scholarly journals Adverse Drug Reaction with Hyoscine and Valethamate for Cervical Dilation during Labour

2019 ◽  
Vol 21 (2) ◽  
pp. 128-133
Author(s):  
Lujaw Ratna Tuladhar ◽  
A. Shrestha ◽  
R.K. Shrestha
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Statistical Significance ◽  
Cross Sectional Study ◽  
Cervical Dilation ◽  
Blurred Vision ◽  
Cross Sectional ◽  
Hyoscine Butylbromide ◽  
Birth Canal ◽  
Life Threatening

 Adverse drug reaction (ADR) is an injury caused by taking medication. ADR may occur following single dose or prolong administration of drug or combination of two or more drugs. While major advancements of discipline of pharmacovigilance have taken place in the West, not much has been achieved in Asian countries. Labour is characterised by forceful and painful uterine contraction that result in cervical dilation and foetus decent from the birth canal. Anti-spasmodic drugs like hyoscine butylbromide and valethamate bromide have been used to accelerate cervical dilation and thus reduce the labor duration. The objective was to observe ADR with hyoscine and valethamate for cervical dilation during labor. It was a hospital based cross sectional study. Investigation was carried out in the form of questionnaire. All the consecutive patients who were in active stage of labor were included in the study. They were given Intravenous (IV) valethamate bromide 8mg and hyoscine butylbromide 20mg, 3 doses half an hour apart. After administration of the drug, the progress of labor was monitored and management was done as per protocol in obstetrics and gynaecology department. ADR reported were blurred vision in 47.7% of the patients, followed by dry mouth (36.9%) and tachycardia (19.2%). Other ADRs were nausea (6.2%), dizziness (3.8%), flushing (2.3%), vomiting (1.5%), fever (1.5%) and constipation (1.5%). No statistical significance was found when ADR was compared between the age group of 18-25 years and 26-35 years. Therefore, ADR reported were irrespective of the age of the patients and no life threatening or severe forms of ADR were seen with hyoscine and valethamate during cervical dilation.

scholarly journals Vitamin D deficiency as adverse drug reaction? A cross-sectional study in Dutch geriatric outpatients

2016 ◽  
Vol 72 (5) ◽  
pp. 605-614 ◽  
Author(s):  
A. C. B. van Orten-Luiten ◽  
A. Janse ◽  
R. A. M. Dhonukshe-Rutten ◽  
R. F. Witkamp
Keyword(s):  
Vitamin D ◽  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Vitamin D Deficiency ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Adverse Drug Reaction Policy in a Tertiary Care Hospital

2015 ◽  
Vol 3 (1) ◽  
pp. 41-47
Author(s):  
V Aggarwal ◽  
Shakti Kumar Gupta ◽  
DK Sharma ◽  
S Arya ◽  
S Singh
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Healthcare Providers ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Cross Sectional ◽  
Study Population ◽  
Personnel Paramédical

ABSTRACT Adverse drug reactions (ADRs) are a significant cause of morbidity and mortality and contribute to the incidence of adverse events, resulting in increased healthcare costs. Healthcare providers need to understand their role and responsibility in the detection, management, documentation, and reporting of ADRs. The purpose of this study is to provide guidelines regarding the procedure of reporting ADRs to hospital authority. It was a descriptive cross-sectional study carried out between April and August 2013. The study population included doctors, nursing personnel, paramedical staff and quality managers of tertiary care hospital from one public and two private hospitals. Interaction was done with study population against the back drop of the checklist and ADR policy was formulated. How to cite this article Singh S, Gupta SK, Arya S, Sharma DK, Aggarwal V. Adverse Drug Reaction Policy in a Tertiary Care Hospital. Int J Res Foundation Hosp Healthc Adm 2015; 3(1):41-47.

Adverse Drug Reaction-Related Hospitalizations in Elderly Australians: A Prospective Cross-Sectional Study in Two Tasmanian Hospitals

Drug Safety ◽  
2017 ◽  
Vol 40 (7) ◽  
pp. 597-606 ◽  
Author(s):  
Nibu Parameswaran Nair ◽  
Leanne Chalmers ◽  
Bonnie J. Bereznicki ◽  
Colin Curtain ◽  
Gregory M. Peterson ◽  
...  
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Predictors of adverse drug reaction-related hospitalisation in Southwest Ethiopia: A prospective cross-sectional study

PLoS ONE ◽  
2017 ◽  
Vol 12 (10) ◽  
pp. e0186631 ◽  
Author(s):  
Mulugeta Tarekegn Angamo ◽  
Colin Michael Curtain ◽  
Leanne Chalmers ◽  
Daniel Yilma ◽  
Luke Bereznicki
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Southwest Ethiopia ◽  
Related Hospitalisation

scholarly journals Generalist practitioners’ self-rating and competence in electrocardiogram interpretation in South Africa

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Langalibalele H. Mabuza ◽  
Pindile S. Mntla
Keyword(s):  
Statistical Significance ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Exact Test ◽  
Cardiac Abnormalities ◽  
Self Rating ◽  
Life Threatening ◽  
Invasive Method ◽  
Electrocardiogram Interpretation ◽  
Ecg Interpretation

Background: Electrocardiogram (ECG) is the only practical, non-invasive method of recording and analysing cardiac abnormalities. It enables a primary healthcare (PHC) clinician to detect cardiac and non-cardiac abnormalities, some potentially life-threatening. Their early detection could save a patient’s life.Aim: The aim of this study was to evaluate the competence of generalist practitioners in ECG interpretation.Setting: This study was conducted at the Annual Refresher Course, Council for Scientific and Industrial Research (CSIR), Pretoria.Methods: A cross-sectional study was conducted amongst 93 generalist practitioners, using a self-administered questionnaire containing 20 ECG tracings, commonly encountered in PHC. The tracings were categorised into primary ECG parameters, ECG emergencies and common ECG abnormalities. Competence was determined by the generalist practitioner’s number of correctly interpreted ECG tracings. Data associations were computed using the Fisher’s exact test. Statistical significance was set at p ≤ 0.05.Results: Correct heart rate calculation was achieved by 14/83 (16.9%), ECG rhythm by 7/83 (8.4%), acute antero-septal myocardial infarction (MI) by 29/83 (34.9%), atrial fibrillation by 19/83 (22.9%) and cute inferior MI by 22/83 (26.5%) generalist practitioners. No correlation was found between the practitioners’ number of years in practice and competence in ECG interpretation (p 0.05). The total number of correct answers achieved by all practitioners was 274/1860 (14.7%).Conclusion: The generalist practitioners had poor competency on ECG interpretation regardless of the number of years in practice. Their poor self-rating corresponded with the number of correct answers they provided. There is a need for continuous education in ECG interpretation.

scholarly journals Knowledge, Attitudes, and Practices of Health Care Professionals Toward Adverse Drug Reaction Reporting in Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia: A Cross-sectional Study

2017 ◽  
Vol 53 (3) ◽  
pp. 177-187 ◽  
Author(s):  
Hussen Shanko ◽  
Jemal Abdela
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Healthcare Professionals ◽  
Adverse Drug Reaction Reporting ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Reaction Reporting ◽  
Adr Reporting

Aims: This study was designed to assess knowledge, attitude and practices of adverse drug reaction reporting among healthcare professionals in Hiwot Fana Specialized University Hospital (HFSUH). Method: Hospital based descriptive cross sectional study was conducted on healthcare professionals of HFSUH. Based on purposive sampling technique, all eligible healthcare professionals (nurses, physicians and pharmacists) were involved in the study. A pretested self-administered questionnaire was used to collect data. Data were coded, entered and analyzed using SPSS version 16. The test of association of selected categorical variables were done using cross tabulation and Pearson Chi-square test. Result: Our study indicated that about 297 participants provided their response to the distributed questionnaires which makes the response rate 91.4%. Of the total healthcare professionals involved in the study, 99 (33.6%) of them were able to understand the difference between adverse drug reaction (ADR) and side effects, of which pharmacists were significantly reported (95.24%, P<0.05). About 175(59.3%) of the respondents engaged in the study were reportedly knew the national ADR reporting system in Ethiopia. On the other hand, 181(61.36%) of the participants were recognized the presence of ADR reporting form while 114 (38.64%) of the respondents had no any information about its presence in the country. Conclusion: The study revealed that a gap in knowledge, awareness and practice of healthcare professionals on ADR reporting. Therefore, specific strategies should be designed in order to improve awareness, knowledge and practice of healthcare professionals to tackle issue related to under-reporting of ADR.

scholarly journals Effect of Educational Intervention on Adverse Drug Reporting by Physicians: A Cross-Sectional Study

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Manisha Bisht ◽  
Shruti Singh ◽  
D. C. Dhasmana
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Educational Intervention ◽  
Adverse Drug Reaction Reporting ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Reporting Rate ◽  
Cross Sectional ◽  
Reaction Reporting ◽  
Adequate Knowledge

In India, the pharmacovigilance program is still in its infancy. National Pharmacovigilance Program of India was started for facilitating the pharmacovigilance activities. The ADR reporting rate is still below satisfactory in India. This cross-sectional questionnaire based study was carried out in a tertiary care teaching hospital in Uttarakhand, which is a peripheral ADR monitoring centre to assess the level of knowledge, attitude, and the practices of pharmacovigilance among the doctors and to compare it with the group of doctors attending educational CME for improving awareness of pharmacovigilance. The most important revelation of this study was that although adequate knowledge and the right attitude about adverse drug reaction reporting were instigated in the doctors after the educational intervention, the practice was still neglectful in both groups, emphasizing the need to design the strategies to develop adverse drug reaction reporting culture.

scholarly journals Prevalence and Characteristics of Adverse Drug Reaction among Patients in Jubail, Saudi Arabia

2021 ◽  
pp. 124-134
Author(s):  
Hussain Alyousif ◽  
Mohammed Tarawneh ◽  
Zainab Al Madan ◽  
Abdulmuhsen Hussein
Keyword(s):  
Adverse Drug Reaction ◽  
Saudi Arabia ◽  
Drug Reaction ◽  
Care Center ◽  
Cross Sectional Study ◽  
Royal Commission ◽  
P Value ◽  
Drug Reactions ◽  
Cross Sectional ◽  
Increased Risk

Introduction: Adverse Drug Reactions (ADRs) often causes prolonged hospitalization and have an increased risk of mortality. Adverse drug reaction can greatly affect the quality of life. It may lead to various undesired outcomes such as use of suboptimal alternative drugs, unnecessary investigations and delayed treatment. This study aims to evaluate the prevalence and characteristics of adverse drug reaction as well as, risk factors of allergic drug reactions among hospitalized patients at the secondary care center Royal Commission Hospital (RCH) in Jubail, Saudi Arabia. Methods: A cross-sectional study conducted at the RCH in Jubail, Saudi Arabia. The study included all patients admitted to RCH during the period from 2017 to 2019. All patients admitted to RCH during the study period were reviewed to identify those with at least one documented drug allergy incident. The data was collected by the study authors from the hospital medical electronic data system by using a structured questionnaire that consists of two sections. The main section is the one adapted from the Adverse Drug Reaction Probability Scale (Naranjo). Results: A total of 93 patients with reported ADR were recruited in the current study, more than half (55.91%) of them were females, with a mean age of 35.79 ± 21.18. There was a statistically significant (P-value 0.042) difference in the prevalence of ADR by gender, and the "definitely" identified ADR cases were all males. Besides, the correlation was also significant (P<0.05) between the prevalence of ADR and the use of specific antagonists as well as the committee action. The suspected medications for ADR were mainly antibiotics by 54%, particularly the third generation cephalosporins at 13%, followed by the penicillin subtype at 11%. Ceftriaxone was the highest at 13.54%, followed by vancomycin at 9.38%, and cefazolin at 8.33%. This was followed by analgesic class at 14%. Conclusion: ADRs reported in the current study were mainly probable, and the definite ones were within the reported prevalence globally. The maximum number of ADRs reported was with antibiotics. The majority of patients had recovered from the ADRs.

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