scholarly journals Age related changes in the primary somatosensory area of the cerebral cortex

2020 ◽  
Vol 11 (5) ◽  
pp. 87-92
Author(s):  
Santos George Joseph ◽  
Anne George
Keyword(s):  
Cerebral Cortex ◽  
Structural Integrity ◽  
Age Groups ◽  
Pyramidal Cells ◽  
Stellate Cells ◽  
Somatosensory Area ◽  
Age Related ◽  
Study Results ◽  
The Impact ◽  
Age Related Changes

Background: Age-related changes in structural and functional part of brain have been the motivation of previous and ongoing neuroscientific research. The focus of most studies done, were on different motor areas of the of the cerebral cortex. Very few studies were done on primary somatosensory areas of the brain. Aims and Objective: The aim of the study was to investigate the age-related changes in primary somatosensory area of the cerebral cortex of the human brain. Materials and Methods: The study was conducted on 50 autopsied brain specimens. The specimens removed were of both sexes belonging to various age groups ranging from 9 months to 75 years. The specimens were collected from the Department of Forensic Medicine, Medical College Kottayam. During the autopsy the meninges were carefully stripped off. The sulci and gyri were then examined carefully. Results: The depth of the upper area of the central sulcus is more than the middle and lower areas, both in the right and left halves of the cerebral cortex. The laminae of the primary somatosensory area have shown that as age advances there is a progressive increase in thickness except in the case of lamina IV. From the ages of 61 years onwards, laminar degeneration takes place. The thickest lamina was lamina V. The thinnest laminawas lamina IV. The stellate cells that dominate in lamina II and IV show a difference in their arrangement. In foetal life, the pyramidal cells were almost indistinguishable from the stellate cells. The pyramidal cells were seen mostly in lamina III and V. Conclusion: The study results suggest the possibility that in the more advanced stages of aging, the structural integrity of lamina IV is more consistent than other layers present in primary somatosensory area of the cerebral cortex. Further study is needed to examine the impact of ageing on somatosensory area.

scholarly journals Morphometric study of the size of the postmortem human kidney

2020 ◽  
Vol 15 (2) ◽  
pp. 61-67
Author(s):  
Fatema Johora ◽  
Abu Sadat Mohammad Nurunnabi ◽  
Dilruba Siddiqua ◽  
Hasna Hena ◽  
Shamim Ara
Keyword(s):  
Young Adult ◽  
Left Kidney ◽  
Age Groups ◽  
Morphometric Study ◽  
Age Related ◽  
Study Results ◽  
Group A ◽  
The Mean ◽  
The Right ◽  
Age Related Changes

Background: Changes in the size of the kidney are evident in humans, as age progresses. Objective: To see the age-related changes in the morphological dimensions of the kidney in a sample of the Bangladeshi population. Methods: This crosssectional study was done in the Department of Anatomy, Dhaka Medical College, Dhaka, from July 2008 to June 2009, based on a collection of 140 postmortem human kidneys collected from 70 unclaimed dead bodies from the morgue of the same institution. All the samples of kidney were divided into three age groups, including A (10-19 years), B (20-39 years) and C (40-59 years). The length, breadth and thickness of all the kidneys were measured by using a slide calipers and recorded. Data were expressed as mean±SD. For statistical analysis, independent sample t test and one way ANOVA was used. Results: The length of the right and left kidneys found were 8.72±0.25 cm and 9.28±0.12 cm; 9.73±0.35 cm and 10.31±0.41 cm; 9.68±0.21 cm and 10.24±0.06 cm in group A, B and C respectively. The breadth of the right and left kidneys found were 4.32±0.09 cm and 4.22±0.11 cm; 4.74±0.29 cm and 4.55±0.28 cm; 4.61±0.21 cm and 4.44±0.21 cm in group A, B and C respectively. The thickness of the right and left kidneys found were 2.84±0.10 cm and 2.64±0.05 cm; 3.31±0.16 cm and 3.11±0.10 cm; 3.17±0.07 cm and 3.11±0.10 cm in group A, B and C respectively. The mean length of the left kidneys was found significantly greater than that of the right , whereas the mean breadth and the thickness of the right kidneys were found greater than that of the left kidney in all age groups. Moreover, age related changes were significant in all dimensions (length, breadth and thickness) of the kidney when compared between group A & B and A & C. Conclusion: This study results concluded that the length of the left kidney was greater than that of the right, but the breadth and the thickness of the right kidney were greater than that of the left one in all age groups. In addition, age related changes in all dimensions (i.e. length, breadth and thickness) of the kidneys were evident in middle age versus young adult and older adult versus young adult. J Bangladesh Soc Physiol. 2020, December; 15(2): 61-67

scholarly journals The bioelectric type of the visual area of the cerebral cortex of rats of all ages and sexes

2018 ◽  
Vol 9 (4) ◽  
pp. 514-521
Author(s):  
V. V. Mizin ◽  
V. P. Lyashenko ◽  
S. M. Lukashov
Keyword(s):  
Cerebral Cortex ◽  
Theta Rhythm ◽  
Age Groups ◽  
Young Age ◽  
Visual Area ◽  
Age Group ◽  
Bioelectric Activity ◽  
Absolute Power ◽  
Age Related ◽  
Age Related Changes

In the ontogenesis process, the cerebral cortex undergoes age-related changes. So far as, unlike practically all other systems of mammalian organs, the brain continues to develop and receive new functionality in the postnatal period. Thus with age, there are changes in the bioelectric characteristics of the neocortex. The purpose of the research is to determine the age and sex changes in the bioelectric activity of the cerebral visual cortex of male and female rats of different ages. In the article, we examined changes in absolute (μV2) and normalized (%) indicators of electrical activity of the visual area of rats of different sexes in four age groups: juvenile, young, mature, and presenile age. The research was carried out by the method of registration of bioelectric activity of electrocorticograms (ECoG). Results of multifactorial dispersion analysis of absolute and normalized ECoG indicators of the visual area of the cerebral cortex of rats of all ages showed that there were reliable changes in the frequency-amplitude characteristics of bioelectric activity related to age. At a young age, males have probably lower absolute and normalized power of the delta-rhythm and the normalized beta-like rhythm rate. There was a tendency of decrease in the theta-rhythm. As a result of this redistribution of rhythms a desynchronization of the electrical activity of young males was observed. Mature males have lower absolute power indicators than younger age groups. According to normalized indicators, a synchronization of rhythms of males in the mature age group was observed, which together with values of absolute power can indicate a decrease of the functional activity level of the neocortex and an increase of the influence of endogenous mechanisms on neuronal activity of the visual area of the cerebral cortex. In the presenile age, there was a desynchronization of rhythms. The indicators of an absolute and normalized power of females in the young age group pointed to the synchronization of the bioecoactivity of the neocortex. Among the low-frequency waves, theta-rhythm rhythm dominated in the females of young age. In the mature and presenile age females, there was a probable increase in the percentage of normalized parameters of high-frequency beta waves. The predominance of this rhythm may indicate an increase of cortical tone. The correlation of values of absolute and normalized indicators of bioelectric activity affirmed the desynchronization of the ECoG rhythms of females of mature and presenile age. Sex differences are expressed by a decrease in the absolute power of all ECoG rhythms of the visual area of the cerebral cortex of females relative to males. The age-related changes occurred in a different way in rats of different sex. At a young age, males had desynchronization of rhythms, and females had synchronization, in the mature age it was vice versa. The age changes of the electric activity of the cerebral visual cortex of rats in our opinion may be largely associated with involutional changes of various neurotransmitter and hormonal systems.

scholarly journals Corticosteroids and Regional Variations in Thickness of the Human Cerebral Cortex across the Lifespan

2019 ◽  
Vol 30 (2) ◽  
pp. 575-586 ◽  
Author(s):  
Nadine Parker ◽  
Didac Vidal-Pineiro ◽  
Leon French ◽  
Jean Shin ◽  
Hieab H H Adams ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Cortical Thickness ◽  
Brain Structure ◽  
Pyramidal Cells ◽  
Brain Atlas ◽  
Variable Degree ◽  
Human Cerebral Cortex ◽  
Age Related ◽  
The Relationship ◽  
Age Related Changes

Abstract Exposures to life stressors accumulate across the lifespan, with possible impact on brain health. Little is known, however, about the mechanisms mediating age-related changes in brain structure. We use a lifespan sample of participants (n = 21 251; 4–97 years) to investigate the relationship between the thickness of cerebral cortex and the expression of the glucocorticoid- and the mineralocorticoid-receptor genes (NR3C1 and NR3C2, respectively), obtained from the Allen Human Brain Atlas. In all participants, cortical thickness correlated negatively with the expression of both NR3C1 and NR3C2 across 34 cortical regions. The magnitude of this correlation varied across the lifespan. From childhood through early adulthood, the profile similarity (between NR3C1/NR3C2 expression and thickness) increased with age. Conversely, both profile similarities decreased with age in late life. These variations do not reflect age-related changes in NR3C1 and NR3C2 expression, as observed in 5 databases of gene expression in the human cerebral cortex (502 donors). Based on the co-expression of NR3C1 (and NR3C2) with genes specific to neural cell types, we determine the potential involvement of microglia, astrocytes, and CA1 pyramidal cells in mediating the relationship between corticosteroid exposure and cortical thickness. Therefore, corticosteroids may influence brain structure to a variable degree throughout life.

Abstract T P136: Potential Contributors to the Declining Impact of Stroke Risk Factors with Age: Implications for Stroke Epidemiology in the Elderly

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
George Howard ◽  
Mary Cushman ◽  
Maciej Banach ◽  
Brett M Kissela ◽  
David C Goff ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Stroke Risk ◽  
Multivariable Analysis ◽  
The Elderly ◽  
Stroke Risk Factors ◽  
Age Related ◽  
Increased Risk ◽  
The Impact ◽  
Age Related Changes

Purpose: The importance of stroke research in the elderly is increasing as America is “graying.” For most risk factors for most diseases (including stroke), the magnitude of association with incident events decreases at older ages. Potential changes in the impact of risk factors could be a “true” effect, or could be due to methodological issues such as age-related changes in residual confounding. Methods: REGARDS followed 27,748 stroke-free participants age 45 and over for an average of 5.3 years, during which 715 incident strokes occurred. The association of the “Framingham” risk factors (hypertension [HTN], diabetes, smoking, AFib, LVH and heart disease) with incident stroke risk was assessed in age strata of 45-64 (Young), 65-74 (Middle), and 75+ (Old). For those with and without an “index” risk factor (e.g., HTN), the average number of “other” risk factors was calculated. Results: With the exception of AFib, there was a monotonic decrease in the magnitude of the impact across the age strata, with HTN, diabetes, smoking and LVH even becoming non-significant in the elderly (Figure 1). However, for most factors, the increasing prevalence of other risk factors with age impacts primarily those with the index risk factor absent (Figure 2, example HTN as the “index” risk factor). Discussion: The impact of stroke risk factors substantially declined at older ages. However, this decrease is partially attributable to increases in the prevalence of other risk factors among those without the index risk factor, as there was little change in the prevalence of other risk factors in those with the index risk factor. Hence, the impact of the index risk factor is attenuated by increased risk in the comparison group. If this phenomenon is active with latent risk factors, estimates from multivariable analysis will also decrease with age. A deeper understanding of age-related changes in the impact of risk factors is needed.

Effects of Aging on Musical Performance in Professional Orchestral Musicians

2018 ◽  
Vol 33 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Dianna T Kenny ◽  
Tim Driscoll ◽  
Bronwen J Ackermann
Keyword(s):  
Psychological Health ◽  
Work Performance ◽  
Perceived Exertion ◽  
Age Groups ◽  
Musical Instrument ◽  
Physical And Mental Health ◽  
Age Related ◽  
Physical And Psychological Health ◽  
Orchestral Musicians ◽  
The Impact

BACKGROUND: The physical and psychological demands of playing a musical instrument are likely to be affected by age-related decline in function, including physical, cognitive, psychological, and organ-related changes. However, the complex neurophysiological demands of playing a musical instrument may delay many normal aging-related changes. AIM: This study compared professional classical musicians of different ages, using a range of physical and psychological measures, to discover how increasing age might affect work performance and to identify possible risk and protective factors for physical and psychological health as the musicians age. SUBJECTS: 377 professional orchestral musicians from eight Australian orchestras (70% response rate), ages 18 to 68 yrs (mean 42.1). Multiple standardized physical and psychological tools were used to evaluate the impact of age on a range of physical and mental health variables. RESULTS: Age was not statistically associated with frequency or severity of performance-related musculoskeletal disorders, ratings of perceived exertion, QuickDASH scores, use of beta-blockers, workplace satisfaction, and most psychological tests. Differences were observed on SPIN (social anxiety) scores, with lowest scores in the oldest age group (10.66 in 55+ yrs vs 17.83 in 18-30 yrs, p=0.016). Older musicians had higher BMIs and fewer practice sessions per day than younger musicians and also were more likely to consume alcohol on 5+ days/wk (44% vs 9%, p=0.003). CONCLUSION: Advancing age does not appear to exert undue negative impacts on physical and psychological health or performance capacity of professional orchestral musicians. However, dwindling numbers in the older age groups may suggest a "survivor" effect, whereby those who develop significant age-related decrements may cease professional performance at earlier ages. Longitudinal studies on the professional trajectories of professional orchestral musicians are needed to explore this question further.

Age-related changes in the ductular system and stellate cells of human pancreas

2015 ◽  
Vol 64 (2) ◽  
pp. 99-106
Author(s):  
Shubhi Saini ◽  
Tony George Jacob ◽  
D.N. Bhardwaj ◽  
Tara Sankar Roy
Keyword(s):  
Stellate Cells ◽  
Human Pancreas ◽  
Age Related ◽  
Age Related Changes

scholarly journals The Impact of Long‐Term Physical Activity on Age‐Related Changes in Protein and Gene Expression

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Ian R Lanza ◽  
Daniel K Short ◽  
Kevin R Short ◽  
Yan W Asmann ◽  
Sreekumar Raghavakaimal ◽  
...  
Keyword(s):  
Gene Expression ◽  
Physical Activity ◽  
Age Related ◽  
The Impact ◽  
Age Related Changes

scholarly journals Age-related changes in behavioural and emotional problems in Smith–Magenis syndrome measured with the Developmental Behavior Checklist

2020 ◽  
pp. 174462951990105 ◽  
Author(s):  
Heidi Elisabeth Nag ◽  
Terje Nærland
Keyword(s):  
Age Groups ◽  
Emotional Problems ◽  
Chromosome 17 ◽  
Adaptive Behaviour ◽  
Genetic Syndrome ◽  
Developmental Behavior ◽  
Age Related ◽  
Autism Symptomatology ◽  
Behavioural And Emotional Problems ◽  
Age Related Changes

Smith–Magenis syndrome (SMS) is a genetic syndrome most often caused by a deletion on chromosome 17 or more rarely by a mutation in the retinoic acid-induced 1 gene. The aim of this study was to investigate the Developmental Behavior Checklist (DBC) profile of persons with SMS and the associations between behavioural and emotional problems, age, gender, adaptive behaviour and autism symptomatology. Twenty-eight persons with SMS were represented by their parents in this study. DBC Total scores are reduced with age, but they still show a mean that is clearly above the cut-off of 46. The differences between the age groups <9 years and 9–17 years ( p = 0.024) and between the age groups <9 years and >18 years ( p = 0.007) are significant. We found a significant decrease in behavioural and emotional problems with age in SMS. We did not find a relationship between adapted behaviour and communication and behavioural and emotional problems.

scholarly journals Investigation of Age-Related Changes in the Skin Microbiota of Korean Women

2020 ◽  
Vol 8 (10) ◽  
pp. 1581
Author(s):  
Minseok Kim ◽  
Tansol Park ◽  
Jung Im Yun ◽  
Hye Won Lim ◽  
Na Rae Han ◽  
...  
Keyword(s):  
Age Groups ◽  
Alpha Diversity ◽  
Amplicon Sequencing ◽  
Diversity Indices ◽  
Rrna Gene ◽  
Korean Women ◽  
Skin Microbiota ◽  
Microbial Distribution ◽  
Age Related ◽  
Age Related Changes

The microbiota of human skin is influenced by host and environmental factors. To determine if chronological age influences the composition of the skin microbiota on the forehead and hands, 73 Korean women were sorted into one of three age groups: (1) 10–29 years (n = 24), (2) 30–49 years (n = 21), and (3) 50–79 years (n = 28). From the 73 women, 146 skin samples (two skin sites per person) were collected. 16S rRNA gene amplicon sequencing was then conducted to analyze the skin microbiota. The overall microbial distribution varied on the forehead but was similar on the hands across the three age groups. In addition, the composition of the skin microbiota differed between the forehead and hands. Commensal microbiota, such as Streptococcus, Staphylococcus, Cutibacterium, and Corynebacterium, which contribute to maintaining skin health via dominant occupation, were affected by increasing age on forehead and hand skin. Alpha diversity indices increased significantly with age on forehead skin. This study indicates that older people may be more susceptible to pathogenic invasions due to an imbalanced skin microbiota resulting from age-related changes. The results of our study may help develop new strategies to rebalance skin microbiota shifted during aging.

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