scholarly journals Ghost cell odontogenic carcinoma: Role of p53 as predictor of progression

2020 ◽  
Vol 10 (1) ◽  
pp. 1675-1678
Author(s):  
Pallavi Srivastava ◽  
Nidhi Anand ◽  
Nuzhat Husain
Keyword(s):  
Distant Metastases ◽  
Proliferation Index ◽  
Ghost Cell ◽  
Ki 67 ◽  
Local Recurrences ◽  
Odontogenic Carcinoma ◽  
Fibular Flap ◽  
Slow Growing

Ghost cell odontogenic carcinoma (GCOC) a rare malignant Odontogenic Carcinoma with an unpredictable behaviour presenting with local recurrences and distant metastases, to best of our knowledge about 38 cases have been reported in the past. This is an additional case of GCOC in a 25-year old female presented with a slow-growing mandibular swelling since 9 months with restricted jaw mobility. The CT scan showed an ill-defined osteodestructive lesion in the mandible. The histological examination confirms the diagnoses as a GCOC. Immunohistochemical examination was performed for Ki-67 proliferation index and p53 a predictor of progression. This case was managed by wide surgical resection of tumor and reconstruction of the defect by free fibular flap. Six months follow- up period shows no signs of recurrence. GCOC is rare Odontogenic Carcinoma with unpredictable behaviour however p53 & Ki67 proliferation index can predict the progression of tumor and help in differentiation from benign precursor lesions as early diagnosis & treatment of GCOC is necessary to prevent local recurrences & distant metastases.

A Clinicopathologic Study on the Role of Estrogen, Progesterone, and Their Classical and Nonclassical Receptors in Cutaneous Neurofibromas of Individuals With Neurofibromatosis 1

2020 ◽  
Author(s):  
Rafaela E Rozza-de-Menezes ◽  
Lilian M Almeida ◽  
Raquel M Andrade-Losso ◽  
Gustavo de Souza Vieira ◽  
Orlando H K Siqueira ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Laboratory Data ◽  
Serum Levels ◽  
Neurofibromatosis 1 ◽  
Proliferation Index ◽  
Computer Assisted ◽  
Ki 67 ◽  
Clinicopathologic Study ◽  
Cutaneous Neurofibromas

Abstract Objectives To evaluate the expression of progesterone receptor (PR), estrogen receptor (ER), and G protein–coupled estrogen receptor 1 (GPER-1) in cutaneous neurofibromas (cNFs) and their correlation with demographic, clinical, and laboratory data of individuals with neurofibromatosis 1 (NF1). The association of PROGINS polymorphism and PR expression in cNFs, as well as the serum steroidal hormones and the number of cNFs, was investigated. Methods The sample comprised 80 large and 80 small cNFs from 80 individuals with NF1. PR, ER, GPER-1, and Ki-67 expression were investigated by immunohistochemistry in tissue micro- and macroarrays and quantified using a digital computer-assisted method. The number of cNFs, the levels of serum 17β estradiol and progesterone, and the PROGINS polymorphism were identified. Results Twelve (8.5%) small cNFs were weakly positive for ER, 131 (92.3%) cNFs expressed PR, and all (100%) cNFs expressed GPER-1. Large cNFs showed a higher expression of PR (P < .0001) and GPER-1 (P = .019) and had a higher intensity of staining for these receptors (P < .0001). The cell proliferation index was positively correlated with PR (P = .001). Persons with more cNFs had higher serum levels of progesterone (P = .001). Conclusions These findings emphasize the role of estrogen and progesterone in cNF development and suggest that these hormones may act on cNF cells via a noncanonical pathway through GPER-1.

scholarly journals The role of radiosurgery for hemangiopericytomas

2003 ◽  
Vol 14 (5) ◽  
pp. 1-5 ◽  
Author(s):  
Steven D. Chang ◽  
Gordon T. Sakamoto
Keyword(s):  
Stereotactic Radiosurgery ◽  
Distant Metastases ◽  
Residual Tumor ◽  
High Rate ◽  
Tumor Control ◽  
Small Subset ◽  
Patient Database ◽  
The Mean

Object Hemangiopericytomas represent a small subset of meningeal tumors. Despite their relatively uncommon nature, they are aggressive tumors known for recurrence. Resection is the standard treatment in most, although regrowth and metastases are common even after resection. The authors evaluate the role of stereotactic radiosurgery in the treatment of recurrent hemangiopericytomas. Methods In a review of the Stanford radiosurgery patient database between 1989 and 2002, the authors found eight patients with recurrent hemangiopericytoma who underwent stereotactic radiosurgery. The mean age of this population was 45.1 years (range 24–67 years). All patients had been previously treated with resection, and five patients (63%) had undergone conventional radiotherapy. The mean radiosurgery dose to the tumor margin was 20.5 Gy (range 16–24 Gy). The mean clinical and radiographic follow-up period was 44 months (range 8–77 months). Of the eight tumors treated with radiosurgery, six decreased in size and two ultimately progressed. There were no radiosurgery-related complications. Conclusions Stereotactic radiosurgery of hemangiopericytomas can result in increased tumor control and should be considered as a treatment option for patients in whom the diagnosis has been established and in whom residual tumor is demonstrated postoperatively. Close clinical and radiographic follow-up evaluation is necessary in this patient population because of the high rate of local recurrence and distant metastases.

Role of follow-up in management of local recurrences of colorectal cancer

1998 ◽  
Vol 41 (9) ◽  
pp. 1127-1133 ◽  
Author(s):  
Nicola Pietra ◽  
Leopoldo Sarli ◽  
Renato Costi ◽  
Choua Ouchemi ◽  
Mario Grattarola ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Local Recurrences

scholarly journals Adjuvant Therapy in Adrenocortical Carcinoma: Reflections and Future Directions

Cancers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 508 ◽  
Author(s):  
Sara Bedrose ◽  
Marilyne Daher ◽  
Lina Altameemi ◽  
Mouhammed Amir Habra
Keyword(s):  
Adjuvant Therapy ◽  
Surgical Resection ◽  
Adrenocortical Carcinoma ◽  
Genetic Alterations ◽  
Disease Stage ◽  
Proliferation Index ◽  
Resection Margins ◽  
Ki 67 ◽  
Platinum Based Chemotherapy

Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with high risk of recurrence despite macroscopically complete surgical resection. The main predictors of ACC recurrence include advanced disease stage, incomplete surgical resection, cortisol production, certain genetic alterations, and high proliferation rate (Ki-67 proliferation index). Mitotane has been the mainstay adjuvant therapy of ACC. However, the use of mitotane is based on retrospective and occasionally conflicting evidence. As mitotane levels can take a few months before reaching therapeutic levels, there is an emerging practice of combining platinum-based chemotherapy with mitotane in the adjuvant setting. Retrospective data indicate that radiotherapy is an option for select patients, particularly those with positive resection margins. There are multiple knowledge gaps in selecting patients for adjuvant therapy. It is of great importance to establish risk calculators to predict recurrence and to implement molecular profiling of ACC to guide adjuvant therapy. The role of immunotherapy in metastatic ACC is emerging and if deemed efficacious, then future studies will be needed to ascertain the role of adjuvant immunotherapy in ACC.

Early breast cancer: evaluation of the prognostic role of the site of the primary tumor.

1998 ◽  
Vol 16 (4) ◽  
pp. 1363-1366 ◽  
Author(s):  
R Zucali ◽  
L Mariani ◽  
E Marubini ◽  
R Kenda ◽  
L Lozza ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Distant Metastases ◽  
Breast Cancers ◽  
Prognostic Role ◽  
Long Term Follow Up ◽  
Internal Mammary

PURPOSE The prognostic role of the site of the primary breast cancer has not been clarified. This study aimed to gather more information about this issue from a large series of patients with long-term follow-up data. PATIENTS AND METHODS Data from 2,396 patients treated for early breast cancer with a conservative approach were reviewed (1973 to 1989). In 1,619 patients, the tumor had a lateral site, while in 777 cases, it was situated in the internal/central quadrants. The characteristics of the two groups were well balanced, apart from axillary nodal metastases, which were more frequent for lateral tumors (38.1% v 26.3%). RESULTS Analysis of distant metastases indicated that the regression coefficient associated with tumor site was significant and the hazards ratio estimate was 1.291, which indicates the risk of distant metastases was increased by approximately 30% for internal/central tumors. The analysis of overall survival yielded a significant coefficient and a hazards ratio of 1.192, which indicates an approximately 20% increase of mortality for internal/central tumors. CONCLUSION Early breast cancers situated in central/ internal quadrants have a worse prognosis compared with those in lateral quadrants, in terms of distant metastases and survival. Irradiation of the internal mammary chain for internal/medial tumors could be suggested, but, to date, the therapeutic strategy is still controversial.

The role of Ki-67 proliferation index vis-à-vis Oncotype DX.

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. e11055-e11055
Author(s):  
S. Sahebjam ◽  
R. Aloyz ◽  
D. Pilavdzic ◽  
M. Brisson ◽  
C. Ferrario ◽  
...  
Keyword(s):  
Oncotype Dx ◽  
Proliferation Index ◽  
Ki 67

scholarly journals The Role of MRI in Prostate Cancer Active Surveillance

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Linda M. Johnson ◽  
Peter L. Choyke ◽  
William D. Figg ◽  
Baris Turkbey
Keyword(s):  
Prostate Cancer ◽  
Active Surveillance ◽  
Treatment Strategies ◽  
Low Grade ◽  
Common Cancer ◽  
High Incidence ◽  
Aggressive Tumors ◽  
Slow Growing

Prostate cancer is the most common cancer diagnosis in American men, excluding skin cancer. The clinical behavior of prostate cancer varies from low-grade, slow growing tumors to high-grade aggressive tumors that may ultimately progress to metastases and cause death. Given the high incidence of men diagnosed with prostate cancer, conservative treatment strategies such as active surveillance are critical in the management of prostate cancer to reduce therapeutic complications of radiation therapy or radical prostatectomy. In this review, we will review the role of multiparametric MRI in the selection and follow-up of patients on active surveillance.

scholarly journals Multifocal recurrence of medulloblastoma: a long follow-up case study

2020 ◽  
Vol 29 (1) ◽  
pp. 93-9
Author(s):  
Benny Zulkarnaien ◽  
Edwin Suharlim ◽  
Eka Susanto ◽  
Soehartati Argadikoesoema Gondhowiardjo
Keyword(s):  
Immunohistochemical Staining ◽  
Pediatric Patients ◽  
Proliferation Index ◽  
Ki 67 ◽  
Negative Results ◽  
Axial Mass ◽  
Positive Results ◽  
Multifocal Recurrence

Medulloblastoma is the most common malignant brain tumor in pediatric patients. Leptomeningeal dissemination often occurs in the spinal canal and rarely into the supratentorial as an extra-axial lesion. This study followed an 8-year progression of multifocal medulloblastoma recurrence as supratentorial metastasis that mimics an intra-axial mass of the temporal lobe. Pathologic examination of the temporal mass showed densely packed small round blue cells that are distributed in a ribboning pattern with areas of necrosis, rosette formation, and mitosis. Ki-67 immunohistochemical staining of the tumor showed a high proliferation index of 40% and revealed positive results for synaptophysin and negative results for glial fibrillary acidic protein and β-catenin. A long follow-up is essential to diagnose the recurrence and elucidate the progression of medulloblastoma.

The Role of Radiotherapy in the Treatment of Malignant Tumors of the Salivary Glands

1980 ◽  
Vol 66 (4) ◽  
pp. 467-474 ◽  
Author(s):  
Marian Reinfuss ◽  
Stanislaw Korzeniowski
Keyword(s):  
Salivary Gland ◽  
Radical Surgery ◽  
Malignant Tumors ◽  
Postoperative Radiotherapy ◽  
Clinical Stage ◽  
Distant Metastases ◽  
Treatment Results ◽  
High Incidence

Treatment results in a group of 70 patients with salivary gland tumors were analyzed. Prognosis appeared to correlate with both clinical stage and malignancy of tumors. In patients irradiated postoperatively because of nonradical operation, a higher 5-year survival rate was achieved than in patients after radical surgery. It is suggested that postoperative radiotherapy improves treatment results in patients with T2 and T3 lesions. In unresectable cases (T4) a 13 % 5-year survival was achieved. In patients with highly malignant cancers a high incidence (41.9 %) of distant metastases was observed during the 5-year follow-up.

Primary Cutaneous Small/Medium CD4+ T-Cell Lymphomas: A Heterogeneous Group of Tumors With Different Clinicopathologic Features and Outcome

2008 ◽  
Vol 26 (20) ◽  
pp. 3364-3371 ◽  
Author(s):  
Adriana Garcia-Herrera ◽  
Luis Colomo ◽  
Mireia Camós ◽  
Joaquín Carreras ◽  
Olga Balague ◽  
...  
Keyword(s):  
T Cell ◽  
Prognostic Significance ◽  
Heterogeneous Group ◽  
Automated Image Analysis ◽  
Proliferation Index ◽  
Image Analysis System ◽  
Ki 67 ◽  
Cutaneous Lymphomas ◽  
Analysis System

Purpose To define the clinical and pathologic characteristics of primary cutaneous small/medium CD4+ T-cell lymphoma (PCSM-TCL) and identify parameters of prognostic significance. Patients and Methods We have investigated 24 patients with primary cutaneous lymphomas composed of small/medium mature T-cells with a βF1, CD3, CD4+ and/or noncytotoxic, CD8– and CD30– phenotype. The proliferation index and CD8+ infiltrating cells were quantified with an automated image analysis system. Results Sixteen patients presenting with solitary or localized plaques or small nodules (< 3 cm) had an indolent course. Only three patients experienced repeated cutaneous relapses, and none of them died as a result of the disease after 1 to 168 months (median, 17 months) of follow-up. The tumors had a low proliferation (median Ki-67, 9% ± 5%) and an intense infiltrate of reactive CD8+ (median, 20% ± 11.7%). Five patients presenting with rapidly evolving large tumors or nodules (≥ 5 cm) had an aggressive disease and died with extracutaneous dissemination 18 to 36 months after diagnosis (median, 23 months). These tumors had a significantly higher proliferation (median Ki-67, 22% ± 11.3%; P < .05) and lower number of infiltrating CD8+ (median, 1% ± 3%; P < .05) than the previous group. A third group of three patients had a peculiar clinical presentation with multifocal relapsing lesions without extracutaneous dissemination after a long period of follow-up ranging from 41 to 92 months. Histologically, these cases had an intense infiltrate of eosinophils. Conclusion PCSM-TCL is a heterogeneous group of tumors with differentiated clinical and pathological characteristics with impact in the outcome of the patients.

Sign in / Sign up

Export Citation Format

Share Document