Diagnosis of neoplastic diseases of reproductive system in context of healthcare system modernization: need for integrated approach

2021 ◽  
pp. 23-29
Author(s):  
I. P. Aminodova ◽  
T. P. Vasilieva ◽  
E. V. Perminova ◽  
E. S. Kastor
Keyword(s):  
Reproductive System ◽  
Data Exchange ◽  
Screening Program ◽  
Reproductive Function ◽  
Integrated Approach ◽  
Risk Groups ◽  
Disease Diagnosis ◽  
Reproductive Organs ◽  
Start Time ◽  
Tumor Diseases

The relevance of the problem of screening of tumor diseases of reproductive organs is caused by high rates of incidence of tendencies to rejuvenation, unsatisfactory results of therapy. In Russia, indicators of active detection of acute respiratory disease, diagnosis in the preinvasive and early stages remain low, adversely affecting the quality and life expectancy of the patient and her reproductive function. The purpose of the study: on the basis of the analysis of literature sources to establish the reasons for the ineffectiveness of screening of tumorous diseases of the reproductive organs. The results of the bibliographic analysis of modern screening principles and methods have shown that the main reasons for unsatisfactory screening and early diagnosis of tumor diseases of reproductive organs should be considered low scoring coverage rates, inconsistency of the legislative base, inconsistency of the start time, end of examination and screening interval, lack of a single information base with the possibility of fiing and archiving results of the survey, violation of the logistics of data exchange conducted research, expressed the dissonance of diagnostic capabilities in different regions, lack of an integrated approach and a single screening program nationwide. One of the possible solutions to decide this problem should be a solution to the implementation of a comprehensive diagnostic survey with a simultaneous assessment of the condition of all organs of the reproductive system, including the mammary glands, in order to timely identify the tumor diseases of reproductive organs with the formation of risk groups for tumor pathology and to correct tactic of reference.

scholarly journals Endometriosis of female reproductive organs. Pathomorphology, diagnosis, treatment and prevention

2018 ◽  
Vol 22 (4) ◽  
pp. 737-742
Author(s):  
Т.М. Korol ◽  
V.P. Sorokoumov ◽  
D.О. Orlova
Keyword(s):  
Social Life ◽  
Inflammatory Diseases ◽  
Reproductive Function ◽  
Pain Syndrome ◽  
Disease Diagnosis ◽  
Reproductive Organs ◽  
Diagnostic Methods ◽  
Correct Treatment ◽  
Therapeutic Goals ◽  
Hereditary Nature

Inflammatory diseases, metrofibroma and endometriosis refer to gynecological diseases, most often causing female infertility. International statistics indicate that endometriosis affects from 5 to 50% of women and it ranks third among the most widespread gynecologic pathologies. Despite the centuries-old history of using diagnostic methods in medicine, it is one of the main unresolved problems of modern gynecology. It has been proven that endometriosis leads to a significant impairment of reproductive function, steady pain syndrome (71–87%) and infertility (21–47%). If over twenty years ago the above-mentioned disease was diagnosed at the age of about 40, then nowadays even a teenager may hear this diagnosis. The objective of this research is to analyze the basics of pathomorphology of genital endometriosis, as well as the principles of diagnosis, prevention and treatment that will help to combat the infertility. The analysis is based on the review of articles and research for 2010-2018, using the PubMed databases, eLIBRARY.RU, Web of Science. Endometriosis is a disease of the most active young women in the social life that may be of hereditary nature. When speaking about the mechanisms of disease progression, there are about 10 theories of its origin, and at the present time none of them explain the diversity of forms and types of this pathology. A distinction is made between genital endometriosis, developing in the genital area, and extragenital endometriosis, developing outside of it. The latter is less common (occurs in 6–8. %) in comparison with genital endometriosis (92–94. %). Genital endometriosis is divided into internal and external, their mechanisms of occurrence are slightly different. But the benign nature of formation is common to both of them. Morphological confirmation of the diagnosis is an important task, as far as endometriosis does not refer either to tumour pathology, or to inflammation, or to pathological regeneration. Accordingly, the treatment will be of a specific nature. This pathology manifests itself in a specific triad of symptoms: dysmenorrhea, dyspareunia and dyschezia. The “golden” standard for the disease diagnosis is a direct visualization of endometrioid heterotopias in the course of laparoscopy and histological examination of biopsy materials of endometriosis. In case of disease detection, the main therapeutic goals are the removal of foci of heterotopias, pain relief and restoration of reproductive function. The main objectives of prevention are strengthening of the immune system, prevention of frequent operations and interventions in pelvic organs, the correct approach to the use of oral contraceptives and women's awareness of the necessity of regular visits to gynecologists. So, a comprehensive approach to the study of pathomorphology and diagnosis of endometriosis allows to determine the expansion degree of heterotopias and to prescribe the correct treatment that will further improve the mental and social life of women and help in restoring the reproductive function.

scholarly journals FEATURES OF INTENSIVE ORGAN-SPARING THERAPY FOR MASSIVE POSTPARTUM HEMORRHAGE

2016 ◽  
Vol 1 (3) ◽  
pp. 11-14
Author(s):  
Сверкунова ◽  
Nataliya Sverkunova ◽  
Ежова ◽  
Irina Ezhova ◽  
Крамарский ◽  
...  
Keyword(s):  
Blood Volume ◽  
Postpartum Hemorrhage ◽  
Reproductive Function ◽  
Risk Groups ◽  
Reproductive Organs ◽  
Massive Bleeding ◽  
Balloon Tamponade ◽  
Mechanical Methods ◽  
Great Vessels ◽  
Perinatal Center

Bleeding in pregnancy, childbirth and the postpartum period is one of the leading causes of maternal morbidity and mortality worldwide. There is no doubt that obstetric bleeding demands the development of improved methods for its diagnostics and treatment. We assessed the effectiveness of the treatment strategy for massive postpartum hemorrhage (PPH) with preservation of reproductive function, applied in the Perinatal Center of Irkutsk. We performed a retrospective analysis of 24 delivery cases, complicated by massive bleeding and successfully treated with preservation of reproductive organs. The massive nature of bleeding (≥ 30 % of blood volume) was registered in 15 (62.5 %) cases, mild (≥ 20 % but ≤ 30 % of blood volume) – in 9 (37.5 %). Emergency operative delivery (cesarean section) was performed in 40 % of massive PPH cases and in 66.7 % of mild PPH cases. Uterotonic drugs were used in all PPH cases. When analyzing complex mechanical methods of PPH arrest, we noticed that in 20 % of cases balloon tamponade was used. In 33.3 % of mild PPH cases, balloon tamponade with great vessels ligation was performed. Thus, the most effective method was balloon tamponade coupled with Baksheev forceps and early surgical hemostasis. All in all, prevention of hemorrhage in risk groups and early fluid and surgical therapy, and also administration of uterotonic drugs in PPH treatment not only provide a hemostatic effect but also preserve reproductive function.

Chaperonin as the normal controls and pathological anti-stress response in the human reproductive system

2016 ◽  
pp. 126-129
Author(s):  
M. Makarenko ◽  
◽  
D. Hovsyeyev ◽  
L. Sydoryk ◽  
◽  
...  
Keyword(s):  
Reproductive System ◽  
Stress Proteins ◽  
Physiological Stress ◽  
Protein Complexes ◽  
Reproductive Function ◽  
Intercellular Signaling ◽  
Toll Like Receptors ◽  
Wide Range ◽  
Protein Functions ◽  
And Function

Different kinds of physiological stress cause mass changes in the cells, including the changes in the structure and function of the protein complexes and in separate molecules. The protein functions is determined by its folding (the spatial conclusion), which depends on the functioning of proteins of thermal shock- molecular chaperons (HSPs) or depends on the stress proteins, that are high-conservative; specialized proteins that are responsible for the correct proteinaceous folding. The family of the molecular chaperones/ chaperonins/ Hsp60 has a special place due to the its unique properties of activating the signaling cascades through the system of Toll-like receptors; it also stimulates the cells to produce anti- inflammatory cytokines, defensins, molecules of cell adhesion and the molecules of MHC; it functions as the intercellular signaling molecule. The pathological role of Hsp60 is established in a wide range of illnesses, from diabetes to atherosclerosis, where Hsp60 takes part in the regulation of both apoptosis and the autoimmune processes. The presence of the HSPs was found in different tissues that are related to the reproductive system. Key words: molecular chaperons (HSPs), Toll-like receptors, reproductive function, natural auto antibody.

Morphological features of endo- and myometrium in patients with uterine leiomyoma and infertility

2020 ◽  
pp. 33-37
Author(s):  
M.A. Flaksenberg ◽  
◽  
Keyword(s):  
Uterine Leiomyoma ◽  
Negative Impact ◽  
Reproductive Function ◽  
Cell Types ◽  
Underlying Disease ◽  
Reproductive Organs ◽  
Pathological Process ◽  
Simple Type ◽  
Morphological Examination ◽  
Blastocyst Implantation

The objective: determination of morphofunctional features of leiomatous nodes and endometrium in women with uterine leiomyoma and infertility to restore reproductive function and prevent recurrence of the underlying disease. Materials and methods. In order to restore reproductive function and prevent recurrence of the underlying disease, morphofunctional features of leiomatous nodes and endometrium in women with uterine leiomyoma and infertility were determined. Thirty samples of leiomyomatous nodes and endometrium were examined, among which 15 were obtained from women with multiple uterine leiomyoma and infertility and 15 samples from women with uterine leiomyoma with isolated uterine leiomyoma. During the study, a general-histological method was used for staining with hematoxylin-eosin and picrofuxin by van Gizon, as well as immunohistochemical methods. Histological examination of the endometrium was performed according to conventional protocol, taking into account the day of the menstrual cycle and R.W. Noyes criteria. Results. In the morphological examination of leiomyomatous nodes in the vast majority of cases the presence of uterine leiomyomas of simple and cell types or their combination was established. In women with multiple uterine leiomyoma, simple-type leiomyoma (53.3%) was predominant, and in patients with isolated leiomyoma the signs of cellular uterine leiomyoma (66.7%) were more frequently found. In 80.0% of women with uterine leiomyoma revealed pathology of the endometrium, such as glandular and glandular-fibrous polyps, simple and complex atypical endometrial hyperplasia, which confirms the theory about the only pathogenetic mechanisms of the emergence of hyperplastic processes of female organs. In 66.7% of women with multiple leiomyomas, signs of chronic endometritis have been found, which exacerbates the pathological process and can have a negative impact on the reproductive function, such as secretory endometrial transformation and impaired blastocyst implantation, and explains a much higher percentage of infertility in the group. Conclusion. In women with impaired reproductive function, patients with uterine leiomyoma, it is necessary to conduct a study of the receptivity of the reproductive organs, namely - the endometrium and leiomatous nodes. This will make it possible to use one or another method of treatment in order to restore reproductive function and prevent recurrence of the underlying disease. Keywords: infertility, uterine leiomyoma, endometrium, receptive apparatus.

Effect of Exposure to Mixture of Heavy Metals Arsenic, Cadmium and Lead on Reproductive Function and Oxidative Stress in Female Rats

2017 ◽  
Vol 9 (03) ◽  
Author(s):  
Choudhuri D. ◽  
Bhattacharjee T.
Keyword(s):  
Oxidative Stress ◽  
Heavy Metals ◽  
Ascorbic Acid ◽  
Reproductive Function ◽  
Reproductive Organs ◽  
Female Rats ◽  
Corpora Lutea ◽  
Oestrus Cycle ◽  
Implantation Sites ◽  
Live Fetus

Background : Toxicological consequences arising from exposure to mixtures of heavy metals especially at low, chronic and environmentally relevant doses are poorly recognised. In the present study, we evaluated effects of chronic exposure to combinations of three metals arsenic (As), cadmium (Cd) and lead (Pb) present frequently in drinking water on reproductive function and oxidative damage caused to reproductive organs of female rats. Method : Female rats were exposed to mixture of metals (As, Cdand Pb) for 90 consecutive days. The gain in body weight and weight of reproductive organs were recorded following autopsy on 91 stday. The oestrus cycle were monitored during entire treatment period. Numbers of corpora lutea, implantation sites, live fetus and survival of the fetus were evaluated in rats mated successfully with untreated male after completion of their respective treatment. Ovarian cholesterol, protein, ascorbic acid and enzyme Δ 5 -3β HSD levels were estimated. Serum levels of steroid hormones oestrogen and progesterone were estimated. Histopathological picture of both ovary and uterus were assessed. Levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidise (GPX) activity, amount of reduced glutathione (GSH) and malondyaldehyde (MDA) in blood, ovary and uterus were measured as biomarkers of oxidative stress. Results : The treated rats showed reduced body weight gain and reduction in the weight of ovary and uterus. Oestrus cycle was disrupted with continuous diestrous in treated animals. Number of corpora lutea, implantation sites and live fetus and the survival of fetus evaluate were reduced significantly in treated groups. The levels of ovarian cholesterol and ascorbic acid increased in treated rats with decrease Δ5 -3β HSD level. There was reduction in serum level of both the ovarian steroid hormones oestrogen and progesterone. The protein levels did not differ between the groups. There was a significant increase in levels of MDA and decrease in levels of all the antioxidant enzymes in treated group. Conclusion : The results revealed there was disruption to reproductive functions with decrease in stereoidogenic activity and associated oxidative stress in female rats treated with combination of mixture of metals (Cd, As and Pb) at low dose for 90 consecutive days.

Development of innovative hygienic technologies for preservation of the workers’ reproductive health

2020 ◽  
pp. 792-792
Author(s):  
M. A. Fesenko ◽  
G. V. Golovaneva ◽  
A. V. Miskevich
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Reproductive Health ◽  
Reproductive System ◽  
Preventive Measures ◽  
Learning Algorithms ◽  
Reproductive Function ◽  
Machine Learning Algorithms ◽  
New Model

The new model «Prognosis of men’ reproductive function disorders» was developed. The machine learning algorithms (artificial intelligence) was used for this purpose, the model has high prognosis accuracy. The aim of the model applying is prioritize diagnostic and preventive measures to minimize reproductive system diseases complications and preserve workers’ health and efficiency.

scholarly journals Presence and Characterization of Cell-Free Seminal RNA in Healthy Individuals: Implications for Noninvasive Disease Diagnosis and Gene Expression Studies of the Male Reproductive System

2009 ◽  
Vol 55 (11) ◽  
pp. 1967-1976 ◽  
Author(s):  
Shiyun Huang ◽  
Honggang Li ◽  
Xiaofang Ding ◽  
Chengliang Xiong
Keyword(s):  
Reproductive System ◽  
Time Course ◽  
Disease Diagnosis ◽  
Male Reproductive System ◽  
Healthy Individuals ◽  
Microcapillary Electrophoresis ◽  
Expression Studies ◽  
Noninvasive Biomarker ◽  
Gene Expression Studies ◽  
Triton X

Abstract Background: We recently detected cell-free seminal RNA (cfsRNA) and set out to study its concentration, integrity, stability in healthy individuals, and mechanisms for its protection from ribonucleases. Methods: We quantified cfsRNA by reverse-transcription quantitative real-time PCR (RT-qPCR) targeting of the 5′ region of the ACTB (actin, beta) transcript. cfsRNA integrity was analyzed by microcapillary electrophoresis and by amplification of full-length ACTB and DDX4 [DEAD (Asp-Glu-Ala-Asp) box polypeptide 4] transcripts, including measurement of the relative amounts of different regions of ACTB and DDX4 transcripts. Stability of cfsRNA was measured by time-course analysis of different regions of ACTB and DDX4 transcripts. To investigate whether cfsRNA was protected in complexed forms, we processed seminal plasma in 2 ways: filtration through pores of different sizes and Triton X-100 treatment before RNA recovery. Results: cfsRNA concentrations varied from 0.87–3.64 mg/L [mean (SD), 1.75 mg/L (0.92 mg/L)]. Most cfsRNA was present in partially degraded forms, with smaller amounts of middle and 3′ amplicons compared with 5′ amplicons. Although the 3′ region of the DDX4 transcript was degraded completely by 90 min, the 5′ regions of ACTB and DDX4 transcripts were stable up to 24 h. Filtration through 0.22-μm pores reduced ACTB and DDX4 mRNA concentrations by 72% and 61%, respectively. Nearly all seminal ACTB and DDX4 mRNA disappeared after Triton X-100 treatment. Conclusions: Although cfsRNA was partially degraded, it represented diverse transcript species and was abundant, fairly stable, and associated with particles in healthy individuals. cfsRNA may represent a potential noninvasive biomarker of the male reproductive system and of germline epigenetics.

Approximate Degree Reduction of NURBS Curves and Surfaces: An Integrated Approach

1994 ◽  
Author(s):  
Srinivasa P. Varanasi ◽  
Athamaram H. Soni
Keyword(s):  
Shape Control ◽  
Data Exchange ◽  
Data Transfer ◽  
Integrated Approach ◽  
Free Form ◽  
Aircraft Industry ◽  
Trimmed Surfaces ◽  
Curves And Surfaces ◽  
High Degree ◽  
Boundary Curves

Abstract Data exchange between different CAD systems usually requires conversion between different representations of free-form curves and surfaces. Also, trimmed surfaces give rise to high degree boundary curves. Accurate conversion of these forms becomes necessary for reliable data transfer. Also important is the issue of shape control, specially in the aircraft industry. The objective of this paper is to investigate conversion methods and effect of shape control on the design and choice of such methods.

scholarly journals COVID-19: A Syndemic Requiring an Integrated Approach for Marginalized Populations

2021 ◽  
Vol 9 ◽  
Author(s):  
Rosemary M. Caron ◽  
Amanda Rodrigues Amorim Adegboye
Keyword(s):  
At Risk ◽  
Collective Responsibility ◽  
Health Inequities ◽  
Integrated Approach ◽  
Risk Groups ◽  
Marginalized Populations ◽  
Structural Barriers ◽  
Public Health Services ◽  
Increased Risk ◽  
Novel Coronavirus

The novel coronavirus, SARS-CoV-2, responsible for the COVID-19 pandemic, has challenged healthcare systems globally. The health inequities experienced by immigrants, refugees, and racial/ethnic minorities have been aggravated during the COVID-19 pandemic. The socioeconomic, political, and demographic profile of these vulnerable populations places them at increased risk of contracting COVID-19 and experiencing significant morbidity and mortality. Thus, the burden of the COVID-19 pandemic is disproportionally higher among these at-risk groups. The purpose of this perspective is to: (1) highlight the interactions among the social determinants of health (SDoH) and their bi-directional relationship with the COVID-19 pandemic which results in the current syndemic and; (2) offer recommendations that consider an integrated approach to mitigate COVID-19 risk for marginalized populations in general. For these at-risk populations, we discuss how individual, structural, sociocultural, and socioeconomic factors interact with each other to result in a disparate risk to contracting and transmitting COVID-19. Marginalized populations are the world's collective responsibility. We recommend implementing the Essential Public Health Services (EPHS) framework to promote those systems and policies that enable optimal health for all while removing systemic and structural barriers that have created health inequities. The pledge of “Health for All” is often well-accepted in theory, but the intricacy of its practical execution is not sufficiently recognized during this COVID-19 syndemic and beyond.

scholarly journals An Efficient PET-MRI Medical Image Fusion based on IHS-NSCT-PCA Integrated Method

2019 ◽  
Vol 9 (2) ◽  
pp. 2073-2079
Keyword(s):  
Structural Data ◽  
Fusion Rule ◽  
Integrated Approach ◽  
Disease Diagnosis ◽  
Weighted Averaging ◽  
Fusion Algorithm ◽  
Integrated Method ◽  
Histogram Matching ◽  
Multiple Imaging ◽  
Fused Image

Merging of multiple imaging modalities leads to a single image that acquire high information content. These find useful applications in disease diagnosis and treatment planning. IHS-PCA method is a spatial domain approach for fusion that offersfinestvisibility but demands vast memory and it lacks steering information. We propose an integrated approach that incorporates NSCT combined with PCA utilizing IHS space and histogram matching. The fusion algorithm is applied on MRI with PET image and improved functional property was obtained. The IHS transform is a sharpening technique that converts multispectral image from RGB channels to Intensity Hue and Saturation independent values. Histogram matching is performed with intensity values of the two input images. Pathological details in images can be emphasized in multi-scale and multi-directions by using PCA withNSCT. Fusion rule applied is weighted averaging andprincipal components are used for dimensionality reduction. Inverse NSCT and Inverse IHS are performed so as to obtain the fused image in new RGB space. Visual and subjective investigation is compared with existing methods which demonstrate that our proposed technique gives high structural data content with high spatial and spectral resolution compared withearlier methods.

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