scholarly journals Evaluation of serum PSA levels as a biomarker for breast carcinoma in north Indian females

2014 ◽  
Vol 5 (4) ◽  
pp. 25-28
Author(s):  
Nikhil Gupta ◽  
Binita Goswami ◽  
Shyamveer S Khangarot ◽  
Niladhar S Hadke
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Benign Breast Disease ◽  
Breast Disease ◽  
Clinical Staging ◽  
Breast Diseases ◽  
Breast Cancer Patients ◽  
Normal Controls

Objective: Breast cancer has emerged as the most common malignancy among females during the last few years. Early diagnosis is essential for disease management so research is underway to identify potential serological bio markers with acceptable sensitivity and specificity. The current study was undertaken to compare the levels of serum PSA in patients with benign breast diseases, carcinoma breast and normal controls. Methods: The study was conducted jointly by the departments of Biochemistry and Surgery. Fifty patients of breast carcinoma were enrolled in the study, along with 50 cases of benign breast disease and 50 healthy controls. Serum PSA levels were estimated by Roche Elecsys modular Cobas e 411(electrochemiluminescence immuno assay) (Manheim Germany). Results: We did not find any significant differences in the PSA levels between normal controls, patients with benign breast disease as well as females presenting with breast carcinoma. No correlation was observed between serum PSA levels with clinical staging as well as histopathological grading. Conclusions: According to previous published studies, tumor levels of PSA are valuable for breast cancer patient prognosis, since patients with PSA positive tumors have much longer disease-free and overall survival. PSA levels in the serum of breast cancer patients are not significantly different from the PSA levels in the serum of normal women. Based on these data we conclude that serum PSA levels are not useful for breast cancer patient diagnosis or monitoring. DOI: http://dx.doi.org/10.3126/ajms.v5i4.7800 Asian Journal of Medical Sciences 2014 Vol.5(4); 25-28

scholarly journals Tumor collagen framework from bright-field histology images predicts overall survival of breast carcinoma patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mindaugas Morkunas ◽  
Dovile Zilenaite ◽  
Aida Laurinaviciene ◽  
Povilas Treigys ◽  
Arvydas Laurinavicius
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Cox Regression ◽  
Regional Lymph Node ◽  
Histological Grade ◽  
Biological Information ◽  
Lymph Node Status ◽  
Bright Field

AbstractWithin the tumor microenvironment, specifically aligned collagen has been shown to stimulate tumor progression by directing the migration of metastatic cells along its structural framework. Tumor-associated collagen signatures (TACS) have been linked to breast cancer patient outcome. Robust and affordable methods for assessing biological information contained in collagen architecture need to be developed. We have developed a novel artificial neural network (ANN) based approach for tumor collagen segmentation from bright-field histology images and have tested it on a set of tissue microarray sections from early hormone receptor-positive invasive ductal breast carcinoma stained with Sirius Red (1 core per patient, n = 92). We designed and trained ANNs on sets of differently annotated image patches to segment collagen fibers and extracted 37 features of collagen fiber morphometry, density, orientation, texture, and fractal characteristics in the entire cohort. Independent instances of ANN models trained on highly differing annotations produced reasonably concordant collagen segmentation masks and allowed reliable prognostic Cox regression models (with likelihood ratios 14.11–22.99, at p-value < 0.05) superior to conventional clinical parameters (size of the primary tumor (T), regional lymph node status (N), histological grade (G), and patient age). Additionally, we noted statistically significant differences of collagen features between tumor grade groups, and the factor analysis revealed features resembling the TACS concept. Our proposed method offers collagen framework segmentation from bright-field histology images and provides novel image-based features for better breast cancer patient prognostication.

scholarly journals Serum levels of oxidative stress marker malondialdehyde in breast cancer patients in relation to pathohistological factors, estrogen receptors, menopausal status, and age

2018 ◽  
Vol 8 (3) ◽  
pp. 154-161
Author(s):  
Jasmina Gubaljevic ◽  
Nahida Srabović ◽  
Adlija Jevrić-Čaušević ◽  
Adaleta Softić ◽  
Adi Rifatbegović ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Benign Breast Disease ◽  
Menopausal Status ◽  
Serum Levels ◽  
Breast Disease ◽  
Breast Cancer Patients ◽  
Node Metastases

Introduction: The aim of this study was to determine the serum levels of malondialdehyde (MDA) in patients with invasive breast cancer in relation to its serum levels in patients with benign breast disease, and to investigate correlation between MDA serum levels with pathohistological prognostic factors (tumor size, lymph node involvement, and histologic grade [HG]), estrogen receptor (ER) status, and with breast cancer patient’s age and menopausal status. Methods: A total of 43 with well-documented invasive breast cancer were included in this study: 27 with positive axillary’s lymph nodes, and 16 with negative axillary’s lymph nodes, and 39 patients with findings of benign breast diseases. MDA determination in serum of breast cancer and benign breast disease patients was performed by the fluorimetric method, immunohistochemical staining was performed for ER, and routine pathohistological examination was conducted for pathohistological factors. Results: MDA serum levels in breast cancer patients were significantly higher than MDA serum levels in benign breast disease patients (p = 0.042). No statistically significant difference between MDA serum levels in breast cancer patients with and without lymph node metastases was found (p = 0.238). No statistically significant correlations between MDA serum levels and tumor size (p = 0.256), HG (p = 0.124), or number of positive lymph nodes (0.113) were found. A statistically significant correlation between serum MDA levels and ages of breast cancer patients with lymph node metastases was found (p = 0.006). Conclusion: Obtained results support the importance of MDA in the carcinogenesis of breast cancer. According to our findings, serum level of MDA could not be a useful prognostic factor in breast cancer.

scholarly journals FAKTOR-FAKTOR KETERLAMBATAN PENDERITA KANKER PAYUDARA DALAM MELAKUKAN PEMERIKSAAN AWAL KE PELAYANAN KESEHATAN

2016 ◽  
Vol 11 (2) ◽  
pp. 276
Author(s):  
Gusti Ayu Resa Dyanti ◽  
Ni Luh Putu Suariyani
Keyword(s):  
Breast Cancer ◽  
Early Detection ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Breast Screening ◽  
Case Control ◽  
Education Level ◽  
Knowledge Level ◽  
Breast Cancer Patients ◽  
Cancer Breast

<p><strong>Abstrak</strong><br /><br />Keterlambatan penderita kanker payudara melakukan pemeriksaan awal ke pelayanan kesehatan di Indonesia mencapai lebih dari 80%. Hal ini mengakibatkan kejadian kanker payudara banyak yang ditemukan pada stadium lanjut. Penelitian ini bertujuan untuk mengetahui faktor yang berhubungan dengan keterlambatan penderita kanker payudara dalam melakukan pemeriksaan awal ke pelayanan kesehatan. Desain penelitian menggunakan studi observasional analitik dengan desain case control yang dilaksanakan pada bulan April-Mei 2015. Teknik pengambilan sampel yang digunakan concecutive sampling dan convenient sampling dengan jumlah sampel 108 orang. Hasil penelitian menunjukkan terdapat enam faktor yang memiliki hubungan bermakna dengan keterlambatan penderita kanker payudara dalam melakukan pemeriksaan awal ke pelayanan kesehatan yaitu tingkat pendidikan (tingkat pendidikan rendah p=0,001;OR 5,67 dan tingkat pendidikan sedang p=0,008;OR 3,65), tingkat pengetahuan (tingkat pengetahuan kurang p&lt;0,001;OR 15,7 dan tingkat pengetahuan cukup p=0,011;OR 9,5), keterjangkauan biaya (p=0,003;OR 5,95), keterpaparan informasi/media massa (p=0,011;OR 2,75), dukungan suami/keluarga (p&lt;0,001;OR 4,35), dan perilaku deteksi dini (tidak pernah SADARI (pemeriksaan payudara sendiri) p&lt;0,001;OR 11,08 dan tidak rutin SADARI p=0,032;OR 5.18)).</p><p>Kata Kunci : Kanker payudara; Keterlambatan Pemeriksaan Payudara; Rumah Sakit Sanglah</p><p> </p><p><em><strong>Abstract</strong></em></p><p>Almost 80% of breast cancer patients In Indonesia have delayed in breast cancer screening. The purpose of this study was to determine some factors associated with breast screening retardation of breast cancer patient. This was an analytical observational study with case control design conducted in April-May 2015. Samples were collected by consecutive sampling and convenient sampling with the number of sample  were 108. The result showed that there were six factors had a significant association with breast screening delay of breast cancer patient. Those were education level (low education level p=0,001;OR 5,67 dan moderate education level p=0,008;OR 3,65), knowledge level (low knowledge level p&lt;0,001;OR 15,7 dan moderate knowledge level p=0,011;OR 9,5), cost affordability (p=0,003;OR 5,95), information/massa media exposure (p=0,011;OR 2,75), partner/family support (p&lt;0,001;OR 4,35), and early detection behavior (have not had early detection p&lt;0,001;OR 11,08 dan infrequently early detection p=0,032;OR 5.18).<br /><br />Keyword : Breast cancer; Breast screening retardation; Sanglah Hospital.</p>

scholarly journals Literature Review: Social Determinant of Health in Breast Cancer Patients Survival

2021 ◽  
Vol 9 (E) ◽  
pp. 624-628
Author(s):  
Azriful Azriful ◽  
Fatmawaty Mallapiang ◽  
Yessy Kurniati
Keyword(s):  
Breast Cancer ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Cancer Patients ◽  
Social Determinants ◽  
Health Determinants ◽  
Free Text ◽  
Breast Cancer Patients ◽  
Access To Health Services ◽  
Medical Subject Headings

BACKGROUND: Social determinants have an important role in the survival of breast cancer patients. AIM: This article aims to reviews the social determinants that affect the survival of breast cancer patient. METHODS: We searched PubMed and Google Scholar for identifying studies related to this review using free-text terms and Medical Subject Headings terms. Both experimental and observational studies on social determinants of breast cancer patient survival which were published in the English language have been included in this review except expert opinions, commentaries, editorials, and review articles. Ten studies were eligible to be included in review. RESULTS: Social health determinants that play a role in the survival of breast cancer patients are education level, place of residence, socioeconomic status, social environment, racial discrimination, and access to health services. CONCLUSION: Social determinants have an influence on the survival of breast cancer patients, so it is important to pay attention to these factors.

Breast cancer patient access to social work

2016 ◽  
Vol 17 (5) ◽  
pp. 531-543
Author(s):  
Yuko K Abbott
Keyword(s):  
Breast Cancer ◽  
Social Work ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Clinical Area ◽  
Oncology Social Work ◽  
The Impact ◽  
Office Location

Summary This study was conducted to understand the impact of oncology social work office location on breast cancer patients’ access and utilization of social work services. It also explored the current status of oncology social work offices and the perceptions among Association of Oncology Social Work Listserv members. The frequency and types of interventions and referral time were determined retrospectively. Association of Oncology Social Work Listserv members were surveyed. Findings From 461 new breast cancer patient charts, 52 were referred to social work during study period. Face-to-face interventions decreased by 0.8 contact ( p = .0221) and telephone interventions increased by 1.8 contacts ( p = .0293) after social work office was relocated away from clinical area. Referral time to social work services decreased unexpectedly by 14.5 days ( p = .076) after office relocation. Association of Oncology Social Work Listserv survey results identify an office location as possible barrier, though most respondents have a private office in clinical area, accessible to patients. Survey finding is limited due to low response rate. Applications There are many challenges to ensuring timey and effective delivery of social work services to breast cancer patients. Social Ecological framework is used to understand the impacts of office location on access to social work services. Study results suggest that office relocation has had mix impacts on patients. Raising awareness of social worker services among patients early in cancer trajectory is needed for patient empowerment and to ensure access to social work services. Further research is needed to understand barriers, identify effective strategies in order to guide and improve clinical practice.

scholarly journals Literature Review: Teknik Relaksasi untuk Penerimaan Diri Pasien Kanker Payudara

2019 ◽  
Vol 10 (2) ◽  
pp. 298
Author(s):  
Ni Made Merlin ◽  
Anggorowati Anggorowati ◽  
Chandra Bagus Ropyanto ◽  
Antonius Rino Vanchapo
Keyword(s):  
Breast Cancer ◽  
Literature Review ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Cancer Patients ◽  
Relaxation Technique ◽  
Evidence Based ◽  
Relaxation Techniques ◽  
Breast Cancer Patients ◽  
Self Acceptance

<p>Breast cancer patients experience low self-acceptance and some of the experiencing psychological problems but not a lot of research to increasing self-acceptance. Additional intervention is needed to improve the effectiveness to increase self-acceptance. Technique relaxation is especially related because easy and quick to learn, it involves no risk, does not need use or purchased equipment and can be used on its own and immediately to tiredness and ill patients. This paper offers a literature review assessing the implications of previous studies order to create evidence-based decisions about the possibility to use of relaxation techniques with adult breast cancer patient for low self-acceptance. The Science Direct, EBSCOhost, Pubmed, DOAJ, Google Scholar database were searched in 2017 in orders to replied two questions: are relaxation technique effective to increase self-acceptance in breast cancer patients, and implications the previous investigation to future research concerning increase self-acceptance in breast cancer patients? Four articles included in the literature review. The relaxation technique for breast cancer patients with low self-acceptance is statically significant, and good evidence-based to practice. Some use of relaxation techniques in this study needs clarification as to whether it can be used directly or need to learn. Procedures in the collection of data in the articles also need to be assessed. In this literature review explain 4 relaxation technique to use for increasing self-acceptance in breast cancer, there are self-forgiveness, meditation, tai-chi, reflection, prayer, mindfulness. This literature review can be used as the basis for the decision to use relaxation techniques for increasing self-acceptance in the breast cancer patient.</p>

scholarly journals Possible Association of Typhoon Hagibis and the COVID-19 Pandemic on Patient Delay in Breast Cancer Patients: a case report

2021 ◽  
Author(s):  
Yudai Kaneda ◽  
Akihiko Ozaki ◽  
Masahiro Wada ◽  
Tomohiro Kurokawa ◽  
Toyoaki Sawano ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Patient Care ◽  
Cancer Patients ◽  
Initial Presentation ◽  
Breast Cancer Patients ◽  
Cancer Management ◽  
Breast Cancer Management

Little is known on how disasters interact in their impacts on patient care. We experienced a breast cancer patient whose initial presentation was delayed for two years due to the COVID-19 pandemic and Typhoon Hagibis. Increasing awareness is needed on the combined impacts of disasters on breast cancer management.

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