatin, and the control group was treated with traditional paclitaxel combined with platinum chemotherapy. After four cycles of treatment, the clinical efficacy and adverse reactions for the two groups were statistically analyzed. Before treatment, there was no statistically significant difference in age, sex, tumor type, and ECOG score between the two groups. After four cycles of treatment, the disease control rate in the observation group was 79.49%, which was significantly higher than that in the control group (38.46%, P <0.05), and the occurrence of myelosuppression, nausea, vomiting, and hyperglycemia in the observation group was significantly lower than that in the control group (P <0.05). Compared with the traditional paclitaxel combined with platinum chemotherapy regimen, the nanoalbumin combined with paclitaxel regimen had significant clinical effect and the adverse reactions were significantly reduced. Thus, it can be considered effective and safe and is suitable for clinical promotion.

scholarly journals Observation on Curative Effect and Adverse Reaction of Acupuncture and Moxibustion in Treating Chronic Functional Constipation

2021 ◽  
Vol 2 (3) ◽  
Author(s):  
Jiayi Lu
Keyword(s):  
Abdominal Pain ◽  
Adverse Reactions ◽  
Clinical Symptoms ◽  
Functional Constipation ◽  
Abdominal Distension ◽  
Control Group ◽  
Observation Group ◽  
Acupuncture And Moxibustion ◽  
Total Incidence ◽  
Universal Application

Objective — To investigate the efficacy of acupuncture and moxibustion in the treatment of chronic functional constipation and the observation of adverse reactions in patients. Methods — A total of 88 patients with chronic functional constipation who were treated from June 2019 to March 2021 were selected as the subjects, and the patients were divided into control group with 44 patients and observation group with 44 patients according to a random number table.The control group was given conventional western medication, and the observation group was given acupuncture based treatment. The scores for clinical symptom and the incidence of adverse reactions were compared between the two groups after treatment. Results — After treatment, the symptom scores of frequency of abdominal pain, incomplete sense of defecation, abdominal distension and difficulty in defecation in the observation group were all lower than those in the control group (P < 0.05). After treatment, the total incidence of adverse reactions of abdominal distension, spasmodic abdominal pain, borborygmus and dizziness in observation group was 4.55%, which was significantly lower than that in control group, 22.73% (P < 0.05). Conclusion — Acupuncture and moxibustion therapy is more effective than conventional western medicine therapy in treatment of chronic functional constipation,which effectively improve the clinical symptoms of patients, reduce the occurrence of adverse reactions, as as result, it is worthy of promotion and universal application.

scholarly journals Clinical Efficacy of Tacrolimus Ointment + 3 % Boric Acid Lotion Joint Chinese Angelica Decoction in Chronic Perianal Eczema

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Weiwei Gao ◽  
Xueli Qiao ◽  
Jinxin Zhu ◽  
Xin Jin ◽  
Yuegang Wei
Keyword(s):  
Skin Lesion ◽  
Boric Acid ◽  
Clinical Efficacy ◽  
Clinical Symptoms ◽  
Life Quality ◽  
Control Group ◽  
Observation Group ◽  
Baseline Information ◽  
Perianal Eczema ◽  
Area Score

Objective. To unearth the clinical efficacy of tacrolimus ointment + 3 % boric acid lotion joint Chinese angelica decoction in chronic perianal eczema. Methods. Patients with chronic perianal eczema admitted to hospital from June 2018 and June 2019 were retrospectively analyzed. Patients in the control group ( n = 38 ) underwent basic therapy with tacrolimus ointment + 3 % boric acid lotion, whereas those in the observation group ( n = 38 ) were given oral Chinese angelica decoction on the basis of the above therapy. Patient’s baseline information before therapy and clinical symptoms after therapy were observed and compared, including pruritus ani score, anus drainage and damp score, skin lesion score, skin lesion area score, life quality index score, and IL-2, IL-4, and IgE levels in serum. Overall efficacy in the two groups was also evaluated. Results. No significant differences were found in the baseline information between the observation group and control group before therapy. After therapy, pruritus ani score ( P = 0.023 ), anus drainage and damp score ( P = 0.041 ), skin lesion score ( P = 0.025 ), and skin lesion area score ( P = 0.035 ) of patients in the observation group were remarkably lower than those in the control group. Significantly higher release levels of clinical symptoms of patients in the observation group were indicated. With respect to the control group, the life quality score ( P = 0.020 ) and IgE level in serum ( P = 0.003 ) of patients in the observation group were significantly lower, while IL-4 level in serum was significantly higher ( P = 0.129 ). The therapy in the observation group achieved better clinical efficacy. Overall efficacy in the observation group was markedly favorable with respect to the control group. Conclusion. With respect to tacrolimus ointment + 3 % boric acid lotion, patients with chronic perianal eczema displayed better clinical efficacy after jointly being treated by Chinese angelica decoction.

scholarly journals Observations on the clinical efficacy of rhaFGF combined with Vitamin B complex for patients with Severe Recurrent Aphthous Ulcer

2021 ◽  
Vol 37 (7) ◽  
Author(s):  
Hui Sun ◽  
Jie Gao ◽  
Dan Li ◽  
Bing Li
Keyword(s):  
Therapeutic Effect ◽  
Clinical Efficacy ◽  
Clinical Symptoms ◽  
Effective Rate ◽  
Healing Time ◽  
Aphthous Ulcer ◽  
Control Group ◽  
Vitamin B ◽  
Observation Group ◽  
Creative Commons

Objectives: To observe the therapeutic effect of rha FGF combined with vitamin B complex on severe recurrent aphthous ulcers (RAUs). Methods: Ninety patients with severe RAU (grade III and IV) admitted to Chinese PLA General Hospital from May 2018 to May 2019 were selected and divided into two groups using a random number table, 45 patients/group. Patients in the control group gargled with a mixture of vitamin B complex (250 ml of 9% normal saline +250 ml of vitamin B complex +160,000 U of gentamicin +25 ml of lidocaine) after oral cleaning; patients in the observation group gargled with a mixture of the same ratio after oral cleaning and then sprayed rhaFGF on their oral ulcers. The clinical symptoms and treatment effects of the 2 groups within 1 week of medication were compared. Results: The total effective rate of treatment was 97.78% in the observation group and 82.22% in the control group; the difference was statistically significant (P <0.05). The time to ulcer pain disappearance and eating recovery and the ulcer healing time in the observation group were significantly shorter than those in the control group (P <0.05). Conclusion: rhaFGF combined with vitamin B complex has a significant therapeutic effect for patients with severe RAU; it can relieve pain and illness faster and shorten the healing time of ulcers. doi: https://doi.org/10.12669/pjms.37.7.4364 How to cite this:Sun H, Gao J, Li D, Li B. Observations on the clinical efficacy of rhaFGF combined with Vitamin B complex for patients with Severe Recurrent Aphthous Ulcer. Pak J Med Sci. 2021;37(7):---------. doi: https://doi.org/10.12669/pjms.37.7.4364 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Comparison of azithromycin and erythromycin in the treatment of mycoplasma pneumonia in children

2019 ◽  
Vol 36 (2) ◽  
Author(s):  
Rui Han ◽  
Qianqian Yu ◽  
Guohui Zhang ◽  
Baoqiang Li ◽  
Shuzhen Han ◽  
...  
Keyword(s):  
Adverse Reactions ◽  
Clinical Symptoms ◽  
Control Group ◽  
Clinical Effects ◽  
Observation Group ◽  
Research Subjects ◽  
Creative Commons ◽  
Significant Difference ◽  
Mycoplasma Pneumonia ◽  
The Difference

Objective: To study and compare the clinical effects of azithromycin and erythromycin on children with mycoplasma pneumonia. Methods: Total 132 children with mycoplasma pneumonia who were admitted to our hospital between November 2017 and September 2018 were selected as the research subjects. All the children were divided into an observation group and a control group according to random number table, 66 each. The observation group was treated with azithromycin, while the control group was treated with erythromycin. The therapeutic effect, incidence of adverse reactions and disappearance time of clinical symptoms were compared between the two groups. Results: The total efficacy of the observation group was 98.04%, and that of the control group was 74.51%; there was a significant difference (X2=7.184, P=0.007). The incidence of adverse reactions in the observation group was 15.69%, significantly lower than that in the control group (41.18%) (X2=6.376, P=0.002). The disappearance of fever, cough, rale and X ray shadow of the observation group was significantly earlier than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: Compared with erythromycin, azithromycin is more effective in the treatment of mycoplasma pneumonia in children. Azithromycin can further shorten the improvement time of clinical symptoms and signs and has few adverse reactions and high safety. It is worth clinical application. doi: https://doi.org/10.12669/pjms.36.2.1441 How to cite this:Han R, Yu Q, Zhang G, Li B, Han S, Li G. Comparison of azithromycin and erythromycin in the treatment of mycoplasma pneumonia in children. Pak J Med Sci. 2020;36(2):---------. doi: https://doi.org/10.12669/pjms.36.2.1441 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Analysis on Nursing Effect of Octreotide on Acute Pancreatitis

2021 ◽  
Vol 7 (4) ◽  
pp. 300-307
Author(s):  
Chenxia Wu ◽  
Li He
Keyword(s):  
Acute Pancreatitis ◽  
Clinical Symptoms ◽  
Nursing Intervention ◽  
Effective Rate ◽  
Occurrence Rate ◽  
Control Group ◽  
Observation Group ◽  
Clinical Value ◽  
Nursing Satisfaction ◽  
Satisfaction Scale

To explore the clinical value of octreotide therapy and nursing intervention in patients with acute pancreatitis. 120 patients with acute pancreatitis admitted to the Department of Digestive Medicine from June 2018 to August 2019 were selected. Two groups of patients were treated with octreotide. They were randomly divided into observation group (intensive nursing intervention) and control group (routine nursing) with 60 patients in each group. Compared with the control group (81.67%), the total effective rate (93.33%) was higher in the observation group (P<0.05%); After treatment, C reactive protein, lactate dehydrogenase, WBC and hemodiastase of patients in the observation group were better than those in the control group (P<0.05); compared with the control group (18.33%), the occurrence rate of hypoglycemia in the observation group (6.67%) was lower (P<0.05%); At the same time, the Nursing Satisfaction Scale of the observation group (95.00%) was higher than that of the control group (78.33%), (P<0.05%). Patients with acute pancreatitis treated with octreotide and strengthened nursing intervention can obtain more obvious therapeutic effect, so that the clinical symptoms and related laboratory indicators of patients have been significantly improved. At the same time, the clinical value was significant with a lower occurrence rate of hypoglycemia and higher nursing satisfaction scale.

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