UJI HEDONISME SEDIAAN GEL ANTIJERAWAT DARI JERUK NIPIS

2021 ◽  
Vol 2 (1) ◽  
pp. 35
Author(s):  
Diah Ratnasari
Keyword(s):  
Facial Skin ◽  
Herbal Preparations ◽  
Physical Evaluation ◽  
Skin Problem ◽  
Optimum Stability ◽  
Herbal Plants ◽  
Gel Preparation ◽  
Disease Free ◽  
Citrus Aurantiifolia

Clean, smooth, and disease-free facial skin is a dream. However, the reality is that many people have skin problems. The skin problem that often occurs is acne. One way to treat acne is by using herbal preparations. Herbal plants that have anti-acne properties include Citrus aurantiifolia and menthol. The purpose of this study was to make antiacne gel preparations from Citrus aurantiifolia and menthol. There are also stages of this research, including formula making, production and physical evaluation of preparations to obtain the best dosage formulas. In addition, the determination of the optimum stability and formula is obtained from the physical evaluation of the gel preparation which includes organoleptic and hedonism test.  Keyword : herbal, Citrus aurantiifolia, menthol, hedonism test

scholarly journals Spectrophotometric indicators of the stability of anthocyanin-containing extracts depending on the color of plant materials

2020 ◽  
Vol 31 (2) ◽  
pp. 88-92
Author(s):  
Vladimir Mikhailovich Koldaev ◽  
Artem Yurevich Manyakhin ◽  
Petr Semenovich Zorikov
Keyword(s):  
Hydrochloric Acid ◽  
Stability Factor ◽  
Plant Materials ◽  
Herbal Preparations ◽  
Violet Color ◽  
The Stability ◽  
Selection Of ◽  
Factor Coefficient ◽  
Anthocyanin Degradation

AbstractThis paper aims at spectrophotometric determination of changes in stability of extractable anthocyanins during drying of plant materials depending on their color. Raw and dried colored parts of 50 plant species from 25 families were used for the study. The extracts were prepared over 95% ethanol acidified with hydrochloric acid (pH ~ 1). The absorption spectra were registered within the range of 210 to 680 nm. The extinction variability factor, coefficient of intensity absorption relative and generalized stability factor were used to determine the anthocyanin degradation. The highest values of the stability factor were obtained for the extracts from fruit shells of burgundy or violet color within the range of 0.934±0.024 to 0.973±0.024, while the extracts from flower petals of the same care featured the stability factor that was 1.19 to 1.44 times less. The values of the stability factor of the extracts from black, red and blue materials are 1.15 to 1.19 times, 1.74 to 2.48 times and 4.65 to 4.84 times less respectively than those of the extracts from violet-burgundy materials. It is appropriate to apply the spectrophotometric factors of anthocyanins stability used in this study to selection of promising plants for industrial cultivation as material of anthocyanin-containing herbal preparations. The most stable anthocyanins are those of burgundy-purple and black fruits.

scholarly journals Determination of the Equilibrium Point According to a Temporal Model of Rehydration in a Population with Cholera in Logistic Growth

2020 ◽  
pp. 1-5
Author(s):  
K. O. Jackob
Keyword(s):  
Equilibrium Point ◽  
Medical Attention ◽  
Logistic Growth ◽  
Cholera Outbreak ◽  
Temporal Model ◽  
Multiple Interaction ◽  
Transmission Pathways ◽  
Untreated Individuals ◽  
Disease Free

Cholera is an infection of the small intestine of humans caused by a gram-negative bacterium called Vibrio cholerae. It is spread through eating food or drinking water contaminated with faeces from an infected person. It causes rapid dehydration and general body imbalance, and can lead to death since untreated individuals suer severely from diarrhea and vomiting. Its dynamics involves multiple interaction between the human host, the pathogen and the environment which contributes to both human to human and indirect environment to human transmission pathways. Rehydration is critical in reducing cholera death. This has been studied by other scholars but they did not consider delay in rehydration on the spread of cholera. In this paper, I formulate a mathematical model based on system of ordinary differential equation with rehydration on the spread of cholera in a logistically growing population. The existence of the steady states and the basic reproduction number is established such that disease free equilibrium point exists. Determination of endemic equilibrium shows that the model has positive points. The findings will be signicant in the sense that timely rehydration should be done during cholera outbreak and will enable individuals with symptoms to seek immediate medical attention.

Re-Evaluating Disease-Free Survival as an Endpoint vs Overall Survival in Stage III Adjuvant Colon Cancer Trials

2021 ◽  
Author(s):  
Jun Yin ◽  
Mohamed E Salem ◽  
Jesse G Dixon ◽  
Zhaohui Jin ◽  
Romain Cohen ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Overall Survival ◽  
Disease Free Survival ◽  
Surrogate Endpoint ◽  
Free Survival ◽  
A Value ◽  
Deficient Mismatch Repair ◽  
Disease Free

Abstract Background Disease-free survival with a 3-year median follow-up (3-year DFS) was validated as a surrogate for overall survival with a 5-year median follow-up (5-year OS) in adjuvant chemotherapy colon cancer (CC) trials. Recent data show further improvements in OS and survival after recurrence, in patients who received adjuvant FOLFOX. Hence, re-evaluation of the association between DFS and OS and determination of the optimal follow-up duration of OS to aid its utility in future adjuvant trials are needed. Methods Individual patient data from nine randomized studies conducted between 1998 and 2009 were included; three trials tested biologics. Trial-level surrogacy examining the correlation of treatment effect estimates of 3-year DFS with 5 to 6.5-year OS was evaluated using both linear regression (R2WLS) and Copula bivariate (R2Copula) models and reported with 95% confidence intervals (CIs). For R2, a value closer to 1 indicates a stronger correlation. Results Data from a total of 18,396 patients were analyzed (median age = 59 years; 54.0% male), with 54.1% having low-risk tumors (pT1-3 & pN1), 31.6% KRAS mutated, 12.3% BRAF mutated, and 12.4% microsatellite instability high/deficient mismatch repair tumors. Trial level correlation between 3-year DFS and 5-year OS remained strong (R2 =0.82, 95% CI = 0.67 to 0.98; R2 =0.92, 95% CI = 0.83 to 1.00) and increased as the median follow-up of OS extended. Analyses limited to trials that tested biologics showed consistent results. Conclusion Three-year DFS remains a validated surrogate endpoint for 5-year OS in adjuvant CC trials. The correlation was likely strengthened with 6 years of follow-up for OS.

RP-HPLC AND HPTLC METHODS FOR THE ESTIMATION OF LUPEOL IN. HEMIDESMUS INDICUS LINN. ROOT EXTRACTS AND POLYHERBAL FORMULATION USING STANDARD MA

INDIAN DRUGS ◽  
2020 ◽  
Vol 57 (07) ◽  
pp. 40-46
Author(s):  
Jayaprakasam Rajendran ◽  
Anita Elizabeth Chacko ◽  
Tresa Thomas ◽  
Neethu Johnson ◽  
Kochupapy Ravi Thengungal
Keyword(s):  
Correlation Coefficient ◽  
Chemical Constituents ◽  
Hemidesmus Indicus ◽  
Polyherbal Formulation ◽  
Ich Guidelines ◽  
Soxhlet Apparatus ◽  
The Family ◽  
Herbal Plants ◽  
Hptlc Method

The roots of Hemidesmus indicus, belonging to the family Ascelpidaceae, are used as blood purifier, antileucorrhoeic, galactogenic, antidiarrhoeal, antirheumatic, antisyphilitic, febrifuge and possesses chemical constituents like triterpenoids (lupeol), flavonoids, glycosides and tannins. Roots were dried and extracted with petroleum ether, chloroform and methanol by using Soxhlet apparatus. Two simple and sensitive chromatographic methods, namely, HPTLC and HPLC, were developed for determination of lupeol from the extract of H. indicus and its polyherbal formulation and validated according to ICH guidelines. The HPTLC method linear regression data for the standard lupeol a concentration range of 400-900ng/spot and correlation coefficient (r) was 0.9904. The HPLC calibration curves of standard lupeol showed good linearity range from 20 to 100μg/ml and correlation coefficient (r) was 0.9929. The HPTLC and HPLC methods are simple, precise, accurate and specific. Hence, these methods can be used for the standardization of lupeol in herbal plants and polyherbal formulations.

scholarly journals Quantitative Determination of Heavy Metal Concentrations in Herbal Teas Marketed in Various Countries Including Libya

2017 ◽  
pp. 1-10 ◽  
Author(s):  
M. A. Elbagermi ◽  
A. I. Alajtal ◽  
H. G. M. Edwards
Keyword(s):  
Heavy Metals ◽  
Analytical Procedure ◽  
Certified Reference Materials ◽  
Tea Leaves ◽  
Herbal Tea ◽  
Regulatory Standards ◽  
Control Centre ◽  
Herbal Plants ◽  
Tea Leaf

This study presents the determination of the amount of some heavy metals (Cu, Cr, Ni, Cd, Mn, Fe, Mg and Pb) present in commercial brand herbal tea samples purchased from local markets in Misurata, Libya, by atomic absorption spectroscopy. The validity of the analytical procedure was monitored by analysing certified reference materials obtained from the Food and Drugs Control Centre, Libya. The concentration of Cu, Cr, Ni, Cd, Mn, Fe, Mg and Pb in all the tea leaf samples ranged from 5.141 to 17.1, 0.890 to 3.4, 0.0833 to 2.349, 0.035 to 0.38, 32.01to 89.46, 79.01-167, 91.98 to 213.83 and 0.463 to 0.901 µg g-1, respectively. The concentration of heavy metals in the tea leaves can be arranged in the following order, Mg> Fe> Mn>Cu >Cr> Ni> Pb> Cd. Moreover, it is observed that the concentrations of all the toxic elements tested in the investigated herbal plants are found below the permitted levels specified by the international regulatory standards for the medicinal plants.

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