THE EFFECT OF BITTER MELON (Momordica charantia L.) JUICE AND BOILED EXTRACTON DIABETIC RATS

2012 ◽  
Vol 2 (1) ◽  
pp. 28-33
Author(s):  
Fitri Electrika D. Surawan ◽  
Zulman Efendi
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Glucose Level ◽  
Diabetic Rats ◽  
The Body ◽  
Bitter Melon ◽  
Weight Percentage ◽  
Glucose Levels ◽  
Chronic Hyperglycaemia ◽  
And Control

Diabetes Mellitus (DM) is the most common of the endocrine disorder and chronic hyperglycaemia due to relative or absolute lack of insulin. The aim of the study is to investigate the the body weight profile, decreased of body weight (%) and glucose level of the bitter melon  juice and boiled extract dietin alloxan induced diabetic rats. Therats were divided randomly into three groups with fed AIN-93, the first group is control with water diet only, whereas the second group was given bitter melon juice extract diet, and third group with bitter melon boiled extract diet.  The diet of bitter melon juice and boiled extract were done by oral administration of 2ml/200 g body weight of rats for 8 days. The result showed that diet with bitter melon juice and boiled extract could improve body weight after 4 days. Additionally, the decreased of body weight percentage  afterbitter melon juice (2.68%) and boiled extract (1.89%) diet  were effective than control (8.81%). Bitter melon juice extract may effective in reduced  blood glucose levels than bitter melon boiled extract and control. The research indicate that bitter melon acts recovery body weight and regulating blood glucose level on diabetic rats.

Hepatoproective Nature of Aerial parts of Caesalpinia pulcherrima in STZ Induced Diabetic Rat Model

2021 ◽  
pp. 3716-3720
Author(s):  
Pooja Pooja ◽  
Mazumder Avijit ◽  
Soumya Das
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Diabetic Rats ◽  
The Body ◽  
Marker Enzymes ◽  
Metabolizing Enzymes ◽  
Standard Drug ◽  
Liver Marker Enzymes

Diabetes is a chronic disease which characterized by hyperglycemia (elevated or abnormally high blood sugar levels) and other metabolic disturbances, including metabolism of lipids and haemostasis. Caesalpinia pulcherrima has previously showed strong anti-diabetic and hepatoprotective potential. The present research work was to investigate the anti-diabetic activity and hepatoprotective activity Caesalpinia pulcherrima in streptozotocin-induced (STZ) diabetic rats. The dose-dependent effects of 45days oral treatment with methanol extract of plant (200 and 300mg/kg) of CPAE on body weight, blood glucose level, total protein, albumin, liver marker enzymes and carbohydrate metabolizing enzymes were evaluated in STZ-induced diabetic rats. Oral administration methanolic extract of Caesalpinia pulcherrima of showed significant restoration of the body weight and decrease in the blood glucose level, liver marker enzymes (ALT, AST ALP) and carbohydrate metabolizing enzymes were observed in diabetic rats. These results suggest that fruit extract of Caesalpinia pulcherrima has valuable anti-diabetic activity in STZ-induced diabetic rats which is comparable to the standard drug metformin and hence might be of use in the management of diabetes.

scholarly journals Anti-diabetic Activity of Ethanolic Extract of Elaeocarpus serratus L. in Streptozotocin-Induced Diabetic Rats

2016 ◽  
Vol 8 (01) ◽  
Author(s):  
DH Geetha ◽  
Indhiramuthu Jayashree ◽  
M. Rajeswari
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
The Body ◽  
Marker Enzymes ◽  
Metabolizing Enzymes ◽  
Liver Marker Enzymes

To investigate the anti-diabetic activity of Elaeocarpus serratus fruit in streptozotocin-induced (STZ) diabetic rats. The dose-dependent effects of 30days oral treatment with ethanol extracts of fruit (200 and 400 mg/kg) of E. serratus on body weight, blood glucose level, total protein, albumin, liver marker enzymes and carbohydrate metabolizing enzymes were evaluated in STZ-induced diabetic rats. Oral administration ethanolic extract of fruit of E. serratus showed significant restoration of the body weight and decrease in the blood glucose level, liver marker enzymes (ALT, AST ALP) and carbohydrate metabolizing enzymes were observed in diabetic rats. These results suggest that fruit extract of E. serratus has valuable anti-diabetic activity in STZ-induced diabetic rats which is comparable to the standard drug glibenclamide and hence might be of use in the management of diabetes.

scholarly journals Effect of Ethanolic Extract of Fruits of Eriobotrya japonica on Lipid Profile and Body weight in Streptozotocin Induced Diabetic Rats

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Sabeeha Shafi ◽  
Nahida Tabassum
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Lipid Profile ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
The Body ◽  
Eriobotrya Japonica ◽  
Control Group ◽  
Glucose Levels ◽  
Blood Glucose Levels

Eriobotrya japonica locally called as loquat in Kashmir has been studied in various parts of the world but little work has been reported on Kashmiri loquat. The chemical nature of fruits and vegetables offers a great diversity of biological properties and plays an important role in the field of pharmacology. There is a quest for newer drugs with few adverse effects and this poses a challenge for the development of new drugs. The study was undertaken to study the activities of ethanolic extract of Eriobotrya japonica fruits in streptozotocin induced diabetic rats. The phytochemical screening of the plant was also done. The animals were divided into five groups. Normal Control group received only the vehicle. Toxic group included those animals in which diabetes was induced by streptozotocin. The 3rd group was those animals which received streptozotocin and standard antidiabetic drug-glibenclamide. 4th group included those diabetic animals which received 50 mg/kg b.w dose of fruits of Eriobotrya japonica. 5th group animals included those diabetic animals which received 100 mg/kg b.w of the plant extract. The biochemical parameters that were evaluated were blood glucose levels and lipid profile tests. The body weight was also checked. Histopathology of pancreas was also done. The results showed significant decrease in blood glucose levels, lipid profile tests in animals treated with different doses of the plant extracts. Histopathology of pancreas also showed positive results.

scholarly journals Effect of bitter melon and garlic on blood glucose level and blood cholesterol level in rats in diabetic condition

2018 ◽  
Vol 5 (3) ◽  
pp. 359-363 ◽  
Author(s):  
Rupaly Akhter ◽  
Imrul Hasan Rasel ◽  
Mohammad Saiful Islam
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Dose Rate ◽  
Cholesterol Level ◽  
Glucose Level ◽  
The Body ◽  
Blood Cholesterol ◽  
Bitter Melon ◽  
Blood Cholesterol Level

The aim of this research was designed to investigate the single and combine effect of bitter melon and garlic on blood glucose level and blood cholesterol level in rats in diabetic condition. In this study 60 rats (12 normal rats and 48 alloxan induced diabetic rats) was used for trials. The rats were divided into 5 groups for each trial, each containing 12 individuals as follows: First group was normal control (A), Second group was diabetic control (B), third group was alloxan with bitter melon treated (C). Group D was alloxan and Garlic treated and Group E was alloxan, bitter melon, garlic treated. Then alloxan injection was injected at the dose rate of 100mg/kg body weight intraperitoneally to each rate to induce diabetes in groups B, C, D and E. On 10th day blood glucose level, blood cholesterol level and the body weights were measured for the first time to ensure diabetic induction as well as hypercholesterolemia. Then all the rats of that group were kept for more 21 days for the treatment of hyperglycemia and hypercholesterolemia. During that period on Day 0, 7, 14 and 21st the body weight, blood cholesterol level and blood glucose level were measured. Aqueous extract of bitter melon and garlic were fed at a dose rate of 300mg/kg and 500 mg/kg body weight for 21 days in group C and D respectively and combine in group E. The blood sugar level and blood cholesterol level were reduced in bitter melon, garlic & combine treatment groups compare with untreated group. From these findings it is concluded that the combination of bitter melon and garlic can be used as anti-hyperglycemic and anti- hypercholesterolemic agent. Res. Agric., Livest. Fish.5(3): 359-363, December 2018

scholarly journals Ameliorative effect of crude and solvent partitioned fractions of Gymnema sylvestre in alloxan-induced hyperglycemic and dyslipidemic Rattus norvegicus

2021 ◽  
Vol 1 (2) ◽  
pp. 11-23
Author(s):  
Rofiyat Omolara Raji ◽  
Hadiza Lami Muhammad ◽  
Hussaini Anthony Makun ◽  
Musa Bola Busari ◽  
Sophia Shekwoyan Maikai ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Serum Lipid ◽  
Diabetic Rats ◽  
The Body ◽  
Lipoprotein Cholesterol ◽  
Gymnema Sylvestre ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Ameliorative Effect

The present study aims to evaluate the ameliorative effect of crude and solvent partitioned fractions of Gymnema sylvestre in alloxan-induced hyperglycemic and dyslipidemic rats. The extract and fractions of Gymnema sylvestre were administered to alloxan (120 mg/kg) induced diabetic rats at doses of 100, 300, and 600 mg/kg. Metformin (100 mg/kg) was used as the reference drug. All treatments were administered daily for 14 days through the oral route. Effects of the treatments on blood glucose levels, body weight, and serum lipid profiles were monitored. The results revealed that all the extracts and fractions were able to reduce the blood glucose levels and improved the body weight of diabetic rats, with more pronounced effects at the treatment of 300 mg/kg of crude methanol and ethyl acetate fraction. The blood glucose of diabetic untreated rats continued to increase up to the time of euthanization. There were significant reductions (p<0.05) in the levels of serum total cholesterol, triglyceride, and low-density lipoprotein cholesterol (LDL-C) of all the treated groups when compared to the diabetic untreated. However, a significant (p<0.05) decrease in the serum concentration of highdensity lipoprotein- cholesterol (HDL- C) was observed in the diabetic untreated rats when compared to the HDL-C levels in the treated rats. The ameliorative effect of the crude extract and the partitioned fractions on the diabetic induced alterations in serum lipid profile occurs in a significant (p<0.05) dosedependent manner. In conclusion, G. sylvestre extracts possess hypoglycaemic effects and attenuated diabetic induced dyslipidemia in rats

Evaluation of Glucose and Lipid Lowering Activity of Arganimide A in Normal and Streptozotocin-Induced Diabetic Rats

2019 ◽  
Vol 19 (4) ◽  
pp. 503-510 ◽  
Author(s):  
Mohamed Eddouks ◽  
Farid Khallouki ◽  
Robert W. Owen ◽  
Morad Hebi ◽  
Remy Burcelin
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Oral Administration ◽  
Lipid Profile ◽  
Plasma Cholesterol ◽  
Diabetic Rats ◽  
Lipid Lowering ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Lowering Activity

Aims: Arganimide A (4,4-dihydroxy-3,3-imino-di-benzoic acid) is a compound belonging to a family of aminophenolics found in fruit of Argania spinosa. The purpose of this study was to investigate the glucose and lipid lowering activity of Arganimide A (ARG A). Methods: The effect of a single dose and daily oral administration of Arganimide A (ARG A) on blood glucose levels and plasma lipid profile was tested in normal and streptozotocin (STZ) diabetic rats at a dose of 2 mg/kg body weight. Results: Single oral administration of ARG A reduced blood glucose levels from 26.50±0.61 mmol/L to 14.27±0.73 mmol/L (p<0.0001) six hours after administration in STZ diabetic rats. Furthermore, blood glucose levels were decreased from 5.35±0.30 mmol/L to 3.57±0.17 mmol/L (p<0.0001) and from 26.50±0.61 mmol/L to 3.67±0.29 mmol/L (p<0.0001) in normal and STZ diabetic rats, respectively, after seven days of treatment. Moreover, no significant changes in body weight in normal and STZ rats were shown. According to the lipid profile, the plasma triglycerides levels were decreased significantly in diabetic rats after seven days of ARG treatment (p<0.05). Moreover, seven days of ARG A treatment decreased significantly the plasma cholesterol concentrations (p<0.001). Conclusion: ARG A possesses glucose and lipid-lowering activity in diabetic rats and this natural compound may be beneficial in the treatment of diabetes.

scholarly journals Hypoglycemic and antioxidative activities of ethanol seed extract of Hunteria umbellate (Hallier F.) on streptozotocin-induced diabetic rats

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Olubanke O. Ogunlana ◽  
Babatunde O. Adetuyi ◽  
Miracle Rotimi ◽  
lohor Esalomi ◽  
Alaba Adeyemi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Seed Extract ◽  
The Body ◽  
High Concentration ◽  
Group 5

Abstract Background Diabetes, a global cause of mortality in developing countries is a chronic disorder affecting the metabolism of macromolecules and has been attributed to the defective production and action of insulin characterized by persistent hyperglycemic properties. This global disorder harms organs of the body such as the liver, kidney and spleen. Medicinal plants such as Hunteria umbellate have been shown to possess hypoglycemic, antioxidative and anti-diabetic properties owing to the high concentration of active phytochemical constituents like flavonoids and alkaloids. The present study seeks to evaluate the hypoglycemic activities of ethanolic seed extract of Hunteria umbellate on streptozotocin-induced diabetes rats. Methods Thirty (30) female experimental rats were randomly divided into five groups with six rats per group and were administered streptozotocin (STZ) and Hunteria umbellate as follows. Group 1 served as control and was given only distilled water, group 2 rats were administered 60 mg/kg STZ; Group 3 was administered 60 mg/kg STZ and 100 mg/kg metformin; group 4 rats were administered 60 mg/kg STZ and 800 mg/kg Hunteria umbellate, group 5 rats 60 mg/kg STZ and 400 mg/kg Hunteria umbellate. The fasting blood glucose level of each rat was measured before sacrifice. Rats were then sacrificed 24 h after the last dose of treatment. Results The results showed that Hunteria umbellate significantly reversed STZ-induced increase in fasting blood glucose and increase in body and organs weight of rats. Hunteria umbellate significantly reversed STZ-induced decrease in antioxidant enzyme in liver, kidney and spleen of rats. Hunteria umbellate significantly reversed STZ-induced increase in oxidative stress markers in liver, kidney and spleen of rats. Conclusion Collectively, our results provide convincing information that inhibition of oxidative stress and regulation of blood glucose level are major mechanisms through which Hunteria umbellate protects against streptozotocin-induced diabketes rats.

scholarly journals Treatment of Diabetic Condition in Streptozotocin Induced Diabetic Wister Rats Using Food Blends Such as Unripe Plantain, Soybean and Ginger

2019 ◽  
pp. 1-12
Author(s):  
I. Iwanegbe ◽  
M. Suleiman ◽  
A. Jimah
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Lipid Profile ◽  
Cell Volume ◽  
Glucose Level ◽  
Normal Control ◽  
Packed Cell Volume ◽  
Diabetic Rats ◽  
Diabetic Patients

Aims: To investigate the effect of food blends (plantain, soybean and ginger) on the blood glucose, lipid profile and haematological indices on streptozotocin induced diabetic rats. Methodology: A total of 35 rats of mean body weight 219.07 g separated into7 groups (5 per group) where induced by a single intraperitoneal (I.P) injection of streptozotocin (0.1 g dissolved in 5 ml of freshly prepared sodium citrate buffer 0.1 M, pH 4.5) at a dose of 40 mg/kg body weight after fasting for 12 hours and fed with flours/blends. The flours were produced from plant materials for different treatments/blends (blend A=100% unripe plantain, B=80% unripe plantain, 14% soybean, 6% ginger, C=70% unripe plantain, 26% soybean, 4% ginger, D= 60% unripe plantain, 38% soybean, 2% ginger, E= 50% unripe plantain, 50% soybean) and the phytochemicals and minerals content were determined. Blood glucose was determined at 5 days interval for 25 days. Diabetes was confirmed in rats with blood glucose concentrations >200 mg/dl. After 25 days rats were anaesthetized with chloroform vapour and blood samples collected by cardiac puncture for haematology and lipid profile determination. Results: The results showed that unripe plantain, soya beans and ginger in adequate proportion(C=70% unripe plantain, 26% soybean, 4% ginger or D= 60% unripe plantain, 38% soybean, 2% ginger) could help to reduce blood glucose, improve haematological parameters and lipid profile. Significant reduction was observed in the blood glucose level of rats fed blends C and D from 286 to 85 mg/dl and 307 to 90 mg/dl respectively at the end of experiment. These results also demonstrated that the inclusion of ginger at 6% causes rise in blood glucose level. Total cholesterol (TC) increased in all the blends. However, the lowest concentration of TC was observed in blends C and D. The highest packed cell volume (60%) and Haemoglobin (20 g/dl) level observed in rats fed blend C was significantly higher than the normal control fed conventional feeds. The increase in packed cell volume (PCV) (50%) and Hb (17 g/dl) in diabetic rats demonstrated that the formulated blend C was able to raise PCV and Hb above 50% and 17 g/dl (Normal control NC) respectively. Significant increase (P<0.05) in low density lipoprotein cholesterol (LDLc) was also observed in all the blends with blend C having the least (4.0 mg/dl) close to NC (2.0 mg/dl). Conclusion: From the results it is evident that blend C will manage and improve the health status of diabetic patients.

scholarly journals HYPOGLYCEMIC ACTIVITY OF A NOVEL POLYHERBAL FORMULATION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS: A THERAPEUTIC STUDY

2019 ◽  
pp. 218-223
Author(s):  
PULAK MAJUMDER ◽  
PARIDHAVI M
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Beta Cells ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Glucose Levels ◽  
Polyherbal Formulation ◽  
Blood Glucose Levels ◽  
Therapeutic Study ◽  
Glutamyl Transferase

Objective: The concept of the synergistic effect of poly-herbalism was as old as medicine history. Present novel polyherbal formulation (PHF) composed of five different herbs. The present investigation aimed to evaluate the synergistic therapeutic hypoglycemic potential of PHF against streptozotocin (STZ) (60 mg/kg b.w, ip)-induced diabetic rats. Methods: For this therapeutic study, the dose was framed orally once a day to the test objects after STZ dosing at 500 mg/kg/5 ml dosage levels for 21 days. The transformation of body weight and blood glucose level was examined, and the histopathological changes of beta cells of the pancreas, cellular architectures of liver and kidney were also perceived after scarification of the objects. Results: The outcomes were compared to that of glibenclamide (5 mg/kg) treated group. Declines of body weight and blood glucose levels were perceived in STZ-induced diabetic animals very significantly (p<0.01 or p<0.05). However, these diabetic changes were significantly (p<0.01 or p<0.05) decreased in PHF-dosing groups revealed more encouraging effects compared to that of glibenclamide. In the other hand, various liver function and enzymes test (creatinine, urea, total bilirubin, total albumin, alkaline phosphatase, gamma-glutamyl transferase, aspartate transaminases, and alanine transaminases) and lipid profile (total cholesterol, triglycerides, high-density lipoprotein cholesterol, total protein, low-density lipoprotein [LDL], and very LDL) studies strongly indicate the potential action of this novel formulation. Conclusions: It is deliberated that PHF has the favorable effect to normalize the blood glucose levels, and also rejuvenation and reproduction of beta cells lead a better futuristic ant diabetic therapy for diabetic management.

scholarly journals Lactobacillus rhamnosus Reduces Blood Glucose Level through Downregulation of Gluconeogenesis Gene Expression in Streptozotocin-Induced Diabetic Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Eko Farida ◽  
Lilis Nuraida ◽  
Puspo E. Giriwono ◽  
Betty S. L. Jenie
Keyword(s):  
Blood Glucose ◽  
Glucose Tolerance ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Lactobacillus Rhamnosus ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
The Body ◽  
Oral Glucose

Some lactic acid bacteria (LAB) are observed to be potential probiotics with functional properties such as lowering fasting blood glucose (FBG), as a promising hyperglycemia management. This study investigated the ability and mechanism of Lactobacillus rhamnosus BSL and Lactobacillus rhamnosus R23 on lowering FBG in diabetic rats induced by streptozotocin (STZ). The rats were orally administered with L. rhamnosus BSL and L. rhamnosus R23 by giving 1 mL cell suspension (109 CFU/mL) daily for 30 days. The body weight (BW) was recorded once in three days, and FBG was recorded once in six days. An oral glucose tolerance test (OGTT) was measured 1 week after injection with STZ and before sacrifice. Fecal samples were collected on days 0, 15, and 30 for LAB population and identification, performed by PCR detecting 16S rRNA. Oral administration of L. rhamnosus BSL and L. rhamnosus R23 decreased FBG and improved glucose tolerance via downregulation of glucose-6-phosphatase (G6pc) expression by 0.57- and 0.60-fold change, respectively (P<0.05). The lipid profiles, BUN, creatinine, SGOT, and SGPT were significantly (P<0.05) different between normal and diabetic rats, but they were not significantly (P>0.05) different among diabetic rats. Both strains were effective in increasing fecal LAB population. Molecular identification of the isolated LAB from fecal sample indicated that they were able to survive and pass through the digestive tract. These results suggested that both strains have the ability to manage blood glucose level and become a promising agent to manage hyperglycemia and diabetes.

Sign in / Sign up

Export Citation Format

Share Document