scholarly journals Antioxidant properties of swertiamarin, from Enicostemma littorale blume. leaves studied in high fat diet fed and low dose streptozotocin induced diabetic rats

2019 ◽  
Vol 5 (2) ◽  
pp. 344-352 ◽  
Author(s):  
R. Selvam ◽  
K. Muruganantham ◽  
S. Subramanian
Keyword(s):  
High Fat Diet ◽  
Low Dose ◽  
Antioxidant Properties ◽  
Diabetic Rats ◽  
High Fat ◽  
Enicostemma Littorale

scholarly journals BIOCHEMICAL EVALUATION OF ANTIDIABETIC PROPERTIES OF SWERTIAMARIN, A SECOIRIDOID GLYCOSIDE OF ENICOSTEMMA LITTORALE LEAVES, STUDIED IN HIGH-FAT DIET–FED LOW-DOSE STREPTOZOTOCIN-INDUCED TYPE 2 DIABETIC RATS

2018 ◽  
Vol 11 (10) ◽  
pp. 486 ◽  
Author(s):  
Selvam R ◽  
Muruganantham K ◽  
Subramanian S
Keyword(s):  
High Fat Diet ◽  
Low Dose ◽  
Fasting Blood Glucose ◽  
Glycogen Metabolism ◽  
Diabetic Rats ◽  
High Fat ◽  
Enicostemma Littorale ◽  
Liver And Kidney ◽  
Secoiridoid Glycoside

Objective: Swertiamarin, a secoiridoid glycoside present in the leaves of Enicostemma littorale, is reported to be responsible for its pharmacological and beneficial properties. The present study was aimed to biochemically evaluate the antidiabetic properties of Swertiamarin in high fat diet fed - low dose streptozotocin (STZ)-treated diabetic rats.Methods: High-fat diet-fed low-dose STZ was used to induce experimental type 2 diabetes in rats. Diabetic rats were orally treated with swertiamarin (50 mg/kg b.w./rat/day) for 30 days. The physiological criterions such as food and fluid intake were recorded. Oral glucose tolerance test was performed. The levels of fasting blood glucose, plasma insulin, glycosylated hemoglobin A1c (HbA1c), hemoglobin, and homeostasis model assessment of insulin resistance (HOMA-IR) values were estimated. The activities of key enzymes involved in carbohydrate and glycogen metabolism in the liver and kidney tissues were assayed. The glycogen content in liver tissue was estimated.Result: Oral administration of swertiamarin to diabetic rats established a significant decline in the levels of fasting blood glucose, HbA1c as well as HOMA-IR values and an increase in plasma insulin and hemoglobin levels. The altered activities of key enzymes of carbohydrate and glycogen metabolism in liver and kidney tissues of diabetic rats were restored to near normalcy by swertiamarin treatment.Conclusion: Swertiamarin treatment maintains normoglycemia in diabetic rats by modulating the activities of key carbohydrate and glycogen metabolizing enzymes in the hepatic and renal tissues.

Sequoyitol ameliorates diabetic nephropathy in diabetic rats induced with a high-fat diet and a low dose of streptozotocin

2014 ◽  
Vol 92 (5) ◽  
pp. 405-417 ◽  
Author(s):  
Xian-Wei Li ◽  
Yan Liu ◽  
Wei Hao ◽  
Jie-Ren Yang
Keyword(s):  
Diabetic Nephropathy ◽  
Blood Glucose ◽  
High Fat Diet ◽  
Low Dose ◽  
Serum Insulin ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
High Fat

Sequoyitol decreases blood glucose, improves glucose intolerance, and enhances insulin signaling in ob/ob mice. The aim of this study was to investigate the effects of sequoyitol on diabetic nephropathy in rats with type 2 diabetes mellitus and the mechanism of action. Diabetic rats, induced with a high-fat diet and a low dose of streptozotocin, and were administered sequoyitol (12.5, 25.0, and 50.0 mg·(kg body mass)−1·d−1) for 6 weeks. The levels of fasting blood glucose (FBG), serum insulin, blood urea nitrogen (BUN), and serum creatinine (SCr) were measured. The expression levels of p22phox, p47phox, NF-κB, and TGF-β1 were measured using immunohistochemisty, real-time PCR, and (or) Western blot. The total antioxidative capacity (T-AOC), as well as the levels of malondialdehyde (MDA) and reactive oxygen species (ROS) were also determined. The results showed that sequoyitol significantly decreased FBG, BUN, and SCr levels, and increased the insulin levels in diabetic rats. The level of T-AOC was significantly increased, while ROS and MDA levels and the expression of p22phox, p47phox, NF-κB, and TGF-β1 were decreased with sequoyitol treatment both in vivo and in vitro. These results suggested that sequoyitol ameliorates the progression of diabetic nephropathy in rats, as induced by a high-fat diet and a low dose of streptozotocin, through its glucose-lowering effects, antioxidant activity, and regulation of TGF-β1 expression.

scholarly journals The Effect of Long-Term Intranasal Serotonin Treatment on Metabolic Parameters and Hormonal Signaling in Rats with High-Fat Diet/Low-Dose Streptozotocin-Induced Type 2 Diabetes

2015 ◽  
Vol 2015 ◽  
pp. 1-17 ◽  
Author(s):  
Kira V. Derkach ◽  
Vera M. Bondareva ◽  
Oxana V. Chistyakova ◽  
Lev M. Berstein ◽  
Alexander O. Shpakov
Keyword(s):  
Type 2 Diabetes ◽  
High Fat Diet ◽  
Low Dose ◽  
Diabetic Rats ◽  
Brain Serotonin ◽  
Serotonin Level ◽  
High Fat ◽  
Brain Serotonin Level ◽  
The Brain

In the last years the treatment of type 2 diabetes mellitus (DM2) was carried out using regulators of the brain signaling systems. In DM2 the level of the brain serotonin is reduced. So far, the effect of the increase of the brain serotonin level on DM2-induced metabolic and hormonal abnormalities has been studied scarcely. The present work was undertaken with the aim of filling this gap. DM2 was induced in male rats by 150-day high-fat diet and the treatment with low dose of streptozotocin (25 mg/kg) on the 70th day of experiment. From the 90th day, diabetic rats received for two months intranasal serotonin (IS) at a daily dose of 20 μg/rat. The IS treatment of diabetic rats decreased the body weight, and improved glucose tolerance, insulin-induced glucose utilization, and lipid metabolism. Besides, it restored hormonal regulation of adenylyl cyclase (AC) activity in the hypothalamus and normalized AC stimulation byβ-adrenergic agonists in the myocardium. In nondiabetic rats the same treatment induced metabolic and hormonal alterations, some of which were similar to those in DM2 but expressed to a lesser extent. In conclusion, the elevation of the brain serotonin level may be regarded as an effective approach to treat DM2 and its complications.

Antidiabetic effect of Ficus racemosa Linn. stem bark in high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats: A mechanistic study

2012 ◽  
Vol 132 (1) ◽  
pp. 186-193 ◽  
Author(s):  
V.P. Veerapur ◽  
K.R. Prabhakar ◽  
B.S. Thippeswamy ◽  
Punit Bansal ◽  
K.K. Srinivasan ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Low Dose ◽  
Stem Bark ◽  
Diabetic Rats ◽  
Mechanistic Study ◽  
High Fat ◽  
Antidiabetic Effect ◽  
Ficus Racemosa ◽  
Type 2 Diabetic

Exercise training prevents the development of cardiac dysfunction in the low-dose streptozotocin diabetic rats fed a high-fat diet

2013 ◽  
Vol 91 (1) ◽  
pp. 80-89 ◽  
Author(s):  
Riley A. Epp ◽  
Shanel E. Susser ◽  
Marc P. Morissette ◽  
D. Scott Kehler ◽  
Davinder S. Jassal ◽  
...  
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Exercise Training ◽  
Protein Content ◽  
Cardiac Dysfunction ◽  
High Fat Diet ◽  
Low Dose ◽  
Diabetic Rats ◽  
Left Ventricular ◽  
High Fat ◽  
Altered Expression

This study tested the hypothesis that exercise training would prevent the development of diabetes-induced cardiac dysfunction and altered expression of sarcoplasmic reticulum Ca2 +-transport proteins in the low-dose streptozotocin-induced diabetic rats fed a high-fat diet (HFD+STZ). Male Sprague–Dawley rats (4 weeks old; 125–150 g) were made diabetic using a high-fat diet (40% fat, w/w) and a low-dose of streptozotocin (35 mg·(kg body mass)–1) by intravenous injection. Diabetic animals were divided among a sedentary group (Sed+HFD+STZ) or an exercise-trained group (Ex+HFD+STZ) that accumulated 3554 ± 338 m·day–1 of voluntary wheel running (mean ± SE). Sedentary animals fed a low-fat diet served as the control (Sed+LFD). Oral glucose tolerance was impaired in the sedentary diabetic group (1179 ± 29; area under the curve (a.u.c.)) compared with that in the sedentary control animals (1447 ± 42 a.u.c.). Although left ventricular systolic function was unchanged by diabetes, impaired E/A ratios (i.e., diastolic function) and rates of pressure decay (–dP/dt) indicated the presence of diastolic dysfunction. Diabetes also reduced SERCA2a protein content and maximal SERCA2a activity (Vmax) by 21% and 32%, respectively. In contrast, the change in each parameter was attenuated by exercise training. Based on these data, it appears that exercise training prevented the development of diabetic cardiomyopathy and the dysregulation of sarcoplasmic reticulum protein content in an inducible animal model of type 2 diabetes.

scholarly journals EVALUATION OF EFFECT 0F SITAGLIPTIN AND COMBINATION THERAPY OF SITAGLIPTIN AND METFORMIN ON HIGH DENSITY LIPOPROTEIN(HDL) AND LOW DENSITY LIPOPROTEIN(LDL) IN DIABETIC RATS

2021 ◽  
pp. 9-10
Author(s):  
Yasmeen A Maniyar ◽  
Siddarameshwar C Bidarurmath
Keyword(s):  
High Fat Diet ◽  
Wistar Rats ◽  
Low Dose ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Low Density ◽  
High Fat ◽  
Standard Drug ◽  
System Disorder

Diabetes mellitus is a multi system disorder leading to multiple complications.Dyslipedemia plays central role in most of the complications.HDL,LDL levels are amongst the parameters which are used to asses dyslipidemia .This study aims to evaluate the effect of sitagliptin and combination of sitagliptin and metformin on HDL,LDL levels in diabetes induced Albino Wistar rats. Albino Wistar rats were divided into 4 groups . Diabetes was induced by high fat diet and low dose streptozotocin . Metformin was used as standard drug. Rats were administered sitagliptin and combination of both metformin and sitagliptin for 21 days.After treatment LDL and HDL levels were evaluated. It was found that in groups treated with metformin, sitagliptin and combination of both drugs there was significant increase in HDL and reduction in LDL levels.

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