scholarly journals Endometriosis of female reproductive organs. Pathomorphology, diagnosis, treatment and prevention

2018 ◽  
Vol 22 (4) ◽  
pp. 737-742
Author(s):  
Т.М. Korol ◽  
V.P. Sorokoumov ◽  
D.О. Orlova
Keyword(s):  
Social Life ◽  
Inflammatory Diseases ◽  
Reproductive Function ◽  
Pain Syndrome ◽  
Disease Diagnosis ◽  
Reproductive Organs ◽  
Diagnostic Methods ◽  
Correct Treatment ◽  
Therapeutic Goals ◽  
Hereditary Nature

Inflammatory diseases, metrofibroma and endometriosis refer to gynecological diseases, most often causing female infertility. International statistics indicate that endometriosis affects from 5 to 50% of women and it ranks third among the most widespread gynecologic pathologies. Despite the centuries-old history of using diagnostic methods in medicine, it is one of the main unresolved problems of modern gynecology. It has been proven that endometriosis leads to a significant impairment of reproductive function, steady pain syndrome (71–87%) and infertility (21–47%). If over twenty years ago the above-mentioned disease was diagnosed at the age of about 40, then nowadays even a teenager may hear this diagnosis. The objective of this research is to analyze the basics of pathomorphology of genital endometriosis, as well as the principles of diagnosis, prevention and treatment that will help to combat the infertility. The analysis is based on the review of articles and research for 2010-2018, using the PubMed databases, eLIBRARY.RU, Web of Science. Endometriosis is a disease of the most active young women in the social life that may be of hereditary nature. When speaking about the mechanisms of disease progression, there are about 10 theories of its origin, and at the present time none of them explain the diversity of forms and types of this pathology. A distinction is made between genital endometriosis, developing in the genital area, and extragenital endometriosis, developing outside of it. The latter is less common (occurs in 6–8. %) in comparison with genital endometriosis (92–94. %). Genital endometriosis is divided into internal and external, their mechanisms of occurrence are slightly different. But the benign nature of formation is common to both of them. Morphological confirmation of the diagnosis is an important task, as far as endometriosis does not refer either to tumour pathology, or to inflammation, or to pathological regeneration. Accordingly, the treatment will be of a specific nature. This pathology manifests itself in a specific triad of symptoms: dysmenorrhea, dyspareunia and dyschezia. The “golden” standard for the disease diagnosis is a direct visualization of endometrioid heterotopias in the course of laparoscopy and histological examination of biopsy materials of endometriosis. In case of disease detection, the main therapeutic goals are the removal of foci of heterotopias, pain relief and restoration of reproductive function. The main objectives of prevention are strengthening of the immune system, prevention of frequent operations and interventions in pelvic organs, the correct approach to the use of oral contraceptives and women's awareness of the necessity of regular visits to gynecologists. So, a comprehensive approach to the study of pathomorphology and diagnosis of endometriosis allows to determine the expansion degree of heterotopias and to prescribe the correct treatment that will further improve the mental and social life of women and help in restoring the reproductive function.

Diagnosis of neoplastic diseases of reproductive system in context of healthcare system modernization: need for integrated approach

2021 ◽  
pp. 23-29
Author(s):  
I. P. Aminodova ◽  
T. P. Vasilieva ◽  
E. V. Perminova ◽  
E. S. Kastor
Keyword(s):  
Reproductive System ◽  
Data Exchange ◽  
Screening Program ◽  
Reproductive Function ◽  
Integrated Approach ◽  
Risk Groups ◽  
Disease Diagnosis ◽  
Reproductive Organs ◽  
Start Time ◽  
Tumor Diseases

The relevance of the problem of screening of tumor diseases of reproductive organs is caused by high rates of incidence of tendencies to rejuvenation, unsatisfactory results of therapy. In Russia, indicators of active detection of acute respiratory disease, diagnosis in the preinvasive and early stages remain low, adversely affecting the quality and life expectancy of the patient and her reproductive function. The purpose of the study: on the basis of the analysis of literature sources to establish the reasons for the ineffectiveness of screening of tumorous diseases of the reproductive organs. The results of the bibliographic analysis of modern screening principles and methods have shown that the main reasons for unsatisfactory screening and early diagnosis of tumor diseases of reproductive organs should be considered low scoring coverage rates, inconsistency of the legislative base, inconsistency of the start time, end of examination and screening interval, lack of a single information base with the possibility of fiing and archiving results of the survey, violation of the logistics of data exchange conducted research, expressed the dissonance of diagnostic capabilities in different regions, lack of an integrated approach and a single screening program nationwide. One of the possible solutions to decide this problem should be a solution to the implementation of a comprehensive diagnostic survey with a simultaneous assessment of the condition of all organs of the reproductive system, including the mammary glands, in order to timely identify the tumor diseases of reproductive organs with the formation of risk groups for tumor pathology and to correct tactic of reference.

3D Whole-Body MRI of the Musculoskeletal System

2021 ◽  
Vol 25 (03) ◽  
pp. 441-454
Author(s):  
Vassiliki Pasoglou ◽  
Sandy Van Nieuwenhove ◽  
Frank Peeters ◽  
Gaetan Duchêne ◽  
Thomas Kirchgesner ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Three Dimensional ◽  
Short Review ◽  
Diagnostic Methods ◽  
Whole Body ◽  
Correct Treatment ◽  
Whole Body Mri ◽  
Imaging Tool ◽  
Technological Advances ◽  
Oncologic Patients

AbstractWith its outstanding soft tissue contrast, spatial resolution, and multiplanar capacities, magnetic resonance imaging (MRI) has become a widely used technique. Whole-body MRI (WB-MRI) has been introduced among diagnostic methods for the staging and follow-up assessment in oncologic patients, and international guidelines recommend its use. In nononcologic applications, WB-MRI is as a promising imaging tool in inflammatory diseases, such as seronegative arthritis and inflammatory myopathies. Technological advances have facilitated the introduction of three-dimensional (3D) almost isotropic sequences in MRI examinations covering the whole body. The possibility to reformat 3D images in any plane with equal or almost equal resolution offers comprehensive understanding of the anatomy, easier disease detection and characterization, and finally contributes to correct treatment planning. This article illustrates the basic principles, advantages, and limitations of the 3D approach in WB-MRI examinations and provides a short review of the literature.

Gynecological diseases in children and adolescents with the acute abdomen syndrome

2021 ◽  
Vol 24 (6) ◽  
pp. 377-382
Author(s):  
I. S. Schneider ◽  
N. A. Tsap
Keyword(s):  
Acute Appendicitis ◽  
Acute Abdomen ◽  
Clinical Symptoms ◽  
Inflammatory Diseases ◽  
Reproductive Function ◽  
Pain Syndrome ◽  
Differential Diagnostics ◽  
Surgical Department ◽  
Gynecological Diseases ◽  
Cause Of Pain

Objective. The differential diagnostics of gynecological diseases with a picture of acute abdomen and acute appendicitis may be challenging and can cause a variety of complications, impaired reproductive function and infertility.Purpose. To assess outcomes after diagnosing and treating girls with the syndrome of “acute abdomen” in whom an acute gynecological pathology was revealed.Material and methods. Case histories of 85 girls with gynecological diseases who were hospitalized to the emergency surgical department of Children City Clinical Hospital No 9 in Yekaterinburg are analyzed. All children were admitted to the emergency department with a picture of “acute abdomen”.Results. All children were operated on laparoscopically, and the cause of their acute abdominal syndrome was clarified. Acute inflammatory diseases of the uterine adnexa prevailed in the structure of causes (59%). In 21% of cases, there was uterine adnexa torsion . The rest of children had apoplexy (11%) and ovarian cysts (9%).Conclusion. The differential diagnostics of acute appendicitis and acute gynecological pathologies is difficult due to various and similar clinical symptoms. Laparoscopy can not only identify the cause of pain syndrome, but also can help to chose a future curative tactics .

Optimization of complex therapy of inflammatory diseases of women pelvic organs

GYNECOLOGY ◽  
2019 ◽  
Vol 21 (3) ◽  
pp. 30-34
Author(s):  
Aydar M Ziganshin ◽  
Viktor A Mudrov
Keyword(s):  
Standard Treatment ◽  
Inflammatory Diseases ◽  
Reproductive Function ◽  
Pain Syndrome ◽  
Reproductive Period ◽  
Main Group ◽  
Control Group ◽  
Duration Of Treatment ◽  
Pelvic Organs ◽  
Complex Therapy

Inflammatory diseases of women pelvic organs in reproductive period reach 60% among outpatients and 30% among inpatient gynecological patients. Aim. The aim of the study was to evaluate therapy effectiveness of women pelvic organs deseases with Galavit as part of combination therapy compared to standard treatment. Materials and methods. The study included 120 patients with diagnosis of inflammatory diseases of pelvic organs, randomized to 2 equal groups (n=60). In the main group, the patient in complex therapy received Galavit, according to the scheme: for 5 days, 100 mg intramuscularly 1 time per day, then 100 mg every 72 hours (No. 20); in the control group - only standard treatment. Results. Improvement of clinical condition (reduction of severity, normalization of body temperature, reduction of pain syndrome) in patients of the main group was observed 2 times faster than in patient of control group. Quickly resolve the signs of inflammation by ultrasound in the main group. The number of leukocytes, ESR, LII in the main group normalized faster than in patient of control group. On the background of treatment complications of inflammatory diseases of women pelvic organs was observed in 6 (5%) patients of the main group and 9 (7.5%) patients of the control group; aftercare of patients of the main group with ineffectiveness of therapy was achieved without tubectomy. The duration of treatment in the study group was 8±2.6 days us 10±3.9 days in the control group. Conclusion. The inclusion of Galavit in the complex therapy of inflammatory diseases of women pelvic organs accelerates relief of inflammation symptoms and reduces frequency of complications, which allows to preserve reproductive function. Galavit can be recommended for treatment inflammatory diseases of women pelvic organs.

scholarly journals Comparative Efficiency of Sepranol and Cefamethrin Use in Postpartum Acute Endometritis in Cows

2020 ◽  
Vol 11 (2) ◽  
pp. 1874-1878 ◽  
Author(s):  
Samat R. Yusupov ◽  
Sergey Yu. Smolentsev ◽  
Zoya G. Churina ◽  
Galiya R. Yusupova ◽  
Alfis R. Hasanov ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Experimental Studies ◽  
Reproductive Function ◽  
Reproductive Organs ◽  
Natural Resistance ◽  
Collective Farm ◽  
Control Groups ◽  
Comparative Efficiency ◽  
Comparative Aspect ◽  
And Control

In the recent times, postpartum inflammatory diseases of the reproductive organs in cows are considered as a typical infectious pathology. The main reason is an increase in the pathogenicity of conditionally pathogenic micro flora against the weakening of the natural resistance of the animal. The postpartum acute endometritis is diagnosed as the most common among the postpartum inflammatory diseases.  It is observed in 22.5...38.4% of calving cows. The aim of the work was to study the effectiveness of preparations of plant based Sepranol and Cefamethrin in the pharmacotherapy of­ postpartum acute endometritis in cows. Experimental studies were carried out on the basis of the SEC collective farm Niva of Medvedevsky district of the Mari El Republic. The clinical­ evaluation of therapeutic efficacy of the proposed drugs in­ combination with other therapeutic methods were carried out in a comparative aspect in scientific and economic experiment with the separation of cows according to the principle of analogues into experimental and control groups under the same conditions of their feeding­, keeping, and exploitation. The main criterion for assessing the therapeutic effectiveness of the­ tested drugs was the restoration of their reproductive function in experimental animals in the shortest time possible. Studies have shown that for postpartum acute endometritis, the use of complex treatment with­ Сefamethrin at a dose of 80 ml intrauterine with a 48-hour interval before­ recovery allowed­ to obtain a therapeutic effect up to 96%, reduce the number of infertility days,­ and increase the fertility percentage.

Morphological features of endo- and myometrium in patients with uterine leiomyoma and infertility

2020 ◽  
pp. 33-37
Author(s):  
M.A. Flaksenberg ◽  
◽  
Keyword(s):  
Uterine Leiomyoma ◽  
Negative Impact ◽  
Reproductive Function ◽  
Cell Types ◽  
Underlying Disease ◽  
Reproductive Organs ◽  
Pathological Process ◽  
Simple Type ◽  
Morphological Examination ◽  
Blastocyst Implantation

The objective: determination of morphofunctional features of leiomatous nodes and endometrium in women with uterine leiomyoma and infertility to restore reproductive function and prevent recurrence of the underlying disease. Materials and methods. In order to restore reproductive function and prevent recurrence of the underlying disease, morphofunctional features of leiomatous nodes and endometrium in women with uterine leiomyoma and infertility were determined. Thirty samples of leiomyomatous nodes and endometrium were examined, among which 15 were obtained from women with multiple uterine leiomyoma and infertility and 15 samples from women with uterine leiomyoma with isolated uterine leiomyoma. During the study, a general-histological method was used for staining with hematoxylin-eosin and picrofuxin by van Gizon, as well as immunohistochemical methods. Histological examination of the endometrium was performed according to conventional protocol, taking into account the day of the menstrual cycle and R.W. Noyes criteria. Results. In the morphological examination of leiomyomatous nodes in the vast majority of cases the presence of uterine leiomyomas of simple and cell types or their combination was established. In women with multiple uterine leiomyoma, simple-type leiomyoma (53.3%) was predominant, and in patients with isolated leiomyoma the signs of cellular uterine leiomyoma (66.7%) were more frequently found. In 80.0% of women with uterine leiomyoma revealed pathology of the endometrium, such as glandular and glandular-fibrous polyps, simple and complex atypical endometrial hyperplasia, which confirms the theory about the only pathogenetic mechanisms of the emergence of hyperplastic processes of female organs. In 66.7% of women with multiple leiomyomas, signs of chronic endometritis have been found, which exacerbates the pathological process and can have a negative impact on the reproductive function, such as secretory endometrial transformation and impaired blastocyst implantation, and explains a much higher percentage of infertility in the group. Conclusion. In women with impaired reproductive function, patients with uterine leiomyoma, it is necessary to conduct a study of the receptivity of the reproductive organs, namely - the endometrium and leiomatous nodes. This will make it possible to use one or another method of treatment in order to restore reproductive function and prevent recurrence of the underlying disease. Keywords: infertility, uterine leiomyoma, endometrium, receptive apparatus.

Effect of Exposure to Mixture of Heavy Metals Arsenic, Cadmium and Lead on Reproductive Function and Oxidative Stress in Female Rats

2017 ◽  
Vol 9 (03) ◽  
Author(s):  
Choudhuri D. ◽  
Bhattacharjee T.
Keyword(s):  
Oxidative Stress ◽  
Heavy Metals ◽  
Ascorbic Acid ◽  
Reproductive Function ◽  
Reproductive Organs ◽  
Female Rats ◽  
Corpora Lutea ◽  
Oestrus Cycle ◽  
Implantation Sites ◽  
Live Fetus

Background : Toxicological consequences arising from exposure to mixtures of heavy metals especially at low, chronic and environmentally relevant doses are poorly recognised. In the present study, we evaluated effects of chronic exposure to combinations of three metals arsenic (As), cadmium (Cd) and lead (Pb) present frequently in drinking water on reproductive function and oxidative damage caused to reproductive organs of female rats. Method : Female rats were exposed to mixture of metals (As, Cdand Pb) for 90 consecutive days. The gain in body weight and weight of reproductive organs were recorded following autopsy on 91 stday. The oestrus cycle were monitored during entire treatment period. Numbers of corpora lutea, implantation sites, live fetus and survival of the fetus were evaluated in rats mated successfully with untreated male after completion of their respective treatment. Ovarian cholesterol, protein, ascorbic acid and enzyme Δ 5 -3β HSD levels were estimated. Serum levels of steroid hormones oestrogen and progesterone were estimated. Histopathological picture of both ovary and uterus were assessed. Levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidise (GPX) activity, amount of reduced glutathione (GSH) and malondyaldehyde (MDA) in blood, ovary and uterus were measured as biomarkers of oxidative stress. Results : The treated rats showed reduced body weight gain and reduction in the weight of ovary and uterus. Oestrus cycle was disrupted with continuous diestrous in treated animals. Number of corpora lutea, implantation sites and live fetus and the survival of fetus evaluate were reduced significantly in treated groups. The levels of ovarian cholesterol and ascorbic acid increased in treated rats with decrease Δ5 -3β HSD level. There was reduction in serum level of both the ovarian steroid hormones oestrogen and progesterone. The protein levels did not differ between the groups. There was a significant increase in levels of MDA and decrease in levels of all the antioxidant enzymes in treated group. Conclusion : The results revealed there was disruption to reproductive functions with decrease in stereoidogenic activity and associated oxidative stress in female rats treated with combination of mixture of metals (Cd, As and Pb) at low dose for 90 consecutive days.

COMPARATIVE ANALYSIS OF KIDNEYS AND HEART ECHOGRAMS IN DOGS WITH ENDOMETRITIS AND CATS WITH PYOMETRA

2020 ◽  
Vol 15 (9) ◽  
pp. 1270-1277
Author(s):  
V.Y. Satskevich ◽  
◽  
A.G. Mamatova ◽  
A.S. Rykhlov ◽  
M.A. Kucheryavenkov ◽  
...  
Keyword(s):  
Heart Failure ◽  
Renal Failure ◽  
Vascular System ◽  
Inflammatory Diseases ◽  
Domestic Animals ◽  
Acute Form ◽  
Hereditary Nature ◽  
Veterinary Hospital ◽  
Abdominal Echography ◽  
Collecting System

According to the data provided by the Veterinary Hospital of the Saratov State Agrarian University, in the cities of Saratov, Balakovo and Engels, renal and heart failure in patients with endometritis and cats with pyometra were registered in 26.8-34.5% of all surveyed domestic animals. The results of abdominal echography, made by sick cats with pyometra and dogs with endometritis, showed the presence of renal failure of the following types: – 92.9% – glomerulonephritis, pyelonephritis; – 2.4% – focal diseases (cysts); in 4.7% – hydronephrosis. In this group of animals with pathologies were identified: – pyelonephritis, glomerulonephritis in 81.3%; – pathologies of a focal nature (cysts, masses) – in 4.0%; – pathologies of a hereditary nature – in 3.1%; – pathology of the collecting system, incl. hydronephrosis, nephrolithiasis in 10.7% and 0.9% of sick dogs and cats, respectively. Echographically, the signs of heart failure (pericarditis, endcardiosis) are fairly objectively detected in 60.6% of the examined patients with endometritis and in 73.5% of patients with pyometra. Moreover, the combination of renal and heart failure in sick dogs and cats is recorded in 56.79% of cases. In inflammatory diseases in dogs in this case with endometritis and cats with pyometra in acute form, ultrasound shows: an increase in size (especially dorsoventral); the contours of the kidneys are indistinct; cortico-medullary differentiation is weak; the thickness of the parenchyma is heterogeneous and uneven, the collecting system of the kidneys is expanded. Echographically, the signs of heart disease and heart failure are quite objectively detected (pericarditis – 23.97%, endcardiosis – 16.83%, arrhythmias of various origins – 44.2% and other diseases of the heart and vascular system – 14.0%), in 60, 6% of the examined sick dogs with endometritis and 73.5% of sick cats with pyometra. Moreover, the combination in sick dogs and cats of renal and heart failure is recorded in 56.79% of cases.

Internet Addiction

2019 ◽  
pp. 1-19
Author(s):  
Shaun Joseph Smyth ◽  
Kevin Curran ◽  
Nigel McKelvey
Keyword(s):  
Internet Addiction ◽  
Family Life ◽  
Social Life ◽  
Internet Use ◽  
Diagnostic Methods ◽  
Increased Risk ◽  
Negative Effect ◽  
Personal Wellbeing ◽  
Excessive Internet Use ◽  
Definition Of

Internet addiction (IA) is typically defined as a condition where an individual has lost control of their internet use and proceeds to use the internet excessively to the point where he/she experiences problematic consequences which ultimately have a negative effect on his/her life. The authors examine what constitutes an addiction, the definition of internet addiction, the complications which exist in the various diagnostic methods of successfully diagnosing internet addiction, the criticism some of these diagnostic methods have taken and the effects of excessive internet use by both students and employees. They also highlight those individuals who are of increased risk of developing this condition including positive diagnosis of the addiction and the resultant effects it has on the individual's family life, employment, social life and personal wellbeing, before finally looking at possible methods and treatments that can be employed for treating internet addiction.

scholarly journals Saphenous nerve entrapment manifested as proximal cruralgia

1997 ◽  
Vol 115 (5) ◽  
pp. 1553-1554 ◽  
Author(s):  
João Neves Camargo Júnior ◽  
Anamarli Nucci
Keyword(s):  
Myofascial Pain ◽  
Femoral Nerve ◽  
Pain Syndrome ◽  
Myofascial Pain Syndrome ◽  
Primary Lesion ◽  
Saphenous Nerve ◽  
Medial Aspect ◽  
Correct Treatment ◽  
The Right ◽  
Pain Distribution

A 16 year old boy had continuous pain in the right testis, groin, and the medial aspect of the thigh and knee for 16 months.The onset of symptoms was acute and pain distribution included a retrograde area in relation to the entrapment site. Tinel's sign was the clue for diagnosis. Diagnosis was confirmed at operation and division of the aponeurosis of Hunter's canal relieved the symptoms for three days. A second surgical exploration, proximal to the former one, was performed after five months.The right femoral nerve was found normal. This new operation was therapeutically ineffective. Causes of pain distribution and relapsed pain are discussed. The relapse was attributed to myofascial pain syndrome. This diagnosis should be considered independently of the correct treatment of the primary lesion.

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