scholarly journals Removal of Cancer Cells Using Thin Layers of Cadmium Oxide (CdO)�?DNA/RNA Sandwiched Complex Composite Plasmonic Nanostructure under Synchrotron Radiation

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Alireza Heidari
Keyword(s):  
Contact Angle ◽  
Cadmium Oxide ◽  
Thin Layers ◽  
Polysorbate 80 ◽  
Polyether Ether Ketone ◽  
Plasmonic Nanostructure ◽  
Usual Form ◽  
Anti Cancer ◽  
Ether Ketone ◽  
Protective Membrane

The current study is aimed to use Polysorbate 80 as surfactant for investigating the effectiveness of permeate TBA on the Polyether Ether Ketone (PEEK) anti–cancer protective membrane and the effect of loading DNA/RNA–CdO sandwiched complex on hydrophilicity and anti–cancer properties. The results showed decreasing surface pore size from 227 to 176 and increasing porosity from 101 to 111 with loading DNA/RNA–CdO sandwiched complex, and the permeate of anti–cancer protective membrane increased from 80 to 220 (L/m2.hr.bar) with loading DNA/RNA–CdO sandwiched complex. In addition, the results of current study showed that by increasing DNA/RNA–CdO sandwiched complex nanohybrides to 0.09Wt% to polymer matrix contact angle decreased from 84.4 to 23 degree. Moreover, the results of current study showed that by increasing DNA/RNA–CdO sandwiched complex nanohybrides to 0.09Wt% to hydrophilicity of anti–cancer protective membranes increased. All of the above results mentioned fouling of hybride anti–cancer protective membrane decreased than usual form. Therefore, hybride anti–cancer protective membranes of (DNA/RNA–CdO sandwiched complex) with the help of Polysorbate 80 as surfactant may be considered as a suitable anti�?cancer protective membrane for treatment of TBA.

scholarly journals INVESTIGATION OF CANCER CELLS USING THIN LAYERS OF CADMIUM OXIDE (CdO)–DNA/RNA SANDWICHED COMPLEX COMPOSITE PLASMONIC NANOSTRUCTURE UNDER SYNCHROTRON RADIATION

2022 ◽  
pp. 1-14
Author(s):  
ALIREZA HEIDARI
Keyword(s):  
Cadmium Oxide ◽  
Amorphous Powder ◽  
Attenuated Total Reflection ◽  
Thin Layers ◽  
X Ray ◽  
Octahedral Cation ◽  
Anti Cancer ◽  
Type Semiconductor ◽  
Polycyclic Aromatic ◽  
Protective Membrane

Triptycene Barrelene Anthracene (TBA) is a polycyclic aromatic hydrocarbon consisting of three benzene rings. The name TBA is a composite of phenyl and TBA. In its pure form, it is found in cigarette smoke and is a known irritant, photosensitizing skin and industrial carcinogenic wastewater. Cadmium Oxide (CdO) is an inorganic compound with the formula CdO. It is one of the main precursors to other cadmium compounds. It crystallizes in a cubic rocksalt lattice-like sodium chloride, with octahedral cation and anion centers. It occurs naturally as the rare mineral monteponite. CdO can be found as a colorless amorphous powder or as brown or red crystals. CdO is an n-type semiconductor with a bandgap of 2.18 eV (2.31 eV) at room temperature (298 K). DNA/RNA, CdO and DNA/RNA–CdO sandwiched complex was characterized by Attenuated Total Reflection–Fourier Transform–Infrared (ATR–FTIR) spectroscopy, Raman spectroscopy, X–Ray Diffraction (XRD) technique and Energy–Dispersive X–Ray (EDAX) spectroscopy. The modified anti–cancer-protective membrane was characterized by Scanning Electron Microscope (SEM), EDAX analysis, 3D–Atomic–Force Microscopy (3D–AFM), Transmission Electron Microscopy (TEM) and contact angle analyses and methods. The current study is aimed to use Polysorbate 80 as a surfactant for investigating the effectiveness of permeate TBA on the Polyether Ether Ketone (PEEK) anti–cancer-protective membrane and the effect of loading DNA/RNA–CdO sandwiched complex on hydrophilicity and anti-cancer properties. The results showed decreasing surface pore size from 227 to 176 and increasing porosity from 101 to 111 with loading DNA/RNA–CdO sandwiched complex, and the permeate of anti–cancer-protective membrane increased from 80 to 220 (L/m2. hr. bar) with loading DNA/RNA–CdO sandwiched complex.

scholarly journals Study of Anti-Cancer Properties of Thin Layers of Cadmium Oxide (CdO) Nanostructure

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Heidari Alireza ◽  
Esposito Jennifer ◽  
Caissutti Angela
Keyword(s):  
Cadmium Oxide ◽  
Thin Layers ◽  
Anti Cancer

Composite Enhancement Polyether-Ether-Ketone for Long Segmental Spinal Column Deformity Orthopedic Treatment

2020 ◽  
Vol 12 (9) ◽  
pp. 1332-1340
Author(s):  
Qingjun Mao ◽  
Jixiang Wang ◽  
Xiaofeng Song ◽  
Haipeng Pang ◽  
Yulin Tao ◽  
...  
Keyword(s):  
Contact Angle ◽  
Spinal Deformity ◽  
Large Scale ◽  
Physical Adsorption ◽  
Copper Substrate ◽  
Leading Edge ◽  
Intervertebral Fusion ◽  
Fusion Device ◽  
Polyether Ether Ketone ◽  
Ether Ketone

Polyether-ether-ketone (PEEK) anterior intervertebral fusion combined with posterior long segment orthopedic surgery is a common method for the therapy of orthopedic deformity of the spine. PEEK material plays an important role in the effect of surgery. Graphene on copper substrate was transferred to the surface of carbon- fiber reinforced polyether-ether-ketone (CFR-PEEK) material by ferric chloride (FeCl3) chemical erosion and physical adsorption, hence the compound enhancement polyether-ether-ketone (Ge-PEEK) was achieved. In terms of characterization, Raman spectrometer was used to analyze the characteristics of the product gener- ation, the scanning electron microscope (SEM) was used to analyze the morphology of the product, and the hydrophilicity of the material was analyzed by the droplet contact Angle. From the perspective of intervertebral fusion, Ge-PEEK material was used in the intervertebral fusion device to analyze the effect of the fusion device in the correction of spinal deformity, such as displacement, convex Angle, and collapse. In the characteriza- tion test, Raman spectrum analysis showed that Ge-PEEK material had the characteristic peaks of graphene, and SEM analysis showed that CFR-PEEK material was covered on a large scale by graphene. In the droplet contact angle test, the contact angle of the graphene-modified CFR-PEEK material was significantly reduced (P < 0.05). The material had good hydrophilicity. In the analysis of lumbar interfusion, the anterior intervertebral fusion rate based on Ge-PEEK material was 95.8% (P < 0.05), and the vertebral deposition rate based on Ge-PEEK fusion device was 7.2% (P < 0.05). At the same time, the distance between the leading edge of the cone after operation and the last follow-up was compared, and it was found that the displacement distance of different segments was smaller (P < 0.05). This study proved that the proposed Ge-PEEK material was feasible for anterior intervertebral fusion in the correction of long-segment spinal deformity.

scholarly journals Encapsulation of Capacitive Micromachined Ultrasonic Transducers (CMUTs) for the Acoustic Communication between Medical Implants

Sensors ◽  
2021 ◽  
Vol 21 (2) ◽  
pp. 421
Author(s):  
Jorge Oevermann ◽  
Peter Weber ◽  
Steffen H. Tretbar
Keyword(s):  
Data Security ◽  
Ultrasonic Transducers ◽  
Surrounding Tissue ◽  
Center Frequency ◽  
Medical Implants ◽  
Research Groups ◽  
Capacitive Micromachined Ultrasonic Transducers ◽  
Polyether Ether Ketone ◽  
High Bandwidth ◽  
Ether Ketone

The aim of this work was to extend conventional medical implants by the possibility of communication between them. For reasons of data security and transmitting distances, this communication should be realized using ultrasound, which is generated and detected by capacitive micromachined ultrasonic transducers (CMUTs). These offer the advantage of an inherent high bandwidth and a high integration capability. To protect the surrounding tissue, it has to be encapsulated. In contrast to previous results of other research groups dealing with the encapsulation of CMUTs, the goal here is to integrate the CMUT into the housing of a medical implant. In this work, CMUTs were designed and fabricated for a center frequency of 2 MHz in water and experimentally tested on their characteristics for operation behind layers of Polyether ether ketone (PEEK) and titanium, two typical materials for the housings of medical implants. It could be shown that with silicone as a coupling layer it is possible to operate a CMUT behind the housing of an implant. Although it changes the characteristics of the CMUT, the setup is found to be well suited for communication between two transducers over a distance of at least 8 cm.

scholarly journals Interfacial Fracture Toughness Comparison of Three Indirect Resin Composites to Dentin and Polyether Ether Ketone Polymer

2020 ◽  
Vol 14 (03) ◽  
pp. 456-461
Author(s):  
Rayhaneh Khalesi ◽  
Mahdi Abbasi ◽  
Zahra Shahidi ◽  
Masoumeh Hasani Tabatabaei ◽  
Zohreh Moradi
Keyword(s):  
Fracture Toughness ◽  
Bond Strength ◽  
Testing Machine ◽  
Composite Resins ◽  
High Wear Resistance ◽  
Luting Cements ◽  
Anterior Teeth ◽  
Polyether Ether Ketone ◽  
Ether Ketone

Abstract Objectives Advances in laboratory composites and their high wear resistance and fracture toughness have resulted in their growing popularity and increasing use for dental restorations. This study sought to assess the fracture toughness of three indirect composites bonded to dental substrate and polyether ether ketone (PEEK) polymer. Materials and Methods This in vitro study was conducted on two groups of dental and polymer substrates. Each substrate was bonded to three indirect composite resins. Sixty blocks (3 × 3 × 12 mm) were made of sound bovine anterior teeth and PEEK polymer. Sixty blocks (3 × 3 × 12 mm) were fabricated of CRIOS (Coltene, Germany), high impact polymer composite (HIPC; Bredent, Germany), and GRADIA (Indirect; GC, Japan) composite resins. Composites were bonded to dentin using Panavia F 2.0 (Kuraray, Japan). For bonding to PEEK, Combo.lign (Bredent) and Visio.Link (Bredent) luting cements were used. In all samples, a single-edge notch was created by a no. 11 surgical blade at the interface. The samples were subjected to 3,500 thermal cycles, and their fracture toughness was measured in a universal testing machine (Zwick/Roell, Germany) by application of four-point flexural load. Statistical Analysis Data were analyzed using one-way analysis of variance, Kruskal–Wallis. Results The fracture toughness of CRIOS–PEEK interface was significantly higher than HIPC–PEEK. The fracture toughness of GRADIA–PEEK was not significantly different from that of HIPC and CRIOS. The fracture toughness of GRADIA–dentin was significantly higher than HIPC–dentin. Conclusion Considering the limitations of this study, GRADIA has the highest bond strength to dentin, while CRIOS shows the highest bond strength to PEEK.

scholarly journals Adhesion Behaviour of Primary Human Osteoblasts and Fibroblasts on Polyether Ether Ketone Compared with Titanium under In Vitro Lipopolysaccharide Incubation

Materials ◽  
2019 ◽  
Vol 12 (17) ◽  
pp. 2739 ◽  
Author(s):  
Korbinian Benz ◽  
Andreas Schöbel ◽  
Marisa Dietz ◽  
Peter Maurer ◽  
Jochen Jackowski
Keyword(s):  
Gene Expression ◽  
Protein Level ◽  
Binding Protein ◽  
Sem Images ◽  
Human Osteoblasts ◽  
Polyether Ether Ketone ◽  
Primary Human Osteoblasts ◽  
Titanium Surfaces ◽  
Ether Ketone

The aim of this in vitro pilot study was to analyse the adhesion behaviour of human osteoblasts and fibroblasts on polyether ether ketone (PEEK) when compared with titanium surfaces in an inflammatory environment under lipopolysaccharide (LPS) incubation. Scanning electron microscopy (SEM) images of primary human osteoblasts/fibroblasts on titanium/PEEK samples were created. The gene expression of the LPS-binding protein (LBP) and the LPS receptor (toll-like receptor 4; TLR4) was measured by real-time polymerase chain reaction (PCR). Immunocytochemistry was used to obtain evidence for the distribution of LBP/TLR4 at the protein level of the extra-cellular-matrix-binding protein vinculin and the actin cytoskeleton. SEM images revealed that the osteoblasts and fibroblasts on the PEEK surfaces had adhesion characteristics comparable to those of titanium. The osteoblasts contracted under LPS incubation and a significantly increased LBP gene expression were detected. This was discernible at the protein level on all the materials. Whereas no increase of TLR4 was detected with regard to mRNA concentrations, a considerable increase in the antibody reaction was detected on all the materials. As is the case with titanium, the colonisation of human osteoblasts and fibroblasts on PEEK samples is possible under pro-inflammatory environmental conditions and the cellular inflammation behaviour towards PEEK is lower than that of titanium.

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