scholarly journals Assessment of In-vivo Anti-diabetic and Anti-diarrheal Effects of Flemingia stricta Roxb. Leaf.

2020 ◽  
Author(s):  
Shahrear Biozid ◽  
Mohammad Nazmul Alam ◽  
Jainul Abeden ◽  
Faruk ◽  
Ahmad Ibtehaz Chowdhury ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Castor Oil ◽  
Methanol Extract ◽  
Fasting Blood Glucose ◽  
Diabetic Mice ◽  
Duration Of Treatment ◽  
Standard Drug

Objective: To evaluate the anti-diabetic and anti-diarrheal activity of methanol extract of Flemingia stricta Roxb. (Fabaceae) leaf.Methods: In anti-diabetic study, the extract was administered to alloxan-induce diabetic mice at two concentrations (200mg/kg and 400mg/kg body weight) for acute (12 hours) and prolong treatments (15 days) and blood glucose levels (Blood glucose level) of diabetic mice were monitored at intervals of hours and days throughout the duration of treatment. Antidiarrheal test was conducted by castor oil induced diarrhea and enteropooling as well as intestinal motility in mice at three different concentration (100mg/kg, 200mg/kg and 400mg/kg body weight).Results: Treatment of alloxan induce diabetic mice with the extract caused a significant reduction in fasting blood glucose level of the diabetic mice both in acute (12 hours) and prolong treatment (15 days) and it was determined that the extract at both concentration (200mg/kg and 400mg/kg) showed the significant (P<0.05) hypoglycemic effect in comparison to the standard drug Metformin (10mg/kg). In the case of castor oil induced diarrheal test, enteropooling test and gastrointestinal motility test, the extract of F. stricta at 100mg/kg, 200mg/kg and 400mg/kg has given significant effect (P<0.05) in comparing to standard drug Loperamide (5mg/kg). Conclusion: These result suggested that the methanol extract of F. stricta Roxb. possess promising anti-diabetic effect on alloxan-induced mice and significant antidiarrheal effect on castor oil induced diarrheal mice.

scholarly journals Anti-hyperglycemic activity of Heliotropium strigosum (Boraginaecae) whole plant extract in alloxan-induced diabetic mice

2017 ◽  
Vol 16 (10) ◽  
pp. 2425-2430
Author(s):  
Huma Aslam ◽  
Arif-ullah Khan ◽  
Najeeb-ur- Rehman ◽  
Fawad Ali ◽  
Humaira Nadeem ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Diabetic Control ◽  
Oral Glucose ◽  
Diabetic Mice ◽  
Whole Plant ◽  
Hyperglycemic Effect

Purpose: To investigate Heliotropium strigosum whole plant extract for its potential to reduce the blood glucose level of alloxan-induced diabetic mice.Methods: Preliminary phytochemical analysis was carried out using standard  procedures. Diabetes was induced in Balb/c mice by injecting alloxan (200 mg/kg i.p.). The crude methanol extract of Heliotropium strigosum (Hs.Cr, 30, 100 and 300 mg/kg doses) was administered daily to alloxan-induced diabetic mice for 15 days and its effect on fasting blood glucose levels, body weight and oral glucose tolerancewas evaluated. Two control groups (non-diabetic control and diabetic control)  received normal saline (0.2 ml). Metformin (500 mg/kg) was used as reference standard.Results: Heliotropium strigosum showed positive for the presence of alkaloids, tannins and flavonoids. The extract (30, 100 and 300 mg/kg) caused significant reduction in the fasting blood glucose level of alloxan-induced diabetic mice on days 5, 10 and 15 compared to diabetic control (p < 0.001). In this regard, the  anti-hyperglycemic effect compared to the reference (metformin). The extract also timedependently decreased the body weight of the treated animals as well as improved tolerance of the oral glucose overload.Conclusion: These results indicate that Heliotropium strigosum possesses  anti-hyperglycemic effect, reduces body weight and enhances the tolerance of  glucose overload in mice. Further studies are therefore required to determine its  feasiilty as an alternate herbal medicine in the management of diabetes in humans.Keywords: Heliotropium strigosum, Anti-hyperglycemic, Alloxan-induced diabetic mice, Blood glucose, Oral glucose tolerance, Body weight

Hepatoproective Nature of Aerial parts of Caesalpinia pulcherrima in STZ Induced Diabetic Rat Model

2021 ◽  
pp. 3716-3720
Author(s):  
Pooja Pooja ◽  
Mazumder Avijit ◽  
Soumya Das
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Diabetic Rats ◽  
The Body ◽  
Marker Enzymes ◽  
Metabolizing Enzymes ◽  
Standard Drug ◽  
Liver Marker Enzymes

Diabetes is a chronic disease which characterized by hyperglycemia (elevated or abnormally high blood sugar levels) and other metabolic disturbances, including metabolism of lipids and haemostasis. Caesalpinia pulcherrima has previously showed strong anti-diabetic and hepatoprotective potential. The present research work was to investigate the anti-diabetic activity and hepatoprotective activity Caesalpinia pulcherrima in streptozotocin-induced (STZ) diabetic rats. The dose-dependent effects of 45days oral treatment with methanol extract of plant (200 and 300mg/kg) of CPAE on body weight, blood glucose level, total protein, albumin, liver marker enzymes and carbohydrate metabolizing enzymes were evaluated in STZ-induced diabetic rats. Oral administration methanolic extract of Caesalpinia pulcherrima of showed significant restoration of the body weight and decrease in the blood glucose level, liver marker enzymes (ALT, AST ALP) and carbohydrate metabolizing enzymes were observed in diabetic rats. These results suggest that fruit extract of Caesalpinia pulcherrima has valuable anti-diabetic activity in STZ-induced diabetic rats which is comparable to the standard drug metformin and hence might be of use in the management of diabetes.

scholarly journals Effects of Fruits Extracts of Three Medicinal Plants on the Blood Glucose Level of Glucose-induced Hyperglycemic and Normal Rabbit Models

2012 ◽  
Vol 3 (1) ◽  
Author(s):  
Ikram Ilahi ◽  
Asghar Khan ◽  
Ubaid Ullah ◽  
Imran Khan ◽  
Jawad Ali ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Medicinal Plants ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Methanol Extract ◽  
Second Phase ◽  
Glucose Lowering ◽  
Fruit Extracts ◽  
Lowering Activity

The fruits of Pistacia integerrima (PI), Withania coagulans (WC) and Withania somnifera (WS) have been reported for their medicinal values. The aim of the present study was to compare the glucose lowering activities of the fruit extracts of these three medicinal plants in glucose induced non-diabetic hyperglycemic and normal rabbit models. During the first phase of experiments, the effects of oral administration of 70% methanol extract of each plant fruit (600 mg/kg body weight) and glibenclamide (5 mg/kg body weight) were studied on the glucose level of glucose induced hyperglycemic rabbits, while in the second phase of experiments, the effects of each fruit extract (600 mg/kg body weight) and glibenclamide (5 mg/kg body weight) were assessed on the glucose level of normal rabbits. Among the three fruit extracts, maximum reduction in the blood glucose level was caused by the PI extract (P ˂0.05). The glucose lowering activity of the PI extract was greater than that of the standard, glibenclamide (5mg/kg), during the first phase of experiments. However during the second phase of experiments the hypoglycemic effect of the PI extract was comparable to that of the standard, glibenclamide (5mg/kg). In conclusion the present study reveals that the 70% methanol extract of Pistacia integerrima fruit can decrease glucose level significantly in glucose induced non-diabetic hyperglycemic and normal rabbit models.

scholarly journals GAMBARAN KADAR GLUKOSA DARAH PUASA MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS SAM RATULANGI ANGKATAN 2011 DENGAN INDEKS MASSA TUBUH ≥ 23 kg/m2

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Gracia Rorong ◽  
Stefana Kaligis ◽  
Diana Purwanto
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Body Mass ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Fasting Blood Glucose Level ◽  
Cross Sectional ◽  
Purposive Sampling

Abstract: Glucose is a main compound that has important role in preparation and development  of energy in human body. Blood glucose level is the amount of glucose in the blood. One of the factors that affects blood glucose level is body weight. Body weight is affected by several factors, such as aged, gender, and physical activities. Overweight may cause insulin resistance, results in increasing of the blood glucose level. This study aimed to describe the fasting blood glucose level at students Faculty of Medicine year 2011 Sam Ratulangi University with Body Mass Index (BMI) ≥23 kg/m2. Research method used for this study was cross sectional descriptive survey with purposive sampling method. From 26 respondents, 12 overweight (BMI ≥23 kg/m2) respondents (46,15%) had average fasting blood glucose level 85,4 mg/dL and 14 obese (BMI ≥25 kg/m2) respondents (53,85%) had average fasting blood glucose level 86 mg/dL. Conclusion: the description of fasting blood glucose level at students Faculty of Medicine year 2011 Sam Ratulangi University with Body Mass Index (BMI) ≥23 kg/m2 is at normal level (80-100 mg/dL). Keywords: BMI ≥23 kg/m2, Fasting blood glucose, students year 2011     Abstrak: Glukosa merupakan suatu molekul utama yang berperan penting dalam penyediaan dan pembentukan energi di dalam tubuh. Kadar glukosa darah adalah jumlah kandungan glukosa dalam darah. Salah satu faktor yang mempengaruhi kadar glukosa darah adalah berat badan. Berat badan dipengaruhi oleh beberapa faktor, antara lain usia, jenis kelamin, dan aktivitas fisik. Kelebihan berat badan dapat menyebabkan resistensi insulin sehingga kadar glukosa dalam darah meningkat. Peningkatan kadar glukosa darah merupakan salah satu penanda sindroma metabolik. Penelitian ini bertujuan untuk mengetahui gambaran kadar glukosa darah puasa pada mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi Angkatan 2011 dengan Indeks Massa Tubuh (IMT) ≥23 kg/m2. Jenis penelitian berupa penelitian survey deskriptif cross sectional dengan metode purposive sampling. Sampel penelitian sebanyak 26 orang responden. Hasil penelitian ini didapatkan 12 orang responden (46,15%) yang overweight (IMT ≥23 kg/m2) memiliki rata-rata kadar glukosa darah puasa 85,4 mg/dL dan 14 orang responden (53,85%) yang obesitas (IMT ≥25 kg/m2) memilki rata-rata kadar glukosa darah puasa 86 mg/dL. Simpulan: semua responden mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi Angkatan 2011 memiliki kadar glukosa darah puasa normal (80-100 mg/dL). Kata Kunci: Glukosa darah puasa, IMT ≥23 kg/m2, mahasiswa angkatan 2011

scholarly journals Effect of Afghan Hibiscus sabdariffa L. and Carum Carvi L. Hydro-alcoholic Extracts Either Alone or in Combination on Blood Glucose Level in Diabetic Rats

2020 ◽  
Vol 11 (4) ◽  
pp. 759-764
Author(s):  
Murtaza Haidari ◽  
Kawsar Alami ◽  
Arefa Hossaini ◽  
Sayed Yousof Mousavi
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Body Weight Loss ◽  
Diabetic Rats ◽  
Hypoglycemic Effect ◽  
Hibiscus Sabdariffa ◽  
Carum Carvi

Combination therapy is considered as a new and effective therapeutic strategy for control of hyperglycemia. The present study aimed to determine the hypoglycemic effect of Afghan Hibiscus sabdariffa L. and Carum Carvi L. hydro-alcoholic extracts either alone or in combination on diabetic rats. Streptozotocin-induced diabetic rats were administered intraperitoneally with hydro-alcoholic extracts of H. sabdariffa (75, 150 and 300 mg/kg), C. carvi (150, 300 and 500 mg/kg) and their combinations for 21 days. The Fasting blood glucose and body weight of rats were determined on 0, 7, 14 and 21st days. The results showed a significant (P<0.0001) hypoglycemic effect of H. sabdariffa extract (75, 150 and 300 mg/kg) on 7, 14 and 21th days, C. carvi extract (500 mg/kg), and their effective doses combination (75:25), especially on 7th day. Only 75 mg/kg of H. sabdariffa had positive effect on body weight loss of diabetic rats (P<0.05). One can conclude that Afghan H. sabdariffa and C. carvi hydro-alcoholic extracts and their combination have a hypoglycemic effect. However, their combinations do not have any synergic effects, so the hypoglycemic effect of H. sabdariffa was much greater and even normalized the blood glucose level.

scholarly journals EVALUATION OF BUCKWHEAT FOR MANAGEMENT OF DIABETES

2020 ◽  
Vol 9 (4) ◽  
pp. 184-189
Author(s):  
Anwaar Ahmed ◽  
Humaira Rani ◽  
Rai Muhammad Amir ◽  
Tabinda Khalid ◽  
Naeem Khalid
Keyword(s):  
Blood Glucose ◽  
Glucose Tolerance ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Diabetic Mice ◽  
Group Iii ◽  
Group I ◽  
Group Ii

Background: Diabetes mellitus is a genetic and endocrine system disease that creates injurious health effects not in Pakistan but throughout the world. Several functional compounds are present in buckwheat which has distinct biological properties of cholesterollowering, anti-hypertension, improving constipation and obesity. The recent research was directed to study the nutritional and hypoglycemic effect of buckwheat in Type 2 diabetic rats induced by alloxan. Methods: Two varieties of buckwheat were examined for their nutritional composition and mineral content according to the methods of AACC (2000) while antioxidant activity was measured by using DPPH and a spectrophotometer. Alloxan induced diabetic mice were applied to investigate the blood-glucose-lowering effect of common buckwheat extract (CBE) and Tartary buckwheat extract (TBE). After type 2 diabetic induced rats were separated randomly into three groups. Results: The results revealed that Common buckwheat flour (CBF) contains12. 93% crude protein, 2.39% crude fat, 9.42% crude fiber and 2.90% ash content, while Tartary buckwheat flour (TBF) contains14.88% crude protein, 3.47% crude fat, 12.03% crude fiber, and 2.86% ash content. TBF contains significantly higher minerals as compared to CBF and also exhibited higher antioxidant activity. The results for diabetes-induced mice showed a significant difference for fasting blood glucose level, glucose tolerance test and body weight among control diabetic mice (group I) and diabetic mice given the CBE (group II) and TBE (group III). The fasting blood glucose level of group I increased while it decreased in group II and group III over time. Group II and group III had more glucose tolerance as compared to group I. Conclusion: The present study demonstrated that TBF contains higher nutritional contact as compared to CBF. Furthermore, it was indicated that the oral administration of CBE and TBE could lower the blood glucose level and can increase glucose tolerance effectively.

scholarly journals Effects of ginger juice on blood glucose in alloxan induced diabetes mellitus in rats

2015 ◽  
Vol 23 (1) ◽  
pp. 14-17 ◽  
Author(s):  
Selima Sultana ◽  
Md Ismail Khan ◽  
Hasanur Rahman ◽  
Abu Sadat Mohammad Nurunnabi ◽  
Rokhsana Dil Afroz
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Zingiber Officinale ◽  
Control Group ◽  
Fasting Blood Glucose Level ◽  
Medical College ◽  
Group D

Objective: To find out the effects of ginger (Zingiber officinale) juice blood glucose in alloxan induced-diabetes mellitus in rats. Methods: This experimental study was done in the Department of Pharmacology & Therapeutics, Dhaka Medical College, Dhaka, in collaboration with the Departments of Pathology, Ibrahim Medical College, Dhaka between January and December 2009. This experimental animal study was divided into two parts, which were Experiment-1 and Experiment-2. Experiment 1 comprises of 12 rats and divided into 2 groups each group having 6 rats. Rats of group-A was non-diabetic normal control group and group-B was fed with ginger (Zingiber officinale) in a dose of 4ml/kg body weight orally through Ryle’s tube. Experiment-2 comprised of 12 rats divided into 2 groups each containing 6 rats labeled as group C, group D. Rats of groups C administered alloxan 150 mg/kg intraperitoneally on the 2nd day of the study. Rats of group D were administered alloxan 150mg /kg intraperitoneally and ginger (4ml/kg of body weight orally) on the 2nd day of the study. Results: The fasting blood glucose level at day 12 in the rats treated with ginger (Zingiber officinale) 4 ml /kg body weight orally daily for 12 days showed reduction in fasting blood glucose level as compared to control group, but not significant, which indicates that ginger has no effect in lowering blood glucose of normal rats. The fasting blood glucose levels at day 12 in the rats of group D (treated with ginger and alloxan) showed highly significant reduction in fasting blood glucose level as compared to diabetic control group (p<0.002). Conclusion: Consumption of ginger produced a significant antihyperglycemic effect in experimentally induced diabetic rats. DOI: http://dx.doi.org/10.3329/jdmc.v23i1.22687 J Dhaka Medical College, Vol. 23, No.1, April, 2014, Page 14-17

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