scholarly journals ADDITIVE-SUBTRACTIVE TECHNOLOGIES – EFFECTIVE TRANSITION TO INNOVATION PRODUCTION

2019 ◽  
Vol 2019 (8) ◽  
pp. 4-10 ◽  
Author(s):  
Алексей Киричек ◽  
Alexey Kirichek ◽  
Олег Федонин ◽  
Oleg Fedonin ◽  
Дмитрий Соловьев ◽  
...  
Keyword(s):  
Arc Welding ◽  
Rapid Development ◽  
Production Costs ◽  
Nc System ◽  
Advantages And Disadvantages ◽  
Full Compliance ◽  
Execution Unit ◽  
Electric Arc Welding ◽  
Subtractive Machining ◽  
Complete Process

At present a rapid development of additive technologies for the growth of metal and alloy products takes place. Each additive technology has its own rational field of application and its own characteristic set of advantages and disadvantages. The most promising technologies are new 3DMP-technologies of wire sedimentation/welding deposition by a method electric arc welding in combination with subtractive machining technologies (additive-subtractive technologies). The application of 3DMP-technologies in comparison with common and some powder technologies results in the considerable decrease of production costs and substantial increase of growth productivity, for them it is characteristic a high coefficient of initial material beneficial use. The advantage in use of additive-subtractive technologies (AST) consists in a possibility of the alternative use of additive and subtractive transitions at the formation of a part within the limits of one technological operation in a full compliance with the principle of community and constancy of technological bases. But AST peculiarity requires a complex solution of interrelated engineering and scientific problems including those in the field of design of products, material machining, engineering procedure automation and CAD systems. For instance, in consequence of that the realization of 3DMP-technology is possible only under conditions of complete process automation, in the presence of a subtractive module having 3-5 controlled coordinates, for the equipment on the whole the NC system is necessary which controls the execution unit displacement along six coordinate axes and more.

An old friend is better than two new ones? Approaches to market research in the context of digital transformation for the antitrust laws enforcement

2020 ◽  
pp. 37-55 ◽  
Author(s):  
A. E. Shastitko ◽  
O. A. Markova
Keyword(s):  
Business Models ◽  
Rapid Development ◽  
Digital Transformation ◽  
Market Definition ◽  
Type I ◽  
Type Ii ◽  
Digital Platforms ◽  
Advantages And Disadvantages ◽  
Pass Through ◽  
Type Ii Errors

Digital transformation has led to changes in business models of traditional players in the existing markets. What is more, new entrants and new markets appeared, in particular platforms and multisided markets. The emergence and rapid development of platforms are caused primarily by the existence of so called indirect network externalities. Regarding to this, a question arises of whether the existing instruments of competition law enforcement and market analysis are still relevant when analyzing markets with digital platforms? This paper aims at discussing advantages and disadvantages of using various tools to define markets with platforms. In particular, we define the features of the SSNIP test when being applyed to markets with platforms. Furthermore, we analyze adjustment in tests for platform market definition in terms of possible type I and type II errors. All in all, it turns out that to reduce the likelihood of type I and type II errors while applying market definition technique to markets with platforms one should consider the type of platform analyzed: transaction platforms without pass-through and non-transaction matching platforms should be tackled as players in a multisided market, whereas non-transaction platforms should be analyzed as players in several interrelated markets. However, if the platform is allowed to adjust prices, there emerges additional challenge that the regulator and companies may manipulate the results of SSNIP test by applying different models of competition.

Electric arc welding and surfacing in repair of rails of Kyiv underground

2018 ◽  
Vol 2018 (2) ◽  
pp. 30-33
Author(s):  
G.V. Kuzmenko ◽  
◽  
V.M. Taganovsky ◽  
V.L. Sidorenko ◽  
◽  
...  
Keyword(s):  
Arc Welding ◽  
Electric Arc ◽  
Electric Arc Welding

Recent Patents on the Angular Contact Ball Bearing of High-Speed Motorized Spindle

2020 ◽  
Vol 13 ◽  
Author(s):  
Yudong Bao ◽  
Linkai Wu ◽  
Yanling Zhao ◽  
Chengyi Pan
Keyword(s):  
High Speed ◽  
Ball Bearing ◽  
Rapid Development ◽  
Ceramic Materials ◽  
Development Trend ◽  
Numerical Control ◽  
Angular Contact Ball Bearing ◽  
Practical Applications ◽  
High Speed Cutting ◽  
Advantages And Disadvantages

Background:: Angular contact ball bearings are the most popular bearing type used in the high speed spindle for machining centers, The performance of the bearing directly affects the machining efficiency of the machine tool, Obtaining a higher value is the direction of its research and development. Objective:: By analyzing the research achievements and patents of electric spindle angular contact bearings, summarizing the development trend provides a reference for the development of electric spindle bearings. Methods:: Through the analysis of the relevant technology of the electric spindle angular contact ball bearing, the advantages and disadvantages of the angular contact ball bearing are introduced, and the research results are combined with the patent analysis. Results:: With the rapid development of high-speed cutting and numerical control technology and the needs of practical applications, the spindle requires higher and higher speeds for bearings. In order to meet the requirements of use, it is necessary to improve the bearing performance by optimizing the structure size and improving the lubrication conditions. Meanwhile, reasonable processing and assembly methods will also have a beneficial effect on bearing performance. Conclusion:: With the continuous deepening of bearing technology research and the use of new structures and ceramic materials has made the bearing's limit speed repeatedly reach new highs. The future development trend of high-speed bearings for electric spindles is environmental protection, intelligence, high speed, high precision and long life.

Advanced submerged arc welding processes for Arctic structures and ice-going vessels

2016 ◽  
Vol 232 (1) ◽  
pp. 114-127
Author(s):  
Pavel Layus ◽  
Paul Kah ◽  
Viktor Gezha
Keyword(s):  
Case Studies ◽  
Arc Welding ◽  
Oil And Gas ◽  
Welding Process ◽  
Submerged Arc Welding ◽  
The Arctic ◽  
Correct Selection ◽  
Advantages And Disadvantages ◽  
Welding Processes ◽  
Submerged Arc

The Arctic region is expected to play an extremely prominent role in the future of the oil and gas industry as growing demand for natural resources leads to greater exploitation of a region that holds about 25% of the world’s oil and gas reserves. It has become clear that ensuring the necessary reliability of Arctic industrial structures is highly dependent on the welding processes used and the materials employed. The main challenge for welding in Arctic conditions is prevention of the formation of brittle fractures in the weld and base material. One mitigating solution to obtain sufficiently low-transition temperatures of the weld is use of a suitable welding process with properly selected parameters. This work provides a comprehensive review with experimental study of modified submerged arc welding processes used for Arctic applications, such as narrow gap welding, multi-wire welding, and welding with metal powder additions. Case studies covered in this article describe welding of Arctic steels such as X70 12.7-mm plate by multi-wire welding technique. Advanced submerged arc welding processes are compared in terms of deposition rate and welding process operational parameters, and the advantages and disadvantages of each process with respect to low-temperature environment applications are listed. This article contributes to the field by presenting a comprehensive state-of-the-art review and case studies of the most common submerged arc welding high deposition modifications. Each modification is reviewed in detail, facilitating understanding and assisting in correct selection of appropriate welding processes and process parameters.

scholarly journals Artificial Cardiac Muscle with or without the Use of Scaffolds

2017 ◽  
Vol 2017 ◽  
pp. 1-15 ◽  
Author(s):  
Yifei Li ◽  
Donghui Zhang
Keyword(s):  
Tissue Engineering ◽  
Cardiovascular Diseases ◽  
Cardiac Tissue ◽  
Contractile Function ◽  
Rapid Development ◽  
Treatment Options ◽  
Cardiac Tissue Engineering ◽  
Hydrogel Scaffold ◽  
Fibrous Matrix ◽  
Advantages And Disadvantages

During the past several decades, major advances and improvements now promote better treatment options for cardiovascular diseases. However, these diseases still remain the single leading cause of death worldwide. The rapid development of cardiac tissue engineering has provided the opportunity to potentially restore the contractile function and retain the pumping feature of injured hearts. This conception of cardiac tissue engineering can enable researchers to produce autologous and functional biomaterials which represents a promising technique to benefit patients with cardiovascular diseases. Such an approach will ultimately reshape existing heart transplantation protocols. Notable efforts are accelerating the development of cardiac tissue engineering, particularly to create larger tissue with enhanced functionality. Decellularized scaffolds, polymer synthetics fibrous matrix, and natural materials are used to build robust cardiac tissue scaffolds to imitate the morphological and physiological patterns of natural tissue. This ultimately helps cells to implant properly to obtain endogenous biological capacity. However, newer designs such as the hydrogel scaffold-free matrix can increase the applicability of artificial tissue to engineering strategies. In this review, we summarize all the methods to produce artificial cardiac tissue using scaffold and scaffold-free technology, their advantages and disadvantages, and their relevance to clinical practice.

Data Mining for ERW Welded Tube Scheduling Rules Based on Decision Tree

2011 ◽  
Vol 403-408 ◽  
pp. 1804-1807
Author(s):  
Ning Zhao ◽  
Shao Hua Dong ◽  
Qing Tian
Keyword(s):  
Data Mining ◽  
Decision Tree ◽  
Arc Welding ◽  
Data Cleaning ◽  
Data Extraction ◽  
Electric Arc ◽  
Welded Tube ◽  
Electric Arc Welding ◽  
Decision Tree Method ◽  
Tree Method

In order to optimize electric- arc welding （ERW） welded tube scheduling , the paper introduces data cleaning, data extraction and transformation in detail and defines the datasets of sample attribute, which is based on analysis of production process of ERW welded tube. Furthermore, Decision-Tree method is adopted to achieve data mining and summarize scheduling rules which are validated by an example.

scholarly journals High-Throughput Quantitative Assay Technologies for Accelerating the Discovery and Optimization of Targeted Protein Degradation Therapeutics

2021 ◽  
pp. 247255522098504
Author(s):  
Jeffrey R. Simard ◽  
Linda Lee ◽  
Ellen Vieux ◽  
Reina Improgo ◽  
Trang Tieu ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Protein Degradation ◽  
Protein Interactions ◽  
Fluorescent Protein ◽  
De Novo ◽  
Rapid Development ◽  
Dependent Manner ◽  
Western Blots ◽  
Advantages And Disadvantages ◽  
Degradation Rates

The aberrant regulation of protein expression and function can drastically alter cellular physiology and lead to numerous pathophysiological conditions such as cancer, inflammatory diseases, and neurodegeneration. The steady-state expression levels of endogenous proteins are controlled by a balance of de novo synthesis rates and degradation rates. Moreover, the levels of activated proteins in signaling cascades can be further modulated by a variety of posttranslational modifications and protein–protein interactions. The field of targeted protein degradation is an emerging area for drug discovery in which small molecules are used to recruit E3 ubiquitin ligases to catalyze the ubiquitination and subsequent degradation of disease-causing target proteins by the proteasome in both a dose- and time-dependent manner. Traditional approaches for quantifying protein level changes in cells, such as Western blots, are typically low throughput with limited quantification, making it hard to drive the rapid development of therapeutics that induce selective, rapid, and sustained protein degradation. In the last decade, a number of techniques and technologies have emerged that have helped to accelerate targeted protein degradation drug discovery efforts, including the use of fluorescent protein fusions and reporter tags, flow cytometry, time-resolved fluorescence energy transfer (TR-FRET), and split luciferase systems. Here we discuss the advantages and disadvantages associated with these technologies and their application to the development and optimization of degraders as therapeutics.

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