scholarly journals Morphological changes in the venous wall under experimental neoplastic intoxication

2021 ◽  
Vol 25 (2) ◽  
pp. 205-207
Author(s):  
P. Bodnar ◽  
Ya. Bodnar ◽  
T. Bodnar ◽  
L. Bodnar
Keyword(s):  
Cancer Patients ◽  
Morphological Changes ◽  
Vascular Wall ◽  
Male Rats ◽  
Experimental Conditions ◽  
Vein Thrombosis ◽  
Oncological Diseases ◽  
Negative Effect ◽  
Thrombotic Complications ◽  
Venous Wall

Annotation. The goal of this study was to investigate the characteristic histological and morphological signs of changes in the venous wall as one of the main pathogenetic links of thrombosis in oncological pathology. Assessment of these changes is necessary to understand the process of occurrence and prevention of thromboembolic and thrombotic complications in patients with oncological diseases. Histological, submicroscopic and polarizing materials of hind limb veins of 11 mature nonlinear male rats weighing 170-180 g on day 30 of chronic neoplastic intoxication complicated by deep limb vein thrombosis were studied. It is established that experimental neoplastic intoxication in rats on histological examination was accompanied by the development of submicroscopic reorganization of endotheliocytes and their desquamation, platelet ligation as one of the causes of future thrombotic complications. Thus installed the negative effect of long-term neoplastic intoxication on the cells and all layers of the venous vascular wall as well as on the blood forming elements was studied. A close connection between the presence of the obtained changes against the background of oncological diseases and the development of such thrombotic complications as phlebothrombosis, pulmonary embolism and thrombophlebitis has been established. The development of complications shows that the prevention of thrombosis is an important component of conservative therapy of cancer patients, to prevent the development of lethal outcomes. High incidence of PE, deep vein thrombosis and thrombophlebitis in the superficial venous system emphasizes the use of preventive means of conservative treatment of cancer patients to prevent these complications, resulting in a high mortality rate. The study of morphological changes of the venous wall under the influence of chronic neoplastic intoxication in experimental conditions allows to carry out a detailed analysis of possible complications.

scholarly journals Enterosgel role in neurodegenerative changes in the retina rats under the influence of Cr (VI) - induced retinopathy by study morphological changes in dynamic

2021 ◽  
pp. 14-20
Author(s):  
Olena Kuzenko ◽  
Yevhen Kuzenko ◽  
Yuri Demin
Keyword(s):  
Drinking Water ◽  
Morphological Changes ◽  
White Male ◽  
Degenerative Changes ◽  
Male Rats ◽  
Control Group ◽  
Fiber Layer ◽  
Experimental Conditions ◽  
Typical Structure ◽  
Ganglion Neurons

Chromium galvanic production have leaded to biosphere pollution. Therefore advisable to study of role in the neurodegenerative development in retinal diseases under experimental conditions. The aim is to study the Enterosgel effect on morphological changes in rats retina with Cr(VI) – induced retinopathy. Materials and methods. An experimental study had carried out on 72 outbred white male rats. The rats had divided into 3 groups: I – control group of intact rats (n = 24). Control rats were received drinking water, II group – rats (n = 24), were received drinking water with Cr (VI) (K2Cr2O7) – 0.02 mol/L, III group – animals (n = 24) were received drinking water with K2Cr2O7– 0.02 mol/L and hydrogel methylsilicic acid (Enterosgel) at a dose of 0.8 mg/kg per day as a corrector. The animals had been decapitated under ether anesthesia. The retina had been studied on days 20, 40 and 60 of the experiment. Morphologically and morphometrically they had analyzed. Results. According to histological studies, it has proved that Cr (VI) causes dystrophic and degenerative changes in all rats retina layers. They increase as the duration of the experiment. The use of Enterosgel as a corrective therapy showed positive results in restoring the morphological structure of rats retina. After Enterosgel 20 days using as a corrector of Cr (VI) exposure, there is a barely noticeable swelling of the outer and inner nuclear layers. Other layers of the retina, morphologically, look undamaged. Forty days Enterosgel treatment have outer and inner nuclear layer edema of retina of animals persists but does not increase. It is easy noticeable swelling of the outer and inner layers of mesh, but no signs of damage processes of cell populations nuclear layers. State ganglionic layer and nerve fiber layer entirely satisfactory. These pathological changes are not critical. After 60 days from the beginning of loading of Cr (VI) and application of Enterosgel in the retina of rats there are initial degenerative changes in the photosensory layer. Cystic dilated outer segments of rods and cones were visible throughout, and areas of their fragmentation were observed. Ganglion neurons are not damaged, but their axons appear somewhat thickened and fluffy. But in general, the typical structure of the retina is preserved. Conclusions. Chromium-induced toxicity in rats is characterized by pronounced histological and morphometric changes and retinal thickness, which appear after 20 days, increase by 40 days and acquire maximum transformations after 60 days of the experiment. The use of Enterosgel improves picture morphological structures of the retina in rats under the influence of Cr (VI). The changes were expressed on days 20 and 40, which indicates the presence of protective properties for the retina

Embolismo pulmonar agudo en pacientes con neumonía por SARS-COV2. Serie de Casos. [Acute Pulmonary Embolism in patients with SARS-COV2 pneumonia. Cases report]

2021 ◽  
Vol 40 (03) ◽  
Author(s):  
Olmedo Villarreal ◽  
Lizeth Pinilla ◽  
Sabrina Trejos
Keyword(s):  
Pulmonary Embolism ◽  
Acute Pulmonary Embolism ◽  
Scoring Systems ◽  
Vascular Wall ◽  
Average Hospital ◽  
Vein Thrombosis ◽  
Thrombotic Complications ◽  
Deep Vein ◽  
Hospital General

<p>El síndrome respiratorio agudo severo coronavirus 2 (SARS-COV-2) descrito en Wuhan, China a finales del 2019, ha causado más de 9 millones de infecciones en el mundo, y más de 480 mil muertes. En Panamá se han reportado más de 28 mil casos, y más de 500 muertes por COVID-19. Se ha observado un alto riesgo de complicaciones trombóticas, probablemente como consecuencia del daño vascular asociado con la infección viral y la inflamación severa, con la contribución patógena de las plaquetas que interactúan con la pared vascular y los leucocitos. Describimos 3 casos de pacientes hospitalizados en un hospital general en la provincia de Panamá, República de Panamá. Dos hombres y una mujer, edad promedio 40.6 años, estadía hospitalaria promedio de 35.3 días; ingresados con diagnóstico de neumonía por SARS-COV-2, niveles elevados de dimero D (&gt; 5 ug/mL), riesgo bajo calculado para embolia pulmonar. Encontrando embolia pulmonar aguda en las ANGIO tomografía y en un caso acompañado de trombosis venosa profunda. Todos recibían dosis profiláctica de heparina de bajo peso molecular. Se necesitan algoritmos para identificar a aquellos susceptibles de desarrollar complicaciones trombóticas y enfermedades graves, determinar el papel de los biomarcadores y sistemas de puntuación para estratificar el riesgo.</p><p><strong>Abstract</strong></p><p>The severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) described in Wuhan, China in late 2019, has caused more than 9 million infections worldwide, and more than 480 thousand deaths. In Panama, more than 28 thousand cases have been reported, and more than 500 deaths from COVID-19. A high risk of thrombotic complications has been observed, probably as a consequence of vascular damage associated with viral infection and severe inflammation, with the pathogenic contribution of platelets that interact with the vascular wall and leukocytes. We describe 3 cases of patients hospitalized in a general hospital in the province of Panama, Republic of Panama. Two men and one woman, average age 40.6 years, average hospital stay of 35.3 days; admitted with a diagnosis of SARS-VOC-2 pneumonia, elevated levels of dimer D (&gt; 5 ug / mL), calculated low risk for pulmonary embolism. Finding acute pulmonary embolism on ANGIO tomography and in one case accompanied by deep vein thrombosis. All received prophylactic doses of low molecular weight heparin. Algorithms are needed to identify those susceptible to developing thrombotic complications and serious diseases, determine the role of biomarkers and scoring systems to stratify risk.</p>

scholarly journals MORPHOLOGICAL PREDICTORS OF VEIN THROMBOSIS DEVELOPMENT UNDER CONDITIONS OF ONCOPATHOLOGY

2019 ◽  
Vol 18 (4) ◽  
pp. 82-89
Author(s):  
P. Ya. Bodnar ◽  
Ya. Ya. Bodnar ◽  
Z. M. Nebesna ◽  
Yu. V. Soroka
Keyword(s):  
Skeletal Muscle ◽  
Colon Cancer ◽  
Endothelial Cells ◽  
Cancer Patients ◽  
Hind Limb ◽  
Coagulation System ◽  
Structural Components ◽  
Vein Thrombosis ◽  
Intravascular Thrombosis ◽  
Venous Wall

Nowadays pulmonary embolism is the second most common cause of death for cancer patients. The reason for this is activation of the blood coagulation system, depression of the coagulation system and fibrinolysis, decrease in the linear velocity of blood flow, phlebohypertension, as well as varicose reorganization of the vascular wall, its valves and endothelial cells. However, structural changes of veins as predictors of vein thrombosis in cancer patients are not sufficiently covered. At the same time, knowledge of these changes is important for understanding pathogenesis and prevention of thromboembolic complications. Objective: to find out the peculiarities of the restructuring of the structural components of the venous wall as a source of possible primary formation of intravascular thrombosis under conditions of oncogenic pathology. Material and methods. Histologic, submicroscopic and polarization data of the study of hind limb veins of 12 sexually mature non-linear rats - males weighing 170-180 g for 30 days of chronic neoplastic intoxication and vein fragments of 12 patients with colon cancer complicated by thrombosis were analyzed. Chronic neoplastic intoxication was simulated by subcutaneously injecting 7.2 mg / kg (based on the active substance) subcutaneously into the interscapular area once a week for 30 weeks, according to the weight of the animal at the rate of 0.1 ml of dimethylhydrazine hydrochloride solution (DMH). 10 grams of the body weight of rat 1,2-DMH (from SIGMA-ALDRICH CHEMIE, made in Japan, series D161802) pre-diluted with isotonic sodium chloride solution. Results and Discussion. Morphological studies of hind limb veins in experimental neoplastic intoxication mainly concerned submicroscopic reorganization of the endothelial cells and their desquamation, as well as platelet sweetening, which may be one of the links in pathogenesis of thrombus formation. Histological and electron microscopic examination of biopsy of the veins of patients with colon cancer found disorders of laminar intima, desquamation of endothelial cells, sclerosis of all membranes of the deep vein and neoplasm of vessels in the middle membrane. Patients with cancer are considred to have dystrophic-necrotic changes of skeletal muscle, which is one of the links in pathogenesis of hemodynamic disorders in the venous system of the lower extremities. Conclusions. The features of restructuring of the structural components of the venous wall, as a source of possible primary formation of intravascular thrombosis under conditions of oncogenic pathology include focal loss of integrity of the endothelial layer, endothelial dysfunction, sweetening of platelets, fibrotic remodeling of tunica intima, tunica media, tunica adventitia, neovascularization of tunica media, dystrophic and sclerotic changes of the skeletal muscle.

scholarly journals PHYSIOLOGICAL AND REPARATIVE OSTEOGENESIS IN THE NORM AND UNDER CONDITIONS OF SELENIUM DEFICIENCY

World Science ◽  
2019 ◽  
Vol 2 (8(48)) ◽  
pp. 17-20
Author(s):  
Kovalchuk P. Ye. ◽  
Tulyulyuk S. V. ◽  
Biryuk I. G.
Keyword(s):  
Traumatic Injury ◽  
Frontal Plane ◽  
Selenium Deficiency ◽  
Male Rats ◽  
Osseous Tissue ◽  
Experimental Conditions ◽  
Reparative Osteogenesis ◽  
Negative Effect ◽  
Post Traumatic ◽  
Osseous Regeneration

The study presents the results of investigation of selenium deficiency condition on the bone tissue and healing post-traumatic bone defects under conditions of selenium deficiency.The experimental part of the study was performed on 63 randomized brand albino male rats of 3-month age. Peculiarities of the reparative osteogenesis were studied on the model of a traumatic injury simulated one-type in the proximal meta-diaphysis of the femoral bone irrespective of the experimental conditions in the frontal plane in the form of perforated defect. The defect was made by means of a drill 1mm in diameter.The results of the study are indicative of a negative effect of selenium deficiency produced on physiological and reparative osteogenesis manifested by inhibition of the process and associated with disorders in the formation of osseous regeneration, deterioration of the structural-functional state of the osseous tissue, development of degenerative-necrotic changes in the osseous tissue and epiphyseal cartilage.

scholarly journals Reorganization of the structural elements of the venous wall in oncogenic pathology

2021 ◽  
Vol 6 ◽  
pp. 32-37
Author(s):  
P.Ya. Bodnar ◽  
Ya.Ya. Bodnar ◽  
T.V. Bodnar ◽  
L.P. Bodnar
Keyword(s):  
Pulmonary Embolism ◽  
Retrospective Analysis ◽  
Cancer Patients ◽  
Structural Changes ◽  
Male Rats ◽  
Structural Elements ◽  
Hind Limbs ◽  
Blood Clots ◽  
The Relationship ◽  
Venous Wall

The objective: an identification of changes and reorganization of structural elements of the venous wall, their correlation with cancer processes in the organism; the establishment of the relationship between structural changes in the wall of the venous vessels and thrombosis, with the following complications; the determination of the necessity of the preventive measures to avoid complications. Materials and methods. Histological, submicroscopic and polarization data of the research of the veins of the hind limbs of 12 sexually mature nonlinear male rats weighing 170–180 g on the 30th day of chronic neoplastic intoxication were analyzed. A retrospective analysis of the autopsy protocols of cancer patients (n=54), the largest incidences – pulmonary embolism, during 2014-2018 in the Ternopil Regional Clinical Oncology Center was performed. The average age of women who died was 61.93±1.51 years and 62.44±2.61 years – for men.Results. As a result of morphological examination of the veins of the hind limbs of rats with experimental neoplastic intoxication revealed mainly submicroscopic reorganization of endothelial cells and their desquamation, as well as platelet aggregation that can be one of the links in the pathogenesis of thrombosis.According to a retrospective analysis of the autopsy protocols, the proportion of pulmonary embolism was higher among women (61.1 %) than men (38.9 %). The structure of oncopathology in this group of patients: bronchial and lung cancer (18.5 %); neoplasms of the uterine body (22.2 %); rectum cancer (13.0 %), colon cancer (7.4 %), rectosigmoid junction cancer (5.6 %); bladder cancer (9.3 %); gastric cancer (7.4 %); ovarian cancer (7.4 %); prostate cancer (5.6 %); thyroid cancer (1.8 %); pancreatic cancer (1.8 %). In all cases of autopsy phlebothrombosis of the deep veins of the leg and thigh with impaired blood flow caused by occlusion by blood clots of various manifestations of the structural organization was revealed. In five cases, fresh red blood clots were found, which were closely connected with the intima by fibrin threads, in five other cases – red blood clots were freely located in the lumen of the vein, swelling of all layers of the vein, fibrous structure and diffuse neutrophil infiltration were found. In the remaining 44 cases, vein occlusion was detected by already organized thrombi with signs of fibrosis, recanalization, and revascularization.Conclusions. The study of the morphology of rat hind limb veins with experimental neoplastic intoxication mainly revealed changes in the shape, structure and function of endotheliocytes, their desquamation and changes in all three layers of the venous wall as well as platelet ligation. The relationship between the presence of changes in the venous wall as a result of cancer and the formation of thrombosis was found. The number of thromboembolic complications emphasizes the necessity to prevent thrombosis in cancer patients.

scholarly journals REPARATIVE OSTEOGENESIS IN NORMAL STATE AND UNDER CONDITIONS OF IODINE DEFICIENCY

World Science ◽  
2019 ◽  
Vol 2 (8(48)) ◽  
pp. 11-13
Author(s):  
Kovalchuk P. Ye. ◽  
Gasko М. V. ◽  
Tulyulyuk S. V. ◽  
Shutka V. J.
Keyword(s):  
Iodine Deficiency ◽  
Traumatic Injury ◽  
Frontal Plane ◽  
Male Rats ◽  
Osseous Tissue ◽  
Experimental Conditions ◽  
Reparative Osteogenesis ◽  
Negative Effect ◽  
Post Traumatic ◽  
Osseous Regeneration

The study presents the results of investigation of iodine deficiency condition on the bone tissue and healing post-traumatic bone defects under conditions of iodine deficiency.The experimental part of the study was performed on 63 randomized brand albino male rats of 3-month age. Peculiarities of the reparative osteogenesis were studied on the model of a traumatic injury simulated one-type in the proximal meta-diaphysis of the femoral bone irrespective of the experimental conditions in the frontal plane in the form of perforated defect. The defect was made by means of a drill 1mm in diameter.The results of the study are indicative of a negative effect of iodine deficiency produced on reparative osteogenesis manifested by inhibition of the process and associated with disorders in the formation of osseous regeneration, deterioration of the structural-functional state of the osseous tissue, development of degenerative-necrotic changes in the osseous tissue and epiphyseal cartilage.

Addressing the Issue of the Pathogenesis of Deep Vein Thrombosis In Cancer

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4220-4220
Author(s):  
Grace M Thomas ◽  
Alexander Brill ◽  
Daphne Schatzberg ◽  
Denisa D. Wagner
Keyword(s):  
Deep Vein Thrombosis ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Conflicts Of Interest ◽  
Mesenteric Arteries ◽  
Vein Thrombosis ◽  
Tumor Bearing ◽  
Thrombotic Complications ◽  
Deep Vein

Abstract Abstract 4220 The risk of thrombotic complications during tumor development has been the focus of several clinical studies over the past decades. Thrombotic disease is a common cause of death in cancer patients and almost one in five of all symptomatic cases of Deep Vein Thrombosis (DVT) are thought to be cancer related. Tumor cells generate and profit from a local and systemic hypercoagulable state, which promotes tumor growth, angiogenesis, and metastasis. The resulting procoagulant state is responsible for the heightened risk for thrombotic complications and the etiology of the resulting DVT event. However, despite the fact that some molecules, such as tissue factor, have recently been described as potential modulators of clot formation in DVT, the true trigger of DVT in cancer patients remains unknown. To determine whether the presence of cancer cells can trigger formation of a thrombus in a deep vein in vivo, we combined a murine model of Trousseau's Syndrome with a model of DVT. First, we induced the development of a tumor by subcutaneous injection of syngeneic pancreatic tumor cells in C57BL/6 mice. It was previously demonstrated that these mice have significantly reduced tail bleeding time and time to occlusion in injured mesenteric arteries and veins compared to control vessels. After 3 hours of partial flow restriction of the inferior vena cava, we observed that all tumor-bearing mice developed an occlusive thrombus (n=8) while only 29% of the control mice (n=7) formed occlusive thrombi. Interestingly, perfusion of cancer-derived microparticles in mice also induced thrombus formation in this DVT model, reproducing the tumor-bearing mice phenotype. This new approach showed that microparticles shed by cancer cells have a key role in the pathogenesis of cancer-associated DVT, and they may become a reasonable pharmaceutical target to prevent thrombosis associated with cancer development. Disclosures: No relevant conflicts of interest to declare.

scholarly journals MORPHOLOGICAL CHANGES AND PRODUCTION OF REACTIVE OXYGEN AND NITROGEN SPECIES IN RAT TESTES UNDER CONDITIONS OF PROLONGED CENTRAL DEPRIVATION OF TESTOSTERONE SYNTHESIS

2020 ◽  
Vol 20 (3) ◽  
pp. 205-210
Author(s):  
Ye.V. Stetsuk ◽  
O.Ye. Akimov ◽  
A.V. Mishchenko
Keyword(s):  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Morphological Changes ◽  
Reactive Oxygen ◽  
Vascular Wall ◽  
Male Rats ◽  
Quantitative Composition ◽  
Interstitial Tissue ◽  
Previous Period ◽  
Testosterone Synthesis

Male sex hormones in general, and testosterone in particular, play an important role not only during puberty in young men; they are also needed to maintain intercellular interaction in the testes. The question regarding the influence of the central regulation of testosterone synthesis on changes in the testes during prolonged deprivation of the stimulus to testosterone production is still open. The aim of this research was to study changes in the production of nitric oxide and superoxide anion radical, morphological changes in the testes of rats under conditions of prolonged (270 and 365 days) central deprivation of testosterone synthesis. The experiments were carried out on 15 sexually mature white male rats of the Wistar line. The animals were divided into 3 groups of 5 animals in each. The first group (control) received subcutaneous injection of sodium chloride 0.9% for 365 days. In the second and third groups, central deprivation of testosterone synthesis was performed for 270 and 365 days, respectively. Central deprivation of testosterone synthesis was modelled by the administration of dipherelin (triptorelin) in a dose of 0.3 mg / kg subcutaneously. On the 270th day of the experiment, changes were noted in the interstitial tissue, with manifestations of fibrosis. Disturbances in the microvascular bed were manifested by endothelial dysfunction and an increase in the density of the vascular wall, associated with both the qualitative and quantitative composition of altered interstitial cells and microvessels. The 365th day of the experiment, like the previous period of the experiment, was characterized by changes in both parenchymal and interstitial components of the testes. In the interstitial tissue, fibrosis can be noted with a decrease in the quantitative composition of interstitial endocrinocytes. The interstitial spaces between the convoluted tubules are enlarged in comparison with the previous period of the experiment. The production of nitric oxide reduced on 270th and 365th days of the experiment by 68.5% and 42.6%, respectively, and the production of superoxide radical anion was increased in 5 and 5.5 times, respectively. Central deprivation of testosterone synthesis on 270th and 365th days leads to fibrosis and systemic stasis of the interstitial tissue with subsequent disruption of the structural organization of the convoluted seminiferous tubules, violation of hemodynamics, endothelial dysfunction, and an increase in the density of the vascular wall of blood vessels. A decrease in the production of nitric oxide by constitutive isoforms of NO-synthase with central deprivation of testosterone synthesis by 270 and 365 days results in an increase in the production of reactive oxygen species in the testes of rats.

scholarly journals Endotelial dysfunction in condition of neoplastic intoxication

2021 ◽  
Vol 25 (3 (99)) ◽  
pp. 19-24
Author(s):  
P. Bodna ◽  
Ya. Bodnar ◽  
T. Bodnar ◽  
Yu. Soroka ◽  
L. Bodnar
Keyword(s):  
Pulmonary Embolism ◽  
Body Weight ◽  
Rheological Properties ◽  
Cancer Patients ◽  
Structural Changes ◽  
Morphological Structure ◽  
Male Rats ◽  
Morphological Examination ◽  
Endothelial Layer ◽  
Venous Wall

In patients with cancer, the risk of pulmonary embolism increases 4-7 times compared to other patients of the same age and similar concomitant diseases. The greatest risk exists after surgery and during chemotherapy. An increase in the risk of thrombosis in cancer patients is a multifactorial complex phenomenon, the causes of which are an increase in the number of platelets, changes in the rheological properties of blood, as well as reactive structural changes in the vascular wall, valves and endotheliocytes. The latter factor of pathogenesis is insufficiently studied and is not used to assess the risks of thrombosis and prevent thrombosis in cancer patients. However, this topic is promising in the search for opportunities to study the pathogenesis of pulmonary embolism, and, accordingly, to assess the risks in different groups of patients and methods of prevention and options for clinical tactics in cases of venous thrombosis.Objective. To find out the dynamics of the concentration of lipid peroxidation products, in particular the activity of phospholipase and catalase in experimental neoplastic intoxication. Material and methods. For the experiment, 12 sexually mature nonlinear male rats with a body weight of 170-180 g were selected. by injecting 7.2 mg/kg into the rat interscapular area at the rate of 0.1 ml of dimethylhydrazine hydrochloride (DMG) solution 1.2 – DMG (SIGMA-ALDRICH CHEMIE, Japan, D161802 series), previously diluted with isotonic sodium chloride solution per 10 grams of rat body weight, a tumor was modeled intoxication. On day 30 of the experiment, the animals were sacrificed, and the material of the venous wall of the lower extremities was studied for the morphological structure of the vascular wall.Results and Discussion. Morphological examination of the drug revealed platelet thinning, desquamation and microscopic reorganization of endotheliocytes, focal loss of endothelial layer integrity, and wavy thickening of the intima. This complex of phenomena can be the basis of the pathogenesis of thrombosis in combination with a violation of hemodynamics and rheological properties of blood. On day 30 of the experiment, a morphological study of the drug was performed on the venous wall of rats.Conclusions. Changes that were detected after modeling chronic tumor intoxication include endothelium changes in the form of desquamation and reorganization, violation of the integrity of the endothelial layer, wavy thickening of the intima, fibrotic changes in all the membranes of the vessel.

scholarly journals Characteristics of the functional status of hemostasis in women after type I hysterectomy according to their body mass index

2021 ◽  
pp. 24-27
Author(s):  
P.Ya. Bodnar ◽  
◽  
Ya.Ya. Bodnar ◽  
T.V. Bodnar ◽  
B.D. Kryvokulsky ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Deep Vein Thrombosis ◽  
Body Mass ◽  
The Body ◽  
Type I ◽  
Vein Thrombosis ◽  
Oncological Patients ◽  
Oncological Diseases ◽  
Thrombotic Complications ◽  
Deep Vein

Neoplastic processes are a pathogenic trigger for the development of thrombotic complications, including deep vein thrombosis and pulmonary artery thromboembolism. Post-operative thrombosis is one of the leading mortality causes of oncological patients due to its asymptomatic course, and therefore due to the late diagnosis and treatment. Purpose — to estimate the coagulation system condition in women after the type I hysterectomy depending on their body mass index. Materials and methods. The study of hemostasis parameters of 50 patients with the uterus and uterine appendages oncological diseases depending on the body mass index was carried out. The results were processed by the method of variation statistics, which became the basis for their generalization. Calculations of the parametric Student's t-test and methods of nonparametric statistics (Mann–Whitney test) were used. Differences between comparable parameters were found statistically significant at p<0.05. Results. The analysis of hemostasis parameters in oncological patients has revealed a twice higher concentration of fibrinogen and soluble fibrin monomer complexes in comparison to the control group. All three groups were characterized by hyperthrombocytopenia. The surgery provoked further activation of I, II, and III phases of coagulation on the background of negative thrombodynamics caused by intraoperative blood loss. In women with I and II obesity grade no statistically significant differences in coagulogram were observed, whereas in patients with III obesity grade the thrombotic potential was significantly more aggressive. Conclusions. Oncological diseases of the female reproductive system are associated with the impairment of coagulation status: lower activated partial thromboplastin, hyperfibrinogenemia, and increased prothrombin index. The surgery was a significant trigger of the increase of hemostatic potential with the progressive increase of the markers of I, II, and III coagulation phases. III obesity grade is an independent risk factor for thrombotic complications. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local Ethics Committee of all participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: oncogenesis, deep vein thrombosis, clotting, obesity, complications.

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