scholarly journals LABORATORY CONTROL OF ANTICOAGULANT PROPHYLAXIS IN PREGNANT WOMEN WITH CARDIOVASCULAR DISEASES

World Science ◽  
2021 ◽  
Author(s):  
V. Medved ◽  
T. Savka
Keyword(s):  
Heart Disease ◽  
Side Effects ◽  
Pregnant Women ◽  
Cardiovascular System ◽  
Laboratory Research ◽  
Primary Hemostasis ◽  
Different Types ◽  
Mechanisms Of Formation ◽  
Negative Effect ◽  
Anticoagulant Prophylaxis

This article examines the effect of anticoagulant prophylaxis on pregnancy, childbirth and the postpartum period in women with heart disease. Тhe main mechanisms of formation of side effects from anticoagulant prophylaxis in pregnant women with diseases of the cardiovascular system were studied by means of laboratory research methods,. Have been studied the effects and interaction of different types of anticoagulant prophylaxis and aspirin prophylaxis on primary hemostasis. An algorithm for diagnosing the negative effect of anticoagulants on platelets has been developed. The study examines the possibility of drug correction of the development of side effects from anticoagulant thromboprophylaxis for women with diseases of the cardiovascular system.

scholarly journals CONDITION OF BONE TISSUE IN PREGNANT WOMEN WITH DISEASES OF THE CARDIOVASCULAR SYSTEM ON THE BACKGROUND OF ANTICOAGULANT PREVENTION

2021 ◽  
Author(s):  
V. Medved ◽  
T. Savka
Keyword(s):  
Heart Disease ◽  
Side Effects ◽  
Pregnant Women ◽  
Cardiovascular System ◽  
Bone Metabolism ◽  
Clinical Manifestations ◽  
Skeletal System ◽  
Sonographic Examination ◽  
Anticoagulant Prophylaxis ◽  
The Relationship

The article presents data on the development of side effects from anticoagulant prophylaxis in pregnant women with diseases of the cardiovascular system. In particular, the anticoagulant effects on the skeletal system. Were studied the features of sonographic examination in this category of patients. The level of the main biomarkers of osteosynthesis and osteoresorption during pregnancy was studied. Were analyzed the influence of anticoagulants on the level of biomarkers of bone metabolism. Has been studied the relationship between densitometry data and calcitonin levels in pregnant women. The main aspects of the formation of osteopenic syndrome and osteoporosis in pregnant women with heart disease are considered. Has been studied the relationship between the clinical manifestations of osteopenic syndrome and the level of biomarkers of bone metabolism. Proposed the drug correction of the development of side effects due to anticoagulant thromboprophylaxis.

scholarly journals Cardiotoxic effects induced by the use of antimetabolites in the chemotherapy of oncological diseases

2021 ◽  
Vol 12 (3) ◽  
pp. 177-181
Author(s):  
Alina A. Aliab'eva ◽  
Galina S. Mal
Keyword(s):  
Side Effects ◽  
Cardiovascular System ◽  
Cancer Patients ◽  
Clinical Manifestations ◽  
Vascular Pathology ◽  
Malignant Neoplasms ◽  
Heart Damage ◽  
Negative Effect ◽  
Modern Medical Practice ◽  
Search For Information

In modern medical practice, the treatment of cancer is one of the most pressing issues. Many of the drugs used in the treatment of cancer have a toxic effect on the cardiovascular system of patients. The main clinical manifestations of cardiotoxicity are ischemic heart damage, rhythm disturbances, thrombosis, angina, asymptomatic changes in the electrocardiogram, and others. Side effects can develop both during the treatment period and months after the end of the course of chemotherapy. This is especially important for patients with concomitant cardiac or vascular pathology, since the severity of developing side effects can lead to disability or death of cancer survivors. The article discusses the data on the frequency of detection of the negative effect of pyrimidine, purine and folic acid antagonists on the cardiovascular system of cancer patients, the mechanisms of cardiotoxic effects of drugs in such patients, the possibilities of preventing heart damage and correcting for already developed lesions. The aim of this work is to collect, compare and systematize the available disparate data on the cardiotoxic effects of antitumor drugs of the antimetabolite group. An important condition for saving and preserving the quality of life of cancer patients is the identification of cardiovascular pathologies at the stage of preparation for chemotherapy, which can be facilitated by the active cooperation of oncologists and cardiologists. The search for information was carried out on the bases of scientific medical publications (eLibrary.ru, PubMed) taking into account the clinical recommendations for the treatment of malignant neoplasms.

scholarly journals Use of Routine Echocardiographic Screening for Structural Heart Disease in At-Risk Pregnant Women in India

2020 ◽  
Author(s):  
Amisha Patel ◽  
Lauren S. Ranard ◽  
Nicole Aranoff ◽  
Hussein Rahim ◽  
Roja Vanukuru ◽  
...  
Keyword(s):  
At Risk ◽  
Heart Disease ◽  
Pregnant Women ◽  
Structural Heart Disease ◽  
Women In India

Effects of ball properties on throwing in young team-handball beginners

2021 ◽  
pp. 174795412110236
Author(s):  
Frowin Fasold ◽  
Benjamin Noël ◽  
André Nicklas ◽  
Fabian Lukac ◽  
Stefanie Klatt
Keyword(s):  
Experimental Study ◽  
Movement Patterns ◽  
Team Handball ◽  
Throwing Accuracy ◽  
Different Types ◽  
Negative Effect ◽  
Study Participants

Throwing a ball is a primary skill in team-handball and can be directly influenced by the properties of different types of balls. Therefore, the use of different balls (i.e., methodic ball) recommended by the handball federations (e.g., IHF) and the education guidelines, are important in teaching throwing. Previous studies have shown that movement patterns and throwing velocity can be influenced by different ball types and sizes. However, the influence of these factors on throwing accuracy has not been investigated in detail yet. This study aims to replicate the findings of previous studies on increasing throwing velocity in children by comparing the use of a soft methodic ball with a size 0 handball. Furthermore, this study investigates the influence of these balls on throwing accuracy. In an experimental study, participants (10-years of age) threw a soft methodic ball and a size 0 ball at target areas in a handball goal. For all the throws, throwing velocity and accuracy were measured. Commensurate with previous research, throwing velocity was higher for the soft methodic ball compared to a size 0 ball. No difference was found in accuracy, although, it is worth mentioning that the participants were only experienced in throwing using the size 0 ball. Moreover, only one-third of the children favored throwing with a size 0 ball, which is what they are used to in training and competition. The results of our study, therefore, confirm that using soft methodic balls additionally, positively influences the throwing velocity and has no negative effect on the accuracy in throwing among young handball beginners.

scholarly journals Comparison of viromes in vaginal secretion from pregnant women with and without vaginitis

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
He-Teng Zhang ◽  
Hao Wang ◽  
Hai-Sheng Wu ◽  
Jian Zeng ◽  
Yan Yang
Keyword(s):  
Human Papillomavirus ◽  
Bacterial Community ◽  
Pregnant Women ◽  
Sequence Comparison ◽  
Pairwise Sequence Comparison ◽  
Vaginal Secretion ◽  
The Family ◽  
Complete Genomes ◽  
Different Types ◽  
Vaginal Tract

Abstract Background Although some studies have investigated the bacterial community in vaginal tract of pregnant women, there are few reports about the viral community (virome) in this type of microenvironment. Methods To investigate the composition of virome in vaginal secretion samples, 40 vaginal secretion samples from pregnant women with vaginitis and 20 vaginal secretion samples from pregnant women without vaginitis, pooled into 4 and 2 sample pools, respectively, were subjected to viral metagenomic analysis. Results Results indicated virus sequences showing similarity to human papillomavirus (HPV), anellovirus, and norovirus were recovered from this cohort of pregnant women. Further analysis indicated that 15 different defined types and one unclassified type of HPV were detected from pregnant women with vaginitis while only 3 defined types of HPV were detected in pregnant women without vaginitis. Five different groups of viruses from the family Anelloviridae were present in pregnant women with but none of them were detected in pregnant women without vaginitis. Norovirus was detected in 3 out of the 4 sample pools from pregnant women with vaginitis but none in the pregnant women without vaginitis. Twelve complete genomes belonging to 10 different types of HPV, and 5 novel anllovirus genomes belonging 2 different genera in Anelloviridae were acquired from these libraries, based on which phylogenetical analysis and pairwise sequence comparison were performed. Phageome in these samples was also briefly characterized and compared between two groups. Conclusion Our data suggested that virome might play an important role in the progression of vaginitis in pregnant women.

scholarly journals Contemporary use of Selexipag in pulmonary arterial hypertension associated with congenital heart disease: a case series

2020 ◽  
Author(s):  
Sarah Blissett ◽  
David Blusztein ◽  
Vaikom S Mahadevan
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Pulmonary Arterial Hypertension ◽  
Side Effects ◽  
Arterial Hypertension ◽  
Exercise Capacity ◽  
Congenital Heart ◽  
Pulmonary Veins ◽  
Case Series ◽  
Pulmonary Arterial

Abstract Background There are significant risks of parenteral prostacyclin use in patients with pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD), which may limit their use. Selexipag is an oral, selective prostacyclin analogue that has been shown to reduce disease progression and improve exercise capacity in patients with PAH-CHD. Administering Selexipag in patients with PAH-CHD could potentially overcome some of the risks of parenteral therapy while improving clinical outcomes. Case summary We report five cases highlighting the clinical uses of Selexipag in patients with PAH-CHD. In the first two cases, Selexipag was initiated as part of a Treat-to-close strategy. In the third case, initiation of Selexipag improved symptoms and objective exercise capacity in a patient with Eisenmenger syndrome. In the fourth and fifth cases, rapid cross-titration protocols were used to transition from parenteral prostacyclins to Selexipag. In the fourth case, Selexipag was initiated in the context of significant side effects limiting parenteral prostacyclin use. In the fifth case, Selexipag was used to down-titrate from parenteral prostacyclins following closure of a sinus venosus atrial septal defect and redirection of anomalous pulmonary veins. Discussion Selexipag is a promising oral therapy for patients with at various stages of the spectrum of PAH-CHD to improve symptoms, exercise capacity and, in some cases, haemodynamics. Our cases also highlight practical aspects of Selexipag use including targeting the individualized maximally tolerated dose for each patient, managing side effects and managing dose interruptions.

scholarly journals ADVERSE CARDIOVASCULAR AND OBSTETRIC DELIVERY COMPLICATIONS IN PREGNANT WOMEN WITH VALVULAR HEART DISEASE

2021 ◽  
Vol 77 (18) ◽  
pp. 3389
Author(s):  
Anum Minhas ◽  
Faisal Rahman ◽  
Nicole Gavin ◽  
Ari Cedars ◽  
Arthur Vaught ◽  
...  
Keyword(s):  
Heart Disease ◽  
Pregnant Women ◽  
Valvular Heart Disease ◽  
Obstetric Delivery ◽  
Delivery Complications

scholarly journals The Nanosystems Involved in Treating Lung Cancer

Life ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 682
Author(s):  
Andreea Crintea ◽  
Alina Gabriela Dutu ◽  
Gabriel Samasca ◽  
Ioan Alexandru Florian ◽  
Iulia Lupan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Side Effects ◽  
Chromosomal Rearrangements ◽  
Sirna Delivery ◽  
Delivery Systems ◽  
Inorganic Nanoparticles ◽  
New Methods ◽  
Different Types ◽  
Or Gene ◽  
The Many

Even though there are various types of cancer, this pathology as a whole is considered the principal cause of death worldwide. Lung cancer is known as a heterogeneous condition, and it is apparent that genome modification presents a significant role in the occurrence of this disorder. There are conventional procedures that can be utilized against diverse cancer types, such as chemotherapy or radiotherapy, but they are hampered by the numerous side effects. Owing to the many adverse events observed in these therapies, it is imperative to continuously develop new and improved strategies for managing individuals with cancer. Nanomedicine plays an important role in establishing new methods for detecting chromosomal rearrangements and mutations for targeted chemotherapeutics or the local delivery of drugs via different types of nano-particle carriers to the lungs or other organs or areas of interest. Because of the complex signaling pathways involved in developing different types of cancer, the need to discover new methods for prevention and detection is crucial in producing gene delivery materials that exhibit the desired roles. Scientists have confirmed that nanotechnology-based procedures are more effective than conventional chemotherapy or radiotherapy, with minor side effects. Several nanoparticles, nanomaterials, and nanosystems have been studied, including liposomes, dendrimers, polymers, micelles, inorganic nanoparticles, such as gold nanoparticles or carbon nanotubes, and even siRNA delivery systems. The cytotoxicity of such nanosystems is a debatable concern, and nanotechnology-based delivery systems must be improved to increase the bioavailability, biocompatibility, and safety profiles, since these nanosystems boast a remarkable potential in many biomedical applications, including anti-tumor activity or gene therapy. In this review, the nanosystems involved in treating lung cancer and its associated challenges are discussed.

Sign in / Sign up

Export Citation Format

Share Document