Antioxidant potential of lichen species and their secondary metabolites. A systematic review

This paper is aimed to investigate the effects of some terricolous lichens on soil bacteria’s growth in natural conditions. It is focused on species of bacteria and also on numbers of colony of soil specimens that were taken from substrates of three different terricolous lichen species. Peltigera rufescens (Weiss) Humb., which has not secondary metabolites, did not show an inhibition effect on soil bacteria. However, Peltigera neckerii Hepp ex Müll. Arg., which has secondary metabolites, has a negative effect on soil bacteria’s growth. Besides, it was observed that Cladonia rangiformis Hoffm., which has many kinds of secondary metabolites, has the highest inhibition effect among the studied species. For this reason, we think that in the next researches, it is convenient to investigate elaborately by soil analysis the effect of lichen’s secondary metabolites that have an effect on soil mineralization, on soil bacteria’s growth.

Download Full-text

Antioxidant potential and content of the polyphenolic secondary metabolites of white rot macrofungi; Flavodon flavus (Klotzsch.) and Xylaria feejeensis (Berk.)

SDRP Journal of Plant Science ◽

10.25177/jps.1.1.2 ◽

2017 ◽

Vol 1 (1) ◽

Author(s):

M D Maduranganie Fernando

Keyword(s):

Secondary Metabolites ◽

Antioxidant Potential ◽

White Rot

Download Full-text

Lichens: traditional use and biological activities

Botanica Pacifica ◽

10.17581/bp.2021.10202 ◽

2021 ◽

Vol 10 (2) ◽

Author(s):

Ruchira R. Sutar ◽

◽

Subhash B. Gaikwad ◽

Sachin V. Mapari ◽

Bhaskar C. Behera ◽

...

Keyword(s):

Secondary Metabolites ◽

Traditional Knowledge ◽

Metabolic Pathways ◽

Biological Activities ◽

Lichen Species ◽

Symbiotic Association ◽

Traditional Use ◽

Rich Diversity ◽

The World ◽

Immense Potential

Lichens are a stable symbiotic association between photobiont (algae and/or cyanobacteria) and mycobiont (fungi). They are utilized in traditional medicine for ages and documented in various pharmacopeia throughout the world. India is having a rich diversity of lichen species represented by about 2400 species. The tribal inhabitant around forests and other difficult terrains acquired unique knowledge about the use of much wide flora and fauna. Most of these are either lesser known or unknown to the outside world. The treasure of traditional knowledge if subjected to scientific scrutiny could benefit humankind in many ways. They produce unique secondary metabolites through various metabolic pathways and are known to exhibit a wide array of bioactivities. We have reviewed the literature for traditional knowledge of the lichen species and biological activities reported to study its inter-relationship. It was observed that that still a major percentage of lichens have remained unexplored. These lichens may have immense potential; and if analysed could be used in pharmaceutical, nutraceutical, cosmetic industries, and many more.

Download Full-text

Metabolic fingerprinting, antioxidant characterization, and enzyme-inhibitory response of Monotheca buxifolia (Falc.) A. DC. extracts

BMC Complementary Medicine and Therapies ◽

10.1186/s12906-020-03093-1 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Joham Sarfraz Ali ◽

Hammad Saleem ◽

Abdul Mannan ◽

Gokhan Zengin ◽

Mohamad Fawzi Mahomoodally ◽

...

Keyword(s):

Liquid Chromatography ◽

Secondary Metabolites ◽

Methanol Extract ◽

Biological Activities ◽

Chloroform Extract ◽

Inhibitory Response ◽

Antioxidant Potential ◽

Total Phenolic ◽

Ms Analysis ◽

Monotheca Buxifolia

Abstract Background Ethnobotanical and plant-based products allow for the isolation of active constituents against a number of maladies. Monotheca buxifolia is used by local communities due to its digestive and laxative properties, as well as its ability to cure liver, kidney, and urinary diseases. There is a need to explore the biological activities and chemical constituents of this medicinal plant. Methods In this work, the biochemical potential of M. buxifolia (Falc.) A. DC was explored and linked with its biological activities. Methanol and chloroform extracts from leaves and stems were investigated for total phenolic and flavonoid contents. Ultrahigh-performance liquid chromatography coupled with mass spectrometry (UHPLC–MS) was used to determine secondary-metabolite composition, while high-performance liquid chromatography coupled with photodiode array detection (HPLC–PDA) was used for polyphenolic quantification. In addition, we carried out in vitro assays to determine antioxidant potential and the enzyme-inhibitory response of M. buxifolia extracts. Results Phenolics (91 mg gallic-acid equivalent (GAE)/g) and flavonoids (48.86 mg quercetin equivalent (QE)/g) exhibited their highest concentration in the methanol extract of stems and the chloroform extract of leaves, respectively. UHPLC–MS analysis identified a number of important phytochemicals, belonging to the flavonoid, phenolic, alkaloid, and terpenoid classes of secondary metabolites. The methanol extract of leaves contained a diosgenin derivative and polygalacin D, while kaempferol and robinin were most abundant in the chloroform extract. The methanol extract of stems contained a greater peak area for diosgenin and kaempferol, whereas this was true for lucidumol A and 3-O-cis-coumaroyl maslinic acid in the chloroform extract. Rutin, epicatechin, and catechin were the main phenolics identified by HPLC–PDA analysis. The methanol extract of stems exhibited significant 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical-scavenging activities (145.18 and 279.04 mmol Trolox equivalent (TE)/g, respectively). The maximum cupric reducing antioxidant capacity (CUPRAC) (361.4 mg TE/g), ferric-reducing antioxidant power (FRAP) (247.19 mg TE/g), and total antioxidant potential (2.75 mmol TE/g) were depicted by the methanol extract of stems. The methanol extract of leaves exhibited stronger inhibition against acetylcholinesterase (AChE) and glucosidase, while the chloroform extract of stems was most active against butyrylcholinesterase (BChE) (4.27 mg galantamine equivalent (GALAE)/g). Similarly, the highest tyrosinase (140 mg kojic-acid equivalent (KAE)/g) and amylase (0.67 mmol acarbose equivalent (ACAE)/g) inhibition was observed for the methanol extract of stems. Conclusions UHPLC–MS analysis and HPLC–PDA quantification identified a number of bioactive secondary metabolites of M. buxifolia, which may be responsible for its antioxidant potential and enzyme-inhibitory response. M. buxifolia can be further explored for the isolation of its active components to be used as a drug.

Download Full-text

Flavonoids and other Non-Alkaloidal Constituents of Genus Erythrina: Phytochemical Review

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207323666200609141517 ◽

2020 ◽

Vol 23 ◽

Author(s):

Ninh The Son ◽

Abdelsamed I. Elshamy

Keyword(s):

Systematic Review ◽

Secondary Metabolites ◽

Herbal Medicines ◽

Original Research ◽

Chemical Structures ◽

Fatty Acid Derivatives ◽

Material Sources ◽

Anti Cancer ◽

The Family ◽

Alkaloidal Constituents

Background: Genus Erythrina belongs to the family Fabaceae, which is widely distributed in tropical and subtropical areas. It has been used in both traditional herbal medicines and pharmacological applications. Original research articles and publications on the overview of alkaloids related to this genus are available, but a supportive systematic review account that highlights phytochemical aspects of other types of secondary metabolites is currently insufficient. Objective: With the utilization of data and information from SCI-Finder, Google Scholar, the Web of Science, Scopus, Science Direct, PubMed, Chemical Abstracts, ACS journals, Springer, Taylor Francis, Bentham Science, and IOP Science, the reliable material sources of this systematic review paper were obtained from various literature published from the 1980s to present. Conclusion: A vast amount of data showed that the non-alkaloidal secondary metabolites were obtained from genus Erythrina with various classes of chemical structures. Herein, approximately five hundred constituents were isolated, including flavonoids, terpenoids, saponins, phytosterols, phenols, arylbenzofurans, coumarins, alcohols, ceramides, monosugars, and fatty acid derivatives. In agreement with the previous phytochemical reports on the plants of the family Fabaceae, flavonoids make up a great percentage in the number of plants of genus Erythrina. Numerous biological activity investigations such as anti-bacteria, anti-cancer, anti-virus using isolated compounds from Erythrina species have suggested that secondary metabolites of Erythrina plants are now becoming the promising agents for drug developments.

Download Full-text

Effect of Geographical and Seasonal Variations on Phenolic Contents and Antioxidant Activity of Aerial Parts of Urtica diocia L.

Current Traditional Medicine ◽

10.2174/2215083804666181012123333 ◽

2019 ◽

Vol 5 (2) ◽

pp. 159-167 ◽

Cited By ~ 2

Author(s):

Vinod Kumar Gautam ◽

Mannu Datta ◽

Ashish Baldi

Keyword(s):

Antioxidant Activity ◽

Secondary Metabolites ◽

Seasonal Variations ◽

Summer Season ◽

Antioxidant Potential ◽

Total Phenolic ◽

Spring Season ◽

Phenolic Contents ◽

Aerial Parts ◽

Phenolic And Flavonoid

Background: Environmental conditions affect the biosynthesis of secondary metabolites as a result of biotic and abiotic factors. In the present study, the effect of different geographical locations and season was studied on total phenolic and flavonoid contents extracted from Urtica dioica Linn. Methodology: The aerial parts of U. dioica collected from Palampur, Shimla and Dharamshala in different seasons were subjected to hydro-alcoholic extraction. Quantitative estimation of total phenolic and flavonoid contents in various extracts was carried out spectrophotometrically. Results: The highest amount of total phenolic (3.987± 0.130) and flavonoid contents (2.847± 0.341) was found in Palampur sample collected in summer season whereas sample collected from Dharamshala in spring season showed the least phenolic contents. In vitro antioxidant activity of all the samples was evaluated by DPPH, NO scavenging and FRPA method. The antioxidant potential was found maximum in the sample collected from Palampur in the summer season, however, the sample collected from Dharamshala in spring season showed the least antioxidant potential. Conclusion: The present study confirms that altitude and seasonal variations significantly affect the levels of secondary metabolites in plant parts.

Download Full-text

Targeting cellular senescence in cancer by plant secondary metabolites: A systematic review

Pharmacological Research ◽

10.1016/j.phrs.2021.105961 ◽

2021 ◽

pp. 105961

Author(s):

Sajad Fakhri ◽

Seyed Zachariah Moradi ◽

Angela Ash-Rafzadeh ◽

Anupam Bishayee

Keyword(s):

Systematic Review ◽

Secondary Metabolites ◽

Cellular Senescence ◽

Plant Secondary Metabolites

Download Full-text