scholarly journals CHANGE OF MINERAL DENSITY OF BONE TISSUE IN WOMEN IN PRE - AND POSTMENPAUSA AND ITS CORRECTION

ASJ. ◽  
2021 ◽  
Vol 1 (56) ◽  
pp. 28-33
Author(s):  
O. Kalinkina ◽  
Yu. Tezikov ◽  
I. Lipatov
Keyword(s):  
Bone Mineral Density ◽  
Hormone Therapy ◽  
Bone Mineral ◽  
Premenopausal Women ◽  
Menopausal Hormone Therapy ◽  
Age Group ◽  
Mineral Density ◽  
Treatment Of Osteoporosis ◽  
Age Related ◽  
Prevention And Treatment

87 patients aged 40-69 years in the period of pre- and postmenopause were examined. In the analysis of age-related dynamics of bone mineral density (BMD) It was found that densitometry indicators corresponding to osteoporosis directly correlate with age and duration of the postmenopausal period. It is advisable in women of this age group with a decrease in bone mineral density, the combined appointment of menopausal hormone therapy (MGT) and non-hormonal therapy affecting bone metabolism (calcitonin). For the purpose of MGT in premenopausal women, the use of femostone 2/10 is effective, in postmenopausal women - femostone 1/10 and femostone 1/5, which does not cause withdrawal bleeding. If there are contraindications to menopausal hormone therapy, the prevention and treatment of osteoporosis should be guided by the appointment of nonhormonal drugs, in particular, calcitonin.

scholarly journals Disparity in bone mineral density of males and females with age

2020 ◽  
Vol 8 (3) ◽  
pp. 429-438
Author(s):  
Nusrat Aziz
Keyword(s):  
Bone Mineral Density ◽  
Bone Mass ◽  
Bone Mineral ◽  
Financial Burden ◽  
Lifestyle Changes ◽  
Control Group ◽  
Age Group ◽  
Mineral Density ◽  
Age Related ◽  
Males And Females

Decline in bone mass with aging leads to osteoporosis and fragility fractures. It has profound effect on the morbidity and health quality of the elderly, creating financial burden on the society. Usually, age related loss in bone mass goes undiagnosed until a fragility fracture occurs. It was observed that the bone mineral density (BMD) was found to be lesser in females compared to males in all age groups. There were significant BMD differences between males and females from age 41 yrs and above, BMD declined with age in both males and females. The maximum decline was observed in age group of 41 yrs -50 yrs compared to the control group of 20 yrs-30 yrs. The decrease in BMD was highly noticeable in females, with osteoporosis from age group 51 yrs-60 yrs. It coincides with peri-menopausal and early after menopause period. In males osteoporosis was not observed until the age of 80yrs, though osteopenia have been observed from 41 yrs onwards. There is a paramount need of awareness about detrimental effects of aging on BMD in order to bring about necessary lifestyle changes and follow therapeutic measures. This enables us to attain higher peak bone mass and maintain higher bone densities.

scholarly journals Evaluation of Osteopenia and Osteoporosis among Female Doctors

2017 ◽  
Vol 32 (1) ◽  
pp. 25-28
Author(s):  
Setara Binte Kasem ◽  
Ferdousi Begum ◽  
Shaikh Abdur Razzaque ◽  
Raisa Adiba ◽  
Selma Anika
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Premenopausal Women ◽  
Cross Sectional Study ◽  
Age Group ◽  
Working Population ◽  
Mineral Density ◽  
Early Menopause ◽  
Cross Sectional ◽  
Care Problems

Osteopenia and Osteoporosis are increasing health care problems due to increased life expectancy. Women are specially vulnerable to osteoporosis at their later ages of lives. Among the working population of Bangladesh, female doctors make a big contribution for nation, so focusing on their wellbeing is very much important. In this study BMD (Bone Mineral density) were measured among 80 female doctors Objective: To find out the Bone Mineral Density (BMD) among working female doctors of Bangladesh. Materials and Methods: A cross sectional study was conducted on 80 female doctors aged between 25-80 years at their reproductive, premenopausal and postmenopausal age group, at a conference venue over a period of two days. Measurement of bone mineral density was done by quantitative ultrasound densitometry1. Result: Majority of women were between 30-64 years of age; 71(88.75%) women had normal BMD, 9(11.25%) women had osteopenia and none of them had osteoporosis. Among women with age between 25-44 years age (total 30) none was suffering from osteopenia or osteoporosis. Between 45-64 years (total 47), 8(17.02%) were suffering from osteopenia and between 65-80 years (total 3), 1(33.33%) was suffering from osteopenia. Nobody had osteoporosis. Conclusion: Among the working female gynaecologists of Bangladesh there were no osteopenia or osteoporosis in reproductive and premenopausal (25-44 years) age group.Only 17.04% of premenopausal women and women at early menopause ( 45-64 years) suffer from osteopenia and 33.33% of women at late menopause (65-80years) had osteopenia. None had osteoporosis. Bangladesh J Obstet Gynaecol, 2017; Vol. 32(1): 25-28

Review of the Literature Examining the Association of Serum Uric Acid with Osteoporosis and Mechanistic Insights into Its Effect on Bone Metabolism

2019 ◽  
Vol 19 (3) ◽  
pp. 259-273 ◽  
Author(s):  
Neelam Kaushal ◽  
Divya Vohora ◽  
Rajinder K Jalali ◽  
Sujeet Jha
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Uric Acid ◽  
Bone Metabolism ◽  
Serum Uric Acid ◽  
Bone Mineral ◽  
Molecular Mechanisms ◽  
Association Studies ◽  
Mineral Density ◽  
Age Related

Background And Objective:Osteoporosis is a common bone disorder that increases susceptibility to fragility bone fractures. The clinical and public health repercussions of osteoporosis are huge due to the morbidity, mortality, and cost of medical care linked with fragility fractures. Clinical assessment of osteoporotic risk factors can help to identify candidates at an early stage that will benefit from medical intervention and potentially lowering the morbidity and mortality seen with fractures and complications. Given this, research is ongoing to evaluate the association of osteoporosis with some novel or less well-studied risk factors/bio-markers such as uric acid (UA).Discussion:Uric acid’s antioxidant activity has been proposed to be one of the factors responsible for increasing longevity and lowering rates of age-related cancers during primate evolution, the level of which increased markedly due to loss of uricase enzyme activity (mutational silencing). Accumulated evidence shows that oxidative stress is the fundamental mechanism of age-related bone loss and acts via enhancing osteoclastic activity and increasing bone resorption. Antioxidant substances such as ascorbic acid scavenge free radicals are positively related to bone health. Thus, it is hypothesized that uric acid holds bone-protective potential owing to its potent antioxidative property. Several correlation studies have been conducted globally to investigate the relationship between serum uric acid with bone mineral density and osteoporosis. Few pre-clinical studies have tried to investigate the interaction between uric acid and bone mineral density and reported important role played via Runt-related transcription factor 2 (RUNX2)/core-binding factor subunit alpha-1 (CBF-alpha-1), Wingless-related integration site (Wnt)-3a/β-catenin signaling pathway and 11β Hydroxysteroid Dehydrogenase type 1.Conclusion:In this review, the authors provided a comprehensive summary of the literature related to association studies reported in humans as well work done until date to understand the potential cellular and molecular mechanisms that interplay between uric acid and bone metabolism.

scholarly journals POS0841 RISK FACTORS OF LOW BONE MINERAL DENSITY IN WOMEN WITH SYSTEMIC SCLEROSIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 674.2-675
Author(s):  
A. Efremova ◽  
N. Toroptsova ◽  
N. Demin ◽  
O. Dobrovolskaya ◽  
O. Nikitinskaya
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Systemic Sclerosis ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Cumulative Dose ◽  
Premenopausal Women ◽  
C Reactive Protein ◽  
Mineral Density ◽  
Reactive Protein

Background:Chronic inflammatory rheumatic diseases are risk factors of bone loss and fractures. Systemic sclerosis (SSc) has been recognized to be another potential inflammatory joint disease that may affect bone tissue.Objectives:to evaluate bone mineral density (BMD) and risk factors of low BMD in women with SSc.Methods:173 women, among them 110 postmenopausal (median age 60[55,63] years) and 63 premenopausal (median age 35[31,44] years). BMD was measured at lumbar spine (LS), femoral neck (FN) and total hip (TH) by dual energy X-ray absorptiometry (DXA, Hologic 4500A). Low BMD was diagnosed if the T-score was < -1.0 standard deviation (SD) in postmenopausal women and if the Z-score was < -2.0 SD in premenopausal women. The relationship between BMD and SSc patients’ characteristics was evaluated using univariate linear regression analysis.Results:Low BMD was found in 66% patients: 79% - in postmenopausal and 18% - in premenopausal women. Among postmenopausal persons osteoporosis was discovered in 47% and osteopenia – in 32% cases. In postmenopausal woman BMD of LS, FN and TH were associated with body mass index (BMI) (β=0.27, p=0.010; β=0.47, p<0,001 and β=0.45, p<0,001, respectively), duration of glucocorticoids (GCs) using (β=-0.31, p=0.008; β=-0.34, p=0.003 and β=-0.27, p=0.022, respectively); BMD of FN and TH with C-reactive protein (β= -0.32, p=0.016 and β= -0.29, p=0.029, respectively) and LS BMD with current and cumulative GCs dose (β= -0.24, p=0.039 and β= -0.29, p=0.014, respectively). In premenopausal women BMD of LS, FN and TH were associated with BMI (β=0.51, p<0,001; β=0.45, p=0.003 and β=0.47, p=0.002, respectively), duration of GCs using (β= -0.45, p=0.004; β= -0.47, p=0.003 and β= -0.48, p=0.002, respectively) and GCs cumulative dose (β= -0.48, p=0.002; β= -0.51, p=0.001 and β= -0.46, p=0.004, respectively); BMD of FN and TH with 25(ОН)D level (β=0.52, p=0.008 and β=0.54, p=0.005, respectively), and LS BMD with SSc duration (β= -0.44, p=0.004).Conclusion:Low BMD was diagnosed in 66% of women with SSc. Low BMI, GCs cumulative dose and duration of GCs using were independent risk factors for low BMD in both premenopausal and postmenopausal persons. Additional factors as SSc duration and low vitamin D level were found out for premenopausal and current GCs dose and C-reactive protein level for postmenopausal women.Disclosure of Interests:None declared

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