scholarly journals Vitamin D Deficiency among Children with Sepsis in a Tertiary Care Center in Eastern Nepal

2021 ◽  
Vol 9 (02) ◽  
pp. 45-49
Author(s):  
Shyam Prasad Kafle ◽  
Eqtedar Ahmad ◽  
Lalan Prasad Rauniyar ◽  
Namu Koirala
Keyword(s):  
Vitamin D ◽  
Severe Sepsis ◽  
Vitamin D Deficiency ◽  
Care Center ◽  
Demographic Data ◽  
Tertiary Care ◽  
Severity Of Illness ◽  
Tertiary Care Center ◽  
Sepsis Severity ◽  
25 Hydroxy Vitamin D

INTRODUCTION: Vitamin D deficiency (VDD) is exceedingly predominant in children leading to dysregulation of the immune system and inflammation. Data on the prevalence of VDD in children with sepsis and its association with sepsis severity are limited from our part of the world. The primary aim of this study was to identify the burden of VDD in children with sepsis. MATERIAL AND METHODS: One hundred and five children (< 15 years) with sepsis were enrolled from April 15, 2017 to April 14, 2018 from a tertiary care center in Eastern Nepal. Demographic data including BMI, sequential organ failure assessment (SOFA) scores were recorded at the time of admission. Plasma 25-hydroxy vitamin D [25(OH)D] levels were measured by chemiluminescence immunoassay technique (CLIA) (MAGLUMI 25-OH Vitamin D; CLIA) within 24 hours of admission. Vitamin D concentrations of <20 ng/mL (50 nmol/L) were considered as deficient. RESULTS: Of the 105 children enrolled, the majority 74 (70.55%) had vitamin D deficiency. Vitamin D was deficient in 77, 65, and 66% of children in 1-5, 5-10, and 10-15 years of age group respectively. Vitamin D deficiency was maximum (80%) in underweight children. In the VDD group, 60% had severe sepsis, whereas only 32% had severe sepsis in vitamin D sufficient group with significant statistical association with sepsis severity and vitamin D deficiency. CONCLUSION: A high burden of VDD is present in children with sepsis which was found to be associated with greater severity of illness.

scholarly journals Prevalence of Vitamin D Deficiency among Patients of Acute Coronary Syndrome in a Tertiary Care Center of Eastern Nepal

2021 ◽  
Vol 59 (235) ◽  
Author(s):  
Richa Nepal ◽  
Prahlad Karki ◽  
Surendra Uraw ◽  
Madhab Lamsal
Keyword(s):  
Vitamin D ◽  
Acute Coronary Syndrome ◽  
Confidence Interval ◽  
Vitamin D Deficiency ◽  
Care Center ◽  
Tertiary Care ◽  
Care Hospital ◽  
Tertiary Care Center ◽  
Hypertensive Patients ◽  
Coronary Syndrome

Introduction: Vitamin D deficiency is an emerging risk factor for cardiovascular diseases. Very few studies have been done to find out vitamin D deficiency status among cardiovascular patients in Nepalese setup. This research aims to find out the prevalence of vitamin D deficiency among patients of acute coronary syndrome admitted in a tertiary care center of eastern Nepal. Methods: This was a descriptive cross-sectional study conducted among patients of acute coronary syndrome admitted in a tertiary care hospital from 1st February 2018 to 31st July 2018. Ethical clearence was taken from Institutional Review Committee of B.P. Koirala Institute of Health Sciences (Reference number: 259/074/075-IRC). Convenience sampling method was used. Data was entered in Microsoft Excel and analyzed using Statistical Package for the Social Sciences version 25. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Results: A total of 33 (64.7%) at 95% Confidence Interval (51.58-77.82) patients of acute coronary syndrome had vitamin D deficiency in our study with 19 (37.3%) having mild deficiency and 14 (27.4%) having moderate deficiency. None of the patients had severe vitamin D deficiency in our study. The mean vitamin D levels were lower in diabetics (23.57±9.28ng/ml) as compared to non-diabetics (31.91±12.50ng/ml), in hypertensive patients (24.36±7.67ng/ml) as compared to non-hypertensive patients (30.97±13.72ng/ml), and in patients with dyslipidemia (22.86±6.44ng/ml) as compared to those without dyslipidemia (37.68±13.15ng/ml). Conclusions: Prevalence of vitamin D deficiency among patients of acute coronary syndrome in our study was comparable to various other homologous international studies.

scholarly journals Study on Vitamin D Deficiency and Its Associating Factors in Tertiary Care Center, Rajasthan

2017 ◽  
Vol 16 (04) ◽  
pp. 01-07 ◽  
Author(s):  
Dr. Manuj Aggrawal ◽  
Dr. Amit Jain ◽  
Dr. R.C. Meena ◽  
Dr. Lakhpat Yadav ◽  
Dr. Parwez Qureshi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center

A prospective analysis of hypovitaminosis D and mortality in 400 patients in the neurocritical care setting

2017 ◽  
Vol 127 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Jian Guan ◽  
Michael Karsy ◽  
Andrea A. Brock ◽  
Ilyas M. Eli ◽  
Holly K. Ledyard ◽  
...  
Keyword(s):  
Vitamin D ◽  
Critical Care ◽  
Hospital Mortality ◽  
Vitamin D Deficiency ◽  
Neurocritical Care ◽  
Care Center ◽  
Demographic Data ◽  
Hypovitaminosis D ◽  
Vitamin D Levels ◽  
The Impact

OBJECTIVEHypovitaminosis D is highly prevalent among the general population. Studies have shown an association between hypovitaminosis D and multiple negative outcomes in critical care patients, but there has been no prospective evaluation of vitamin D in the neurological critical care population. The authors examined the impact of vitamin D deficiency on in-hospital mortality and a variety of secondary outcomes.METHODSThe authors prospectively collected 25-hydroxy vitamin D levels of all patients admitted to the neurocritical care unit (NCCU) of a quaternary-care center over a 3-month period. Demographic data, illness acuity, in-hospital mortality, infection, and length of hospitalization were collected. Univariate and multivariable logistic regression were used to examine the effects of vitamin D deficiency.RESULTSFour hundred fifteen patients met the inclusion criteria. In-hospital mortality was slightly worse (9.3% vs 4.5%; p = 0.059) among patients with deficient vitamin D (≤ 20 ng/dl). There was also a higher rate of urinary tract infection in patients with vitamin D deficiency (12.4% vs 4.2%; p = 0.002). For patients admitted to the NCCU on an emergency basis (n = 285), higher Simplified Acute Physiology Score II (OR 13.8, 95% CI 1.7–110.8; p = 0.014), and vitamin D deficiency (OR 3.0, 95% CI 1.0–8.6; p = 0.042) were significantly associated with increased in-hospital mortality after adjusting for other factors.CONCLUSIONSIn the subset of patients admitted to the NCCU on an emergency basis, vitamin D deficiency is significantly associated with higher in-hospital mortality. Larger studies are needed to confirm these findings and to investigate the role of vitamin D supplementation in these patients.

scholarly journals Symptomatic Hypocalcemiain Neonates Due to Maternal Hypovitaminosis D in Rural Tertiary Care Center: A Case Series

2021 ◽  
pp. 81-87
Author(s):  
Nitin S. Lingayat ◽  
Saloni Manwani ◽  
Bratati S. Mishra
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Complete Blood Count ◽  
Care Center ◽  
Tertiary Care ◽  
Clinical Manifestations ◽  
Case Series ◽  
Hypovitaminosis D ◽  
Vitamin D Supplementation ◽  
Suspected Sepsis

Vitamin D deficiency in neonates is not uncommon and is characterized by severe hypocalcemic symptoms. In babies with poor vitamin D resources, calcium, phosphorus, and homeostasis are affected, leading to neonatal hypocalcaemia clinical manifestations. Newborn babies with vitamin D deficiency are at risk of deficiency and hypocalcaemia. Therefore, vitamin D supplementation in pregnant and lactating mothers should be routinely considered. Of newborns with symptomatic hypocalcaemia admitted in Level III NICU in the rural part of western Maharashtra from October 2019 to September 2020 were reviewed. These babies were admitted to NICU due to several illnesses, including suspected sepsis, tachypnea, jaundice, etc. They were investigated for sepsis screen including Complete Blood count, CRP, Blood culture, CSF analysis. Cranial USG through anterior fontanelle and Neuro imaging and Electroencephalogram were done wherever necessary. This study intends to highlight the manifestation of maternal hypovitaminosis D on the mother and its effects on the neonate. Maternal hypovitaminosis leads to neonatal hypovitaminosis D and can present as hypocalcaemia.

scholarly journals Prevalence of vitamin d deficiency and its correlation with anthropometric measurements in neonates in a tertiary care center: a cross sectional study

2021 ◽  
Vol 8 (2) ◽  
pp. 295
Author(s):  
Ashvini A. ◽  
Nalini A. ◽  
N. S. Raghupathy
Keyword(s):  
Vitamin D ◽  
Birth Weight ◽  
Care Center ◽  
Tertiary Care ◽  
Hypovitaminosis D ◽  
Cross Sectional Study ◽  
Anthropometric Measurements ◽  
Tertiary Care Center ◽  
Sectional Study ◽  
Cross Sectional

Background: Globally hypovitaminosis D is highly prevalent among all population unsparing pregnant mothers. Maternal hypovitaminosis has negative implications on growing fetus. In India, only limited data available on prevalence of neonatal vitamin D level. Hence this study was done to estimate the prevalence of cord blood vitamin D levels and its relation with anthropometric measurements in newborns.Methods: A cross sectional study was conducted in a tertiary care center on 30 newborns. Cord blood 25 OHD levels and anthropometric measurements were taken. Data were analyzed statistically.Results: Among 30 newborns, 10%, 43% and 46% of babies had vitamin D deficiency (<12 ng/ml), insufficiency and sufficiency respectively. 23% were low birth weight. 43% of low-birth-weight babies had statistically significant (p value<0.0001) hypovitaminosis D. No correlation found between vitamin D status and other anthropometric measurements.Conclusions: Prevalence of hypovitaminosis D has negative implications on birth weight which needs further studies.

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