Effi cacy and safety of carboxytherapy in patients with ischemic stroke

2022 ◽  
Vol 26 (6) ◽  
pp. 52-62
Author(s):  
G. R. Ramazanov ◽  
E. A. Chukina ◽  
E. V. Shevchenko ◽  
S. A. Abudeev ◽  
E. V. Klychnikova ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Clinical Laboratory ◽  
Integrated Approach ◽  
Neurological Status ◽  
The Body ◽  
Physical Factors ◽  
Negative Consequences ◽  
Duration Of Treatment ◽  
Duration Of Hospitalization ◽  
The Impact

The modern integrated approach to the treatment of ischemic stroke (IS), in addition to pharmacotherapy, provides for the impact of physical factors. Among them is injectable carboxytherapy (ICBT). Objective. The aim of the study was to evaluate the effi cacy and safety of using ICBT in combination with a standard treatment program in patients with acute ischemic stroke. Material and methods. The main group (MG) included 39 patients with acute IS, the comparison group (GC) — 31 patients. On the second day of hospitalization, patients with MG underwent ICBT on the background of standard therapy, and GC — procedures that mimic ICBT. Clinical, laboratory and instrumental data, IS outcomes, complications, timing were assessed.Results. There were no statistically signifi cant diff erences in physiological parameters (heart rate, blood pressure, SpO2) between MG and GC during and after the course of treatment. Positive dynamics of the neurological status was observed in both groups in the form of a decrease in the NIHSS score — in the MG from 6 to 4 (p = 0.047), in the GC — also from 6 to 4 (p = 0.25). In patients with MG, trophic disorders were less likely to develop in comparison with GC — 1 (2.6%) versus 6 (19.4%), p = 0.039. ICBT did not aff ect the duration of hospitalization of patients, the duration of treatment in the intensive care unit and carrying of resuscitation and also did not contribute to reducing mortality. Changes in the indicators of the acid-base state of the blood were compensatory in nature and did not lead to changes in the pH of the blood. The decrease in pH from 7.5 to 7.4 in 30–90 minutes after the procedures was a physiological reaction of the body to the introduction of CO2 and was not accompanied by negative consequences. Conclusions. ICBT is a safe method, does not aff ect the duration of hospital stay and mortality, help lower the likelihood of complications.

Effect of age on outcome in patients with cerebral stroke

2020 ◽  
pp. 41-45
Author(s):  
G. R. Kuchava ◽  
E. V. Eliseev ◽  
B. V. Silaev ◽  
D. A. Doroshenko ◽  
Yu. N. Fedulaev
Keyword(s):  
Ischemic Stroke ◽  
Neurological Deficit ◽  
Neurological Status ◽  
Statistical Correlation ◽  
Multiple Organ ◽  
The Body ◽  
Social Adaptation ◽  
Cerebral Stroke ◽  
Septic Complications ◽  
Risk Of Death

The aim of the study was to assess the course and outcome of cerebral infarction, depending on the age factor and duration of stay in the neuroblock. Materials and methods: a dynamic observation of 494 patients, men and women, aged 38–84 years with acute ischemic stroke of hemispheric localization, which were divided into the three groups depending on age, was performed. Group 1 – younger than 60 years old, group 2–60–70 years old, group 3 – older than 60 years. All patients underwent standard therapy, according to the recommendations for the treatment of ischemic stroke. The patients underwent comprehensive clinical and instrumental monitoring, which included assessment of somatic and neurological status according to the NIH‑NINDS scales at 1st, 3rd, 10th days and at discharge or death; assessment of the level of social adaptation according to the Bartel scale on 1st, 3rd, 10th days and at discharge, clinical and biochemical blood tests, computed tomography of the brain. Assessment of the quality of therapy was carried out according to specially developed maps using methods of statistical correlation analysis. Results: the most pronounced positive dynamics of neurological status was in the 1st group of patients. The regression of neurological deficit in the 2nd group was worse. The minimal dynamics of neurological deficit was in the 3rd group of patients with cerebral stroke. Most often, the death of patients with cerebral stroke occurred from the development of multiple organ disorders. Conclusions: patients over 70 years of age have the greatest risk of death, due to: a decrease in the reactivity of the body, the presence of initially severe concomitant somatic pathology in patients with admission to hospital; accession of secondary somatic and purulent‑septic complications.

scholarly journals Selecting informative biomarkers for early diagnosis of occupational neurological diseases

2021 ◽  
Vol 100 (9) ◽  
pp. 953-958
Author(s):  
Inna V. Lapko
Keyword(s):  
Insulin Resistance ◽  
Carbohydrate Metabolism ◽  
The Body ◽  
Working Environment ◽  
Total Testosterone ◽  
Physical Factors ◽  
Lumbosacral Radiculopathy ◽  
Vibration Disease ◽  
Neurohumoral Regulation ◽  
The Impact

Introduction. At present, the patterns of changes in the levels of biomarkers and the relationship of changes in their values with the pathogenesis of diseases caused by the impact of adverse factors of labour activity are not sufficiently studied. The most unresolved issues are the choice of informative laboratory indicators and diagnostic test systems in investigating the impact of physical factors on the working environment (vibration and physical overload) neurohumoral regulation: pituitary-adrenal pituitary-thyroid, pituitary-gonadal system and hormonal indicators of carbohydrate metabolism. The aim of the study was to determine diagnostic hormonal markers and integral indices to identify early changes in the neurohumoral status in the body of workers under the influence of working environment factors. Materials and methods. 330 workers of mining and machine-building enterprises were examined. Of these, 128 people with vibration disease, 45 people - with lumbosacral radiculopathy, combined pathology (vibration disease and lumbosacral radiculopathy) was detected in 60 persons. The preclinical stage (initial signs of diseases) was noted in 97 workers. Laboratory studies included hormones and integral indices of the pituitary-adrenal, pituitary-thyroid, pituitary-gonadal system, carbohydrate metabolism. To select the diagnostic significance of laboratory biomarkers, diagnostic sensitivity, prenosological value, pathognomonicity, direction, severity, and selectivity of changes in biomarker levels were evaluated. Results. The combined effect of vibration and physical overload on the body of workers was found to have a unidirectional and systemic impact on the levels of hormones of the pituitary-adrenal, pituitary-thyroid and pituitary-gonadal systems, increases insulin resistance. The severity of changes in neurohumoral regulation indicators depends on the nature and severity of the occupational neurological disease. The highest diagnostic sensitivity (Df = 72-74%) in vibration disease and its combination with lumbosacral radiculopathy was obtained for pituitary-gonadal hormones and indicators of insulin resistance. The lowest values of Dh are typical for the hormones of the pituitary-thyroid system (no more than 14%). To identify early changes in neurohumoral regulation in the body under the influence of vibration and physical exertion, it is most informative to determine the concentration of total testosterone, luteinizing hormone and insulin, as well as the integral pituitary-adrenal index, insulin resistance indices. To identify hidden disorders of the pituitary-thyroid system, the definition of the essential thyroid index can be used. Discussion. The results obtained allowed us to assess the nature of changes in the levels of hormones of the pituitary-adrenal, pituitary-thyroid and pituitary-gonadal systems and carbohydrate metabolism and to propose informative laboratory biomarkers reflecting early changes in neurohumoral regulation under the influence of physical factors of the working environment. Conclusions. To identify early changes in neurohumoral regulation in the body of workers under the influence of vibration and physical exertion, the most informative is the determination of the concentration of total testosterone, luteinizing hormone and insulin, the integral pituitary-adrenal index, and insulin resistance indices. To identify hidden disorders of the pituitary-thyroid system, the definition of the integral thyroid index can be used.

Abstract WP88: Volumetric Measures of Hemorrhagic Transformation After Acute Ischemic Stroke Predicts Neurological Deterioration Better Than Radiologic Classification

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Ali Hamzehloo ◽  
Atul Kumar ◽  
Laura Heitsch ◽  
Daniel Strbian ◽  
Agnieszka Slowik ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Neurological Status ◽  
Hemorrhagic Transformation ◽  
Neurological Deterioration ◽  
Receiver Operating Curve ◽  
Early Neurological Deterioration ◽  
Hemorrhage Volume ◽  
The Difference ◽  
The Impact

Introduction: Hemorrhagic transformation (HT) after acute ischemic stroke (AIS) may contribute to neurologic deterioration. The current radiologic classification of HT is qualitative and distinguishes petechial hemorrhagic infarction from parenchymal hematoma (PH-1 and PH-2). However, this grading scheme is subjective and may not accurately reflect the impact of HT on neurological status and outcome. We sought to evaluate whether the volume of hemorrhage was a better marker of deterioration. Methods: We evaluated AIS patients with follow-up CT imaging from a prospective stroke genetics study. HT seen within 36 hours of AI was classified using ECASS criteria. In addition, we outlined all confluent areas of hemorrhage to derive hemorrhage volume (HV). We calculated ΔNIHSS as the difference between baseline and 24-hour NIHSS. Early neurological deterioration (END) was defined as ΔNIHSS of -4 points or more. Association of radiologic HT grade and HV with ΔNIHSS and END were analyzed using linear regression and receiver-operating-curve testing. Results: We analyzed 948 stroke patients with median NIHSS 7 (IQR 4-14), 64% receiving tPA and ΔNIHSS +2 (IQR 0-5). 294 (31%) had HT (146 HI1, 63 HI2, 42 PH1 and 43 PH2). HT was associated with higher baseline NIHSS but not with tPA treatment or ΔNIHSS. END occurred in 113 (12%) including 46 with HT (16%) vs. 67 (10%) without HT (p=0.02). Amongst those with HT, the radiologic grade was not associated with ΔNIHSS or END (20% of PH2, 20% of PH1 vs. 15% of HI1/HI2, p=0.40). However, greater HV was associated with ΔNIHSS (adjusting for baseline NIHSS and tPA, estimate -1.5 point per 10-ml, p=0.0001) and with END (those with END had median HV 7 vs. 3-ml, p=0.001). A cut-off of 12-ml had 45% sensitivity and 90% specificity for END (AUC of 0.72). Conclusion: We demonstrated that while HT was associated with a higher risk of END, the ECASS classification alone did not distinguish those who worsened. It appears that hemorrhage volume may better predict worsening NIHSS and END with moderate sensitivity.

scholarly journals Impact of Lifestyles (Diet and Exercise) on Vascular Health: Oxidative Stress and Endothelial Function

2020 ◽  
Vol 2020 ◽  
pp. 1-22 ◽  
Author(s):  
Andy W. C. Man ◽  
Huige Li ◽  
Ning Xia
Keyword(s):  
Oxidative Stress ◽  
Metabolic Diseases ◽  
Healthy Lifestyle ◽  
Current Knowledge ◽  
Vascular Dysfunction ◽  
The Body ◽  
Physical Factors ◽  
Normal Functions ◽  
The Impact ◽  
And Oxidative Stress

Healthy lifestyle and diet are associated with significant reduction in risk of obesity, type 2 diabetes, and cardiovascular diseases. Oxidative stress and the imbalance between prooxidants and antioxidants are linked to cardiovascular and metabolic diseases. Changes in antioxidant capacity of the body may lead to oxidative stress and vascular dysfunction. Diet is an important source of antioxidants, while exercise offers many health benefits as well. Recent findings have evidenced that diet and physical factors are correlated to oxidative stress. Diet and physical factors have debatable roles in modulating oxidative stress and effects on the endothelium. Since endothelium and oxidative stress play critical roles in cardiovascular and metabolic diseases, dietary and physical factors could have significant implications on prevention of the diseases. This review is aimed at summarizing the current knowledge on the impact of diet manipulation and physical factors on endothelium and oxidative stress, focusing on cardiovascular and metabolic diseases. We discuss the friend-and-foe role of dietary modification (including different diet styles, calorie restriction, and nutrient supplementation) on endothelium and oxidative stress, as well as the potential benefits and concerns of physical activity and exercise on endothelium and oxidative stress. A fine balance between oxidative stress and antioxidants is important for normal functions in the cells and interfering with this balance may lead to unfavorable effects. Further studies are needed to identify the best diet composition and exercise intensity.

Development and distribution of karst and suffusion processes on the territory of the Belgorod region, assessment of their impact on the environment

2021 ◽  
Vol 27 (2) ◽  
pp. 42-51
Author(s):  
D. Sarychev ◽  
◽  
А. Sarychev ◽  
I. Arkhiptsev ◽  
N. Demchenko ◽  
...  
Keyword(s):  
Mathematical Modeling ◽  
Agricultural Land ◽  
Integrated Approach ◽  
Physical Models ◽  
Negative Consequences ◽  
Economic Activities ◽  
Industrial Enterprises ◽  
Geological Processes ◽  
Industrial Buildings ◽  
The Impact

Relevance. The problem of studying karst-suffusion processes is that soluble rocks in Russia occupy large areas. The Belgorod region is rich in Cretaceous deposits, which are widespread throughout the territory. Due to the fact that carbonate rocks are susceptible to dissolution by surface and groundwater leads to the formation of karst forms. Such forms open and form places of karst waters’ accumulation, open fissure and cave systems and are becoming areas with an increased environmental hazard to the life of people, infrastructure, civil and industrial buildings. Dangerous exogenous geomorphological processes negatively affect the economic development of the region. The purpose of the article is to study the factors influencing the development and distribution of karst and suffusion processes, the reasons for their occurrence, as well as the impact on the environment. Among hazardous exogenous geological processes, karst-suffusion processes are the most unpredictable. Their occurrence has negative consequences for the economics and economic activities of the region. The main methods used in this study are observation method, laboratory experiment and mathematical modeling. The method of mathematical modeling has relatively recently come into the use by the researchers and allows for a better reproduction of processes on physical models. This study is aimed at determining the interaction of karst and suffusion processes, as well as assessing their impact on the environment. The zoning of the karst and suffusion distribution on the territory of the Belgorod region has made it possible to identify the causes of these processes. To prevent the development and spread of karst-suffusion processes, an integrated approach to the analysis of manifestation, drawing up a forecast plan and measures to counter negative consequences is required. Based on the results of the study, measures were proposed to minimize damage to agricultural land, residential and farm buildings, as well as measures to combat karst and suffusion processes. It should be noted that the results of the study and the developed measures to prevent the negative consequences of karst and suffusion processes can be used in human agricultural activities, construction of civil and industrial enterprises, their reconstruction, laying of communications and development of carbonate new deposits

Well-being and the worshipper: a scientific perspective of selected contemplative practices in Islam

Humanomics ◽  
2017 ◽  
Vol 33 (2) ◽  
pp. 163-188 ◽  
Author(s):  
Mohamed Safiullah Munsoor ◽  
Hannah Safiullah Munsoor
Keyword(s):  
Health Benefits ◽  
Integrated Approach ◽  
Well Being ◽  
The Body ◽  
Social Implications ◽  
Negative Consequences ◽  
Contemplative Practices ◽  
Content Type ◽  
The Social ◽  
The Mind

Purpose Modern life is characterized by its hectic life-style, which invariably leads to high levels of stress having negative consequences for the mind-body. Thus, people are seeking for natural ways to achieve a sense of equilibrium and peace. Neuroscience has identified beneficial findings from contemplative practices like meditation, prayers and fasting. Within the Islamic framework, these practices were found to be beneficial for both the body and the mind. However, comparatively little research has been carried out on Islamic contemplative practices. Thus, there is a dire need to carry out further research, where the focus needs to be more on the inward aspects of Islam especially the contemplative practices. Design/methodology/approach The study took an integrated approach, whereby, objective experimental data from various sources were combined with the religious narratives from the Qur’an and the Hadiths or the practice of the Prophet in Islam. This was augmented by the subjective experiences of the participants of the study and all of these woven to present a case for Islamic contemplative practices. Findings Worship, be it Yogic, Buddhist and Islamic, seems to have positive mental and physical benefits for individuals. Much has been documented within the field of Yoga and Buddhist practices, and it is only recently that Islamic practices are beginning to be studied and are yielding similar results. It has been found that Islamic ritual prayers, fasting and meditation (dhikr) have an impact on the well-being of the worshipper. The communities of practice commonly known as “tariqas” and other religio-spiritual orders can serve as a vehicle to further these practices. This opens the door for more extensive research in this direction. Research limitations/implications This study clearly indicates that Islamic practices have positive benefits; however, the number of studies are limited. Moreover, there are a whole system of practices as the contemplative tree in this paper points out, which needs more robust as well as longitudinal studies to outline more conclusive evidence to this effect. Practical implications Muslims have been looking at other traditions like Yoga and Buddhist meditation to find ways of improving their physical and mental health. This meta-study indicates that Islamic contemplative practices have positive benefits, and thus, there are a variety of practices like ritual prayers, fasting and meditation, which is found to demonstrate positive health benefits. Thus, it has direct practical reasons to pursue these practices and derive the innate benefits from them. Social implications The data from the various neuroscience studies have demonstrated the neurological and physiological impact on individuals directly relating to worship. However, the studies on the Islamic ritual prayer (salat) cited in this study points out to its social implications, where congregational prayers was found to be more beneficial than the individual prayers. Thus, this indicates the social implications that collective worship can have. Further research is needed in terms of understanding the social impact on the various collective contemplative practices. Originality/value The originality of this literature review and analysis is bringing together the various strands of neuroscience and health data to demonstrate the positive impact of worship emanating from others faiths, while building a case for Islamic contemplative practices. This is further augmented by its integrated approach of weaving hard and soft data and synthesizing it to present health benefits of worship.

scholarly journals Emergency Medicine Pharmacist Impact on Door-to-Needle Time in Patients With Acute Ischemic Stroke

2017 ◽  
Vol 8 (2) ◽  
pp. 60-65 ◽  
Author(s):  
Joshua S. Jacoby ◽  
Heather M. Draper ◽  
Lisa E. Dumkow ◽  
Muhammad U. Farooq ◽  
G. Robert DeYoung ◽  
...  
Keyword(s):  
Emergency Medicine ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Length Of Hospital Stay ◽  
Stroke Care ◽  
Neurological Status ◽  
National Institutes Of Health ◽  
Discharge Disposition ◽  
Scale Scores ◽  
The Impact

Background and Purpose: Decreased door-to-needle (DTN) time with tissue plasminogen activator (tPA) for acute ischemic stroke is associated with improved patient outcomes. Emergency medicine pharmacists (EMPs) can expedite the administration of tPA by assessing patients for contraindications, preparing, and administering tPA. The purpose of this study was to determine the impact of EMPs on DTN times and clinical outcomes in patients with acute ischemic stroke who receive tPA in the emergency department. Methods: A retrospective, single-center, cohort study of patients who received tPA between August 1, 2012, and August 30, 2014, was conducted to compare DTN times with or without EMP involvement in stroke care. Secondary outcomes included changes in neurological status as measured by the National Institutes of Health Stroke Scale (NIHSS), length of hospital stay, discharge disposition, symptomatic intracranial hemorrhage, and in-hospital all-cause mortality. Results: A total of 100 patients were included. The EMPs were involved in the care of 49 patients. The EMP involvement was associated with a significant improvement in DTN time (median 46 [interquartile range IQR: 34.5-67] vs 58 [IQR: 45-79] minutes; P = .019) and with receiving tPA within 45 minutes of arrival (49% vs 25%, odds ratio [OR]: 2.81 [95% confidence interval [CI]: 1.21-6.52]). National Institutes of Health Stroke Scale scores were significantly improved at 24 hours post-tPA in favor of the EMP group (median NIHSS 1 [IQR: 0-4] vs 2 [IQR: 1-9.25]; P = .047). Conclusions: The EMP involvement in initial stroke care was associated with a significant improvement in DTN time.

scholarly journals Bringing Objectification into Social Relationships Research: Is Self-Objectification Harmful for Authenticity?

2016 ◽  
Vol 19 ◽  
Author(s):  
Chiara Rollero
Keyword(s):  
Social Relationships ◽  
Past Research ◽  
The Body ◽  
Body Parts ◽  
Negative Consequences ◽  
Appearance Anxiety ◽  
Step Model ◽  
And Performance ◽  
Self Objectification ◽  
The Impact

AbstractSelf-objectification is a pervasive process in contemporary Western societies and psychological literature has largely shown its negative consequences in terms of body shame, appearance anxiety, mental health and performance. Mass media play a key role in promoting such process through the extensive sexualization of individuals’ body and the separation of sexualized body parts from the rest of the body. The purpose of the present study was to extend past research by examining the effects of self-objectification in the context of social relationships among young adults. Participants were 235 undergraduates (55.7% females). A three-step model was successfully tested: results showed that internalization of media standards is related to increased self-objectification (β = .33, SE = .08, p = .01), which in turn is associated with authenticity, being high self-objectifiers less devoted to authentic living (β = –.21, SE = .09, p = .01) and more self-alienated (β = .14, SE = .08, p = .04) and dependent on others’ influence (β = .50, SE = .01, p = .01). The pattern of these relationships did not significantly vary across gender (χ2 = 6.29; p = .18). Implications concerning the impact of self-objectification in the domain of social relationships are discussed.

scholarly journals Impact of Dietary, Socioeconomic, and Physical Factors on Obese and Overweight Schoolchildren Living in Sidi-Bel-Abbes (West of Algeria) and Ain Defla (Centre)

2018 ◽  
Vol 25 (1) ◽  
pp. 37-46 ◽  
Author(s):  
Hayat Didaoui ◽  
Méghit Boumediene Khaled
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Environmental Factors ◽  
Body Mass ◽  
School Children ◽  
Task Force ◽  
The Body ◽  
Physical Factors ◽  
Obesity And Overweight ◽  
The Impact

Abstract Background and aims: The aim of the current study was to assess the impact of environmental factors; food, socio-economic, and physical activity, on a group of obese children living in Ain-Defla (Center Algeria) and Sidi-Bel-Abbes (West Algeria). Material and methods: The protocol was carried out on a cohort of 125 school children aged of 5 to 11 years, including 64 boys and 61 girls, and 139 school children, including 93 boys and 46 girls in Ain Defla and Sidi-Bel-Abbes respectively. Concerning the classification of obesity and overweight, we referred to the International Obesity Task Force and the French References' curves. Results: Regarding dietary intake our results showed that 34% of students from both regions took their breakfast, compared to 66% who did not take. Furthermore, 73% of students skipped at least one meal, however 23% respected meals frequency i.e. 4 meals a day. Regarding socio-economic factors and physical activity, our findings showed that obesity rates were high (36%) among children whose fathers are workers. However, for mothers who are housewives, obesity increases among their children (88%). The relationship was reversed between the parents' education level and the Body Mass Index. We found an opposite relationship between Body Mass Index and physical activity, and investigated children use screen devices for long time periods. Conclusions: Our study showed a positive relationship between obesity and overweight and environmental factors.

scholarly journals Biomedical aspects of problems safe usage of transport maglev

2016 ◽  
Vol 2 (4) ◽  
pp. 114-127 ◽  
Author(s):  
Artemiy V Rubinskiy ◽  
Leonid A Noskin
Keyword(s):  
Magnetic Fields ◽  
Exposure Dose ◽  
The Body ◽  
Practical Significance ◽  
Human Organism ◽  
Physical Factors ◽  
Human Beings ◽  
Stress Theory ◽  
Key Factor ◽  
The Impact

Among the external physical factors that require attention during the process of projecting maglev transport, the key factor is the protection of staff and passengers from electromagnetic fields and mechanical accelerations that can cause extreme states in biochemical and physiological systems of living organisms. Objective: creation of tools, methods and recommendation systems, allowing to objectify the assessment of collective and individual security of the human beings being under the influence of maglev transport; assess the maximum allowable parameters. Methods: The most efficient way to achieve this goal is to use the methodology of polysystemic predictive diagnostics that allows to dynamically track in the degree of balance in regulative system of homeostasis which is a determining factor of individual adaptogenesis. In accordance with the laws of biomechanics, biomagnetism and stress theory, the impact of these adverse factors is causing resistive and adaptive restoration physiological responses at the same time, which subsequently, with the continuation of action and increase of dose and load, modify and lead to extreme and critical (pathological) states in human organism. From the literature on Biomagnetism, it follows that even weak magnetic fields can provide highly efficient action, and after organism being exposed to inductive magnetic fields of various intensity one-sided physiological shifts were observed. Organism's reactions to acceleration show similar behavior. The practical significance of the work lies in the fact that the study will specify hygiene requirements in absolute values and duration of adverse factors on the railways. Exceeding the exposure dose exposure on these indicators can cause irreversible negative condition of the body. However, due to the emergence of a fundamentally new transport technology, existing concepts require refinement and updating.

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