THE USE OF IMMUNOLOGICAL INDICATORS IN ORDER TO FORM AN IMMUNOCOMPROMISED GROUP FOR VACCINATION AGAINST PNEUMOCOCCAL INFECTION

2021 ◽  
Author(s):  
T.V. Bushueva ◽  
◽  
N.A. Roslay ◽  
A.K. Labzova ◽  
Keyword(s):  
Adult Population ◽  
Pneumococcal Infection ◽  
Professional Groups ◽  
Production Factors ◽  
Working Age ◽  
High Level ◽  
Families With Children ◽  
Secretory Immunoglobulin ◽  
Healthy Carriers ◽  
Increased Susceptibility

Abstract: Pneumococci (Streptococcus pneumoniae) are one of the leading causes of morbidity and mortality among people over 60 years of age and workers in some professional groups. According to the medical literature, the frequency of invasive forms of pneumococcal infection among people of working age is 3.8 per 100,000 population. Increased susceptibility to colonization of the respiratory tract and subsequent morbidity may be due to concomitant pathology, exposure to immunocompromising, including harmful production factors. It should be noted that the source of the pathogen is not only sick people, but also healthy carriers. The level of asymptomatic colonization in the adult population is 5-7%, and in families with children increases to 30%. Vaccination is a way to effectively prevent respiratory diseases caused by this infection. The purpose of our study is to substantiate immunological indications for the formation of immunocompromised groups among workers exposed to the aerogenic factor at work for subsequent vaccination against pneumococcal infection. Results: It has been shown that low bactericidal activity of neutrophils (NBT-test) and a high level of secretory immunoglobulin can be used as a marker of immunodeficiency in workers of a ferrous metallurgy enterprise. When a doctor assesses the immune status of workers, he needs to take into account the presence of diseases that are part of the groups of immunological syndrome complexes (infectious-inflammatory, autoimmune, allergic, immunoproliferative) and the composition of industrial aerosols

Pneumococcal infection in Russia: state of the issue

2021 ◽  
Vol 76 (1) ◽  
pp. 28-42
Author(s):  
Nikolay I. Briko ◽  
Vladimir A. Korshunov ◽  
Kirill S. Lomonosov
Keyword(s):  
Adult Population ◽  
Herd Immunity ◽  
Pneumococcal Infection ◽  
Community Acquired Pneumonia ◽  
Morbidity And Mortality ◽  
School Age Children ◽  
Economic Significance ◽  
Chronic Lung Diseases ◽  
One Year ◽  
High Level

Background: Pneumococcal disease is common cause of morbidity and mortality in adults and children worldwide. The severity of pneumococcal diseases determines their high socio-economic significance. Aims: Estimate the burden of pneumococcal infection and vaccination coverage in Russia. Methods: The data was obtained from federal surveillance system. The information obtained was analyzed using descriptive statistics methods. Results: The annual incidence of community-acquired pneumonia in Russia was 491.7/100000 in 2011-2019. It ranges from 359.8/100000 among adults of working age to 1505.4/100000 among children 1-2 years old. The upward trend of incidence is observed throughout the period, most expressive among school-age children (7-17 years old). Total 29.2% of all pneumonia have an identified etiology. 94% of pneumonia with known etiology are bacterial, 8.4% among it are pneumococcal. Pneumonia accounts for 57% of all deaths from respiratory diseases among children under five (3.7/100000) and 34% among elderly. The death rate from pneumonia in 2009-2018 tends to decrease. In 2018, 25.5 thousand deaths from pneumonia were registered (17.5/100000). The highest rate is observed among children under one year (14.0 /100000) and elderly (41.2 /100000). There is a downward trend in incidence of otitis media. The incidence in children under 14 was 2612.6/100 000 in 2018. The incidence of bacterial meningitis is 1.4/100 000. Every year 2-3 thousand cases are registered, 43-52% of which are among children (3.04/100000., maximally in children under one year old, 13.2/100000). The level of vaccination against pneumococcal infection is increasing annually, but the proportion of children who have received a completed course of vaccination remains insufficient (64.6% in 2019). Coverage among the adult population was 2.3% (3.8% among those over 60). The main contingents of vaccinated adults are conscripts (coverage 67.4%) and people with chronic lung diseases (coverage 15.1%). Conclusions: The socio-economic and epidemiological burden of diseases associated with pneumococcal infection in Russia remains high. Accurate assessment of morbidity and mortality rates caused by St. pneumoniae diseases isnt possible due to the insufficient level of their ethological identification. Further efforts are required to achieve high level of herd immunity against pneumococcal infection through vaccine prevention during COVID-19 pandemic.

scholarly journals The prevalence of circulating S. pneumoniae serotypes in people older than 18 years: healthy carriers, patients with acute otitis media, community-acquired pneumonia, and invasive pneumococcal infections (epidemiological study «SPECTRUM»)

2019 ◽  
Vol 21 (4) ◽  
pp. 275-281
Author(s):  
Alexander A. Muravyev ◽  
Aida N. Chagaryan ◽  
Nataly V. Ivanchik ◽  
Anastasia A. Kurkova ◽  
I.A. Tsvetkova ◽  
...  
Keyword(s):  
Otitis Media ◽  
Adult Population ◽  
Pneumococcal Infection ◽  
Acute Otitis Media ◽  
Community Acquired Pneumonia ◽  
Central Laboratory ◽  
Pneumococcal Infections ◽  
Serotype 1 ◽  
Invasive Pneumococcal Infection ◽  
Healthy Carriers

Objective. To estimate the prevalence of S. pneumoniae serotypes in adults aged of 18 years and older, including healthy carriers and patients with acute otitis media (AOM), community-acquired pneumonia (CAP) and invasive pneumococcal infection (IPI). Materials and Methods. A total of 230 isolates of S. pneumoniae from 10 centers were included in the study from 01.06.2019 to 01.10.2019. Re-identification and typing using real-time PCR with 22 primer pairs were performed in the central laboratory (Institute of Antimicrobial Chemotherapy, Russia). Results. In healthy nasopharyngeal carriers (n = 31), the following serotypes of S. pneumoniae were detected: 19F (29.0%), 6А/В (22.6%), 3 (16.1%), 11A/D and 23F (9.7% each), 23A (6.4%), 14 and 15A/F (3.2% each); PCV-13 and PPV-23 covered 80.6% and 90.3% of those serotypes, respectively. In patients with AOM (n = 18), serotypes were: 3 (16.7%), 11A/D and 6A/B (11.1%, each), 16, 19А, 19F, 23F, 7A/F (5.55%, each); PCV-13 and PPV-23 covered 50% and 61.1% of those serotypes, respectively. Among 166 isolates from patients with CAP, the following serotypes were detected: 3 (12.0%), 19F and 6A/B (10.2%, each), 14 and 11A/D (5.4% each), 15A/F and 23A (4.8% each), 9N/L (4.2%), 18 and 22A/F (2.4% each), 19A and 23F (1.8% each), 16, 9V/A (1.2% each), 4 and 33A/33F/37 (0.6% each), non-vaccine serotypes (30.3%); PCV-13 and PPV-23 covered 45.6% and 57.0% of those serotypes, respectively. Isolates from patients with IPI (n=15) belonged to the following serotypes: 3 (26.7%), 12F, 23F and 9N/L (13.3% each), serotypes 4 and 15A/F (6.7%), non-vaccine serotype – 1 isolate (6.7%); PCV-13 and PPV-23 covered 46.7% and 73.3% of those serotypes, respectively. Conclusions. The majority of S. pneumoniae serotypes in adult population in Russia are included in PPV-23, but not in PCV-13 (primarily due to serotype 11A/D). There was a high PCV-13 and PPV-23 coverage of serotypes from healthy nasopharyngeal carriers. PPV-23 covered more than 60% of clinical isolates, whereas PCV-13 covered less than 60% (AOM – 50.0%, CAP – 45.6%, IPI – 46.7%), thus indicating a potentially lower efficacy of PCV-13 in adult population.

scholarly journals ANALYSIS OF PRIMARY DISABILITY DUE TO EYE DISEASES IN MOSCOW IN DYNAMICS FOR 10 YEARS (2007-2016 YEARS)

2018 ◽  
Vol 21 (3-4) ◽  
pp. 149-151
Author(s):  
S. N Puzin ◽  
Marina G. Nazaryan ◽  
P. M Arbukhanova ◽  
O. Yu Vertash
Keyword(s):  
Quality Of Life ◽  
Adult Population ◽  
Age Groups ◽  
Eye Diseases ◽  
Present Stage ◽  
Persons With Disabilities ◽  
Primary Disability ◽  
Working Age ◽  
High Level

One of the priority medical and social problems at the present stage is the problem of disability and rehabilitation of patients and persons with disabilities due to eye diseases. The relevance of this problem is due to the significant prevalence of eye diseases, high level of disability of people of working age and reduced quality of life. The article analyzes the level of primary disability due to eye diseases in Moscow in different age groups among the adult population.

The role of production and non-production factors in the formation of male mortality (on the example of two Arctic single-industry towns)

2020 ◽  
Vol 60 (11) ◽  
pp. 738-741
Author(s):  
Maria S. Bryleva
Keyword(s):  
Negative Impact ◽  
Well Being ◽  
Malignant Neoplasms ◽  
Male Mortality ◽  
Occupational Factors ◽  
Copper Nickel ◽  
Production Factors ◽  
Single Industry ◽  
Working Age ◽  
Quality Of Medical Care

Introduction. One of the priority socio-economic and medical-demographic problems in Russia is the high mortality. The study aim is to identify the most significant factors that determine the mortality on the example of two single-industry towns. Materials and methods. Mortality in two single-industry towns specializing in copper-nickel production, differenced in climate, environmental, and socio-economic indicators, was studied using age-standardized indicators averaged over 8 years (2010-2017). Results. In Monchegorsk, compared to Russia, with similar non-production characteristics, working-age mortality from cardiovascular diseases (CVD) was higher by 49.0%, from malignant neoplasms (MN) by 34.7%, from diseases of the digestive system by 35.5%, which confirms the negative impact of occupational factors on the mortality of the population of a single-industry city. In Norilsk city, with the worst characteristics of the environment and climate, compared to Monchegorsk, mortality from CVD was lower in working age by 40.6%, in post-working age by 41.4%; from MN - in working age lower by 37.2% that shows the compensating influence of socio-economic factors on mortality. Conclusion. Risk factors for increased mortality rates in single-industry towns with copper-nickel enterprises are the influence of harmful occupational factors, as well as environmental pollution. Along with primary prevention, an effective mechanism for reducing mortality is to improve socio-economic well-being, and the quality of medical care.

Clinical and epidemiological characteristics of chickenpox in the adult population at the present stage

2020 ◽  
pp. 17-24
Author(s):  
Ekaterina Peredelskaya ◽  
Tatyana Safyanova ◽  
Mikhail Druchanov
Keyword(s):  
Health Care ◽  
Adult Population ◽  
Final Diagnosis ◽  
Health Care Institution ◽  
Federal State ◽  
Economic Damage ◽  
Clinical Hospital ◽  
Care Institution ◽  
High Level ◽  
Epidemiological Characteristics

Chickenpox is an urgent problem, as it is widely spread with a high level of morbidity and an increasing share in the structure of the General infectious pathology with significant economic damage. The aim of the study is to study the epidemiological and clinical features of chickenpox in adults hospitalized in Krai government-owned publicy funded health care institution «City clinical hospital No. 5, Barnaul» for the period 2008‑2018. Content analysis included statistical reporting forms No. 2 of Federal state statistical supervision «Data on infectious and parasitic diseases» in the city of Barnaul during the period 2008‑2018 of medical archival documents adult infectious Department Krai government-owned publicy funded health care institution «City clinical hospital №5, Barnaul» for the same period. Data processing was performed using calculation of intensive and extensive indicators, calculation of the arithmetic mean (X) and standard error of the average (m). Calculations were made using the STATISTICA-10 program. Consistently high rates were recorded, with an average of 64.32 ± 3.46 per 100,000 population. The percentage of hospitalized adults averaged 18.5% during the study period. Adults aged 18‑30 were more likely to be admitted to the hospital (90.3%); 41.6% were students. Adults with moderate severity were hospitalized more often (70.6%); 7 patients (1.3%) had complications: aphthous stomatitis (3 cases), pustulosis (2 cases), and pneumonia (2 cases). Patients with severe severity of the disease accounted for 2.4%, the premorbid background was burdened in 48% (HIV infection, tuberculosis). In 35% of patients with severe severity, the final diagnosis of Herpes zoster was made, all patients older than 40 years, stayed in the hospital for 20‑25 days.

Assessment of professional risk of health of workers of the enterprise for repair of railway carriage

2020 ◽  
pp. 9-19
Author(s):  
O. Klepikov ◽  
A. Boreyko ◽  
G. Kurenkova
Keyword(s):  
Relative Risk ◽  
Working Conditions ◽  
Light Level ◽  
Occupational Risk ◽  
Rolling Stock ◽  
Joint Stock Company ◽  
Stock Company ◽  
Production Factors ◽  
Object Of Study ◽  
High Level

The aim of the study was to assess the professional risk of developing diseases in workers of the railway car repair enterprise. The Voronezh Car Repair Plant, a branch of Vagonremmash Joint-Stock Company, was chosen as the object of study. Methods: «The methodology for calculating individual occupational risk depending on the working conditions and the health status of the employee», developed by the Klin Institute for Protection and Working Conditions in conjunction with the Research Institute of Occupational Medicine (2013), the main professions; cohort study with the calculation of the relative risk of morbidity with temporary disability, the odds ratio, the etiological share of factors in the formation of morbidity (group size: 250 people, experimental group — workers of the main specialties, 95 people — comparison group). Results. According to the research results, the priority factors of occupational health risk include: chemical, noise, heating microclimate, low light level. For certain professions, the share of the contribution of priority factors to the risk profile (PV) reaches 40 %. The indicator of individual occupational risk is 0.12 to 0.26 units. The high level of professional risk (0.22 ÷ 0.26) is characterized by the working conditions of the mechanics for the repair of rolling stock, machine tools (woodworking), casters (metal), thermists, plastic casters. In professional groups with medium and high risk, the indicator of the relative risk of morbidity with temporary disability is higher than 1 (RR = 1.75 and 1.39, respectively), and the etiological share of production factors in the formation of diseases is from 27.95 (subgroup with secondary professional risk) up to 42.88 % (a subgroup with high professional risk), which indicates the professional condition of the disease. Discussion. In general, our data are consistent with the results of similar studies conducted earlier at the car building and car repair enterprises. In order to ensure hygienically safe working conditions and preserve the health of workers, it is necessary to reduce the level of exposure to production factors, including through the introduction of modern equipment and improvement of technological processes.

scholarly journals Factors Influencing SARS-CoV-2 Vaccine Acceptance and Hesitancy in a Population-Based Sample in Italy

Vaccines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 633
Author(s):  
Marco Del Riccio ◽  
Sara Boccalini ◽  
Lisa Rigon ◽  
Massimiliano Alberto Biamonte ◽  
Giuseppe Albora ◽  
...  
Keyword(s):  
Online Survey ◽  
Adult Population ◽  
Herd Immunity ◽  
Population Based ◽  
Vaccine Hesitancy ◽  
Convenience Sample ◽  
Major Barrier ◽  
Trust In Institutions ◽  
General Adult Population ◽  
High Level

Vaccination against SARS-CoV-2 represents an effective and safe tool to protect the population against the disease; however, COVID-19 vaccine hesitancy could be a major barrier to achieving herd immunity. Despite the severity of the current pandemic, the population’s intention to get vaccinated against COVID-19 is still not clear. The aim of this study was to evaluate the intention to get vaccinated against COVID-19 among a convenience sample of the general population resident in Italy and the factors associated with hesitancy and acceptance of the vaccine in the context of the current pandemic before the rolling out of COVID-19 vaccines. An anonymous online survey was diffused among a general adult population living in Italy. Participants aged 18 or older and living in Italy were considered eligible. Incomplete questionnaires were excluded. Overall, 7605 valid questionnaires were collected. Most of the participants (81.9%) were inclined to get vaccinated; male sex (OR 1.38, 95% CI 1.12–1.71), a high level of trust in institutions (OR 3.93, 95% CI 2.04–7.83), and personal beliefs about high safety of COVID-19 vaccines (OR 56.33, 95% CI 31.57–105.87) were found to be among the significant predictors of COVID-19 acceptance. These data could help design larger studies to address the problem of COVID-19 vaccine hesitancy in the current pandemic.

On priority development of knowledge economy

2021 ◽  
pp. 15-22
Author(s):  
A.G. Aganbegyan ◽  
Keyword(s):  
Mortality Rate ◽  
Knowledge Economy ◽  
Federal Budget ◽  
The Public ◽  
National Economic ◽  
Working Age ◽  
Low Efficiency ◽  
Child Mortality Rate ◽  
Main Component ◽  
High Level

A.G. Aganbegyan considers the knowledge economy as the main component of human capital. He analyzes certain areas of the knowledge economy (R&D, healthcare and education) by comparing relevant results demonstrated by Russian regions with similar indices reported for other countries. The article points out positive and negative aspects, e.g. high level and quality of education v. low efficiency of its application; lower cancer mortality rate and particularly child mortality rate v. high mortality from cardiovascular disease among working-age population, etc. Major causes of negative phenomena include insufficient funding of the public sector and inefficient administration. In order to remedy the situation, the author recommends the development of a new federal budget, transition to national economic planning and adjustment of national projects.

HYGIENIC ANALYSIS OF WORKING CONDITIONS IN THE PRODUCTION OF TABLETS AND CAPSULE

2021 ◽  
pp. 39-44
Author(s):  
S.V. Arabei ◽  
◽  
А.V. Hindziuk ◽  
Keyword(s):  
Working Conditions ◽  
Pharmaceutical Preparations ◽  
General Purpose ◽  
Production Environment ◽  
Chemical Factor ◽  
Professional Groups ◽  
Production Factors ◽  
Modern Enterprise ◽  
Packaging Machine ◽  
Machine Operator

In the present research, the working conditions of workers employed in the production of medicines in the form of tablets and capsules of a modern enterprise of the pharmaceutical industry have been studied. Based on the results of attestation of workplaces and data of industrial laboratory control of the factors of the production environment for the period from 2016 to 2019, a complex of harmful production factors at workplaces was determined and a comprehensive hygienic assessment of the working conditions of a general purpose machine operator of chemical and pharmaceutical preparations, packaging machine operator, stacker-packer and processor of technological containers and tares. It has been established that the labor activity of the leading professional groups of workers in production is associated with the influence of a predominantly chemical factor due to the presence of harmful chemicals in the air of the working area. According to the data obtained, the air of the working area at the workplace of the operator of a wide profile of chemical and pharmaceutical preparations of the tableting and filling of capsules section is contaminated with harmful chemicals (doxycycline, nystatin, lincomycin, rifampicin, tetracycline, etc.), the concentrations of which exceed the maximum permissible. A hygienic assessment of the parameters of the microclimate, noise and tension of the labor process at the studied workplaces established that there are no deviations from hygienic standards and the working conditions according to these factors are permissible. Thus, the data obtained allow us to conclude that the working conditions of the operator of a wide profile of chemical and pharmaceutical preparations belong to class 3.3, the stacker-packer — 3.1, and the working conditions of the operator of filling and packaging machines and the processor of technological containers and tares are assessed as acceptable.

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