scholarly journals Biochemical and hematological parameters in chronic kidney disease

2018 ◽  
Vol 4 (1) ◽  
pp. 4-11
Author(s):  
S. Singh ◽  
S. Bhatta
Keyword(s):  
Chronic Kidney Disease ◽  
Platelet Count ◽  
Kidney Disease ◽  
Blood Cell ◽  
Biochemical Parameters ◽  
Leukocyte Count ◽  
Hematological Parameters ◽  
Total Leukocyte Count ◽  
Blood Cell Count ◽  
Red Blood Cell Count

Background: Chronic kidney disease is a worldwide public health problem. It is associated with various biochemical and hematological abnormalities that leads to morbidity and mortality. The aim of this study was to evaluate the biochemical and hematological parameters in chronic kidney disease patients.Methods: This is a prospective cross sectional study conducted over a period of six months on 52 chronic kidney disease patients at Kist Medical College Teaching Hospital, Lalitpur, Nepal. Biochemical parameters such as urea, creatinine, calcium, phosphorous, sodium, potassium and hematological parameters like hemoglobin, hematocrit, red blood cell count, total leukocyte count, platelet count were measured using standard techniques in chronic kidney disease cases and the findings were compared with age and sex matched controls. Results were analyzed using SPSS 21 for Windows.Results: Hemoglobin, hematocrit, red blood cell count, total leukocyte count and platelet count were reduced and statistically significant in chronic kidney disease patients compared to controls(p <0.05).In biochemical parameters, serum urea, creatinine, phosphorous were increased and calcium was reduced which was found statistically significant as compared to controls (p <0.05). The combination of diabetes and hypertension was the lead cause of chronic kidney disease found in 38.46% followed by hypertension alone in 30.76%Conclusion: Biochemical and hematological parameters are deranged in patients with chronic kidney disease. Routine evaluation of these parameters is useful in the management of these patients.

scholarly journals Effects of Cnidoscolus aconitifolius on Some Hematological Parameters of Male Wistar Rats

2020 ◽  
pp. 1-5
Author(s):  
Ijeoma Ezebuiro ◽  
Chibuike Obiandu ◽  
Friday Saronee ◽  
Ikechukwu I. Weleh ◽  
Adesua C. Obiandu
Keyword(s):  
Platelet Count ◽  
Blood Cell ◽  
Cell Count ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Hematological Parameters ◽  
Blood Cell Count ◽  
Cnidoscolus Aconitifolius ◽  
Male Wistar Rats ◽  
Red Blood Cell Count

Introduction: Medicinal plants have become increasingly useful as a form of alternative therapy. Cnidoscolus aconitifolius is a medicinal plant applied in folklore remedies in the treatment and prevention of various diseases. Aim: The aim of this study is to assess the effects of Cnidoscolus aconitifolius on some hematological parameters of male Wistar rats. Methodology: A total of 15 male Wistar rats weighing between 100-250 g were randomly placed in groups. Group 1 served as control and received distilled water only; group 2 received 200 mg/kg and group 3 received 400 mg/kg of the hydromethanolic leaf extract of Cnidoscolus aconitifolius. Extract was administered once daily using oro-gastric cannula for 30 days. Blood samples were collected by direct cardiac puncture into appropriate sample tubes for estimation of hematological parameters including red blood cell count (RBC), packed cell volume (PCV), haemoglobin (Hb) concentration, white blood cell count (WBC) and platelet count. Results: Results showed a significant (P<0.05) increase in RBC, PCV, Hb and platelet count with the higher dose of 400 mg/kg body weight of the extract compared to control group. However, the WBC count was not significantly (P>0.05) altered. Conclusion: Oral administration of the leaf extract of Cnidoscolus aconitifolius increases red blood cell count, packed cell volume, hemoglobin level and platelet count at 400 mg/kg body weight.

scholarly journals Association between body size and selected hematological parameters in men and women aged 45 and above from a hospitalized population of older adults: an insight from the Polish Longitudinal Study of Aging (1960–2000)

2017 ◽  
Vol 80 (2) ◽  
pp. 171-190 ◽  
Author(s):  
Piotr Chmielewski ◽  
Bartłomiej Strzelec ◽  
Jolanta Chmielowiec ◽  
Krzysztof Chmielowiec ◽  
Krzysztof Borysławski
Keyword(s):  
Older Adults ◽  
Body Size ◽  
Blood Cell ◽  
Cell Count ◽  
Red Blood Cell ◽  
Hematological Parameters ◽  
Body Height ◽  
Blood Cell Count ◽  
Duodenal Ulcers ◽  
Red Blood Cell Count

AbstractIn elderly people, anemia occurs with increasing frequency with each advancing decade and can be a harbinger of very serious health conditions, including gastrointestinal bleeding, gastric and duodenal ulcers, and cancer. Therefore, age-dependant changes in hematological parameters deserve special attention. Nonetheless, very few longitudinal studies of aging have focused on possible associations between basic anthropometric characteristics and hematological parameters in older people. Here, we present some evidence that body size can be associated with red blood cell count as well as some other selected hematological parameters in adults aged 45 to 70 years. Longitudinal data on anthropometric and hematological parameters have been obtained from physically healthy residents at the Regional Psychiatric Hospital for People with Mental Disorders in Cibórz, Lubuskie Province, Poland (142 individuals, including 68 men and 74 women). The residents who took psychoactive drugs were excluded from the study. To evaluate the studied relationships, three anthropometric traits were used and three dichotomous divisions of the study sample were made. The medians of body height, body weight, and body mass index at the age of 45 years were used to divide the sample into: shorter and taller, lighter and heavier, and slimmer and stouter individuals, respectively. Student’s t-test, Pearson’s correlation, and regression analysis were employed. The results of the present study suggest that the relationship between body size and red blood cell count is slightly more pronounced in men and its strength depends on age. However, the correlations between body size and red blood cell count proved to be weak in both sexes. With aging, the strength of the relation decreased gradually, which might have been caused by the aging-associated changes in the hematopoietic system, anemia, or was an artifact. Further studies are needed to elucidate the unclear association between body size and hematological parameters in older adults.

scholarly journals A Rapid Method for Estimation of the Total Leukocyte Count

Blood ◽  
1958 ◽  
Vol 13 (7) ◽  
pp. 677-683 ◽  
Author(s):  
NAOMI R. BENJAMIN
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Rapid Method ◽  
Leukocyte Count ◽  
Screening Method ◽  
Total Leukocyte Count ◽  
Blood Cell Count ◽  
Microscope Slide ◽  
Standard Size ◽  
Microscopic Appearance

Abstract A technic has been devised for the estimation of the white blood cell count by examination of a stained drop of blood of standard size. The drop is measured by immersing a pinhead in the blood and then touching onto a microscope slide the blood which adheres to the surface of the pinhead. The drop is dried and stained and the count is estimated by comparing its microscopic appearance with photographs or "standard" preparations. It was developed to be used as a screening procedure in case of atomic war, but it may prove useful in epidemics or as a routine screening method in the hematology laboratories of large hospitals.

Fresh Human Blood as the Source of a Regional Quality Survey Programme in Haematology

1982 ◽  
Vol 19 (6) ◽  
pp. 438-441 ◽  
Author(s):  
J M W A Van Gend
Keyword(s):  
Platelet Count ◽  
Blood Cell ◽  
Cell Count ◽  
Human Blood ◽  
Red Blood Cell ◽  
Packed Cell Volume ◽  
Blood Cell Count ◽  
Blood Samples ◽  
Red Blood Cell Count ◽  
Edta Anticoagulated Blood

In a regional quality survey programme in haematology with a limited number of participants (15 in the region described), it appeared possible to use unpreserved, fresh, EDTA-anticoagulated blood samples. With such samples only the results from hospital laboratories with different instruments and methods could adequately be compared. From the results of single analyses obtained in ten different samples, the systematic differences as well as the precision of the analyses were calculated for each hospital laboratory with respect to haemoglobin, packed cell volume, red blood cell count, white blood cell count, and platelet count.

scholarly journals Clinical impact of advanced chronic kidney disease in patients with non-HIV pulmonary cryptococcosis

2020 ◽  
Author(s):  
Hiroki Tashiro ◽  
Tetsuro Haraguchi ◽  
Koichiro Takahashi ◽  
Hironori Sadamatsu ◽  
Ryo Tajiri ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Blood Cell ◽  
Serum Albumin ◽  
Cell Count ◽  
Clinical Characteristics ◽  
C Reactive Protein ◽  
Pulmonary Cryptococcosis ◽  
Blood Cell Count ◽  
Reactive Protein

Abstract Background Pulmonary cryptococcosis is an uncommon infectious disease that can develop in both immunocompromised and immunocompetent patients. The severity of chronic kidney disease (CKD) was reported to be one of the risk factors for pulmonary cryptococcosis, but its clinical characteristics have not been fully assessed. The purpose of this study was to clarify the clinical characteristics of advanced CKD in patients with pulmonary cryptococcosis. Methods The present study retrospectively investigated 56 patients who had non-human immunodeficiency virus (HIV) pulmonary cryptococcosis and were treated at Saga University Hospital between 2005 and 2018.The clinical characteristics were evaluated and compared between patients with estimated glomerular filtration rate (eGFR) >45 mL/min/1.73 m2 (n = 42, early CKD) and those with eGFR <45 mL/min/1.73 m2 (n = 14, advanced CKD. Results Compared with patients with early CKD, those with advanced CKD had significantly higher rate of disseminated cryptococcosis (21.4% vs. 2.4%, p = 0.03); lower percentage of patients who recovered after treatment (63.6% vs. 92.5%, p = 0.02); and more frequent clinical features of fever (57.1% vs. 19.0%, p <0.01), pleural effusion (21.4% vs. 2.4%, p = 0.03), high white blood cell count (8550/mL vs. 6150/mL, p = 0.01) and C-reactive protein (CRP) (2.1 mg/dL vs. 0.2 mg/dL, p = 0.02), and low level of serum albumin (3.0 g/dL vs. 3.8 g/dL, p <0.01). Multivariate analysis adjusted by immunosuppressive drug use indicated the significant factors of fever (odds ratio or β value [95% confidence interval] 6.4 [1.65 – 20.09], p <0.01), high white blood cell count (1293.2 [110.2 – 2476.2], p = 0.03), C-reactive protein (0.89 [0.18 – 1.59], p = 0.01) and low level of serum albumin (- 0.34 [-0.54 – -0.14], p <0.01) in patients with eGFR <45 mL/min/1.73m2. Conclusion Advanced CKD was associated with poor clinical characteristics and outcomes in patients with non-HIV pulmonary cryptococcosis.

scholarly journals Clinical impact of severe chronic kidney disease in patients with non-HIV pulmonary cryptococcosis

2020 ◽  
Author(s):  
Hiroki Tashiro ◽  
Tetsuro Haraguchi ◽  
Koichiro Takahashi ◽  
Hironori Sadamatsu ◽  
Ryo Tajiri ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell Count ◽  
Clinical Characteristics ◽  
C Reactive Protein ◽  
Pulmonary Cryptococcosis ◽  
Blood Cell Count ◽  
Reactive Protein

Abstract BackgroundPulmonary cryptococcosis is an uncommon infectious disease that can develop in both immunocompromised and immunocompetent patients. Severity of chronic kidney disease (CKD) was reported to be one of the risk factors for pulmonary cryptococcosis, but its clinical characteristics have not been fully assessed. The purpose of this study is to clarify clinical characteristics of severe CKD in patients with pulmonary cryptococcosis.MethodsThe present study retrospectively investigated 56 patients who had pulmonary cryptococcosis with non-human immunodeficiency virus (HIV) infection and were treated at Saga University Hospital between 2005 and 2018. The clinical characteristics were evaluated and compared between patients with estimated glomerular filtration rate (eGFR) >45 mL/min/1.73m2 (n = 42) (preserved eGFR) and those with eGFR <45 mL/min/1.73m2 (n = 14) (declined eGFR).ResultsCompared with patients with preserved eGFR, those with declined eGFR had significantly higher rate of disseminated cryptococcosis (p = 0.03); higher percentage of patients who did not recover after treatment (p = 0.02); and more frequent clinical features of fever (p <0.01), pleural effusion (p = 0.03), high white blood cell count (p <0.01) and C-reactive protein (p <0.01), and low level of albumin (p <0.01). Multivariate analysis adjusted by immunosuppressive drug use indicated significant differences of fever (p <0.01), high white blood cell count (p = 0.03), C-reactive protein (p = 0.01) and low level of albumin (p <0.01) in patients with eGFR <45 mL/min/1.73m2.ConclusionSevere CKD is associated with poor clinical characteristics and outcomes in patients with non-HIV pulmonary cryptococcosis.

scholarly journals CORRELATION OF SEVERITY OF DISEASE AND CHANGES IN BASIC HEMATLOLOGICAL PARAMETERS IN PATIENTS OF COVID -19

2021 ◽  
Vol 29 (03) ◽  
pp. 69-73
Author(s):  
Muhammad ihtesham Khan ◽  
Maria Mehmood ◽  
Syed osama Husain ◽  
Saman Waqar ◽  
Muhammad Asim ◽  
...  
Keyword(s):  
Platelet Count ◽  
Clinical Features ◽  
Complete Blood Count ◽  
Leukocyte Count ◽  
Hematological Parameters ◽  
Tertiary Care ◽  
Ventilatory Support ◽  
Total Leukocyte Count ◽  
Female Ratio ◽  
Severity Of Disease

Objective: To determine the correlation between disease severity and changes in basic hematological parameters in cases of Covid 19 in a tertiary care center.Methodology: This Cross Sectional analytical study was done in Khyber Teaching Hospital from March to June 2020 . Covid-19 cases diagnosed by nasal swab PCR were included in the study. Clinical features were noted by Doctor on duty and Complete blood count was done. Data was analysed by SPSS . Mean and standard deviation were used for quantitative data. Frequency and percentages were used for qualitative data. Shapiro Wilk’s test was done to find normality of the data. Point biserial correlation test was applied to determine association between continuous and dichotomous variables.Levels of hemoglobin leukocyte count and platelet counts in severe cases were shown by box plots.Results: Mean age of 101 cases of Covid-19 was 56±15.7 years. Male to female ratio was 1.5:1. The commonest clinical features were generalized body aches and fever, seen in 53(52.5%) and 48(47.5%) cases respectively. 36 (35.6%) cases were serious and needed ventilatory support. In serious cases, hemoglobin and platelet count were normal in most cases i.e 16(44.4%) and 30(83.3%) respectively, while the leukocyte count was increased in 26 (72%). There was no association between the severity of disease and basic hematological parameters. Conclusion: Leukocyte count is high in cases of Covid-19. There is no significant correlation between severity level and hemoglobin and platelet count. The raised total leukocyte count is associated with severe disease in Covid19.

scholarly journals Association of hsCRP, White Blood Cell Count and Ferritin with Renal Outcome in Chronic Kidney Disease Patients

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e52775 ◽  
Author(s):  
Yi-Chun Tsai ◽  
Chi-Chih Hung ◽  
Mei-Chuan Kuo ◽  
Jer-Chia Tsai ◽  
Shih-Meng Yeh ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Renal Outcome ◽  
Blood Cell Count
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