scholarly journals Costly habitual avoidance is reduced by concurrent goal-directed approach in a modified devaluation paradigm

2021 ◽  
Author(s):  
Valentina Glück ◽  
Katharina Zwosta ◽  
Uta Wolfensteller ◽  
Hannes Ruge ◽  
Andre Pittig

Avoidance habits potentially contribute to maintaining maladaptive, costly avoidance behaviors that persist in the absence of threat. However, experimental evidence about costly habitual avoidance is scarce. In two experiments, we tested whether extensively trained avoidance impairs the subsequent goal-directed approach of rewards. Healthy participants were extensively trained to avoid an aversive outcome by performing simple responses to distinct full-screen color stimuli. After the subsequent devaluation of the aversive outcome, participants received monetary rewards for correct responses to neutral object pictures, which were presented on top of the same full-screen colors. These approach responses were either compatible or incompatible with habitual avoidance responses. Notably, the full-screen colors were not relevant to inform approach responses. In Experiment 1, participants were not instructed about post-devaluation stimulus-response-reward contingencies. Accuracy was lower in habit-incompatible than in habit-compatible trials, indicating costly avoidance, whereas reaction times did not differ. In Experiment 2, contingencies were explicitly instructed. Accuracy differences disappeared, but reaction times were slower in habit-incompatible than in habit-compatible trials, indicating low-cost habitual avoidance tendencies. These findings suggest a small but consistent impact of habitual avoidance tendencies on subsequent goal-directed approach. Costly habitual responding could, however, be inhibited when competing goal-directed approach was easily realizable.

2021 ◽  
Vol 18 ◽  
Author(s):  
Abolfazl Olyaei ◽  
Zahra Ghahremany ◽  
Madieh Sadeghpour

: A green and efficient protocol was developed for the one-pot three-component synthesis of novel 2-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-(arylamino)-1H-indene-1,3(2H)-dione derivatives by the reaction of 4-hydroxycoumarin, ninhydrin and aromatic amines in the presence of guanidine hydrochloride as an organocatalyst under solvent-free conditions. The present approach offers several advantages such as low cost, simple work-up, short reaction times, chromatography-free purification, high yields and greener conditions.


Sensors ◽  
2018 ◽  
Vol 18 (11) ◽  
pp. 3721 ◽  
Author(s):  
Usman Rashid ◽  
Imran Niazi ◽  
Nada Signal ◽  
Denise Taylor

Texas Instruments ADS1299 is an attractive choice for low cost electroencephalography (EEG) devices owing to its low power consumption and low input referred noise. To date, there have been no rigorous evaluations of its performance. In this EEG experimental study we evaluated the performance of the ADS1299 against a high quality laboratory-based system. Two self-paced lower limb motor tasks were performed by 22 healthy participants. Recorded power across delta, theta, alpha, and beta EEG bands, the power ratio across the motor tasks, pre-movement noise, and signal-to-noise ratio were obtained for evaluation. The amplitude and time of the negative peak in the movement-related cortical potentials (MRCPs) extracted from the EEG data were also obtained. Using linear mixed models, no statistically significant differences (p > 0.05) were found in any of these measures across the two systems. These findings were further supported by evaluation of cosine similarity, waveform differences, and topographic maps. There were statistically significant differences in MRCPs across the motor tasks in both systems. We conclude that the performance of the ADS1299 in combination with wet Ag/AgCl electrodes is analogous to that of a laboratory-based system in a low frequency (<40 Hz) EEG recording.


2021 ◽  
Vol 4 (3) ◽  
pp. 156-162
Author(s):  
André Sevenius Nilsen ◽  
Bjørn Erik Juel ◽  
Nadine Farnes ◽  
Luis Romundstad ◽  
Johan Frederik Storm

AbstractBackground and aimsWhile psychedelic agents are known to have powerful, but largely unexplained, effects on contents of consciousness, there is an increasing interest in the potential clinical usefulness of such drugs for therapy, and legalization is discussed in some countries. Thus, it is relevant to study the effects of psychedelic compounds not only on experience, but also on behavioral performance.MethodsSeven healthy participants performed a motor response inhibition task before, during, and after sub-anesthetic doses of intravenously administered ketamine. The infusion rate was individually adjusted to produce noticeable subjective psychedelic effects.ResultsWe observed no statistically significant impact of sub-anesthetic ketamine on reaction times, omission errors, or post error slowing, relative to the preceding drug-free condition. However, we did observe significant correlations between performance impairment and self-reported, subjective altered states of consciousness, specifically experience of “anxiety” and “complex imagery.”ConclusionsConsidering the limited number of participants and large variation in strength of self-reported experiences, further studies with wider ranges of ketamine doses and behavioral tasks are needed to determine the presence and strength of potential behavioral effects.


2013 ◽  
Vol 81 (1) ◽  
pp. 57-66 ◽  
Author(s):  
Helmut Hildebrandt ◽  
Frauke Fink ◽  
Paul Eling ◽  
Heiner Stuke ◽  
Jan Klein ◽  
...  

2015 ◽  
Vol 21 (7) ◽  
pp. 545-557 ◽  
Author(s):  
Bruno Fimm ◽  
Klaus Willmes ◽  
Will Spijkers

AbstractBased on previous studies demonstrating detrimental effects of reduced alertness on attentional orienting our study seeks to examine covert and overt attentional orienting in different arousal states. We hypothesized an attentional asymmetry with increasing reaction times to stimuli presented to the left visual field in a state of maximally reduced arousal. Eleven healthy participants underwent sleep deprivation and were examined repeatedly every 4 hr over 28 hr in total with two tasks measuring covert and overt orienting of attention. Contrary to our hypothesis, a reduction of arousal did not induce any asymmetry of overt orienting. Even in participants with profound and significant attentional asymmetries in covert orienting no substantial reaction time differences between left- and right-sided targets in the overt orienting task could be observed. This result is not in agreement with assumptions of a tight coupling of covert and overt attentional processes. In conclusion, we found differential effects of lowered arousal induced by sleep deprivation on covert and overt orienting of attention. This pattern of results points to a neuronal non-overlap of brain structures subserving these functions and a differential influence of the norepinephrine system on these modes of spatial attention. (JINS, 2015,21, 545–557)


Synthesis ◽  
2018 ◽  
Vol 50 (21) ◽  
pp. 4325-4335 ◽  
Author(s):  
Hongyu Tian ◽  
Baoguo Sun ◽  
Rui Ding ◽  
Jiaqi Li ◽  
Wenyi Jiao ◽  
...  

The pairing of DMSO and oxalyl bromide is reported as a highly efficient brominating reagent for various alkenes, alkynes and ketones. This bromination approach demonstrates remarkable advantages, such as mild conditions, low cost, short reaction times, provides excellent yields in most cases and represents a very attractive alternative for the preparation of dibromides and α-bromoketones.


1998 ◽  
Vol 87 (1) ◽  
pp. 175-185 ◽  
Author(s):  
René Arcelin ◽  
Didier Delignieres ◽  
Jeanick Brisswalter

The aim of the present study was to examine the effects of an exercise of moderate intensity (60% of maximal aerobic power) on specific information-processing mechanisms. 22 students completed 3 10-min. exercise bouts on a bicycle ergometer. Concomitantly, participants performed six manual choice-reaction tasks manipulating task variables (Signal Intensity, Stimulus–Response Compatibility, and Time Uncertainty) on two levels. Reaction tests, randomly ordered, were administered at rest and during exercise. A significant underadditive interaction between Time Uncertainty and exercise was found for the highest quartiles of the distribution of reaction times. No other interaction effects were obtained for the other variables. These results reasonably support that moderate aerobic exercise showed selective rather than general influences on information processing.


2016 ◽  
Vol 28 (7) ◽  
pp. 1024-1038 ◽  
Author(s):  
Theresa H. McKim ◽  
Daniel J. Bauer ◽  
Charlotte A. Boettiger

Learned habitual responses to environmental stimuli allow efficient interaction with the environment, freeing cognitive resources for more demanding tasks. However, when the outcome of such actions is no longer a desired goal, established stimulus–response (S-R) associations or habits must be overcome. Among people with substance use disorders (SUDs), difficulty in overcoming habitual responses to stimuli associated with their addiction in favor of new, goal-directed behaviors contributes to relapse. Animal models of habit learning demonstrate that chronic self-administration of drugs of abuse promotes habitual responding beyond the domain of compulsive drug seeking. However, whether a similar propensity toward domain-general habitual responding occurs in humans with SUDs has remained unclear. To address this question, we used a visuomotor S-R learning and relearning task, the Hidden Association between Images Task, which employs abstract visual stimuli and manual responses. This task allows us to measure new S-R association learning and well-learned S-R association execution and includes a response contingency change manipulation to quantify the degree to which responding is habit-based, rather than goal-directed. We find that people with SUDs learn new S-R associations as well as healthy control participants do. Moreover, people with an SUD history slightly outperform controls in S-R execution. In contrast, people with SUDs are specifically impaired in overcoming well-learned S-R associations; those with SUDs make a significantly greater proportion of perseverative errors during well-learned S-R replacement, indicating the more habitual nature of their responses. Thus, with equivalent training and practice, people with SUDs appear to show enhanced domain-general habit formation.


2002 ◽  
Vol 55 (4) ◽  
pp. 1175-1191 ◽  
Author(s):  
Stefan Mattes ◽  
Hartmut Leuthold ◽  
Rolf Ulrich

Romaiguère, Hasbroucq, Possamaï, and Seal (1993) reported a new compatibility effect from a task that required responses of two different target force levels to stimuli of two different intensities. Reaction times were shorter when high and low stimulus intensities were mapped to strong and weak force presses respectively than when this mapping was reversed. We conducted six experiments to refine the interpretation of this effect. Experiments 1 to 4 demonstrated that the compatibility effect is clearly larger for auditory than for visual stimuli. Experiments 5 and 6 generalized this finding to a task where stimulus intensity was irrelevant. This modality difference refines Romaiguère et al.'s (1993) symbolic coding interpretation by showing that modality-specific codes underlie the intensity-force compatibility effect. Possible accounts in terms of differences in the representational mode and action effects are discussed.


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