scholarly journals Spectrophotometric Quantification of Iron in Different Pharmaceuticals

2021 ◽  
Vol 42 (1) ◽  
pp. 51-55
Author(s):  
Kshama Parajuli ◽  
Kamala Sharma ◽  
Narayan Bhattarai ◽  
Ganga G.C
Keyword(s):  
Spectrophotometric Method ◽  
Analytical Methods ◽  
Acidic Medium ◽  
Manufacturing Companies ◽  
Maximum Absorbance ◽  
Chelating Complex

Quantification of iron in different pharmaceuticals can be performed by different analytical methods. In this study, a rapid, sensitive and simple spectrophotometric method was used for the determination of iron (II) in different iron tablets. A spectrophotometric method is based on the reaction of iron (II) with 1,10-phenanthroline to form an orange-red chelating complex in an acidic medium. The maximum absorbance of the chelating complex was measured at 510 nm. The Beer Lambert’s law was found to be obeyed in the range of 0.4-4.0 mg/L of iron (II). Out of ten samples analyzed, the observed amount of iron (II) in nine samples were range from 105 to 96 mg whereas in one sample it was observed only 81 mg per 100 mg of the labeled amount of iron(II) by the manufacturer. Thus the results obtained by the spectrophotometric method using 1,10-phenanthroline as a color developing agent were nearly equal to the claimed values of iron (II) in different iron tablets from manufacturing companies.

scholarly journals New Spectrophotometric Method for Determination of Cadmium

2009 ◽  
Vol 6 (s1) ◽  
pp. S496-S500
Author(s):  
K. S. Parikh ◽  
R. M. Patel ◽  
K. N. Patel
Keyword(s):  
Stability Constant ◽  
Spectrophotometric Method ◽  
Basic Medium ◽  
Buffer Solution ◽  
Solution Ph ◽  
Yellow Colour ◽  
Maximum Absorbance ◽  
The Stability

The reagent 2-hydroxy-4-n-butoxy-5-bromopropiophenone thiosemicarbazone (HBBrPT) has been used for the determination of Cd(II) by using spectrophotometric method. The reagent HBBrPT gave an intense yellow colour with Cd(II) solution in basic medium. The maximum absorbance was observed at 440 nm, in basic buffer solution (pH 10.00). The molor absorptivity and Sandell’s sensitivity of Cd(II)-HBBrPT complex were 4035 mol-1cm-1and 0.02765 μg cm-2respectively. The stability constant of 1:2 Cd(II)-HBBrPT complex was 8.46×106. The effect of various iron was also studied.

A new optical sensor for spectrophotometric determination of uranium (VI) and thorium (IV) in acidic medium

2017 ◽  
Vol 105 (12) ◽  
Author(s):  
O. A. Elhefnawy
Keyword(s):  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Optical Sensor ◽  
Acidic Medium ◽  
Complexation Reaction

AbstractA spectrophotometric method was developed for U(VI) and Th(IV) determination in acidic medium by using proposed optical sensor. This sensor is base on the complexation reaction of the ionophore midodrine hydrochloride (

scholarly journals Kinetic- spectrophotometric Method for the Determination of Naringenin in Pure and Supplements Formulations

2019 ◽  
Vol 16 (3) ◽  
pp. 0595
Author(s):  
ALmashhadani Et al.
Keyword(s):  
Prussian Blue ◽  
Correlation Coefficient ◽  
Spectrophotometric Method ◽  
Limit Of Detection ◽  
Fixed Time ◽  
Calibration Graph ◽  
Maximum Absorbance ◽  
Kinetic Spectrophotometric

          Simple, cheap, sensitive, and accurate kinetic- spectrophotometric method has been developed for the determination of naringenin in pure and supplements formulations. The method is based on the formation of Prussian blue. The product dye exhibits a maximum absorbance at 707 nm. The calibration graph of naringenin was linear over the range 0.3 to 10 µg ml-1 for the fixed time method (at 15 min) with a correlation coefficient (r) and percentage linearity (r2%) were of 0.9995 and 99.90 %, respectively, while the limit of detection LOD was 0.041 µg ml-1. The method was successfully applied for the determination of naringenin in supplements with satisfactory results.

scholarly journals Development of an Assay Method for Simultaneous Determination of Ciprofloxacin and Naproxen by UV Spectrophotometric Method

1970 ◽  
Vol 4 (1) ◽  
pp. 84-90 ◽  
Author(s):  
Rajia Sultana Nijhu ◽  
Yeakuty Marzan Jhanker ◽  
Kumar Bishwajit Sutradhar
Keyword(s):  
Simultaneous Determination ◽  
Spectrophotometric Method ◽  
Calibration Curve ◽  
Regression Line ◽  
Assay Method ◽  
Distilled Water ◽  
Maximum Absorbance ◽  
Key Words Ciprofloxacin ◽  
The Media

The PDF for this article was updated on 18/11/2011.YM Jhanker and KB Sutradhar were added as authors to this paper on 18/11/2011.The Objective of the present study was to develop a simple, reproducible and economical spectrophotometric method for simultaneous determination of Ciprofloxacin and Naproxen. Both Drugs obey Beer's law in the range of 1-5μg/ml concentration. The Standard curve of Ciprofloxacin and Naproxen in the media of 0.1N HCl, Distilled water and Phosphate buffer are obtained by plotting absorbance versus concentration where calibration curve was found to be linear (R2>0.99) with optimum value of standard error for the entire analytical medium used. The plot of the residuals was normally distributed around the regression line, which reflects the accuracy of the method. For simultaneous determination of Ciprofloxacin and Naproxen, the linear plot was found in the media of distilled water and 0.1N HCl acid. The maximum absorbance was found in the media of distilled water for Ciprofloxacin at wavelength 278nm and for Naproxen at 228nm. The calibration curve was to be linear for Ciprofloxacin as R2 >0.99 and for Naproxen as R2 >0.99.The maximum absorbance was found in the media of 0.1N HCl for Ciprofloxacin at wavelength 277nm and for Naproxen at 228nm. The calibration curve was to be linear for Ciprofloxacin as R2 >0.98 and for Naproxen as R2 >0.99. Key words: Ciprofloxacin; Naproxen; Spectrophotometric analysis; Simultaneous equation method. DOI: http://dx.doi.org/10.3329/sjps.v4i1.8876 SJPS 2011; 4(1): 84-90

Spectrophotometric Determination of Pentaerythritol Tetranitrate in Tablets

1984 ◽  
Vol 67 (6) ◽  
pp. 1123-1124
Author(s):  
Dattatray M Shingbal ◽  
Ramesh M Agni
Keyword(s):  
Quantitative Determination ◽  
Calcium Chloride ◽  
Spectrophotometric Method ◽  
Acidic Medium ◽  
Analytical Determination ◽  
Pentaerythritol Tetranitrate ◽  
Nitroso Compound ◽  
Absorbance Maximum ◽  
Sensitive Spectrophotometric Method

Abstract A sensitive spectrophotometric method is reported for the quantitative determination of pentaerythritol tetranitrate in tablets. The method is based on reduction of pentaerythritol tetranitrate with zinc and calcium chloride, and reaction of the nitroso compound thus formed with 1-naphthylamine in acidic medium. The reaction gives a purple product having an absorbance maximum at 545 nm. Beer's law is obeyed in the concentration range of 1-10 μg/mL of reaction mixture. The presence of meprobamate in tablets does not interfere with the proposed analytical determination.

scholarly journals A simple method for the spectrophotometric determination of cephalosporins in pharmaceuticals using variamine blue

2018 ◽  
Vol 33 (2) ◽  
pp. 41
Author(s):  
Chand Pasha ◽  
Badiadka Narayana
Keyword(s):  
Sodium Hydroxide ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Acidic Medium ◽  
Simple Method ◽  
Lactam Ring ◽  
Ph Range ◽  
Variamine Blue ◽  
Hydrolysis Of

A simple spectrophotometric method for the determination of cefotaxime, ceftriaxone, cefadroxil and cephalexin with variamine blue is presented. The determination is based on the hydrolysis of β-lactam ring of cephalosporins with sodium hydroxide which subsequently reacts with iodate to liberate iodine in acidic medium. The liberated iodine oxidizes variamine blue to violet colored species of maximum absorption at 556 nm. The absorbance is measured within the pH range of 4.0-4.2. Beer’s law is obeyed in the range of 0.5-5.8 μg mL–1, 0.2-7.0 μg mL–1, 0.2-5.0 μg mL–1 and 0.5-8.5 μg mL–1 for cefotaxime, ceftriaxone, cefadroxil and cephalexin respectively. The analytical parameters were optimized and the method is successfully applied for the determination of cefotaxime, ceftriaxone, cefadroxil and cephalexin in pharmaceuticals.

scholarly journals Spectrophotometric determination of neomycin sulphate in tablets form via reaction with ninhydrin reagent

2019 ◽  
Vol 10 (2) ◽  
pp. 1392-1396 ◽  
Author(s):  
Khalaf F Alsamarrai ◽  
Menaa Abdulsalam Al-Abbasi ◽  
Eman Thiab Alsamarrai
Keyword(s):  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Calibration Curve ◽  
Limit Of Detection ◽  
Basic Medium ◽  
Optimal Conditions ◽  
Limit Of Quantification ◽  
Maximum Absorbance ◽  
Ninhydrin Reagent

A new, sensitive, simple and cheap spectrophotometric method for the determination of Neomycin Sulphate (NEO) in pharmaceutical forms has been developed. The method is based on the reaction between NEO and NIN in basic medium. The maximum absorbance was at 574 nm. The conditions affecting the reaction were optimized. Under the optimal conditions, the calibration curve was linear over the range of 0.0002-0.0011 mol/L. The limit of detection and limit of quantification were 5.423×10-6 mol/L, and 1.643×10-5 mol/L, RSD% of seven replicate was 0.8217- 0.8321% and Rec% was between 99.2168-100.8857%. The proposed method was successfully applied to the determination of NEO tablets form.

scholarly journals A Rapid Extractive Spectrophotometric Method for the Determination of Tin with 6-Chloro-3-hydroxy-2-(2′-thienyl)-4-oxo-4H-1-benzopyran

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Ramesh Kataria ◽  
Harish Kumar Sharma
Keyword(s):  
Spectrophotometric Method ◽  
Metal Ion ◽  
Molar Absorptivity ◽  
Platinum Metals ◽  
Maximum Absorbance ◽  
Beer's Law ◽  
Beer’S Law ◽  
Hcl Medium

An extractive spectrophotometric method for the determination of the trace amounts of tin has been carried out by employing 6-chloro-3-hydroxy-2-(2′-thienyl)-4-oxo-4H-1-benzopyran (in acetone) (CHTB) for the complexation of the metal ion in HCl medium. The colored species thus produced is quantitatively extracted into dichloromethane and shows the maximum absorbance at 432–437 nm. The method obeys Beer’s law in the range 0.0–1.3 μg mL−1 of tin with molar absorptivity and Sandell’s sensitivity of 5.81×104 L mol−1 cm−1 and 0.0020 μg Sn cm−2, respectively, at 435 nm. The method is highly selective and free from the interference of a large number of elements including platinum metals. The ratio of metal to ligand in the extracted species is 1 : 2. Utilizing this method, the analysis of various synthetic and technical samples including gun metal and tin can have been carried out satisfactorily.

scholarly journals Development of Spectrophotometric Method for the Determination of Atenolol in Normoten Drug

2017 ◽  
Vol 9 (1) ◽  
pp. 58 ◽  
Author(s):  
Isam Eldin Hussein Elgailani ◽  
Tofeeg Haseen Alghamdi
Keyword(s):  
Linear Regression ◽  
Spectrophotometric Method ◽  
Acidic Medium ◽  
Antihypertensive Drugs ◽  
Pharmaceutical Formulations ◽  
Molar Absorptivity ◽  
Phenol Red ◽  
Regression Correlation ◽  
Detection And Quantification

This research aimed to develop inexpensive, safe, rapid, efficent spectrophotometric method for the assay of atenolol in some antihypertensive drugs namely Normoten in its pharmaceutical formulation. The studied method is depend on the reaction of the drug with phenol red in acidic medium, at pH 3.0. The analytical parameters have been investigated. The maximum absorbance was obtained at 429 nm and the molar absorptivity of 0.054 L mol-1 cm-1. Beer’s law is linear in the concentration range of 0.5-100 μg/mL for atenolol in Normoten. The detection and quantification limits were found to be 0.038 and 0.113μg/mL for the atenolol in Normoten respectively, and with a linear regression correlation coefficient of 0.997. The recovery was found to be 98.94 to 100.31%. The studied method is can be applied for the determination of atenolol (active ingredient) of the antihypertensive drugs in their pharmaceutical formulations.

scholarly journals A Simple and Rapid Spectrophotometric Method for Determination of Thiophanate-Methyl in Commercial Formulations and Its Residues in Foodstuffs

2004 ◽  
Vol 87 (4) ◽  
pp. 811-814 ◽  
Author(s):  
Balbir C Verma ◽  
Sumita Sood ◽  
Chetan Chauhan ◽  
Devender K Sharma
Keyword(s):  
Spectrophotometric Method ◽  
Thiophanate Methyl ◽  
Green Color ◽  
Yellowish Green ◽  
Titration Procedure ◽  
Maximum Absorbance ◽  
Photometric Titration ◽  
Formulation Analysis ◽  
Sensitive Spectrophotometric Method

Abstract A new, simple, rapid, and sensitive spectrophotometric method for the determination of thiophanate-methyl, based on its reaction with cobalt(II) in the presence of triethylamine, has been developed. The yellowish green color that develops instantaneously on mixing the fungicide with the reagents in dimethylformamide is stable for at least 2 h and has maximum absorbance at 360 nm. The method has been successfully applied to the determination of thiophanate-methyl in its commercial formulations and residues on grains and apples. A photometric titration procedure for formulation analysis of the fungicide has also been developed.

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