SCREENING CYTOCHEMICAL METHODS IN THE DIAGNOSIS OF PROFESSIONAL AND PROFESSIONALLY CAUSED SKIN PATHOLOGY

2021 ◽  
Author(s):  
E.K. Krasavina ◽  
◽  
I.V. Yatsyna ◽  
I.Y. Zhadan
Keyword(s):  
Early Diagnosis ◽  
Working Conditions ◽  
Skin Diseases ◽  
Hydrolytic Enzymes ◽  
The Body ◽  
Social Adaptation ◽  
Social Significance ◽  
Low Levels ◽  
Degree Of Severity ◽  
Cytochemical Parameters

Abstract: Introduction: Skin diseases of professional etiology remain to this day an urgent problem, despite the low levels of morbidity according to official statistics, due to the high medical and social significance of this pathology. For early diagnosis of occupational and occupational-related skin pathology, it is necessary to investigate laboratory markers that correlate with this pathology. In this regard, a promising direction is to study the activity indicators of hydrolytic enzymes of neutrophils: alkaline and acid phosphatases, the level of myeloperoxidase. Objective: to study and evaluate the effectiveness of cytochemical methods for diagnosing the reactivity of the body in workers exposed to a chemical factor in the workplace. Research methods: hygienic assessment of working conditions of woodworking workers, assessment of the health status and cytochemical parameters of workers. Analysis of the obtained data by methods of mathematical statistics. Results: A hygienic assessment of working conditions and an inspection, with a complex of cytochemical studies, of 148 employees of the chipboard manufacturing enterprise were carried out. The leading factor affecting the body of workers is chemical. A direct strong correlation (r=0.7) was established between the level of dermatological morbidity and the indicators of air pollution of the working area with formaldehyde. Skin pathology was detected in 32.4% of the examined workers. At the same time, the indicators of cytochemical activity in the examined group correlated with the degree of severity of the skin process. Conclusions: Cytochemical indicators in combination with other clinical and diagnostic studies allow us to assess the risk of developing professional and professionally caused skin pathology, which allows us to use them for early diagnosis, and thus contribute to the preservation of labor potential and social adaptation of workers exposed to occupational hazards.

scholarly journals The main aspects of the immunopathogenesis of atopic dermatitis in children

2021 ◽  
pp. 27-34
Author(s):  
Olga Olegovna Pobezhimova ◽  
Alexander Viktorovich Zhestkov
Keyword(s):  
Atopic Dermatitis ◽  
Rural Areas ◽  
Skin Diseases ◽  
Secondary Infection ◽  
Allergic Diseases ◽  
Developed Countries ◽  
Severe Form ◽  
Pathological Process ◽  
The Body ◽  
Social Adaptation

Research objective Atopic dermatitis (AtD) is the earliest and most frequent manifestation of the body’s hypersensitivity reaction to environmental allergens. Often manifested in severe form, affecting the skin, can occur in early infancy, childhood. The disease is genetically determined and is chronic. AtD is one of the most common skin diseases (from 20 to 40% in the structure of skin diseases), which occurs in all countries in people of both sexes. In recent years, there has been an increase in the incidence of AtD throughout the world. The disease is more common in highly developed countries and cities (less commonly in rural areas). AtD significantly reduces the quality of life of children, causing psychological discomfort and disrupting their social adaptation. AtD in children is a risk factor for the «atopic march» — the further sequential development of other allergic diseases: allergic rhinitis, pollinosis, allergic conjunctivitis, bronchial asthma. With a reduced immune response of the body, AtD in children can be complicated by the addition of a secondary infection (bacterial, viral, fungal). Such a high incidence rate, a debut in early childhood, a frequently recurring course of the pathological process, and a tendency towards an increase in the forms of the disease resistant to traditional therapy make the details of the pathogenesis of AtD particularly relevant. One of the main roles in the pathogenesis of AtD belongs to the cells of the immune system. The purpose of this article: to systematize the information available today on the immunopathogenesis of atopic dermatitis.

Effect of age on outcome in patients with cerebral stroke

2020 ◽  
pp. 41-45
Author(s):  
G. R. Kuchava ◽  
E. V. Eliseev ◽  
B. V. Silaev ◽  
D. A. Doroshenko ◽  
Yu. N. Fedulaev
Keyword(s):  
Ischemic Stroke ◽  
Neurological Deficit ◽  
Neurological Status ◽  
Statistical Correlation ◽  
Multiple Organ ◽  
The Body ◽  
Social Adaptation ◽  
Cerebral Stroke ◽  
Septic Complications ◽  
Risk Of Death

The aim of the study was to assess the course and outcome of cerebral infarction, depending on the age factor and duration of stay in the neuroblock. Materials and methods: a dynamic observation of 494 patients, men and women, aged 38–84 years with acute ischemic stroke of hemispheric localization, which were divided into the three groups depending on age, was performed. Group 1 – younger than 60 years old, group 2–60–70 years old, group 3 – older than 60 years. All patients underwent standard therapy, according to the recommendations for the treatment of ischemic stroke. The patients underwent comprehensive clinical and instrumental monitoring, which included assessment of somatic and neurological status according to the NIH‑NINDS scales at 1st, 3rd, 10th days and at discharge or death; assessment of the level of social adaptation according to the Bartel scale on 1st, 3rd, 10th days and at discharge, clinical and biochemical blood tests, computed tomography of the brain. Assessment of the quality of therapy was carried out according to specially developed maps using methods of statistical correlation analysis. Results: the most pronounced positive dynamics of neurological status was in the 1st group of patients. The regression of neurological deficit in the 2nd group was worse. The minimal dynamics of neurological deficit was in the 3rd group of patients with cerebral stroke. Most often, the death of patients with cerebral stroke occurred from the development of multiple organ disorders. Conclusions: patients over 70 years of age have the greatest risk of death, due to: a decrease in the reactivity of the body, the presence of initially severe concomitant somatic pathology in patients with admission to hospital; accession of secondary somatic and purulent‑septic complications.

Assessment of indicators of nervous and emotional stress in medical center personnel depending on the characteristics of their professional activity

2020 ◽  
Vol 60 (10) ◽  
pp. 650-657
Author(s):  
Irina V. Fedotova ◽  
Tatyana N. Vasilyeva ◽  
Tatyana V. Blinova ◽  
Irina A. Umnyagina ◽  
Yuliya V. Lyapina ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Emotional Stress ◽  
Functional State ◽  
Working Conditions ◽  
Medical Staff ◽  
Medical Center ◽  
The Body ◽  
Office Workers ◽  
Glutathione System ◽  
Medical Centers

Introduction. Digital technologies are actively used in the work of specialists of medical centers of various profiles, which causes the impact on employees of a number of professional factors that determine the characteristics of their work. The aim of the study is to evaluate the influence of professional factors on the functional state of the employees' body and the glutathione system as an objective indicator of stress based on the analysis of the subjective perception of the medical center employees of the specifics of working with personal computers and psychophysiological testing. Materials and methods. The study involved 109 specialists of medical centers (25 ophthalmologists, 31 representatives of the secondary medical staff - nurses and paramedics, 53 office employees). The anonymous survey concerned the assessment of working conditions and their impact on the functional state of the body of the respondents. Performance and stress tolerance indicators were evaluated using three standard questionnaires. The study of 66 subjects' levels of glutathione in the blood: total, reduced, oxidized and the ratio of reduced and oxidized - was used to analyze the relationship of the neuro-emotional nature of labor with the reaction of oxidative stress. Statistical processing of the obtained data was carried out using traditional methods of variation statistics and calculating the value of the odds ratio (OR) with a 95% confidence interval (CI). Results. The survey revealed a significant proportion of people in all groups of respondents who constantly use computer technology in their work. Describing the quality of the processed information, doctors more than representatives of other groups note its complexity, importance, negative emotional color, a high degree of responsibility and tension. Doctors more often than average medical staff and office workers associate the manifestation of fatigue with an uncomfortable state of the visual organ, nervous system, and musculoskeletal system. The subjects showed reduced performance and stress tolerance with the most pronounced negative trends in the group of doctors. Changes in the glutathione system were detected, indicating the presence of oxidative stress in 40% of ophthalmologists and office workers, and in half of nurses. Conclusions. The work of specialists of medical centers of various profiles in accordance with their assessment is characterized by high nervous and emotional stress, due to the need to process a significant amount of complex and important professionally significant information. Subjectively noted by respondents the influence of working conditions on the functional state of the body is confirmed by indicators of the glutathione system, which can be used as indicators of nervous and emotional stress.

Molecular Targets of Phytochemicals for Skin Inflammation

2018 ◽  
Vol 24 (14) ◽  
pp. 1533-1550 ◽  
Author(s):  
Jong-Eun Kim ◽  
Ki Won Lee
Keyword(s):  
Skin Diseases ◽  
Molecular Targets ◽  
Skin Inflammation ◽  
Mechanisms Of Action ◽  
The Body ◽  
Cellular Damage ◽  
Aesthetic Appearance ◽  
Immune Mediated ◽  
Skin Conditions ◽  
Effects Of Aging

Skin is a protective organ and the largest of the human body. Due to its pivotal role in aesthetic appearance, skin health has a significant impact on quality of life. Chronic inflammation of the skin often marks the beginning of various skin diseases. Immune-mediated responses serve to protect the body from external insults and require succinct control, and can lead to ongoing cellular damage and various skin conditions if left unchecked. Studies have shown that phytochemicals can alter processes involved in skin inflammation and alleviate the effects of aging, cancer, atopic dermatitis, psoriasis, and vitiligo. Direct molecular targets of some phytochemicals have been identified and their precise mechanisms of action investigated. In this review, we summarize recent findings on the effects of phytochemicals on skin inflammation and the mechanisms of action involved.

AI-Provided Instant Differential Diagnosis of Pemphigus Vulgaris and Bullous Pemphigoid: Qualitative Study (Preprint)

2020 ◽  
Author(s):  
Xiaoyu He ◽  
Juan Su ◽  
Guangyu Wang ◽  
Kang Zhang ◽  
Navarini Alexander ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Early Diagnosis ◽  
Image Classification ◽  
Bullous Pemphigoid ◽  
Skin Diseases ◽  
Pemphigus Vulgaris ◽  
Classification Model ◽  
Clinical Image ◽  
Clinical Images ◽  
Multimodal Classification

BACKGROUND Pemphigus vulgaris (PV) and bullous pemphigoid (BP) are two rare but severe inflammatory dermatoses. Due to the regional lack of trained dermatologists, many patients with these two diseases are misdiagnosed and therefore incorrectly treated. An artificial intelligence diagnosis framework would be highly adaptable for the early diagnosis of these two diseases. OBJECTIVE Design and evaluate an artificial intelligence diagnosis framework for PV and BP. METHODS The work was conducted on a dermatological dataset consisting of 17,735 clinical images and 346 patient metadata of bullous dermatoses. A two-stage diagnosis framework was designed, where the first stage trained a clinical image classification model to classify bullous dermatoses from five common skin diseases and normal skin and the second stage developed a multimodal classification model of clinical images and patient metadata to further differentiate PV and BP. RESULTS The clinical image classification model and the multimodal classification model achieved an area under the receiver operating characteristic curve (AUROC) of 0.998 and 0.942, respectively. On the independent test set of 20 PV and 20 BP cases, our multimodal classification model (sensitivity: 0.85, specificity: 0.95) performed better than the average of 27 junior dermatologists (sensitivity: 0.68, specificity: 0.78) and comparable to the average of 69 senior dermatologists (sensitivity: 0.80, specificity: 0.87). CONCLUSIONS Our diagnosis framework based on clinical images and patient metadata achieved expert-level identification of PV and BP, and is potential to be an effective tool for dermatologists in remote areas in the early diagnosis of these two diseases.

Shakespeare’s Dancing Bodies

2019 ◽  
pp. 172-196
Author(s):  
Brandon Shaw
Keyword(s):  
Early Modern ◽  
Modern Dance ◽  
The Body ◽  
Literary Texts ◽  
Somatic Psychology ◽  
Body Parts ◽  
Social Significance ◽  
Romeo And Juliet ◽  
Modern Times ◽  
Early Modern Times

Romeo’s well-known excuse that he cannot dance because he has soles of lead is demonstrative of the autonomous volitional quality Shakespeare ascribes to body parts, his utilization of humoral somatic psychology, and the horizontally divided body according to early modern dance practice and theory. This chapter considers the autonomy of and disagreement between the body parts and the unruliness of the humors within Shakespeare’s dramas, particularly Romeo and Juliet. An understanding of the body as a house of conflicting parts can be applied to the feet of the dancing body in early modern times, as is evinced not only by literary texts, but dance manuals as well. The visuality dominating the dance floor provided opportunity for social advancement as well as ridicule, as contemporary sources document. Dance practice is compared with early modern swordplay in their shared approaches to the training and social significance of bodily proportion and rhythm.

scholarly journals Microbiota of the Tongue and Systemic Connections: The Examination of the Tongue as an Integrated Approach in Oral Medicine

Hygiene ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 56-68
Author(s):  
Cinzia Casu ◽  
Giovanna Mosaico ◽  
Valentino Natoli ◽  
Antonio Scarano ◽  
Felice Lorusso ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Survival Rates ◽  
Integrated Approach ◽  
Potential Method ◽  
The Body ◽  
Oral Medicine ◽  
Next Generation Sequencing Technology ◽  
Advanced Phase ◽  
Holistic Concept ◽  
Unique Method

The tongue is able to quickly reflect the state of health or disease of the human body. Tongue inspection is an important diagnostic approach. It is a unique method that allows to explore the pathogenesis of diseases based on the guiding principles of the holistic concept that involves the observation of changes in the lining of the tongue in order to understand the physiological functions and pathological changes of the body. It is a potential method of screening and early detection of cancer. However, the subjective inspection of the tongue has a low reliability index, and therefore computerized systems of acquisition of diagnostic bioinformation have been developed to analyze the lining of the tongue. Next-generation sequencing technology is used to determine the V2–V4 hypervariable regions of 16S rRNA to study the microbiota. A lot of neoplasms are identified only at an advanced phase, while in the early stages, many subjects remain in an asymptomatic form. On the contrary, the early diagnosis is able to increase the prognosis of cancer and improve the survival rates of subjects. Evidently, it is necessary to develop new strategies in oral medicine for the early diagnosis of diseases, and the diagnosis of the tongue as a minimally invasive method is certainly one of them.

Wegener’s granulomatosis: diagnostic dilemma

2001 ◽  
Vol 115 (1) ◽  
pp. 46-47 ◽  
Author(s):  
A. Banerjee ◽  
J. M. Armas ◽  
J. H. Dempster
Keyword(s):  
Early Diagnosis ◽  
Wegener’S Granulomatosis ◽  
Systemic Disease ◽  
Wegener's Granulomatosis ◽  
The Body ◽  
Facial Nerve Paralysis ◽  
Diagnostic Dilemma ◽  
Nerve Paralysis ◽  
Atypical Presentations ◽  
High Index Of Suspicion

Wegener’s granulomatosis is a systemic disease characterized by a granulomatous lesion that can affect any organ throughout the body.This case-report illustrates the problem posed by a patient presenting with bilateral serous otitis media with marked sensorineural hearing loss, facial nerve paralysis and an atypical serological picture. The importance of early diagnosis and the protocol for the management of a patient with an uncertain diagnosis is discussed. Due to atypical presentations, only a high index of suspicion will ensure an early diagnosis.

scholarly journals Movement Patterns in Students Diagnosed with ADHD, Objective Measurement in a Natural Learning Environment

2021 ◽  
Vol 18 (8) ◽  
pp. 3870
Author(s):  
Mireia Sempere-Tortosa ◽  
Francisco Fernández-Carrasco ◽  
Ignasi Navarro-Soria ◽  
Carlos Rizo-Maestre
Keyword(s):  
Rating Scale ◽  
The Body ◽  
Social Adaptation ◽  
Assessment Tools ◽  
Control Group ◽  
Childhood And Adolescence ◽  
Clinical Group ◽  
Body Parts ◽  
Psychological Processes ◽  
Strengths And Difficulties

Attention deficit hyperactivity disorder is the most common neuropsychological disorder in childhood and adolescence, affecting the basic psychological processes involved in learning, social adaptation and affective adjustment. From previous research, the disorder is linked to problems in different areas of development, with deficiencies in psychological processes leading to the development of the most common characteristics of the disorder such as inattention, excess of activity and lack of inhibitory control. As for the diagnosis, in spite of being a very frequent disorder, there are multiple controversies about which tools are the most suitable for evaluation. One of the most widespread tools in the professional field is behavior inventories such as the Strengths and Difficulties Questionnaires for Parents and Teachers or the ADHD Rating Scale-V. The main disadvantage of these assessment tools is that they do not provide an objective observation. For this reason, there are different studies focused on recording objective measures of the subjects’ movement, since hyperkinesia is one of the most characteristic symptoms of this disorder. In this sense, we have developed an application that, using a Kinect device, is capable of measuring the movement of the different parts of the body of up to six subjects in the classroom, being a natural context for the student. The main objective of this work is twofold, on the one hand, to investigate whether there are correlations between excessive movement and high scores in the inventories for the diagnosis of ADHD, Rating Scale-V and Strengths and Difficulties Questionnaire (SDQ) and, on the other hand, to determine which sections of the body present the most significant mobility in subjects diagnosed with ADHD. Results show that the control group, composed of neurotypical subjects, presents less kinaesthetic activity than the clinical group diagnosed with ADHD. This indicates that the experimental group presents one of the main characteristics of the disorder. In addition, results also show that practically all the measured body parts present significant differences, being higher in the clinical group, highlighting the head as the joint with the highest effect size.

Estimation of the body mass increase in early diagnosis of complications in pregnants

1998 ◽  
Vol 79 (4) ◽  
pp. 274-275
Author(s):  
I. K. Bayteryak ◽  
A. K. Yarullin ◽  
I. I. Bayteryak ◽  
A. A. Akinfiev ◽  
N. B. Akhmetzyanova ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Body Mass ◽  
The Body ◽  
Consultation Clinic ◽  
Special Program ◽  
Mass Increase ◽  
Two Sectors

The investigations to reveal the regulations of the body mass increase in women were performed within 5 years on a special program at two sectors of the women's consultation clinic. Women were registered (2741 persons) for gestation periods of 8 9 weeks with weekly presence. The data were processed on computer following the biometry laws. The regulations of the body mass increase in women of ten weight categories within first and second half of pregnancy development and within 40 weeks as a whole are derived.

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