PSYCHOVEGETATIVE PREREQUISITES FOR ARTERIAL HYPERTENSION SYNDROME INUNDERGROUND WORKERS

2021 ◽  
Author(s):  
S.V. Paramonova ◽  
◽  
N.N. Malyutina ◽  
N.S. Sedinina
Keyword(s):  
Arterial Hypertension ◽  
Cardiovascular System ◽  
Clinical Laboratory ◽  
Vegetative State ◽  
Negative Relationship ◽  
Risk Groups ◽  
Main Group ◽  
Laboratory Diagnostics ◽  
Aged People ◽  
Age Related

Abstract: We examined 109 men working at а mining enterprise exposed to occupational and psychosocial factors. The patients were divided into two groups: the main group - 60 men working in underground conditions, the conditions are assigned to classes 3.3 - 3.4; comparison group - 49 men performing ground work, whose conditions are classified as 3.2. In connection with the established diagnosis of "Syndrome of arterial hypertension" in middle-aged people of the main group, it was divided into two subgroups in terms of age - people under 45 years old (n = 20, age 38.45 ± 2.95 years), and people older 45 years old (n = 40, age 50.90 ± 1.46 years.). Purpose: to study the prerequisites for the development of hypertension based on the psychovegetative status and some changes in the biochemical and functional indicators of the CVS, depending on the age-related changes in these indicators. Materials and methods: the patient underwent a study of the psycho-vegetative state with an assessment of the level of neuropsychic stress, personal and situational anxiety, attention function, subjective reflection of psycho-vegetative distress. The state of the cardiovascular system was investigated according to the results of functional and clinical laboratory diagnostics. Results: A decrease in attention, an increase in personal anxiety and an increase in the number of psychovegetative complaints were significantly more often detected in the group of patients with hypertension (OR 7.50; 95% CI 2.39-23.58; OR 11.06 95% - CI - 4.35 - 28.10; CI 22.50; 95% CI - 7.09 - 71.41). Adaptive psychovegetative phenotypes were distinguished in two subgroups. In patients over 45 years old, a negative relationship was established between age, experience and some parameters of psycho-vegetative status, as well as a direct relationship between these parameters and some indicators of homeostasis in the diagnosis of hypertension syndrome in 95% of patients in this subgroup. Conclusions: with an increase in age and experience, there is a transformation of the adaptive psychovegetative phenotype with an inversion of connections with psychovegetative parameters against the background of increased functional disorders of the cardiovascular system. Diagnostics of the transformation of this phenotype makes it possible to assess the risk of developing arterial hypertension and contributes to the prevention of hypertension by forming risk groups.

scholarly journals Risk of developing hypertension in underground workers when psycho-vegetative status is transforming

2021 ◽  
pp. 100-108
Author(s):  
N.N. Malyutina ◽  
◽  
S.V. Paramonova ◽  
N.S. Sedinina ◽  
O.Yu. Ustinova ◽  
...  
Keyword(s):  
Cardiovascular System ◽  
Working Conditions ◽  
Clinical Laboratory ◽  
Reference Group ◽  
Research Work ◽  
Circulatory System ◽  
Test Group ◽  
Risk Groups ◽  
Laboratory Diagnostics ◽  
Vegetative Status

The present research work is vital given the importance of studying risk factors that can cause mortality due to diseases of the circulatory system, especially among population of employable age. Our research aim was to establish what factors might induce developing hypertension based on examining psycho-vegetative status, biochemical and functional parameters of the cardiovascular system in underground workers depending on their age. We examined 109 men who were employed at a chromium mining enterprise and were exposed to occupational and psy-chosocial factors. The patients were divided into two groups; the test group was made up of 60 men who worked under ground under working conditions ranked as “hazardous” and belonging to hazard category 3.3–3.4; the reference group consisted of 49 men who dealt with surface works under working conditions belonging to hazard category 3.2. The test group was further divided into two sub-groups depending on workers’ age: people younger than 45 (n = 20, average age was 38.45 ± 2.95) and people older than (n = 40, average age was 50.90 ± 1.46). The reference group was also divided accordingly. The patients had their psycho-vegetative status examined profoundly with assessing neuropsychic stress, personal and situational anxiety, attention function, and subjective reflection of psycho-vegetative distress. The state of the cardiovascular system (CVS) was examined using results of functional and clinical-laboratory diagnostics. Decreased attention, greater personal anxiety and a greater number of psycho-vegetative complaints were detected authenti-cally more frequently among patients with hypertension (OR 7.50, 95 % CI 2.39–23.58; OR 11.06, 95 % CI 4.35–28.10; OR 22.50; 95 % CI 7.09–71.41). We detected differences in adaptation psycho-vegetative phenotypes between two sub-groups. A correlation between age and working experience and indicators of psycho-vegetative status was established for patients younger than 45 but there was no correlation with homeostasis indicators. There was a negative correlation between age and working experience and some indicators of psycho-vegetative status revealed for patients older than 45; there was a direct correlation between these parameters and certain homeostasis indicators given hypertension diagnosed in 95 % patients in this sub-group. As age and working experience grew, adaptation psycho-vegetative phenotype transformed and the process involved inversion of correlations with psycho-vegetative indicators together with aggravating functional disorders of the CVS. When transformation of this phenotype is diagnosed, it allows assessing risks of developing hypertension and makes for primary hypertension prevention through determining risk groups among workers.

scholarly journals functional hemispheric asymmetry in boys and girls with arterial hypertension

2016 ◽  
Vol 1 (5) ◽  
pp. 46-48
Author(s):  
Ревякина ◽  
Yuliya Revyakina ◽  
Прохорова ◽  
Zhanna Prokhorova ◽  
Косовцева ◽  
...  
Keyword(s):  
Arterial Hypertension ◽  
Cardiovascular System ◽  
Hemispheric Asymmetry ◽  
Comparison Group ◽  
Statistical Significance ◽  
Main Group ◽  
Healthy Children ◽  
Normal Functioning ◽  
The Asymmetry ◽  
The One

Peculiarities of hemispheric asymmetry in 59 boys and 39 girls with arterial hypertension (mean age – 15.1 ± 1.5) were studied. The comparison group of healthy children included 60 boys and 37 girls (mean age – 14.9 ± 1.3).The total indicators of sensorimotor asymmetry showed significant deviations in formation of functional hemispheric asymmetry only in the group of boys. At the same time, differences of the asymmetry indicators between main group of girls and the one of comparison were quite moderate and did not reach the level of statistical significance. It is associ-ated with adaptation features of the boys with hypertension to changes of normal functioning of cardiovascular system.

scholarly journals Preoperative Preparation Of Elderly Patients With Concomitant Hypertension In The Practice Of Ophthalmic Surgery

2020 ◽  
Vol 02 (11) ◽  
pp. 8-15
Author(s):  
Mansur Muratovich Matlubov ◽  
◽  
Jasur Tolibovich Yusupov ◽  
Nigina Ulugbekovna Mukhamedieva ◽  
◽  
...  
Keyword(s):  
Heart Rate ◽  
Arterial Hypertension ◽  
Antihypertensive Therapy ◽  
Preoperative Assessment ◽  
Cataract Extraction ◽  
Risk Groups ◽  
Clinical State ◽  
Ophthalmic Surgery ◽  
Age Related ◽  
Department Of Ophthalmology

Background: The relevance of the problem of arterial hypertension (AH) is determined by its high frequency in the population, the influence on the state of health, working capacity and longevity of the population. Persons of old and old age, as a rule, have a significant amount of risk factors for cardiovascular diseases, very often there are lesions of target organs and associated clinical conditions, therefore, the majority of painful AHs of these age-related categories belong to high and very high-risk groups. Purpose of the research: To optimize the existing methods of managing elderly and senile patients with hypertension during cataract extraction, including preoperative assessment of patients' condition and preparation, intraoperative protection. Materials and methods: Clinical observations cover 150 patients aged 60 to 89 years (74.7 ± 0.5), who were required for surgical treatment for age-related cataracts in the department of ophthalmology at the Sam clinic. Depending on the method of anesthesiology, all patients were divided into 2 groups. Results: All patients with hypertension on the background of an antihypertensive therapy have clinically achieved the target numbers for arterial pressure. . Arterial hypertension before surgery in patients of the II group testified to a pressurized reaction of the cardiovascular system (CCC) in response to psycho-emotional irritation and a short-term associated with it. After the operative period, indicators of the functional state of the CVS improved, however, tachycardia of the heart rate of 85.4 ± 1.4 use of antihypertensive and pain-relieving drugs. In patients of the I-group, the SAD stabilized at 87.7 ± 3.7 mm Hg, heart rate 66.2 ± 3.4 beats. in minutes at the I-stage already after premedication. Conclusion. The results of the study suggest that conducting adequate antihypertensive therapy in combination with drugs that reduce mental and emotional stress in the preoperative period, exclusion of eye contact, psychoemotional stress through sedation and neuroleptanalgesia in waiting rooms allows to stabilized the clinical state of patients, clearly correlating with an improvement in hemodynamic parameters.

scholarly journals Value of psychological adaptation of labor-intensive underground workers in formation of arterial hypertension regarding age aspect

2021 ◽  
Vol 38 (3) ◽  
pp. 22-31
Author(s):  
N. N. Malyutina ◽  
S. V. Paramonova ◽  
N. S. Sedinina ◽  
O. Yu. Ustinova ◽  
E. M. Vlasova
Keyword(s):  
Arterial Hypertension ◽  
Cardiovascular System ◽  
Risk Group ◽  
Negative Relationship ◽  
Psychological Adaptation ◽  
Status Change ◽  
Length Of Service ◽  
Psychophysiological Testing ◽  
Relationship Of ◽  
Vegetative Status

Objective. To study the prerequisites for the development of hypertension based on the manifestation of psychovegetative dysfunction and some changes in the biochemical and functional parameters of CVS in the age aspect. Psychological adaptation of a group of underground miners in conditions of intensive labor was analyzed on the basis of indicators of psycho-vegetative status taking into account the influence of professional and psychosocial factors. In connection with the established diagnosis i.e. arterial hypertension (AH) syndrome, especially in middle-aged persons, it is of interest to study the indicators of psycho-vegetative status in the age aspect and to compare them with some changes in biochemical and functional state of cardiovascular system (CVS) in this contingent of patients. Materials and methods. The results of the study of psycho-vegetative status of 60 underground miners with AH syndrome (age 46.8 2.0 years, experience 22.0 2.4 years) using the method of psychophysiological testing as well as analysis of some clinical, functional and laboratory parameters are presented. Results. The adaptive psycho-vegetative phenotypes in a group of underground workers with AH syndrome in the age aspect were identified. Conclusions. With an increase in the length of service among labor-intensive workers, the characteristics of psycho-vegetative status change qualitatively in the form of elevated anxiety and neuro-psychical stress with a decrease in the function of attention combined with a negative relationship of these parameters with increasing age, that is accompanied by dysfunction of CVS; studying of this aspect allows identifying the prerequisites for the development of hypertension so as to form a risk group in time.

scholarly journals Blood pressure level and laboratory indicators of disease severity in patients with arterial hypertension and COVID-19

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
K Popov ◽  
A Novitskiy ◽  
Y Shvarts
Keyword(s):  
Blood Pressure ◽  
Multivariate Analysis ◽  
Arterial Hypertension ◽  
Negative Correlation ◽  
Diastolic Pressure ◽  
Negative Relationship ◽  
Laboratory Parameters ◽  
Acute Period ◽  
Nonparametric Correlation ◽  
The Relationship

Abstract Funding Acknowledgements Type of funding sources: None. Background. Many patients with COVID-19 suffer from arterial hypertension and have marked variations in blood pressure (BP) during the acute period of infection. The reasons for such changes are poorly understood. Purpose. To assess the relationship between the level of BP and the severity of changes in the main clinical and laboratory parameters in patients with arterial hypertension and with a moderate course of COVID-19 at the stage of the height of the disease. Materials and methods. The study included 86 hospitalized patients with verified coronavirus disease of moderate severity: 46 of them were male, the median age was 65 years. Patients received adequate hypertension therapy for a long time. After hospitalization, treatment was adjusted if necessary. The level of laboratory parameters in the acute period of the disease was determined, including the electrolytes, C-reactive protein (CRP), albumin, ferritin, general blood test, etc. BP measured daily. The relationship between laboratory parameters and BP level was evaluated by nonparametric correlation using the Spearman coefficient and multivariate analysis based on the "generalized nonlinear model". Results. In 67.44% of patients with hypertension, an elevated BP level (>140/90) was observed against the background of moderate COVID-19. There was a significant negative correlation between the levels of CRP and BP throughout the stay in the hospital, the most significant is the 5th day of hospitalization. At the same time, a slightly stronger relationship is observed with diastolic BP (r = -0.4425) than with systolic BP (r = -0.3525). A similar trend is observed in all BP measurements. Besides, a negative correlation was found between potassium levels and BP values. The strongest association of potassium levels is with systolic BP on the day of hospitalization (r = -0.4850) and diastolic pressure on the 1st day of hospitalization (r = -0.3561). Multivariate analysis confirmed independent and reliable "influence" of CRP (p = 0.00018) and potassium (p = 0.03921) as independent predictors of diastolic pressure. Conclusions. Most patients with hypertension and moderate COVID-19 have elevated BP levels. There is a statistically significant negative relationship between the values of BP and levels of CRP and potassium. The obtained data may correspond to the existing hypothesis about the significant role of the kinin–kallikrein system in the pathogenesis of COVID-19.

Early clinical and laboratory diagnostics of allergodermatoses in electroplating shop workers

2021 ◽  
Vol 65 (4) ◽  
pp. 365-371
Author(s):  
Elena N. Kryuchkova ◽  
Irina V. Jatcyna ◽  
Larisa I. Antoshina
Keyword(s):  
Skin Diseases ◽  
Nickel Content ◽  
Allergic Diseases ◽  
Risk Groups ◽  
Machine Building ◽  
Control Group ◽  
Laboratory Diagnostics ◽  
Production Environment ◽  
Nickel Compounds ◽  
Allergic Skin

Introduction. At the present stage, the occupational pathology of the skin remains one of the significant medical and social problems. In this regard, special attention is paid to the early diagnosis of sensitization to industrial chemical allergens to target occupational allergic diseases. The aim of the study was to study the changes in clinical and laboratory parameters in the formation of allergic skin diseases in workers during nickel plating. Material and methods. Three hundred eighty-nine employees of the machine-building enterprise were examined. The leading group consisted of 214 people exposed to harmful chemical factors of production. Group of intact persons 175 people is represented by employees who do not come into contact with harmful factors of the production environment. The condition of the skin of workers was analyzed. Laboratory studies of oxidative metabolism and immune status were performed according to unified methods. The nickel content in the urine was determined by voltammetry. Results. At the studied enterprise, 38,3% of workers were diagnosed with occupational skin diseases (epidermosis, allergic dermatitis, eczema). In the formation of dermatological morbidity, an increase in the activity of alkaline (ALPn) and acid (ACPn) phosphatase of neutrophils by 1,7-2.2 times and inhibition of succinate dehydrogenase (SDH) and neutrophil myeloperoxidase (MPn) by 1.2-1.5 times relative to the control group was found. On the part of the immune system, there was an activation of the suppressor function of T-lymphocytes (CD8+); B-lymphocytes (CD20+), an increase in the content of immunoglobulins IgG, total IgE, circulating immune complexes by 1.5-2.0 times and a decrease in the levels of immunoglobulins IgA, IgM by 3.0-5.0 times compared to the control. The relationship between the nickel content in the urine of workers and changes in the indicators of ACPn (r = 0.76), MPn (r = -0.87), (CD4+) (r = -0.91), (CD8+) (r = 0,86), general IgE (r = 0.92), indicating the priority role of nickel compounds in the formation of allergodermatoses in workers. Conclusion. The proposed complex of biomarkers aims to detect early the initial forms of allergodermatosis and the formation of risk groups for the timely rehabilitation of electroplating workers.

Organization of the work of the medical laboratory service in accordance with the requirements of the standard GOST ISO 15189–2015 «Medical laboratories. Particular requirements for quality and competence»

2020 ◽  
pp. 15-22
Author(s):  
Elena Vitalievna Perminova
Keyword(s):  
Clinical Laboratory ◽  
Medical Laboratory ◽  
Laboratory Research ◽  
Laboratory Diagnostics ◽  
Clinical Diagnostic Laboratory ◽  
Diagnostic Laboratory ◽  
Iso 15189 ◽  
Laboratory Service ◽  
Medical Laboratories

Clinical laboratory diagnostics is a medical specialty, which is based on in vitro diagnostic studies of biomaterial obtained from an individual. At the present stage, there are three main types of organization of the laboratory research process — a laboratory service as part of a medical and preventive institution, a centralized laboratory where biomaterials are delivered for research from various healthcare institutions, as well as mobile laboratories that allow conducting the research directly at the patient’s bedside. This discipline involves the use of a wide variety of diagnostic research methods and the use of a huge number of specific techniques. Their list should include carrying out hematological, microbiological, virological, immunological, serological, parasitic, and biochemical studies. Also, when organizing laboratory diagnostic activities, a number of other studies (cytological, histological, toxicological, genetic, molecular biological, etc.) are provided. A laboratory report is formulated after obtaining clinical data and comparing them with the obtained test results. The quality of laboratory tests is ensured through the systematic implementation of internal laboratory control, as well as participation in a national program for external quality assessment. The activities of the clinical diagnostic laboratory should be organized in accordance with the requirements of the standard GOST R ISO 15189–2015 «Medical laboratories. Particular requirements for quality and competence», which is based on the provisions of two more fundamental standards — ISO 9001 and ISO 17025, and adds a number of special requirements related to medical laboratories.

scholarly journals BIOMARKERS OF OSTEO-DEFFICIENCY IN THE COURSE OF SECONDARY OSTEOPOROSIS IN PATIENTS WITH COMORBID CHRONIC PANCREATITIS AND ARTERIAL HYPERTENSION

2020 ◽  
Vol 20 (4) ◽  
pp. 16-20
Author(s):  
T.I. Viun ◽  
L.M. Pasieshvili ◽  
S.V. Viun ◽  
A.S. Marchenko ◽  
O.V. Karaya
Keyword(s):  
Chronic Pancreatitis ◽  
Acid Phosphatase ◽  
Arterial Hypertension ◽  
Comparison Group ◽  
Practical Importance ◽  
Main Group ◽  
Secondary Osteoporosis ◽  
Control Group ◽  
Tartrate Resistant Acid Phosphatase ◽  
Detection Of Biomarkers

The prevalence of comorbidities has been growing for the last decades. Therefore, the detection of biomarkers for diagnostic and prognostic purposes is of great practical importance. The aim of this study was to assess the biomarkers of osteo-defficiency in the course of secondary osteoporosis in patients with comorbid chronic pancreatitis and arterial hypertension. We examined 110 patients with chronic pancreatitis: 70 of them had comorbid hypertension, and 40 patients were found as having no comorbidities. The age of patients ranged from 33.2 ± 2.1 (main group) and 32.9 ± 3.1 years (comparison group); women predominated (72.9% and 70%, respectively). The control group includes 78 healthy individuals of the same age and sex. Diagnostic investigation included studying clinical and anamnestic characteristics of patients (duration of the disease, manifestations of the course, frequency of recrudescence, fractures) and biochemical parameters of bone metabolism: osteocalcin, total bone phosphatase and tartrate-resistant acid phosphatase and the establishment of correlations between these parameters and incidence of complications. It was found that in the isolated course of chronic pancreatitis there is a high (R = 0.60) statistically significant (p <0.01) correlation between the levels of osteocalcin and pancreatic elastase-1. A negative statistically significant (p <0.01) mean correlation (R = -0.49) was found between the content of tartrate-resistant acid phosphatase and age of the patients having comorbidity of chronic pancreatitis and hypertension, as well as there is a moderate correlation between the content of tartrate-resistant acid phosphatase and the duration of hypertension, which is statistically significant (R = 0.36, p <0.01). The levels of total bone phosphatase and tartrate-resistant acid phosphatase in the main group exceeded the reference values in 2.5 and 1.9 times respectively (CMU; U = 866.0; p <0.01), while in the comparison group were 2 times (total bone phosphatase) and 1.3 times higher (tartrate-resistant acid phosphatase) times, respectively (CMU; U = 821.0; p <0.01) that enables to diagnose the development of osteopenic conditions. That is, the combined course of chronic pancreatitis and hypertension should be considered as unfavourable tandem in the development of secondary osteoporosis and requires early osteoporotic screening.

Sign in / Sign up

Export Citation Format

Share Document