scholarly journals Persoalan-Persoalan Kontemporer dalam Ilmu Hukum

2020 ◽  
Vol 4 (1) ◽  
pp. 83-98
Author(s):  
Catharina Dewi Wulansari ◽  
Yenny Yorisca
Keyword(s):  
21St Century ◽  
Large Scale ◽  
Continuous Process ◽  
Human Welfare ◽  
Interdisciplinary Science ◽  
Legal Studies ◽  
New Knowledge ◽  
Research Problems ◽  
Advanced Information Technology ◽  
Research Facilities

Through science, we generate new knowledge and discovery, become inspired as we coax nature to reveal her myriad secrets and expand our understanding of the physical and living world. Since the beginning of human civilization, science and technology have progressed in a continuous process. As we know, Science is essentially an attempt to help human solve the problem. Increasingly interdisciplinary science is driving many changes. Some disciplines are becoming irrevocably intertwined. Progress in one field of science makes possible progress in seemingly disparate fields, and increasingly the most exciting research problems involve multidisciplinary collaborations, require the use of large-scale research facilities, and use advanced information technology. In the 21st century, legal studies offer equal promise for improving human welfare. The advances that we have made and will be making, especially in understanding human behavior and its very deep origins, will be translated into interventions of diverse sorts that will have a much bigger impact in terms of improving human welfare. Keywords : Science, Legal Studies, 21st Century.

Next-Generation Sequencing: An Emerging Tool for Drug Designing

2019 ◽  
Vol 25 (31) ◽  
pp. 3350-3357 ◽  
Author(s):  
Pooja Tripathi ◽  
Jyotsna Singh ◽  
Jonathan A. Lal ◽  
Vijay Tripathi
Keyword(s):  
Next Generation Sequencing ◽  
High Throughput ◽  
Large Scale ◽  
Massively Parallel Sequencing ◽  
Genomic Research ◽  
Biological Research ◽  
Next Generation ◽  
Human Welfare ◽  
Drug Designing ◽  
Generation Sequencing

Background: With the outbreak of high throughput next-generation sequencing (NGS), the biological research of drug discovery has been directed towards the oncology and infectious disease therapeutic areas, with extensive use in biopharmaceutical development and vaccine production. Method: In this review, an effort was made to address the basic background of NGS technologies, potential applications of NGS in drug designing. Our purpose is also to provide a brief introduction of various Nextgeneration sequencing techniques. Discussions: The high-throughput methods execute Large-scale Unbiased Sequencing (LUS) which comprises of Massively Parallel Sequencing (MPS) or NGS technologies. The Next geneinvolved necessarily executes Largescale Unbiased Sequencing (LUS) which comprises of MPS or NGS technologies. These are related terms that describe a DNA sequencing technology which has revolutionized genomic research. Using NGS, an entire human genome can be sequenced within a single day. Conclusion: Analysis of NGS data unravels important clues in the quest for the treatment of various lifethreatening diseases and other related scientific problems related to human welfare.

scholarly journals Methodology for Determining the Location of River Ports on a Modernized Waterway Based on Non-Cost Criteria: A Case Study of the Odra River Waterway

2021 ◽  
Vol 13 (6) ◽  
pp. 3571
Author(s):  
Bogusz Wiśnicki ◽  
Dorota Dybkowska-Stefek ◽  
Justyna Relisko-Rybak ◽  
Łukasz Kolanda
Keyword(s):  
Large Scale ◽  
Multicriteria Decision Making ◽  
Research Process ◽  
Optimal Selection ◽  
Investment Projects ◽  
Odra River ◽  
Research Problems ◽  
Selection Of ◽  
Construction Works

The paper responds to research problems related to the implementation of large-scale investment projects in waterways in Europe. As part of design and construction works, it is necessary to indicate river ports that play a major role within the European transport network as intermodal nodes. This entails a number of challenges, the cardinal one being the optimal selection of port locations, taking into account the new transport, economic, and geopolitical situation that will be brought about by modernized waterways. The aim of the paper was to present an original methodology for determining port locations for modernized waterways based on non-cost criteria, as an extended multicriteria decision-making method (MCDM) and employing GIS (Geographic Information System)-based tools for spatial analysis. The methodology was designed to be applicable to the varying conditions of a river’s hydroengineering structures (free-flowing river, canalized river, and canals) and adjustable to the requirements posed by intermodal supply chains. The method was applied to study the Odra River Waterway, which allowed the formulation of recommendations regarding the application of the method in the case of different river sections at every stage of the research process.

A Systematic Method for the Selection of Independent Variables in the Investigation of Complex Systems

1988 ◽  
Vol 32 (17) ◽  
pp. 1179-1182 ◽  
Author(s):  
P. Jay Merkle ◽  
Douglas B. Beaudet ◽  
Robert C. Williges ◽  
David W. Herlong ◽  
Beverly H. Williges
Keyword(s):  
Large Scale ◽  
Subjective Ratings ◽  
Systematic Method ◽  
Independent Variables ◽  
Integrated Strategy ◽  
Literature Reviews ◽  
Systematic Methodology ◽  
Research Problems ◽  
Inquiry System ◽  
Selection Of

This paper describes a systematic methodology for selecting independent variables to be considered in large-scale research problems. Five specific procedures including brainstorming, prototype interface representation, feasibility/relevance analyses, structured literature reviews, and user subjective ratings are evaluated and incorporated into an integrated strategy. This methodology is demonstrated in the context of designing the user interface for a telephone-based information inquiry system. The procedure was successful in reducing an initial set of 95 independent variables to a subset of 19 factors that warrant subsequent detailed analysis. These results are discussed in terms of a comprehensive sequential research methodology useful for investigating human factors problems.

Enhanced Comprehension of the Continuous Fusion Bonding Process of Multi-Material Structures

2018 ◽  
Vol 939 ◽  
pp. 197-204 ◽  
Author(s):  
Tobias Reincke ◽  
Sven Hartwig ◽  
Klaus Dilger
Keyword(s):  
Composite Structures ◽  
Large Scale ◽  
Lightweight Design ◽  
Continuous Process ◽  
Peel Test ◽  
Roll Forming ◽  
Scale Production ◽  
Continuous Manufacturing ◽  
Fusion Bonding ◽  
Reinforced Thermoplastics

In comparison to monolithic composite structures, tailored multi-material structures offer high potential considering lightweight design approaches in combination with cost efficient manufacturing processes. Roll forming enables flexible large scale production of hybrid structures, due to the continuous manufacturing process as well as high degree of automation. The multi-material structures consist of steel sheets which are selectively reinforced by unidirectional carbon fibre reinforced thermoplastics (CFR-TP). In view of minimizing process steps and decreasing cycle times, both materials are joined by fusion bonding. Therefore, CFR-TP is heated above melting temperature of thermoplastic matrix and joined to the steel surface under defined pressure and time. However, joining of both materials within a continuous process is still challenging due to a lack in terms of process comprehension. Consequently, multi-material specimens were manufactured depending on various process parameters as temperature of either material or processing speed and tested mechanically by floating roller peel test for the evaluation of the adhesion between both materials. Furthermore, viscosity of matrix was determined and investigations of CFR-TP interface were performed by Fourier transform infrared spectroscopy. The results show the requirement of a defined CFR-TP temperature and the change in crystalline structure of the matrix in dependency of the processing.

scholarly journals THE LEGAL STUDIES OF TRUCKING AND WAREHOUSING IN SUPPORTING THE SMOOTHNESS OF OUTFLOW AND INCOMING GOODS AT THE PORT

2017 ◽  
Vol 29 (2) ◽  
pp. 321
Author(s):  
Sulistiowati S ◽  
Saida Rusdiana
Keyword(s):  
Descriptive Analysis ◽  
Institutional Capacity ◽  
Related Services ◽  
Related Research ◽  
Legal Study ◽  
Port Authority ◽  
Legal Studies ◽  
Port Authorities ◽  
Study Results ◽  
Research Problems

AbstractThis legal study discusses the provision of trucking and warehousing of goods services and services at the port. This study is intended to address issues related research problems and directions arrangements in the provision of trucking and warehousing of goods services and services at the port. This study uses empirical juridical approach of practices in the truck transportation of goods and warehousing services in the port, while the results of the study are presented in the form of descriptive analysis. The study results conclusion that it is necessary for institutional capacity of port authorities as the organizer of the cultivated commercially port so as to perform the function of government in the harbor. Port Authority set the capacity of the service, organizing auctions and provision of related services to cooperate with trucking and warehousing services provider in the harbor. IntisariKajian hukum ini membahas mengenai penyediaan jasa truk angkutan barang dan jasa pergudangan di pelabuhan. Kajian ini dimaksudkan untuk menjawab permasalahan penelitian terkait permasalahan dan arah pengaturan dalam penyediaan jasa truk angkutan barang dan jasa pergudangan di pelabuhan. Kajian ini menggunakan pendekatan yuridis empirik dari praktek penyediaan jasa  truk angkutan barang dan jasa pergudangan di pelabuhan, sedangkan hasil penelitian disajikan dalam bentuk deskriptif analitis. Hasil kajian diperoleh kesimpulan bahwa diperlukan peningkatan kapasitas kelembagaan otoritas pelabuhan sebagai penyelenggara pelabuhan yang diusahakan secara komersial sehingga mampu menjalankan fungsi pemerintahan di pelabuhan. Otoritas Pelabuhan menetapkan kapasitas layanan, menyelenggarakan lelang penyediaan jasa terkait dan melakukan kerjasama penyedia jasa trucking dan warehousing di pelabuhan. 

scholarly journals Conversion of Fructose to HMF in a Continuous Fixed Bed Reactor with Outstanding Selectivity

Molecules ◽  
2018 ◽  
Vol 23 (7) ◽  
pp. 1802 ◽  
Author(s):  
Eric Weingart ◽  
Sarah Tschirner ◽  
Linda Teevs ◽  
Ulf Prüße
Keyword(s):  
Large Scale ◽  
Continuous Process ◽  
Fixed Bed ◽  
Fixed Bed Reactor ◽  
Water Addition ◽  
Batch Systems ◽  
Formation Conditions ◽  
High Yields ◽  
Optimized Conditions ◽  
By Products

5-Hydroxymethylfurfural (HMF) is a very promising component for bio-based plastics. Efficient synthesis of HMF from biomass is still challenging because of fast degradation of HMF to by-products under formation conditions. Therefore, different studies, conducted mainly in monophasic and biphasic batch systems with and without water addition have been published and are still under investigation. However, to produce HMF at a large scale, a continuous process is preferable. Until now, only a few studies have been published in this context. In this work, it is shown that fluorous alcohol hexafluoroisopropanol (HFIP) can act as superior reaction solvent for HMF synthesis from fructose in a fixed bed reactor. Very high yields of 76% HMF can be achieved in this system under optimized conditions, whilst the catalyst is very stable over several days. Such high yields are only described elsewhere with high boiling reaction solvents like dimethylsulfoxide (DMSO), whereas HFIP with a boiling point of 58 °C is very easy to separate from HMF.

Essential Skills for the 21st Century Workforce

2019 ◽  
pp. 134-147
Author(s):  
Maureen N. Short ◽  
Yolanda Keller-Bell
Keyword(s):  
Critical Thinking ◽  
Labor Markets ◽  
Technological Innovation ◽  
21St Century ◽  
Thinking Skills ◽  
Critical Thinking Skills ◽  
First Century ◽  
Knowledge And Skills ◽  
New Knowledge ◽  
Workforce Skills

This chapter contends that increasing technological innovation has disrupted and continues to disrupt the labor markets making some jobs obsolete and workers redundant. The key to success in the twenty-first century and future labor markets is to combine hard and soft skills into a comprehensive package tailored to specific needs including the ability to think clearly about complex problems, apply creative and innovation solutions to solve problems, and apply new knowledge and skills in new settings. This chapter will provide a discussion of some of the reasons underlying the demand for higher workforce skills and a descriptive overview of curricula and pedagogy that promote students' acquisition and application of critical thinking skills as well as other skills considered essential for 21st century workforce.

An Overview of Multilingual Learners' Literacy Needs for the 21st Century

2020 ◽  
pp. 1-21
Author(s):  
MaryAnn Christison ◽  
Denise E. Murray
Keyword(s):  
Critical Literacy ◽  
21St Century ◽  
Large Scale ◽  
Literacy Skills ◽  
Human Migration ◽  
Multimodal Literacy ◽  
Common Definition ◽  
Societal Changes ◽  
Definition Of ◽  
Theoretical Considerations

The most common definition of literacy is the ability to read and write. However, for teachers working with multilingual learners, the development of literacy skills is much more complex than this simple definition would suggest. Notions of literacy in the 21st century have evolved in response to a number of societal changes, such as globalization, large-scale human migration, and advances in digital technologies. This chapter considers how these societal changes have influenced conceptions and practices of literacy. It provides a brief overview of some important theoretical considerations that inform understandings of literacy development for multilingual learners, including critical literacy, multiliteracies, multimodal literacy, and translanguaging, and explores current conceptions of literacy to help second and foreign language (SFL) teachers better understand how to meet the literacy needs of multilingual learners in the 21st century, offering practical suggestions for teaching from a multiliteracies perspective.

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