Malignant triton tumors of the spine

2008 ◽  
Vol 8 (6) ◽  
pp. 567-573 ◽  
Author(s):  
Greg James ◽  
Matthew Crocker ◽  
Andrew King ◽  
Istvan Bodi ◽  
Ahmed Ibrahim ◽  
...  
Keyword(s):  
Survival Data ◽  
Cauda Equina ◽  
Neurofibromatosis Type ◽  
Radical Resection ◽  
Spinal Tumors ◽  
Female Ratio ◽  
Spinal Stabilization ◽  
Peripheral Nerve Sheath Tumors ◽  
Male Female Ratio ◽  
Age Range

✓Malignant triton tumors (MTTs) are malignant peripheral nerve sheath tumors with rhabdomyosarcomatous differentiation. Malignant triton tumors affecting the spine are rare but present special challenges to the neurosurgeon. The authors report on 2 new cases of spinal MTTs, and analyze the 8 previously reported cases found via database search. The patients include a 15-year-old girl with thoracic MTT, and a 24-year-old man with lumbosacral MTT; both patients underwent radical resection with spinal stabilization. When these cases were combined with the literature results there was a male/female ratio of 6:4, and an age range of 15–67 years (median 37.5). Nine patients presented with symptoms related to the spinal cord, cauda equina, or nerve root compression. Four patients had undergone previous radiotherapy, and 2 had neurofibromatosis Type 1. Five cases of MTT were lumbosacral, 4 were thoracic, and 1 was cervical. Seven patients had intradural extension of tumor. All patients underwent some form of surgery, with 8 having total macroscopic excision. However, 6 patients required subsequent operations. In the 8 patients for which survival data was available, median time from diagnosis to death was 12 months (range 3–16). Malignant triton tumors are rare but should be included in the differential diagnosis of spinal tumors, particularly in patients who have undergone previous radiotherapy or who have neurofibromatosis. The authors suggest roles for radical surgery and multidisciplinary management.

scholarly journals Clinical features of spinal schwannomas in 65 patients with schwannomatosis compared with 831 with solitary schwannomas and 102 with neurofibromatosis Type 2: a retrospective study at a single institution

2016 ◽  
Vol 24 (1) ◽  
pp. 145-154 ◽  
Author(s):  
Peng Li ◽  
Fu Zhao ◽  
Jing Zhang ◽  
Zhenmin Wang ◽  
Xingchao Wang ◽  
...  
Keyword(s):  
Clinical Features ◽  
Cauda Equina ◽  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
Spinal Tumors ◽  
Female Ratio ◽  
Initial Symptoms ◽  
Lumbar Area

OBJECT The aim of this study was to evaluate the clinical features of spinal schwannomas in patients with schwannomatosis and compare them with a large cohort of patients with solitary schwannomas and neurofibromatosis Type 2 (NF2). METHODS The study was a retrospective review of 831 patients with solitary schwannomas, 65 with schwannomatosis, and 102 with NF2. The clinical, radiographic, and pathological data were extracted with specific attention to the age at onset, location of tumors, initial symptoms, family history, and treatment outcome. RESULTS The male-to-female ratio of patients with schwannomatosis (72.3% vs 27.7%) was significantly higher than that of patients with solitary schwannomas (53.3% vs 46.7%) and NF2 (54.0% vs 46.0%), respectively (chi-square test, p = 0.012). The mean age at the first spinal schwannoma operation of patients with NF2 (24.7 ± 10.2 years) was significantly younger than that of patients with solitary schwannomas (44.8 ± 13.2 years) and schwannomatosis (44.4 ± 14.1 years; 1-way ANOVA, p < 0.001). The initial symptoms were similar among the 3 groups, with pain being the most common. The distribution of spinal tumors among the 3 groups was significantly different. The peak locations of spinal schwannomas in patients with solitary schwannomas were at C1–3 and T12–L3; in schwannomatosis, the peak location was at T12-L5. A preferred spinal location was not evident for intradural-extramedullary tumors in NF2. Only a slight prominence in the lumbar area could be observed. The patients in the 3 groups obtained similar benefits from the operation; the recovery rates in the patients with solitary schwannomas, NF2, and schwannomatosis were 50.1%, 38.0%, and 53.9%, respectively. The prognosis varied among spinal schwannomas in the patients with schwannomatosis. Up until the last date of follow-up, most patients with schwannomatosis (81.5%) had undergone a single spinal operation, but 12 patients (18.5%) had undergone multiple spinal operations. Patients with nonsegmental schwannomatosis or those with early onset disease seemed to have a poor prognosis; they were more likely to undergo multiple spinal operations. Small cauda equina nodules were common in patients with schwannomatosis (46.7%) and NF2 (86.9%); these small schwannomas appeared to have relatively static behavior. Two patients suspicious for schwannomatosis were diagnosed with NF2 with the detection of constitutional NF2 mutations; 1 had unilateral vestibular schwannoma, and the other had suspicious bilateral trigeminal schwannomas. CONCLUSIONS The clinical features of spinal schwannomas vary among patients with solitary schwannomas, NF2, and schwannomatosis. Spinal schwannomas of patients with NF2 appear to be more aggressive than those in patients with solitary schwannomas and schwannomatosis. Spinal schwannomas of schwannomatosis predominate in the lumbar area, and most of them can be treated successfully with surgery. The prognosis varies among spinal schwannomas of schwannomatosis; some patients may need multiple operations due to newly developed schwannomas. Sometimes, it is difficult to differentiate schwannomatosis from NF2 based on clinical manifestations. It is prudent to perform close follow-up examinations in patients with undetermined schwannomatosis and their offspring.

scholarly journals Clinicopathological features of pilomatricoma cases: Analysis of 21 cases

2014 ◽  
Vol 4 (7) ◽  
pp. 530-533
Author(s):  
D Ghartimagar ◽  
A Ghosh ◽  
K Gautam ◽  
S Thapa ◽  
SR Shrestha ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Needle Aspiration ◽  
Common Finding ◽  
Clinical Impression ◽  
Aspiration Cytology ◽  
Female Ratio ◽  
Male Female Ratio ◽  
Needle Aspiration Cytology ◽  
Age Range ◽  
Slow Growing

Background: Pilomatricoma is a slow-growing, asymptomatic tumour originating from outer sheath cells of hair follicle. In this study, we describe the clinical presentation and histopathological features of pilomatricoma. Materials and Methods: This was a hospital based retrospective study carried out in all patients who were diagnosed as pilomatricoma over a period of January 2001 to December 2013. The study was done in department of pathology, Manipal Teaching Hospital, Nepal. Results: A total of 21 cases of pilomatricoma were reported with age range of 9-53 years (mean age 23.7) and male female ratio of 1:1.1. The most common site of occurrence was neck and preauricular region. The size of the tumour ranged from 0.3 to 4.7cm with a mean of 1.2cm. Multiple occurrences were seen in 3 patients and ossifying pilomarticoma was seen in 4 cases. Conclusion: Pilomatricoma is a benign skin neoplasm of hair follicle matrix cells. Calcification is a common finding while dystrophic ossification also can occur in the tumour. Histopathology gives the definite diagnosis as fine needle aspiration cytology and clinical impression may be misleading. DOI: http://dx.doi.org/10.3126/jpn.v4i7.10293 Journal of Pathology of Nepal (2014) Vol. 4, 530-533

scholarly journals Multiple Fatal Intoxications Caused by Improper Consumption of an Alcoholic Para-Pharmaceutical Product

2019 ◽  
Vol 70 (7) ◽  
pp. 2471-2476
Author(s):  
Camelia Liana Buhas ◽  
Bogdan Adrian Buhas ◽  
Lucia Georgeta Daina ◽  
Bianca Hanganu ◽  
Irina Smaranda Manoilescu ◽  
...  
Keyword(s):  
Pharmaceutical Products ◽  
Pharmaceutical Product ◽  
Chronic Ethanol ◽  
Deep Coma ◽  
Female Ratio ◽  
Examination Result ◽  
Chronic Ethanol Consumption ◽  
Male Female Ratio ◽  
Severe Intoxication ◽  
Age Range

Ingestion of cheap para-pharmaceuticals (such as disinfectants, deodorizing solutions, etc.) which are designed only for external use is an unfortunate habit encountered in the recent decades in the economically disadvantaged areas of Romania inhabited by poor, uninformed, and sanitary uneducated population. These para-pharmaceutical products are based on different concentrations of ethanol. Occasionally, the manufacturer modifies the product formula, or worse omits on the label that the ethanol was replaced with methanol, resulting in mass poisoning with a large number of casualties. The authors present a case of mass poisoning by methanol that occurred during one month and resulted in 40 cases of methanol intoxication. Only 5 out of the 40 victims survived the intoxication. All the dead victims underwent medico-legal autopsy which revealed only general features, liable to poisoning. The toxicological examination result was positive for methanol in all the cases. All the intoxicated victims were homeless; they were heavy ethanol consumers, especially of the product rubbing alcohol. The male: female ratio was 31:4 and the age range was between 25 and 70 years old, with an average of 50 years. All the victims were hospitalized in deep coma, showing obvious pathological changes specific to chronic ethanol consumption. Conclusions: some alcoholic para-pharmaceutical products manufactured for external use are ingested by chronic ethanol drinkers. When these products contain methanol, they can cause severe intoxication followed by an impressively large number of deaths.

scholarly journals Early Outcome of Laparoscopic Abdominoperineal Resection, Our Experience in Bangabandhu Sheikh Mujib Medical University

2014 ◽  
Vol 8 (2) ◽  
pp. 53-55
Author(s):  
Mohammed Tanvir Jalal ◽  
Shahadot Hossain Sheikh ◽  
Md Rayhanur Rahman ◽  
Mesbah Uddin Noman ◽  
Jesmin Akhter Leena ◽  
...  
Keyword(s):  
Abdominoperineal Resection ◽  
Operative Procedure ◽  
Operation Time ◽  
Postoperative Outcomes ◽  
Female Ratio ◽  
Early Outcome ◽  
Male Female Ratio ◽  
Laparoscopic Abdominoperineal Resection ◽  
Medical University ◽  
Age Range

Anorectal malignancies that require abdominoperineal resection (APR) is very common. Laparoscopic APR can be a better option. Laparoscopic APR has been seldom studied. This study aims to evaluate perioperative and early postoperative outcomes of laparoscopic APRs performed for the treatment of ano-rectal carcinomas. Patients operated for ano-rectal carcinoma between June 2011 to June 2013 in Bangabandhu Sheikh Mujib Medical University (BSMMU) were observed. Demographics, tumor and procedure-related parameters, perioperative results, early postoperative outcomes and survival were observed. Total 22 patients were under went laparoscopic APR. Male: Female ratio was 15:7 (68.18%: 31.82%). Age range was from 30-65 years with a mean age of 36.55 years. Mean operation time was 165 minutes and mean post-operative hospital stay was 6.8 days. Overall complication rate was 45.45%. Laparoscopic APR is a safe, effective and technically feasible procedure. It can be a better operative procedure than open APR. DOI: http://dx.doi.org/10.3329/fmcj.v8i2.20281 Faridpur Med. Coll. J. 2013;8(2): 53-55

scholarly journals Cognitive Style of Humanities, Commerce and Science Students – A Study on Higher Secondary Students from West Bengal

2016 ◽  
Vol 3 (2) ◽  
Author(s):  
Sukrita Mukherjee ◽  
Dr. Ishita Chatterjee
Keyword(s):  
Cognitive Style ◽  
Secondary Students ◽  
Economic Status ◽  
Science Students ◽  
School Students ◽  
Female Ratio ◽  
Male Female Ratio ◽  
Educational Guidance ◽  
And Gender ◽  
Age Range

Cognitive style or thinking style is a term used in cognitive psychology to describe the way individuals think, perceive and remember information. The present study aims to understand the cognitive style adapted by higher secondary students. The study sample consists of 90 higher secondary school students (30 each from science, humanities and commerce background). The male female ratio was 50:50. The age range was from 16-18 years. They were all from middle socio-economic status. They were administered an adapted version of cognitive style questionnaire by Ancona, Kochan, Scully, Van maanen and Westney. The results indicate for the dimension of Sensing there was significant effect of stream of study and gender. For the Intuition dimension again there was a significant effect of stream and gender. For Perceiving dimension also there was a significant effect of stream and gender. Sensing was highest for the science stream and lowest for the Humanities. Again Intuition was highest for the Humanities stream and lowest for the Science stream. The males have always scored highest in the dimension of Perceiving than their female counterparts both in Humanities and Science stream. And the female irrespective of the stream of study has scored higher in the Intuitive dimension. The present study is helpful in the field of designing educational guidance and curriculum for the Higher Secondary Students.

scholarly journals Prevalence of Lymphoma Cancer in Punjab, Pakistan

2015 ◽  
Vol 3 (2) ◽  
pp. 342-346
Author(s):  
Muhammad Zohaib Nawaz ◽  
Muhammad Bilal ◽  
Muhammad Aamer Mehmood ◽  
Muhammad Asgher
Keyword(s):  
Health Program ◽  
Cancer Type ◽  
Future Health ◽  
Female Ratio ◽  
Low Socioeconomic ◽  
Leading Role ◽  
High Magnitude ◽  
Male Female Ratio ◽  
Age Range ◽  
Registry Record

Pakistan has a high magnitude of cancer from its independence. The burden of lymphoma cancer continues to increase in Pakistan. The low socioeconomic districts of Punjab such as those in Faisalabad most severely affected by lymphoma. The objective of this study was to analyze the lymphoma cancer registry record of patients from the districts in Faisalabad in order to achieve a net lymphoma incidence for use in raising future health program against cancer. The medical records of 110 patients registered at the Punjab Institute of Nuclear Medicine in Faisalabad were investigated. Information regarding age, gender, socioeconomic status, affected sites and cancer type were obtained. Among 110 cases of lymphoma cancer, the male: female ratio was 3:1, with an age range of 5-85 years. Of the 110 patients, 74% were male and 26% were female. Similar to the subtype distribution of lymphoma in the different areas of Faisalabad and its surroundings, Non-Hodgkin’s lymphoma (NHL) was more frequent, 74 cases (67%) than Hodgkin’s disease (HD), 36 cases (33%).The leading cancers were breast 36% (n=248), lymphoma 16% (n=110), and prostate cancer 10% (n=68). The growing burden of cancer especially lymphoma in Faisalabad is extremely alarming. Since the current work was an initial investigation, it could play a leading role in prevention and future planning regarding the battle against lymphoma in Pakistan.Int J Appl Sci Biotechnol, Vol 3(2): 342-346 DOI: http://dx.doi.org/10.3126/ijasbt.v3i2.12756 

Demographic Analysis Of 90 Polycythemia Vera Egyptian Cases :  An Egyptian Reference Center Experience

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 5245-5245
Author(s):  
Mervat Mattar ◽  
Nihad Tawfik ◽  
Noha Elhosseiny ◽  
Mohamed Morad
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Polycythemia Vera ◽  
Gastrointestinal Symptoms ◽  
Female Ratio ◽  
Reference Center ◽  
Vein Thrombosis ◽  
Male Female Ratio ◽  
Lost To Follow Up ◽  
Age Range

Abstract Objective We report 90 cases of Polycythemia Vera ( PV )during the period between 2003 and 2013 followed up in an adult Cairo  hematology reference center Results Among 90 PV cases registered between 2003 and 2013, sixty eight cases (75.6%) of  whompresented in the last three years alone.  The age range was between 19 and 72 years with a mean of 53.5 years and 25 cases ( 27.78%) presented in the age group between 50-55 years.   Male : female ratio was 1.3:1.Fifty per cent of patients were urban while 50% lived in the country. Symptoms included headache (24 cases) (26.67%), tinnitus (7 cases) (7.78%), fatigue (14 cases) (15.56%), weight loss (5 cases)(5.56%), fever and sweating( 7 cases)( 7.78%) , bone or joint pains (22 cases)(24.44%), parasthesias (13 cases)(14.44%), pruritis(7 cases) (7.78%)  or abdominal discomfort (16 cases)(17.78% (Fig 1) Figure (1) : Incidence Of Symptoms Among 90 Egyptian PV Cases Severity of symptoms was assessed by a simple score of zero (none), +1 (mild),+ 2 (moderate) and +3 (severe) (table1) Nine cases (10%) presented by venous thrombosis , 4 of whom had portal vein thrombosis (4.44%) Cerebro-vascular strokes were noted in 5 cases (5.56%) and acute myocardial infarction in 2 cases (2.22%). Splenomegaly was noted in 29 cases (32.22%) of cases and hepatomegaly in 13 cases (14.44%). Associated conditions included hypertension in 24 cases (26.67%), gastrointestinal symptoms in 16 cases(17.78%) Diabetes mellitus in 15 cases (16.67%),Hepatitis C virus infection in 6 cases ( 6.67%), Hepatitis B in 2 cases ( 2.26%), coronory heart disease in 5 cases (5 .56%) and renal problems in 3 cases ( 3.33%). Bleeding episodes included 6 (6.67%) GI and 3(3.33%) gum bleeds. Familial MPN, Cancer prostate, intestinal Schistosomiasis   and post-liver transplant done post- hepatitis C virus cirrhosis were reported in one case each. Twenty two cases(24.44%) were controlled on Hydroxyuria only,16 cases 17.78%) on venesection plus hydroxyuria,16 cases(17.78%) on venesection only. Progression  was noted in 13 cases (14.44%) with marrow fibrosis in five cases (5.56%) and 14 cases (15.56%) were lost to follow-up. Mortality was seen in 10% (nine cases). Conclusion PV among Egyptians may have distinct presentations regarding incidence, age and  presentation.Simpler methods of symptom severity assessments may be more suitable for Egyptian patients. Disclosures: Mattar: Novartis, BMS, Amgen: Honoraria.

scholarly journals Symptomatic and Asymptomatic Protist Infections in Hospital Inpatients in Southwestern China

Pathogens ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 684
Author(s):  
Shun-Xian Zhang ◽  
David Carmena ◽  
Cristina Ballesteros ◽  
Chun-Li Yang ◽  
Jia-Xu Chen ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Giardia Duodenalis ◽  
Female Ratio ◽  
Cryptosporidium Spp ◽  
Male Female Ratio ◽  
Blastocystis Sp ◽  
Stool Samples ◽  
Etiological Agents ◽  
Age Range ◽  
Protist Species

Cryptosporidium spp., Entamoeba histolytica, Giardia duodenalis, and Blastocystis sp. infections have been frequently reported as etiological agents for gastroenteritis, but also as common gut inhabitants in apparently healthy individuals. Between July 2016 and March 2017, stool samples (n = 507) were collected from randomly selected individuals (male/female ratio: 1.1, age range: 38‒63 years) from two sentinel hospitals in Tengchong City Yunnan Province, China. Molecular (PCR and Sanger sequencing) methods were used to detect and genotype the investigated protist species. Carriage/infection rates were: Blastocystis sp. 9.5% (95% CI: 7.1–12.4%), G. duodenalis 2.2% (95% CI: 1.1–3.8%); and E. histolytica 2.0% (95% CI: 0.9–3.6%). Cryptosporidium spp. was not detected at all. Overall, 12.4% (95% CI: 9.7–15.6) of the participants harbored at least one enteric protist species. The most common coinfection was E. histolytica and Blastocystis sp. (1.0%; 95% CI: 0.3–2.2). Sequence analyses revealed that 90.9% (10/11) of the genotyped G. duodenalis isolates corresponded to the sub-assemblage AI. The remaining sequence (9.1%, 1/11) was identified as sub-assemblage BIV. Five different Blastocystis subtypes, including ST3 (43.7%, 21/48), ST1 (27.1%, 13/48), ST7 (18.8%, 9/48), ST4 (8.3%, 4/48), and ST2 (2.1%, 1/48) were identified. Statistical analyses confirmed that (i) the co-occurrence of protist infections was purely random, (ii) no associations were observed among the four protist species found, and (iii) neither their presence, individually or jointly, nor the patient’s age was predictors for developing clinical symptoms associated with these infections. Overall, these protist mono- or coinfections are asymptomatic and do not follow any pattern.

Radiation-induced intradural malignant peripheral nerve sheath tumor of the cauda equina with diffuse leptomeningeal metastasis

2014 ◽  
Vol 21 (5) ◽  
pp. 719-726 ◽  
Author(s):  
Darryl Lau ◽  
Dominic H. Moon ◽  
Paul Park ◽  
Shawn Hervey-Jumper ◽  
Paul E. McKeever ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Management Strategies ◽  
Cauda Equina ◽  
Leptomeningeal Metastasis ◽  
Neurofibromatosis Type ◽  
Nerve Sheath Tumor ◽  
Testicular Seminoma ◽  
Peripheral Nerve Sheath Tumors ◽  
Metastatic Lesions ◽  
Nerve Sheath

Malignant peripheral nerve sheath tumors (MPNSTs) are rare, affecting only a small portion of the general population. In many cases, MPNSTs occur in association with neurofibromatosis Type 1 and at times arise secondary to previous radiation therapy (RT). These tumors can be found essentially anywhere a peripheral nerve is present, but they rarely originate primarily from the spinal nerve or cauda equina and cause leptomeningeal spread. This report describes the treatment course of a 43-year-old man with a history of testicular seminoma treated with RT a decade before, who was found to have a large sacral MPNST. The patient underwent complete sacrectomy for gross-total resection. Despite this effort, he was eventually found to have metastatic lesions throughout the spine and brain, ultimately resulting in acute hydrocephalus and death. Biopsy results of these metastatic lesions proved to be characteristic of his original MPNST. The literature is also reviewed and the diagnostic modalities, management strategies, and prognosis of MPNST are discussed.

scholarly journals Hansen's Neuritis Revisited – A Clinicopathological Study

2018 ◽  
Vol 09 (01) ◽  
pp. 042-055
Author(s):  
Navya Jaiswal ◽  
Shrijeet Chakraborti ◽  
Kashinath Nayak ◽  
Shivananda Pai ◽  
B. P. Shelley ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Nerve Biopsy ◽  
Skin Lesions ◽  
Common Finding ◽  
Diagnostic Challenge ◽  
Female Ratio ◽  
Tuberculoid Leprosy ◽  
Male Female Ratio ◽  
Uncommon Condition ◽  
Age Range

ABSTRACT Introduction: Leprosy affecting the nerve solely or with concomitant skin lesions is not an uncommon condition in clinical practice. It is responsible for extensive morbidity and often poses a diagnostic challenge. This study aims to highlight the clinicopathological features of Hansen's neuritis (HN). Materials and Methods: In this retrospective study, cases of histologically diagnosed HN, from January 2010 to July 2017, were reviewed in the light of clinical features, treatment history, and outcome. Results: There were 18 cases of HN which accounted for 3.97% of total nerve biopsy samples (n = 453) and 0.02% of total histopathology samples (n = 81,013). The male: female ratio was 5:1 in the cases of HN. Age range was 20–79 years with a mean age of 42.4 years (standard deviation: ±14.03). Among the HN cases, there were 13 cases of pure neuritic leprosy (61.1%). Mononeuritis multiplex was the most common finding in the nerve conduction study. Six (33.3%) cases exhibited histological features of borderline tuberculoid leprosy, followed by five (27.8%) cases of mid-borderline features, three (16.7%) cases each of borderline lepromatous and burnt-out HN, and one (5.6%) case of polar tuberculoid leprosy. Lepra bacilli were detected on Fite-Faraco stain in 44.4% cases. Conclusion: Diagnosis of HN depends on astute search for skin lesions, nerve thickening or tenderness, sensory or motor symptoms, histopathological examination, and demonstration of lepra bacilli.

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