Exhaled Breath Analysis in Tuberculosis Case Detection: The New Horizon

2013 ◽  
Vol 3 (2) ◽  
pp. 243-244
Author(s):  
Ranabir Pal ◽  
S Dahal ◽  
A Gurung
Keyword(s):  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Gaseous Mixture ◽  
Nobel Prize Winner ◽  
Exhaled Breath ◽  
Tuberculosis Case ◽  
Exhaled Breath Analysis ◽  
Organ Systems ◽  
Volatile Organic ◽  
Health And Disease

Sixty years ago, Nobel Prize winner Linus Pauling proposed the concept that human breath is a complex and dynamic gaseous mixture of more than 200 different endogenous volatile organic compounds (VOCs) that are continually being released in different quantities within the internal environment during health and disease. The researchers estimate that more than a thousand chemicals produced in different organ-systems as metabolic end products come out every minute through the respiratory tract. Volatile organic compounds and other products of oxidative stress are a big chunk among these exhaled breath elements.DOI: http://doi.dx.org/10.3126/nje.v3i2.8509

scholarly journals Breath Biopsy and Discovery of Exclusive Volatile Organic Compounds for Diagnosis of Infectious Diseases

2021 ◽  
Vol 10 ◽  
Author(s):  
José E. Belizário ◽  
Joel Faintuch ◽  
Miguel Garay Malpartida
Keyword(s):  
Volatile Organic Compounds ◽  
Respiratory Tract ◽  
Organic Compounds ◽  
Pathogenic Bacteria ◽  
Quantitative Methods ◽  
Bacterial Species ◽  
Microbial Interactions ◽  
Exhaled Breath ◽  
Organ Systems ◽  
Volatile Organic

Exhaled breath contains thousand metabolites and volatile organic compounds (VOCs) that originated from both respiratory tract and internal organ systems and their microbiomes. Commensal and pathogenic bacteria and virus of microbiomes are capable of producing VOCs of different chemical classes, and some of them may serve as biomarkers for installation and progression of various common human diseases. Here we describe qualitative and quantitative methods for measuring VOC fingerprints generated by cellular and microbial metabolic and pathologic pathways. We describe different chemical classes of VOCs and their role in the host cell-microbial interactions and their impact on infection disease pathology. We also update on recent progress on VOC signatures emitted by isolated bacterial species and microbiomes, and VOCs identified in exhaled breath of patients with respiratory tract and gastrointestinal diseases, and inflammatory syndromes, including the acute respiratory distress syndrome and sepsis. The VOC curated databases and instrumentations have been developed through statistically robust breathomic research in large patient populations. Scientists have now the opportunity to find potential biomarkers for both triage and diagnosis of particular human disease.

scholarly journals Breath Tests in Respiratory and Critical Care Medicine: From Research to Practice in Current Perspectives

2013 ◽  
Vol 2013 ◽  
pp. 1-20 ◽  
Author(s):  
Attapon Cheepsattayakorn ◽  
Ruangrong Cheepsattayakorn
Keyword(s):  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Exhaled Breath ◽  
Home Setting ◽  
Exhaled Breath Analysis ◽  
Low Concentrations ◽  
Volatile Organic ◽  
Normal Human ◽  
Novel Method ◽  
The Individual

Today, exhaled nitric oxide has been studied the most, and most researches have now focusd on asthma. More than a thousand different volatile organic compounds have been observed in low concentrations in normal human breath. Alkanes and methylalkanes, the majority of breath volatile organic compounds, have been increasingly used by physicians as a novel method to diagnose many diseases without discomforts of invasive procedures. None of the individual exhaled volatile organic compound alone is specific for disease. Exhaled breath analysis techniques may be available to diagnose and monitor the diseases in home setting when their sensitivity and specificity are improved in the future.

Exhaled Breath Analysis For Volatile Organic Compounds (VOCs) Can Distinguish COPD From Controls

2012 ◽  
Author(s):  
Yasir I. Syed ◽  
Chris O. Phillips ◽  
Juan J. Rodriguez ◽  
Neil Mac Parthalain ◽  
Ludmila I. Kuncheva ◽  
...  
Keyword(s):  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Breath Analysis ◽  
Exhaled Breath ◽  
Exhaled Breath Analysis ◽  
Volatile Organic

Macromolecular hexa-asymmetric zinc(II) phthalocyanines bearing triazole-modified triphenylene core: Synthesis, spectroscopy and analysis towards volatile organic compounds on Surface Acoustic Wave devices

2019 ◽  
Vol 23 (04n05) ◽  
pp. 477-488 ◽  
Author(s):  
Funda Kus ◽  
Cihat Tasaltin ◽  
Mohamad Albakour ◽  
Ayşe Gül Gürek ◽  
İlke Gürol
Keyword(s):  
Volatile Organic Compounds ◽  
Acoustic Wave ◽  
Surface Acoustic Wave ◽  
Organic Compounds ◽  
Spectroscopic Techniques ◽  
Exhaled Breath ◽  
H Nmr ◽  
Exhaled Breath Analysis ◽  
Volatile Organic ◽  
Acoustic Wave Devices

The synthesis and characterization of novel asymmetric zinc(II) phthalocyanines (4–9) and their linking through peripheral and nonperipheral positions on the phthalocyanine ring via click coupling to alkyne-functionalized 2,3,6,7,10,11-hexakis(prop-2-ynyloxy)triphenylene core are described for the first time. These phthalocyanines (Pcs) (4–12) were characterized by elemental analysis and different spectroscopic techniques such as UV-vis, 1H-NMR, FT-IR and mass spectroscopy. Furthermore, the utilization of thin films of novel Pcs as a sensitive layer for detection of lung cancer from exhaled human breath at room temperature under exposure to marker volatile organic compounds (VOCs) are presented. The developed sensors were tested for acetone, ethanol, [Formula: see text]-hexane, toluene, chloroform and isoprene in a range of 300–14560 ppm. The obtained results have confirmed the possibility of utilization of Pc-based Surface Acoustic Wave (SAW) sensors for medical diagnosis based on exhaled breath analysis.

Volatile Organic Compounds in Exhaled Breath of Idiopathic Pulmonary Fibrosis for Discrimination from Healthy Subjects

Lung ◽  
2017 ◽  
Vol 195 (2) ◽  
pp. 247-254 ◽  
Author(s):  
Yu-ichi Yamada ◽  
Gen Yamada ◽  
Mitsuo Otsuka ◽  
Hirotaka Nishikiori ◽  
Kimiyuki Ikeda ◽  
...  
Keyword(s):  
Volatile Organic Compounds ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Organic Compounds ◽  
Healthy Subjects ◽  
Exhaled Breath ◽  
Volatile Organic

scholarly journals Influence of age and gender on the profile of exhaled volatile organic compounds analyzed by an electronic nose

2016 ◽  
Vol 42 (2) ◽  
pp. 143-145 ◽  
Author(s):  
Silvano Dragonieri ◽  
Vitaliano Nicola Quaranta ◽  
Pierluigi Carratu ◽  
Teresa Ranieri ◽  
Onofrio Resta
Keyword(s):  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Electronic Nose ◽  
Principal Component ◽  
Exhaled Breath ◽  
Age And Gender ◽  
Volatile Organic ◽  
Older Subjects ◽  
Never Smokers ◽  
And Gender

We aimed to investigate the effects of age and gender on the profile of exhaled volatile organic compounds. We evaluated 68 healthy adult never-smokers, comparing them by age and by gender. Exhaled breath samples were analyzed by an electronic nose (e-nose), resulting in "breathprints". Principal component analysis and canonical discriminant analysis showed that older subjects (≥ 50 years of age) could not be distinguished from younger subjects on the basis of their breathprints, as well as that the breathprints of males could not distinguished from those of females (cross-validated accuracy, 60.3% and 57.4%, respectively).Therefore, age and gender do not seem to affect the overall profile of exhaled volatile organic compounds measured by an e-nose.

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