scholarly journals CONDITION OF BONE TISSUE IN PREGNANT WOMEN WITH DISEASES OF THE CARDIOVASCULAR SYSTEM ON THE BACKGROUND OF ANTICOAGULANT PREVENTION

2021 ◽  
Author(s):  
V. Medved ◽  
T. Savka
Keyword(s):  
Heart Disease ◽  
Side Effects ◽  
Pregnant Women ◽  
Cardiovascular System ◽  
Bone Metabolism ◽  
Clinical Manifestations ◽  
Skeletal System ◽  
Sonographic Examination ◽  
Anticoagulant Prophylaxis ◽  
The Relationship

The article presents data on the development of side effects from anticoagulant prophylaxis in pregnant women with diseases of the cardiovascular system. In particular, the anticoagulant effects on the skeletal system. Were studied the features of sonographic examination in this category of patients. The level of the main biomarkers of osteosynthesis and osteoresorption during pregnancy was studied. Were analyzed the influence of anticoagulants on the level of biomarkers of bone metabolism. Has been studied the relationship between densitometry data and calcitonin levels in pregnant women. The main aspects of the formation of osteopenic syndrome and osteoporosis in pregnant women with heart disease are considered. Has been studied the relationship between the clinical manifestations of osteopenic syndrome and the level of biomarkers of bone metabolism. Proposed the drug correction of the development of side effects due to anticoagulant thromboprophylaxis.

scholarly journals LABORATORY CONTROL OF ANTICOAGULANT PROPHYLAXIS IN PREGNANT WOMEN WITH CARDIOVASCULAR DISEASES

World Science ◽  
2021 ◽  
Author(s):  
V. Medved ◽  
T. Savka
Keyword(s):  
Heart Disease ◽  
Side Effects ◽  
Pregnant Women ◽  
Cardiovascular System ◽  
Laboratory Research ◽  
Primary Hemostasis ◽  
Different Types ◽  
Mechanisms Of Formation ◽  
Negative Effect ◽  
Anticoagulant Prophylaxis

This article examines the effect of anticoagulant prophylaxis on pregnancy, childbirth and the postpartum period in women with heart disease. Тhe main mechanisms of formation of side effects from anticoagulant prophylaxis in pregnant women with diseases of the cardiovascular system were studied by means of laboratory research methods,. Have been studied the effects and interaction of different types of anticoagulant prophylaxis and aspirin prophylaxis on primary hemostasis. An algorithm for diagnosing the negative effect of anticoagulants on platelets has been developed. The study examines the possibility of drug correction of the development of side effects from anticoagulant thromboprophylaxis for women with diseases of the cardiovascular system.

scholarly journals Side Effects Experience on Behavior of Pregnant Women Consuming Iron Tablets

2020 ◽  
Vol 2 (2) ◽  
pp. 69-73
Author(s):  
Istiana Intan ◽  
Munayarokh Munayarokh ◽  
Siti Rofi'ah
Keyword(s):  
Developing Countries ◽  
Data Analysis ◽  
Side Effects ◽  
Pregnant Women ◽  
Random Sampling ◽  
Health Workers ◽  
Deficiency Anemia ◽  
Stratified Random Sampling ◽  
Cross Sectional ◽  
The Relationship

Background: Anemia was a disease that attracts worldwide concern and was a very big problem, especially in developing countries. The factor that caused high iron deficiency anemia in pregnant women was the low compliance of pregnant women in consuming iron tablets. Side effects in the form of nausea were the reason pregnant women did not comply with Iron tablets. The purpose of this study was to determine the relationship between the side effects experience and the behavior of pregnant women in consuming Iron tablets. This type of research was quantitative with analytic survey and using a cross sectional approach.Methods: This type of research was quantitative with analytic survey and using a cross sectional approach. The population in this study were pregnant women in the second and third trimesters in the working areaof the Puskesmas Tempuran, Magelang Regency based on the February-March 2019 cohort, totaling 177 pregnant women with a sample of 123 pregnant women, calculated using the Slovin formula. The samplingtechnique used Proportionate Stratified Random Sampling. Data analysis used Kendall tau test.Results: The results showed that most of the pregnant women who consumed Iron tablets had side effectsexperience caused by the behavior of pregnant women in consuming Iron tablets, mostly in the low category.Conclusion: There was a relationship between the side effects experience and the behavior of pregnant women in consuming Iron tablets. It was recommended that pregnant women consume Iron tablets regularly in accordance with the recommendations of health workers so that they can prevent anemia.

scholarly journals EFFECT OF OBESITY ON BONE METABOLISM

2021 ◽  
Vol 67 (2) ◽  
pp. 67-75
Author(s):  
I.G. Litovka ◽  
Keyword(s):  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Energy Metabolism ◽  
Bone Metabolism ◽  
Current Literature ◽  
The State ◽  
Skeletal System ◽  
Treatment And Prevention ◽  
Prevalence Of Obesity ◽  
The Relationship

The review of current literature presents data on the prevalence of obesity and its impact on bone metabolism. These results suggest that there is a complex multilevel relationship between the skeletal system, adipose tissue and energy metabolism. However, informational analysis of the problem has shown that there are still many unresolved issues regarding the relationship between metabolic and osteopenic syndromes. At the same time, studies of the state of the skeletal system in metabolic syndrome and obesity can contribute to a deeper understanding of the pathogenesis of osteopenic syndrome to develop its treatment and prevention.

Severe Acute Respiratory Syndrome by COVID-19 in pregnant and postpartum women

2021 ◽  
Vol 21 (suppl 2) ◽  
pp. 461-469
Author(s):  
Ana Paula Nogueira Godoi ◽  
Gilcelia Correia Santos Bernardes ◽  
Nivea Aparecida de Almeida ◽  
Saulo Nascimento de Melo ◽  
Vinícius Silva Belo ◽  
...  
Keyword(s):  
Heart Disease ◽  
Severe Acute Respiratory Syndrome ◽  
Pregnant Women ◽  
Descriptive Analysis ◽  
Ventilatory Support ◽  
Clinical Manifestations ◽  
Morbidity And Mortality ◽  
Epidemiological Surveillance ◽  
Postpartum Women ◽  
Risk Of Death

Abstract Objectives: to evaluate the morbidity and mortality profile and factors associated with death due to severe acute respiratory syndrome (SARS) by COVID-19 in pregnant and postpartum women. Methods: this is a quantitative and retrospective research that analyzed the SIVEP-gripe Database (Influenza Epidemiological Surveillance Information System), from 01/01/2020 to 04/01/2021. All pregnant women and postpartum women diagnosed with SARS caused by COVID-19 in the State of Minas Gerais were included. After the descriptive analysis of the hospitalizations profile, the association between different exposure variables and the occurrence of death was evaluated. Results: of the 227 records obtained, 94.3% required hospitalization. Among hospitalizations in the Intensive Care Unit, 29.8% used invasive ventilatory support. Fifteen deaths were recorded. The most frequent clinical manifestations were: cough and fever; the predominant comorbidities were cardiovascular disease and diabetes mellitus. The variables “ICU stay”, “use of ventilatory support” and “heart disease” were associated with the occurrence of deaths. Conclusions: hospitalization was necessary for most pregnant women with SARS and the presence of previous heart disease increased the risk of death. Knowing the SARS morbidity and mortality profile is important in the definition of public health strategies aimed at reducing the impacts of COVID-19 during pregnancy and the puerperium.

scholarly journals Topical issues of cardiovascular disease in patients with new coronoviral infection COVID-19. Clinical and morphological study

2021 ◽  
Vol 40 (2) ◽  
pp. 63-68
Author(s):  
Elizaveta V. Zbyshevskaya ◽  
Tatyana I. Makeeva ◽  
Fatima I. Bitakova ◽  
Marina N. Bakholdina ◽  
Elena V. Sivtsova ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
Acute Myocardial Infarction ◽  
Pulmonary Embolism ◽  
Cardiovascular System ◽  
Histological Study ◽  
Clinical Manifestations ◽  
Study Results ◽  
Coronavirus Infection ◽  
The Relationship

In about 30% of cases, Sars-CoV-2 pneumonia is complicated by damage to the cardiovascular system myocardial infarction, pulmonary embolism, strokes, which are often fatal. There is still little data on the relationship between clinical manifestations and structural changes in the cardiovascular system during a new coronavirus infection. The material for the study was the data of the case histories and autopsies of 185 patients suffering from COVID-19 infection in the period SeptemberDecember 2020. In the deceased patients, a higher percentage of lung tissue damage was recorded on CT data, and a low level of oxygen saturation at the time of hospitalization. Most of the patients had a history of cardiovascular disease, diabetes mellitus, chronic kidney disease, and cancer. The pronounced course of systemic immune inflammation was manifested by a high average level of indicators such as D-dimmer, ferritin, C-reactive protein and fibrinogen. Among the causes of death, respiratory failure prevailed against the background of infectious-toxic shock. Damage to the cardiovascular system was manifested by the development of acute myocardial infarction, pulmonary embolism, stroke. Evaluation of the data of postmortem examination revealed a higher prevalence of stroke and a lower incidence of pulmonary embolism and acute myocardial infarction. In a histological study, damage to the cardiovascular system is represented by direct damage to the myocardium in the form of microcytolysis of cardiomyocytes with the development of necrotic areas. The data obtained from the analysis of the study results allow us to draw conclusions about the relationship between the severity of the course of a new coronavirus infection and the frequency of damage to the cardiovascular system, as well as make assumptions about individual links in the pathogenesis of cardiovascular disease in COVID-19 (1 figure, 2 tables, bibliography: 10 refs).

scholarly journals Cardiotoxic effects induced by the use of antimetabolites in the chemotherapy of oncological diseases

2021 ◽  
Vol 12 (3) ◽  
pp. 177-181
Author(s):  
Alina A. Aliab'eva ◽  
Galina S. Mal
Keyword(s):  
Side Effects ◽  
Cardiovascular System ◽  
Cancer Patients ◽  
Clinical Manifestations ◽  
Vascular Pathology ◽  
Malignant Neoplasms ◽  
Heart Damage ◽  
Negative Effect ◽  
Modern Medical Practice ◽  
Search For Information

In modern medical practice, the treatment of cancer is one of the most pressing issues. Many of the drugs used in the treatment of cancer have a toxic effect on the cardiovascular system of patients. The main clinical manifestations of cardiotoxicity are ischemic heart damage, rhythm disturbances, thrombosis, angina, asymptomatic changes in the electrocardiogram, and others. Side effects can develop both during the treatment period and months after the end of the course of chemotherapy. This is especially important for patients with concomitant cardiac or vascular pathology, since the severity of developing side effects can lead to disability or death of cancer survivors. The article discusses the data on the frequency of detection of the negative effect of pyrimidine, purine and folic acid antagonists on the cardiovascular system of cancer patients, the mechanisms of cardiotoxic effects of drugs in such patients, the possibilities of preventing heart damage and correcting for already developed lesions. The aim of this work is to collect, compare and systematize the available disparate data on the cardiotoxic effects of antitumor drugs of the antimetabolite group. An important condition for saving and preserving the quality of life of cancer patients is the identification of cardiovascular pathologies at the stage of preparation for chemotherapy, which can be facilitated by the active cooperation of oncologists and cardiologists. The search for information was carried out on the bases of scientific medical publications (eLibrary.ru, PubMed) taking into account the clinical recommendations for the treatment of malignant neoplasms.

scholarly journals Relationship Between Nuchal Fold Thickness and Fetal Heart Disease in Pregnant Women Referred to a Pediatric Hospital in Bandar Abbas During 2018-2019

2019 ◽  
Vol 8 (2) ◽  
pp. 130-134
Author(s):  
Sepideh Fuladi ◽  
Maziar Rastegar
Keyword(s):  
Heart Disease ◽  
Pregnant Women ◽  
Fetal Heart ◽  
Fetal Echocardiography ◽  
Screening Method ◽  
Nuchal Translucency ◽  
Pediatric Hospital ◽  
Abdominal Sonography ◽  
Bandar Abbas ◽  
The Relationship

Background: Congenital heart disease (CHD) is of the most common congenital anomalies. Most of the major cardiac defects can be diagnosed by fetal echocardiography at 20 weeks of gestation. Evaluation of nuchal thickness can be the first stage of screening in the diagnosis of CHD. Therefore, this study aimed to investigate the relationship between nuchal translucency (NT) and CHD in pregnant women. Materials and Methods: The current study is an analytical-descriptive study conducted on fetuses of 44 pregnant women. Abdominal sonography of the participants at 10-14 weeks of gestation was performed, and they referred to a pediatric hospital in Bandar Abbas in order to undergo fetal echocardiography at 17-18 weeks of gestation. Results: The mean age of the participants was 28±6 years. Out of 44 pregnant women, fetal heart disease was diagnosed in 4 pregnancies (9%), one of whom was reported as 2.5≤NT<3.5 and three cases were reported as 3.5≤NT. Out of 40 women with no fetal heart disease, two cases had NT≥3.5, 12 cases had 2.5≤NT<3.5 and 26 cases had NT>2.5. Conclusion: The results of this study showed that 6.8% of the cases of CHD had an increase in the thickness of NT (NT≥3.5) at 10-14 weeks of gestation. The sensitivity of this screening method was 75% at 18-20 weeks of gestation which is low for general population. Therefore, NT cannot be regarded as the only or main screening tool for CHD.

scholarly journals Short-Term Outcomes of Atosiban in the Treatmentof Preterm Labour at the Sultan Qaboos University Hospital, Muscat, Oman

2021 ◽  
Vol 21 (2) ◽  
pp. e260-265
Author(s):  
Nihal Al-Riyami ◽  
Hanin Al-Badri ◽  
Sanjay Jaju ◽  
Silja Pillai
Keyword(s):  
Side Effects ◽  
Pregnant Women ◽  
Preterm Labour ◽  
Patient Outcome Assessment ◽  
Neonatal Outcomes ◽  
University Hospital ◽  
Sultan Qaboos University ◽  
Secondary Objective ◽  
The Relationship ◽  
Tocolytic Agents

Objectives: This study aimed to generate baseline evidence regarding the effectiveness of atosiban in delaying delivery by ≥48 hours among pregnant women presenting with threatened preterm labour (TPL). The secondary objective was to assess the relationship between atosiban success and various perinatal factors and neonatal outcomes. Methods: This retrospective study was conducted between June 2008 and May 2018 at the Sultan Qaboos University Hospital, Muscat, Oman. The medical records of all pregnant women who received atosiban between 24–34 gestational weeks for TPL during this period were reviewed. Results: A total of 159 women were included in the study. Atosiban was successful in delaying delivery by ≥48 hours in 130 cases (81.8%). Approximately half of the women (50.9%) achieved uterine quiescence in <12 hours. Failure to delay delivery by ≥48 hours was significantly lower among women with normal versus abnormal cervical findings (11.1% versus 25.6%; P = 0.023). Only 9.4% of women experienced minor side-effects. Mean birth weight (2,724.55 versus 1,707.59 g; P <0.001) and Apgar scores at 5 minutes (9.66 versus 8.28; P <0.001) were significantly higher among neonates delivered at ≥48 versus <48 hours post-atosiban, whereas the rate of neonatal respiratory distress syndrome was significantly lower (18.4% versus 81.6%; P <0.001). Conclusion: Atosiban was highly effective in delaying delivery by ≥48 hours and resulted in few adverse maternal side-effects and neonatal outcomes. To the best of the authors’ knowledge, this is the first study conducted in Oman to evaluate the effectiveness of atosiban in preventing preterm labour. Keywords: Preterm Labor; Atosiban; Tocolytic Agents; Treatment Outcome; Patient Outcome Assessment; Oman.

Results of study of biochemical markers of bone metabolism in men with coronary heart disease

2020 ◽  
pp. 39-43
Author(s):  
A. V. Voronkina ◽  
T. A. Raskina ◽  
M. V. Letaeva ◽  
Yu. V. Averkieva ◽  
O. S. Malyshenko ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Bone Formation ◽  
Bone Metabolism ◽  
Biochemical Markers ◽  
Coronary Atherosclerosis ◽  
Cathepsin K ◽  
Arterial Calcification ◽  
Mineral Density ◽  
Bone Remodeling Markers

The development of atherosclerosis is closely related to the calcification of the vessel intima and fibrous plaques, being a complex and multifactorial process, in which the markers of bone formation and resorption play an important role. Objective. To study the biochemical markers of bone metabolism in men with stable coronary heart disease (CHD). Material and methods. The study included 102 men with verified CHD. Data were evaluated by densitometry, coronary angiography, multispiral computed tomography, color duplex scanning of brachiocephalic arteries, serum lipids (total cholesterol, triglycerides [TG], high-density [LHD] and low-density lipoprotein cholesterol), concentrationsin the blood of osteocalcin (OC), bone alkaline phosphatase (BAP), cathepsin K and C-telopeptides (CTx). Results. Concentrations of BAP, cathepsin K and CTx in patients with CHD were significantly higher than in men without CHD. The concentration of OC in men with normal bone mineral density was significantly lower than in patients with osteopenic syndrome. There was a direct correlation between OC and antiatherogenic HDL cholesterol and the inverse correlation between OC and TG, CTx and TG. There was no correlation between the level of bone remodeling markers and coronary artery (CA) lesion variant and the severity of coronary atherosclerosis on SYNTAX scale. The correlation analysis did not reveal the connection of biochemical markers of bone metabolism with the severity of coronary atherosclerosis and calcification and thickness of intima-media complex of carotid arteries. Absolute values of bone formation indices (BAP, OC) were significantly higher in patients with severe СA calcification than in patients without signs of calcification. Summary. Increased rates of osteogenesis and osteoresorption characterize the accelerated process of bone metabolism and indicate in favor of high rates of bone loss in men with CHD, which confirms the likelihood of common pathophysiological mechanisms of bone resorption and arterial calcification.

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