scholarly journals Constitutional markers of urticaria and their prognostic significance (analysis of scientific literature)

2021 ◽  
Vol 25 (4) ◽  
pp. 668-671
Author(s):  
Aladwan Amjed Mashoor Ahmad
Keyword(s):  
Clinical Practice ◽  
Scientific Literature ◽  
Prognostic Significance ◽  
Clinical Manifestations ◽  
Individual Variability ◽  
Adverse Outcomes ◽  
Phenotypic Marker ◽  
Genetic Predictors ◽  
The Individual ◽  
Made In

Annotation. The purpose of the work is to analyze the scientific literature regarding the constitutional markers of urticaria and their prognostic significance. The analysis of modern scientific literature in the scientometric databases PubMed and MEDLINE is carried out. A review of the literature indicates that significant progress has been made in understanding the etiopathogenesis of urticaria in recent decades, with some clinical and anamnestic signs suggestive of adverse outcomes. However, identifying patients with the highest risk of complications remains an unresolved issue. In connection with the development and implementation in clinical practice of methods of genetic typing, much attention is paid to the search for genetic predictors of adverse course of this dermatosis. To date, phenotypic marker profiles that have been little modified over a lifetime and available for visualization in everyday clinical practice have not been properly considered in assessing the risk of urticaria. Modern anthropocentric approach to solving the problem of risk prediction in urticaria opens up the prospect of taking into account constitutional (personality-typological, somato-typological) and genetic factors that are the basis of psychobiological reactivity of the individual, determining individual variability of pathogenesis and clinical manifestations, patterns severity and frequency of complications.

scholarly journals The Flexural Strength of Traditional and Modern Acrylic Prosthetic Bases

2020 ◽  
Vol 57 (3) ◽  
pp. 111-116
Author(s):  
Liviu Gavrila-Ardelean ◽  
Mihaela Gavrila-Ardelean
Keyword(s):  
Clinical Practice ◽  
Clinical Utility ◽  
Scientific Literature ◽  
Mechanical Test ◽  
Test Machine ◽  
Statistical Correlations ◽  
Dental Acrylic ◽  
Prosthesis Material ◽  
Made In

The aim of this paper is to investigate the resistance to flexure of traditional and modern dental acrylic prosthetic bases. The practical utility of the laboratory studies carried out in this research is to apply the physical properties of plastic in medical technology, for improved clinical practice. The clinical utility of this research on prosthetic acrylic bases resistance is reflected in the quality of life of patients, the quality of mastication and durability of the prosthesis. Material and methods: experimental research, using a mechanical test machine. The results were analysed through quantitative methodes. Statistical correlations were made in the final experimental part. In conclusion, the values obtained in our experiments are comparable with those found in scientific literature. This fact enables us to recommend the use of the injection molding technique in clinical practice in our country, as well as the abandonment of the traditional manual stuffingpressing process.

scholarly journals Response and Toxicity to Cytarabine Therapy in Leukemia and Lymphoma: From Dose Puzzle to Pharmacogenomic Biomarkers

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 966
Author(s):  
Raffaele Di Francia ◽  
Stefania Crisci ◽  
Angela De Monaco ◽  
Concetta Cafiero ◽  
Agnese Re ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Clinical Outcome ◽  
Genetic Variants ◽  
Neoplastic Meningitis ◽  
Individual Variability ◽  
Intracellular Accumulation ◽  
Pyrimidine Nucleoside ◽  
Comprehensive Information ◽  
Multiagent Chemotherapy ◽  
The Individual

Cytarabine is a pyrimidine nucleoside analog, commonly used in multiagent chemotherapy regimens for the treatment of leukemia and lymphoma, as well as for neoplastic meningitis. Ara-C-based chemotherapy regimens can induce a suboptimal clinical outcome in a fraction of patients. Several studies suggest that the individual variability in clinical response to Leukemia & Lymphoma treatments among patients, underlying either Ara-C mechanism resistance or toxicity, appears to be associated with the intracellular accumulation and retention of Ara-CTP due to genetic variants related to metabolic enzymes. Herein, we reported (a) the latest Pharmacogenomics biomarkers associated with the response to cytarabine and (b) the new drug formulations with optimized pharmacokinetics. The purpose of this review is to provide readers with detailed and comprehensive information on the effects of Ara-C-based therapies, from biological to clinical practice, maintaining high the interest of both researcher and clinical hematologist. This review could help clinicians in predicting the response to cytarabine-based treatments.

scholarly journals Secondary exocrine pancreatic insufficiency. Features of the choice of the enzyme

2021 ◽  
pp. 192-199
Author(s):  
I. G. Pakhomova
Keyword(s):  
Clinical Practice ◽  
Enzyme Preparation ◽  
Pancreatic Insufficiency ◽  
Clinical Manifestations ◽  
Exocrine Pancreatic Insufficiency ◽  
Individual Characteristics ◽  
Negative Consequences ◽  
Exocrine Insufficiency ◽  
Enzyme Replacement ◽  
The Individual

Exocrine pancreatic insufficiency is quite common in clinical practice of doctors of many specialties. Decrease in intraduodenal lipase levels below 5–10% of normal leads to pancreatic steatorrhea, weight loss and a potential decrease in quality of life. These clinical manifestations are more often presented in patients with a primary genesis of exocrine pancreatic insufficiency, while secondary exocrine insufficiency is more often subclinical, which predetermines its early diagnosis. However, many methods for diagnosing exocrine pancreatic insufficiency, which have been developed and used in clinical practice in recent years, have low sensitivity or specificity, or are time-consuming and poorly tolerated by patients. The method for determining the level of coprological elastase is not always reliable, especially in patients with chronic diarrhea, which predetermines its implementation in formalized stool, for example, during therapy. It is important to take into account the fact that with moderate exocrine pancreatic insufficiency, the sensitivity and specificity of assessing the level of fecal elastase can weaken by 30%. However, regardless of the receipt of diagnostic data and the cause of the development of exocrine pancreatic insufficiency, the goal of therapy is to eliminate the processes of maldigestion and malabsorption, reduce the severity of symptoms of indigestion and prevent their negative consequences. At the  same time, it is necessary to include an enzyme preparation in the complex therapy, the choice of which, its dosage and duration of therapy are determined taking into account the individual characteristics of the patient and the severity of exocrine pancreatic insufficiency. In addition, in patients with suspected exocrine pancreatic insufficiency due to clinical manifestations, it is possible to use empirical enzyme replacement therapy. An example of such an approach for patients with secondary exocrine insufficiency is the appointment of the enzyme preparation containing pancreatin.

scholarly journals Plasma levels of long-acting injectable antipsychotics in outpatient care: a retrospective analysis

2020 ◽  
Author(s):  
Martin Hýža ◽  
Šilhán Petr ◽  
Češková Eva ◽  
Skřont Tomáš ◽  
Kacířová Ivana ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Plasma Levels ◽  
Drug Application ◽  
Individual Variability ◽  
Therapeutic Drug ◽  
Fluphenazine Decanoate ◽  
Blood Samples ◽  
Usual Clinical Practice ◽  
Long Acting ◽  
The Individual

Abstract Background The antipsychotic efficacy in schizophrenia depends on its availability in the organism. Although therapeutic outcomes remain still far from satisfactory, therapeutic drug monitoring is not a common part of clinical practice during a treatment with long-acting injectable antipsychotics (LAI AP). The real effectiveness of LAI AP is thus uncertain. Methods We made a retrospective evaluation of plasma levels of LAI AP. Collection of blood samples was performed just before the drug application and one week later. Fourty patients with a stabilized clinical condition and steady-state plasma levels were included. Results In the observed cohort of patients, flupentixol decanoate (n = 23) was the most often used drug, followed by fluphenazine decanoate (n = 7), haloperidol decanoate (n = 5), paliperidon palmitate (n = 3), and risperidone microspheres (n = 2). Just 5 of 40 patients were treated with a monotherapy. At the time before the application, 60% of the patients did not reach the therapeutic reference range (TRR) and 20% of the patients had an undetectable plasma level. At the time of collection of the second blood samples performed after 7 days, 24% of the patients were under the TRR. Conclusion We have found the surprisingly high incidence of plasma levels under the TRR in patients treated with LAI AP. Notwithstanding the individual variability in pharmacokinetics, it seems the LAI AP may be underdosed in the usual clinical practice.

Diagnosis and Management of Cardiomyopathies – A Focus on Genetics, Cardiac Magnetic Resonance and Clinical Features

2011 ◽  
Vol 7 (3) ◽  
pp. 225
Author(s):  
Gianfranco Sinagra ◽  
Michele Moretti ◽  
Giancarlo Vitrella ◽  
Marco Merlo ◽  
Rossana Bussani ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Imaging Techniques ◽  
Molecular Genetic ◽  
Molecular Genetic Analysis ◽  
Routine Clinical Practice ◽  
Clinical Approach ◽  
Diagnosis And Management ◽  
Made In

In recent years, outstanding progress has been made in the diagnosis and treatment of cardiomyopathies. Genetics is emerging as a primary point in the diagnosis and management of these diseases. However, molecular genetic analyses are not yet included in routine clinical practice, mainly because of their elevated costs and execution time. A patient-based and patient-oriented clinical approach, coupled with new imaging techniques such as cardiac magnetic resonance, can be of great help in selecting patients for molecular genetic analysis and is crucial for a better characterisation of these diseases. This article will specifically address clinical, magnetic resonance and genetic aspects of the diagnosis and management of cardiomyopathies.

THE STUDY OF THE INDIVIDUAL VARIABILITY OF THE LINEAR DIMENSIONS OF THE SPHENOID SINUS

2019 ◽  
Vol 21 (1) ◽  
pp. 64-70
Author(s):  
O.V. Mareev ◽  
◽  
G.O. Mareev ◽  
M.E. Gutynina ◽  
D.A. Maksimova ◽  
...  
Keyword(s):  
Sphenoid Sinus ◽  
Individual Variability ◽  
Linear Dimensions ◽  
The Individual

Disseminated intravascular coagulation syndrome

2020 ◽  
pp. 22-40
Author(s):  
A. Kulikov
Keyword(s):  
Clinical Practice ◽  
Disseminated Intravascular Coagulation ◽  
Blood Cells ◽  
Physical State ◽  
Clinical Manifestations ◽  
Vascular Wall ◽  
Stages Of Development ◽  
Intravascular Coagulation ◽  
Hemostatic Disorder

Presented material reveals main links in the pathogenesis of hemostatic disorder. In particular, attention is paid to the role of the lungs, liver and other organs in the development of this process. Role of vascular wall and blood cells in regulation of the physical state of blood is described in detail. The most frequent factors leading to hypercoagulation are indicated. Difference between hypercoagulation and thrombophilia is shown. The latter is found in clinical practice quite often, but at the same time, it is poorly diagnosed. Such a terrible complication of hemostatic disorder as disseminated intravascular coagulation is described. Its classification, stages of development, clinical manifestations are offered to the readers.

STUDYING SOME CLINICAL AND PARACLINICAL CHARACTERISTICS OF POSMATURE BABIES CARED IN NICU AT HUE UNIVERSITY HOSPITAL

2012 ◽  
pp. 74-84
Author(s):  
Thi Kieu Nhi Nguyen
Keyword(s):  
Respiratory Rate ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
University Hospital ◽  
Maternal Characteristics ◽  
Exact Test ◽  
Menstrual Cycles ◽  
Term Newborns ◽  
Student’S T ◽  
The Individual

Objectives: 1. Estimating the ratios of clinical and paraclinical signs of post-term newborns hospitalized at Pediatric Department of Hue University Hospital. 2. Identifying the relation between clinical signs and paraclinical signs. Materials and Method: 72 post- term babies < 7 days of life hospitalized at NICU from 2010/5 to 2011/4. Classification of post - term newborn was based on WHO 2003: gestational age ≥ 42 weeks with clinical manifestations: desquamation on press with fingers or natural desquamation, withered or meconial umbilicus, meconial long finger nails (*) or geatational age still < 42 weeks with theses clinical manifestations (*). Data were recorded on a clinical record form. Per-protocol analysis of clinical outcomes was performed by using Medcalc 11.5 and Excell 2007. Analyses used the χ2 test or Fisher's exact test for categorical data; Student's t test was used for continuous data and the Mann-Whitney U test for nonparametric data. Data were presented as means or proportions with 95% CIs. Results: Clinical characteristics: Tachypnea and grasp were main reasons of hospitalisation (48.61%). Poor feeding, vomitting (16.67%). Asphyxia (8.34%). Jawndice (6.94%). Hypothermia < 36.50C (13.89%), fever (13.89%). Tachypnea (59.72%). Bradycardia (1.39%). Poor feeding (11.11%). Hypertonia (9.72%). Paraclinical characteristics: Erythrocytes < 4.5.1012/l (51.39%), Leucocytes 5 – 25.103/mm3 (81.94%), Thrombocytes 100- 400.103/mm3 (94.44%). Hemoglobinemia < 10mg/l (67.61%). Maternal characteristics: Menstrual cycles regular (75%). Primiparity (75%). Amniotic volume average (70.42%), little (29.58%). Aminiotic liquid clair (62.5%), aminiotic liquid yellow (4.17%), aminiotic meconial liquid (33.33%). Maternal manifestation of one of many risk factors consist of genital infection; urinary infection; fever before, during, after 3 days of birth; prolonged delivery; medical diseases influence the foetus (75%). The relation between clinical signs and paraclinical signs: There was significantly statistical difference: between gestationnal age based on obstetrical criteria and amniotic volume on ultrasound (p < 0.05); between birth weight and glucosemia p < 0.02). There was conversional correlation of average level between erythroctes number and respiratory rate (r = - 0.5158; p < 0,0001), concordance correlation of weak level betwwen leucocytes number and respiratory rate r = 0.3045; p = 0.0093). Conclusion: It should made diagnosis of postterm baby based on degree of desquamation. The mother who has menstrual cycles regular is still delivered of a postterm baby. A postterm baby has the individual clinical and paraclinical signs.

A Handbook to Eddic Poetry: Myths and Legends of Early Scandinavia, ed. Carolyne Larrington, Judy Quinn, and Brittany Schorn. Cambridge: Cambridge University Press, 2016, xii, 413 pp., 12 b/w ill.

Mediaevistik ◽  
2018 ◽  
Vol 31 (1) ◽  
pp. 366-366
Author(s):  
Albrecht Classen
Keyword(s):  
Old Norse ◽  
Entire Volume ◽  
Cambridge University ◽  
Critical Studies ◽  
Individual Contributions ◽  
The Many ◽  
The Individual ◽  
Made In ◽  
Scandinavian Literature

Eddic poetry constitutes one of the most important genres in Old Norse or Scandinavian literature and has been studied since the earliest time of modern-day philology. The progress we have made in that field is impressive, considering the many excellent editions and translations, not to mention the countless critical studies in monographs and articles. Nevertheless, there is always a great need to revisit, to summarize, to review, and to digest the knowledge gained so far. The present handbook intends to address all those goals and does so, to spell it out right away, exceedingly well. But in contrast to traditional concepts, the individual contributions constitute fully developed critical article, each with a specialized topic elucidating it as comprehensively as possible, and concluding with a section of notes. Those are kept very brief, but the volume rounds it all off with an inclusive, comprehensive bibliography. And there is also a very useful index at the end. At the beginning, we find, following the table of contents, a list of the contributors, unfortunately without emails, a list of translations and abbreviations of the titles of Eddic poems in the Codex Regius and then elsewhere, and a very insightful and pleasant introduction by Carolyne Larrington. She briefly introduces the genre and then summarizes the essential points made by the individual authors. The entire volume is based on the Eddic Network established by the three editors in 2012, and on two workshops held at St. John’s College, Oxford in 2013 and 2014.

The Chemical Effect in Medicine Interaction Determining the Form and Speed of Psychical Involution in the Prosthetic Restauration in the Edentulous

2018 ◽  
Vol 69 (8) ◽  
pp. 2306-2310
Author(s):  
Aureliana Caraiane ◽  
Razvan Leata ◽  
Veronica Toba ◽  
Doina Vesa ◽  
Luana Andreea Macovei ◽  
...  
Keyword(s):  
Practical Importance ◽  
Psychosocial Problems ◽  
Well Being ◽  
The Elderly ◽  
Chemical Effect ◽  
Special Importance ◽  
Dramatic Form ◽  
Specific Disorders ◽  
The Individual ◽  
Made In

The progress made in dentistry during the latest decades is due, conceptually, to the new, systemic vision of man, which has also taken place in this field of medicine. In this context, the link between organic and psychic is indestructible. Thus illness is understood as a drama in which the somatic process has a psychic value, and the mental one has a body value. It is known that the morphological and functional integrity of the dental system, health and vigorousness, gives the individual a state of well-being that affects his somatic and psychic health, as any disturbance at this level entails repercussions in psychological and social behavior. Such a disruption is the total edification that seriously alters not only the dental system but the whole organism, putting various biological and psychosocial problems to the practitioner. The total expression represents not only a physical disability but also a psychological one. A special importance in studying psychological changes at total edentulous presents the psychological aspects of senile involution. This is not only a theoretical but also a practical importance due to the increase in the number of elderly people. Through the researches of the present paper we intend to present the reality of the psychological manifestations in the total edentation, which is objectified on different methods of psychodiagnosis in the first part, in order for the second part to be addressed to problems of prosthetic psychotherapy.The study comprises a group of 43 patients, of whom 24 were men and 19 women with total uni or bimaxilar edentation. Total edentation can be and is responsible for somatopsychic alterations, along with other pathogens, general, local, social, which sometimes can take a dramatic form, converting, where the area is also favorable, a pure somatic disease, for those who are not in psychopathy or even psychosis, although these latter cases are extremely rare and especially in youngsters, which would disrupt not only the person�s behavior as an individual, but also their status, function and social integrity. The treatment of dental and psychological complex is mandatory for any patient, but especially for the elderly, where recovery is more difficult, with disease-specific disorders adding to those of senescence.

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