scholarly journals Prognostic Value of Baseline High-Sensitivity C–Reactive Protein in Patients Undergoing Replacement Arthroplasty

2009 ◽  
Vol 48 (174) ◽  
pp. 144-8 ◽  
Author(s):  
S Ghosh ◽  
Suhrita Paul ◽  
D P Bhattacharjee ◽  
P Ghosh ◽  
N Chatterjee
Keyword(s):  
Postoperative Complication ◽  
Operative Time ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Hscrp Level ◽  
College Hospital ◽  
Medical College ◽  
Reactive Protein ◽  
Replacement Arthroplasty ◽  
The Difference

Introduction:A prospective hospital based blinded study was carried out in an orthopedics department in a medical college hospital of Kolkata, West Bengal, India, with the objective of assessing the role of pre-operative high-sensitivity C-reactive protein (hsCRP) level in predicting postoperative complications in replacement arthroplasty. Methods:One hundred and twenty one study subjects were selected. The blood collected in pre-operative, perioperative and postoperative states were stored and fi nally analyzed after the data collection was over after the stipulated follow-up time of post operative Day-14. The patients were divided into two groups according to baseline hsCRP level <3mg/dl and >3mg/dl. The other preoperative parameters measured were found to be statistically comparable.Results: Among important fi ndings, operative time was signifi cantly higher in the group with hsCRP>3mg/dl, postoperative complication rate was also signifi cantly more in that group. Postoperative complication in Day-7 though quite high among both the groups (45% and 50.9%), the difference was not statistically signifi cant. Comparison of hsCRP levels at baseline, perioperative, postoperative D7 and D14 also showed no significant changes.Conclusions:We concluded that high hsCRP level(>3mg/dl), in patients with apparently no other risk factors may be at higher risk of developing complications after post operative D14 of replacement arthroplasty and operative time also signifi cantly increases with high baseline hsCRP level. Key Words: postoperative morbidity, reactive protein, replacement arthroplasty

scholarly journals HUBUNGAN INDEKS MASSA TUBUH DENGAN KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN SERUM PADA MAHASISWA OBES DAN TIDAK OBES DI FAKULTAS KEDOKTERAN UNIVERSITAS SAM RATULANGI MANADO

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Christy Rattu ◽  
Alexander S. L. Bolang ◽  
Shirley E. S. Kawengian
Keyword(s):  
High Sensitivity ◽  
Medical Faculty ◽  
Obesity Prevalence ◽  
C Reactive Protein ◽  
Hscrp Level ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Meaningful Relationship ◽  
The Difference ◽  
Age Range

Abstract: The increasing of Metabolic syndrome become a problem nowadays. The prevalence of metabolic symbol can be confirmed tend to increase with the increasing of obesity prevalence. The indicator to measure body’s fat is Body Mass Index (BMI). For obesity patient, their adiposity system produce duce protein messenger that cause inflamation. The level of High Sensitivity C-Reactive Protein (hsCRP) is one of the parameter that used to detect inflamation process. This research is conducted with the purpose to know the difference of hsCRP level between Obese students and Non-Obese students in Medical Faculty, to know the relation between BMI and hsCRP level between Obese and Non-Obese students in Medical Faculty. This is an analitic research with cross sectional approach that used 59 sample that consists of 30 Man and 29 woman, with the age range between 18-22 years old. The result of this research shown that there is a big difference of hsCRP level between obese and non-obese students. Cobclusion: There is a meaningful positif relationship between BMI with hsCRP level for obese students, and there is no meaningful relationship between BMI with hsCRP level for the non-obese students in Medical Faculty. Keywords: BMI, hsCRP, obesity     Abstrak: Meningkatnya sindroma metabolik menjadi masalah sekarang ini. Prevalensi sindroma metabolik dapat dipastikan cenderung meningkat dengan meningkatnya prevalensi obesitas. Indikator untuk mengukur lemak tubuh adalah indeks massa tubuh (IMT). Pada penderita obesitas, jaringan adiposity menghasilkan protein-protein duta yang menyebabkan adanya inflamasi. Kadar High Sensitivity C-Reactive Protein (hsCRP) merupakan salah satu parameter uji yang dipakai untuk mendeteksi proses inflamasi. Penelitian ini telah dilakukan dengan tujuan untuk mengetahui perbedaan kadar hsCRP pada mahasiswa obes dan non-obes di Fakultas Kedokteran, untuk mengetahui hubungan antara IMT dengan kadar hsCRP pada mahasiswa obes dan non-obes di Fakultas Kedokteran. Penelitian ini bersifat analitik dengan pendekatan cross sectional menggunakan 59 sampel yang terdiri 30 laki-laki dan 29 wanita, berusia 18-22 tahun. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang bermakna kadar hsCRP pada mahasiswa obes dan non-obes. Simpulan: Ada hubungan positif yang bermakna antara IMT dengan kadar hsCRP pada mahasiswa obes, dan tidak terdapat hubungan yang bermakna antara IMT dengan kadar hsCRP pada mahasiswa non-obes di Fakultas Kedokteran. Kata kunci: IMT, hsCRP, obesitas.

A STUDY TO EVALUATE THE ROLE OF HIGH SENSITIVITY C-REACTIVE PROTEIN IN CEREBROVASCULAR ACCIDENT IN THE DARBHANGA MEDICAL COLLEGE AND HOSPITAL

2021 ◽  
pp. 71-73
Author(s):  
Amit Kumar Tiwari ◽  
Umesh Chandra Jha ◽  
Debarshi Jana
Keyword(s):  
Cerebrovascular Accident ◽  
High Sensitivity ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Abrupt Onset ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Medical College ◽  
Reactive Protein ◽  
Hs Crp

INTRODUCTION:Cerebrovascular accident (commonly called stroke) is dened as an abrupt onset of a neurologic decit that is attributable to a focal vascular cause. Thus, the diagnosis of stroke is clinical and laboratory studies including brain imaging are used to support the diagnosis AIMS AND OBJECTIVES: To evaluate the serum levels of high sensitivity C-reactive protein (hsCRP) in different types of cerebrovascular accidents on admission. MATERIALS AND METHODS: This study was an institution based cross-sectional study designed to investigate the association of hs-CRP levels with stroke and its types in Indian patients. The study was done in the Department of Medicine, Darbhanga Medical College and Hospital, Laheriasarai, Bihar from march 2019 to March 2020. 50 patients of either sex above 12 years of age admitted in Medicine Department of DMCH, Laheriasarai, Bihar with clinically or radiologically diagnosed stroke. RESULT: The mean level of hsCRP (mean ± s.d.) of the cases in our study was 7.65±7.01 with range 1.4 – 26 and the median was 3.7 and 58% of the cases were having level of hsCRP≥3 (p=0.023).Mean level of hsCRPof cases was signicantly higher than that of control (t98=7.25;p=0.001). CONCLUSION:We concluded that hs-CRPlevel is increased in cases of cerebrovascular accident- ischemic as well as haemorrhagic, suggesting an inammatory response in acute cerebrovascular accident. hs-CRP level is increased in patients with ischemic cerebrovascular accident dramatically but not in haemorrhagic cerebrovascular accident which might be considered as useful adjunct method for determining type of stroke in patients with cerebrovascular problems.

Higher level of high sensitivity C-reactive protein is associated with more fibrocalcific plaque and longer lesion in patients with acute coronary syndrome

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
M Katamine ◽  
Y Minami ◽  
K Asakura ◽  
A Kato ◽  
A Katsura ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Morphological Characteristics ◽  
High Sensitivity ◽  
Current Smoker ◽  
Lesion Length ◽  
Culprit Lesion ◽  
C Reactive Protein ◽  
Hscrp Level ◽  
Reactive Protein ◽  
Coronary Syndrome

Abstract Background The association between the level of high sensitivity C-reactive protein (hsCRP) and coronary plaque characteristics in patients with acute coronary syndrome (ACS) remains to be elucidated. Purpose To clarify the morphological characteristics of culprit lesion in patients with ACS according to the hsCRP levels using optical coherence tomography (OCT). Methods A total of 215 consecutive patients with ACS, who underwent OCT imaging of culprit lesions were included. The patients were classified into either the higher hsCRP group (hsCRP ≥0.14 mg/dL, n=108) or the lower hsCRP group (hsCRP &lt;0.14 mg/dL, n=107) according to the median preprocedural hsCRP level. The morphological characteristics of culprit lesion assessed by OCT were compared between the two groups. Results The higher hsCRP group had higher prevalence of insulin therapy (14 vs. 6%, p=0.037) and current smoker than the lower hsCRP group (37 vs. 18%, p=0.002). The prevalence of long lesion (≥25 mm, 67 vs. 53%, p=0.041) and fibrocalcific plaque (53 vs. 33%, p=0.003) was significantly higher in the higher hsCRP group than in the lower hsCRP group (Figure). On the other hand, the prevalence of plaque rupture (36 vs. 46%, p=0.174) and lipid-rich plaque (47 vs. 64%, p=0.011) was rather lower in the higher hsCRP group than in the lower hsCRP group (Figure). In a multivariate analysis, fibrocalcific plaque (odds ratio [OR]: 2.098, 95% confidence interval [CI]: 1.125–3.913, p=0.019), lesion length (mm, OR: 1.036, 95% CI: 1.010–1.061, p=0.004) and current smoker (OR: 2.757, 95% CI: 1.388–5.476, p=0.003) was independently associated with higher hsCRP level. Conclusions ACS patients with high hsCRP levels had more fibrocalcific plaque and longer lesion than those with low hsCRP levels. The association between high hsCRP levels and vulnerable characteristics of culprit plaque was not demonstrated. Funding Acknowledgement Type of funding source: None

scholarly journals Association between weekend catch-up sleep and high-sensitivity C-reactive protein levels in adults: a population-based study

SLEEP ◽  
2020 ◽  
Vol 43 (8) ◽  
Author(s):  
Kyu-Man Han ◽  
Heon-Jeong Lee ◽  
Leen Kim ◽  
Ho-Kyoung Yoon
Keyword(s):  
Sleep Duration ◽  
High Sensitivity ◽  
Low Grade ◽  
C Reactive Protein ◽  
Hscrp Level ◽  
Obese People ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Significant Difference ◽  
Catch Up

Abstract Study Objectives To investigate the association between weekend catch-up sleep (WCS) and the levels of high-sensitivity C-reactive protein (hsCRP)—a serum inflammatory maker—in adults Methods Data of 5,506 adults aged 19 years or older were obtained from the nationwide cross-sectional Korea National Health and Nutrition Examination Surveys conducted in 2016. Serum hsCRP level, weekday and weekend sleep durations, and sociodemographic and health-related characteristics were assessed. Participants whose weekend sleep duration was more than 1 h longer than their weekday sleep duration were included in the WCS group. hsCRP level was categorized into quartiles (i.e. highest, middle-high, middle-low, and lowest). Obesity was defined by body mass index ≥ 25.0 kg/m2. Results The WCS group included 1,901 participants (34.5%). In the logistic regression analysis controlling for all variables, adults in the WCS group were significantly less likely to show the highest hsCRP level (versus the lowest level) compared with those without WCS in the complete sample (adjusted odds ratio = 0.795, 95% confidence interval [CI] = 0.662 to 0.955). In a subgroup analysis, this association was significant only for those with weekday sleep duration of 6 h or lower. Longer WCS (≥3 h) was not associated with hsCRP levels. Non-obese people with WCS demonstrated a lower risk for high hsCRP levels, while there was no significant difference in obese people with WCS. Conclusions Our findings indicate that WCS may be beneficial for low-grade systemic inflammation in adults, particularly among those with shorter weekday sleep durations. WCS may also interact with obesity.

scholarly journals High sensitivity C-reactive protein: Potential biomarker of inflammation in acute mTBI

Neurology ◽  
2018 ◽  
Vol 91 (23 Supplement 1) ◽  
pp. S18.1-S18
Author(s):  
Teena Shetty ◽  
Cogsil Taylor ◽  
Aashka Dalal ◽  
Kristin Halvorsen ◽  
Kelianne Cummings ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Binary Logistic Regression ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Hscrp Level ◽  
Reactive Protein ◽  
Blood Biomarker ◽  
Diagnosis And Prognosis ◽  
Potential Factors ◽  
Delayed Time

ObjectiveThis study investigated the utility of high-sensitivity C-Reactive Protein (hsCRP) as a blood biomarker for mild traumatic brain injury (mTBI).BackgroundValidation of a blood biomarker panel will greatly improve mTBI diagnosis and prognosis. hsCRP has been validated as a sensitive biomarker for inflammation. Previous studies have established relationships between CRP levels and TBI, but the utilization of hsCRP levels in assessing mTBI requires further exploration.MethodsRetrospective chart review collected hsCRP values in acute mTBI patients seen within 30 days of injury. Patients with any comorbid diagnosis known to cause elevation of inflammatory proteins were excluded. Continuous hsCRP levels were transformed into quartiles: <0.200 mg/L for Quartile 1 (Q1); 0.200–0.415 mg/L for Quartile 2 (Q2); 0.415–1.100 mg/L for Quartile 3 (Q3); and ≥1.100 mg/L for Quartile 4 (Q4). Multivariable binary logistic regression modeling identified potential factors for elevated hsCRP at first visit. Cox regression analysis identified potential factors for delayed time to recovery.ResultsThree hundred twelve injuries in 311 patients were reviewed (mean age 21 ± 12 years, 53% female). Mean hsCRP was elevated patients who presented within 2 days of injury and was found to significantly decrease between first visit and 4 weeks post-injury (p = 0.016). Initial hsCRP level was positively correlated with age (r = 0.163, p = 0.004) and negatively associated with previous concussion history (p = 0.031). When analyzed as quartiles, patients in Q4 were more likely to have endorsed headache (p = 0.036) or fatigue (p = 0.030). Age significantly increased between quartiles (p = 0.013). Multivariable binary logistic regression showed that increased age (OR: 3.48) and patients presenting with headache (OR: 3.48) or fatigue (OR: 2.16) were significantly associated with increased risk of having an hsCRP level in Q4. Females (HR: 0.32) and increased age (HR: 0.95) were associated delayed time to recovery.ConclusionshsCRP may be a viable addition to acute and longitudinal biomarker panels for diagnosis and prognosis of mTBI.

scholarly journals MON-099 The Association Between C-Reactive Protein, Metabolic Syndrome, and Pre-Diabetes in Korean Children and Adolescents

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Jihyun Kim ◽  
Jong Bin Lee ◽  
Jung Sub Lim
Keyword(s):  
Metabolic Syndrome ◽  
Children And Adolescents ◽  
Geometric Mean ◽  
High Sensitivity ◽  
Low Grade ◽  
C Reactive Protein ◽  
Hscrp Level ◽  
Cross Sectional ◽  
Korean Children ◽  
Reactive Protein

Abstract Objective: Cardiovascular disease (CVD) is a leading cause of death worldwide, including in Korea. In adults, the risk for CVD is increased approximately three-fold in subjects with metabolic syndrome (MetS), and the hazard ratio for subjects with MetS has been reported as 1.37 for mortality from CVD after adjustment for other confounders. Furthermore, MetS in childhood predicts adult MetS and T2DM 25 to 30 years later. Because MetS is a state of chronic low-grade inflammation, measurements of the circulating levels of the inflammatory molecules might provide diagnostic and therapeutic approaches to modulate or alter disease progression. High sensitivity C-reactive protein (hsCRP), a biomarker of inflammation, has emerged as an independent predictor of CVD and T2DM development. The aim of this paper is to evaluate the association between hsCRP and MetS and its components in Korean children and adolescents. Methods: We performed a cross-sectional analysis using data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2016–2017. We analyzed the data of 1,247 subjects (633 males, 14.2 ± 2.7 years) from the KNHANES 2016–2017. MetS were defined by the modified NCEP-ATP III criteria. Results: Among the 1,247 subjects (mean age: 14.2 ± 2.7 years), the prevalence of MetS was 5.8% (7.0% in male subjects and 4.6% in female subjects; p = 0.070). The mean hsCRP level was 0.861 ± 1.567 mg/l (median and interquartile range: 0.370 and 0.430mg/l). Subjects with MetS had higher hsCRP levels than subjects without MetS (geometric mean: 1.08 vs. 0.46 mg/l, p &lt; 0.001). The prevalence of MetS in the lowest, second, third, and highest hsCRP quartiles were 1.8%, 2.4%, 3.5%, and 15.2%, respectively. Compared to the lowest quartile, the odds ratio (OR) for having MetS in the highest quartile was 8.414 (3.272–21.638), adjusting for age and sex. The OR for having abdominal obesity and low HDL-C in the highest quartile were 9.657 (4.818–19.355) and 2.408 (1.286–4.510), adjusting for age, sex, and other components of the MetS. Additionally, the OR for having pre-diabetes (HbA1c ≥ 5.7%) in the highest quartile was 2.061 (1.097–3.870). Conclusion: Serum hsCRP level is positively associated with MetS and pre-diabetes in Korean children and adolescents.

scholarly journals Role and Usefulness of C-reactive Protein in Women with Polycystic Ovarian Syndrome

2021 ◽  
pp. 64-72
Author(s):  
Indra Prasad Adhikari ◽  
Shreya Nigoskar ◽  
Amresh Kumar Singh ◽  
Arun Mishra
Keyword(s):  
Biochemical Parameters ◽  
Medical Condition ◽  
Polycystic Ovary ◽  
Density Lipoprotein ◽  
Low Grade ◽  
C Reactive Protein ◽  
College Hospital ◽  
Medical College ◽  
Reactive Protein ◽  
Serum Crp

Background: Polycystic ovary syndrome (PCOS) is a complex medical condition characterized by elevated androgen levels, menstrual irregularities, and small cysts on one or both ovaries. The prevalence of PCOS is 6 to 10% in women. C-reactive protein (CRP) is an acute-phase protein produced by the hepatic cells and it’s levels increased in inflammation that increases interleukin-6 by macrophages and T cells. Aims and Objective: A correlative study of role and usefulness of CRP in women with PCOS and its correlation with different biochemical parameters. Materials and Methods: This was hospital based case-control study carried out among PCOS was conducted in the Department of Obstetrics & Gynaecology, Index Medical College Hospital, Indore. This study was conducted from 1st January 2018 to 31st December 2019. A total of 260 subjects with age group between 15 to 45 years were divided into two group; cases (130) and controls (130). Results: Among a total of 260 cases, based on clinical and different biochemical parameters, 130 were diagnosis with PCOS and 130 were apparently healthy women. The mean ±SD of various parameters among PCOS cases were; body mass index (BMI) 32.97±8.466, P (<0.001) total cholesterol (TC) 188.42±31.126, P (<0.001), triglyceride (TG) 134.43±50.01, P (<0.001), high density lipoprotein (HDL) 36.29±9.55 TC/HDL ratio, 5.54±1.865 serum CRP, 3.41±0.94 versus BMI 22.87±2.470, P (<0.001), TC155.42±26.333, TG 110.00±42.19, HDL 41.22±10.912, TC/HDL ratio 4.08±1.39, serum CRP 2.25±0.83 P (<0.001) in healthy control. Conclusion: In this study, the role of inflammation and different biochemical markers were studied among PCOS. It was found that a majority of PCOS patients were obese, having insulin resistance. The levels of CRP as a marker of chronic low grade inflammation were higher in newly diagnosed PCOS as compared to the controls. The CRP values correlated well (statistically significant) with increased in BMI and age.

Associations of Serum Pepsinogens and Helicobacter Pylori Infection with High-Sensitivity C-Reactive Protein in Medical Examination Population

2020 ◽  
Vol 52 (1) ◽  
pp. 57-63
Author(s):  
Huixing Liu ◽  
Chunrong Fei ◽  
Jun Zhang
Keyword(s):  
Helicobacter Pylori ◽  
High Sensitivity ◽  
Medical Examination ◽  
Infection Status ◽  
Serum Pepsinogen ◽  
C Reactive Protein ◽  
Hscrp Level ◽  
Infection Group ◽  
Reactive Protein ◽  
H Pylori

Abstract Objective This study aimed to clarify the distribution characteristics of serum pepsinogen (PG) and Helicobacter pylori in the medical examination population and to explore the relationships of PG level and H. pylori infection status with the high-sensitivity C-reactive protein (hsCRP) level and their significance in health examination. Methods We detected H. pylori infection by C13 urea breath test, the serum pepsinogen I (PGI) and pepsinogen II (PGII) contents were measured by chemiluminescence microparticle immunoassay, and the PGI/PGII ratio was calculated. In addition, the serum hsCRP level was determined by the Abbott C16000 automatic biochemical analyzer. Results The PGI and hsCRP levels were significantly higher in men than in women, and the PGII level was slightly higher in men than in women (both P &lt;.05). The PGI, PGII, and hsCRP levels were positively correlated with age (r = 0.210, 0.287, and 0.133, respectively; P &lt;.05), whereas the PGI/PGII ratio was negatively correlated with age (r = –0.190; P &lt;.05). The positive H. pylori infection rate was 30.2% among the patients in this study; H. pylori infection was not related to sex (P &gt;.05), and the difference in age stratification was not statistically significant (P &gt;.05). The abnormal PGI/PGII ratio in the medical examination population was not correlated with sex (P &gt;.05). In the H. pylori positive infection group, the proportion of PGI/PGII ratio &lt;3, the PGI and PGII levels were significantly higher than those in the H. pylori negative infection group, and the PGI/PGII ratio was significantly lower than that in the negative group (both P &lt;.05). The hsCRP level was not associated with H. pylori infection (P &gt;.05), and it was significantly higher in the PGI/PGII ratio &lt;3 group than in the PGI/PGII ratio ≥3 group (P &lt;.05). Conclusion The PGI and PGII levels and the PGI/PGII ratio are correlated with H. pylori infection. The abnormal PGI/PGII ratio is closely related to H. pylori infection and hsCRP level. Therefore, H. pylori infection status and hsCRP level should be considered when determining atrophic gastritis by the PGI/PGII ratio.

scholarly journals E-cigarette Smoking (Vaping) and Markers of Vascular Wall Damage in Young Subjects without Cardiovascular Disease

2021 ◽  
Vol 17 (4) ◽  
pp. 521-527
Author(s):  
V. I. Podzolkov ◽  
A. E. Bragina ◽  
N. A. Druzhinina ◽  
L. N. Mohammadi
Keyword(s):  
Multivariate Regression ◽  
Ankle Brachial Index ◽  
High Sensitivity ◽  
Vascular Wall ◽  
Multivariate Regression Analysis ◽  
C Reactive Protein ◽  
Hscrp Level ◽  
Reactive Protein ◽  
Daily Urine ◽  
Young Subjects

Aim: to investigate the effect of nicotine-containing vapes in comparison with traditional tobacco smoking on markers of vascular wall damage: high sensitivity C-reactive protein (hsCRP), albuminuria (AU), and ankle-brachial index (ABI).Material and Methods: We examined 369 young subjects without cardiovascular diseases (age median 21 [20;21] years) (159 men and 210 women). The hsCRP levels in the serum were assessed by immunochromatographic express method. AU was investigated in daily urine by a quantitative reflex photometry. ABI was determined by plethysmography.Results: All subjects were divided into groups: non-smokers (n=196, 53.1%), smokers of traditional cigarettes (n=83, 22.5%) and smokers of nicotine-containing vapes (n=90, 24.4%). The groups did not differ in main anthropometric data. Median hsCRP levels in smokers (14.30 [11; 16.5] mg/l in tobacco-smokers and 13.15 [9.65; 17.5] mg/l in vapers) were significantly higher vs nonsmokers (3.0 [2; 5.6] mg/l). In tobacco-smokers (33.0  [21.5;  60]  mg)  and  vape  smokers  (45.0  [20;  115]  mg),  the  median  AU  was  statistically  significantly  higher  than  in  non-smokers  (12.0 [10; 20] mg). ABI levels were significantly lower in the groups of tobacco smokers (0.98 [0.91; 0.99]) and vapers (0.85 [0.79; 0.93]) when compared with nonsmokers (1.125 [1.01; 1.18]), and the median ABI in vapers was lower than in tobacco smokers (p<0.001). In the group of tobacco smokers, the hsCRP level correlated with the smoker's index (rs=0.31, p<0.05), and AU (rs=0.54, p<0.05) and ABI (rs=-0.28, p<0.05) with a daily inhaled nicotine dose. In the group of vapers, CRP was associated with smoking experience (rs=0.338, p<0.05), AU with a daily inhaled nicotine dose (rs=0.79,  p<0.05), and  ABI with  BMI (rs=-0.33,  p<0.05), heart  rate (rs=-0.24,  p<0.05) and  smoking experience  (rs=-0.235, p<0.05). According to the results of multivariate regression analysis the hsCRP level was related with only the smoking experience (B=0.91±0.19, p=0.000005), AU level with the daily inhaled nicotine dose (B=1.59±0.7, p=0.0121) and smoking experience (B=3.07±1.23, p=0.0179), and ABI level with only smoking experience (B=-0.09±0.004, p=0.0419).Conclusion: In smokers, both traditional and vapers, the levels of hsCRP, AU are significantly higher, and the ABI is lower than in healthy young nonsmokers. The most significant influence on the level of hsCRP is exerted by the experience of  tobacco  and  vape  smoking;  to  the  AU  level  – the experience of tobacco and vaping and the daily inhaled nicotine dose, and by the value of the ABI – the experience of vaping.

scholarly journals Association between C - reactive protein and Premature Rupture of Membrane

2016 ◽  
Vol 4 (2) ◽  
pp. 26-31
Author(s):  
Mitheel Ibna Islam ◽  
Monowara Khatun ◽  
Md Shahidul Islam ◽  
Md Nurul Amin ◽  
Shitil Ibna Islam
Keyword(s):  
Amniotic Fluid ◽  
Cross Sectional Study ◽  
C Reactive Protein ◽  
Premature Rupture ◽  
College Hospital ◽  
Cross Sectional ◽  
Predictive Values ◽  
Medical College ◽  
Reactive Protein ◽  
Wbc Count

Background and Objectives: Early diagnosis of clinical chorioamnionitis (ChAm) in patients with premature rupture of membrane (PROM) is essential for its prompt treatment with antibiotics. Amniocentesis may be used to detect subclinical infections in cases of PROM. But the procedure is an invasive one. The present study was undertaken to study the role of plasma C-reactive protein (CRP) in the prediction of clinical chorioamnionitis in case of PROM. Materials & Methods The cross-sectional study was carried out in the of Departments of Obstetrics & Gynaecology, Khulna Medical College Hospital, Khulna over a period 1 year from July 2014 to June 2015. A total of 90 clinically diagnosed cases of PROM (rupture of the membrane with release of the amniotic fluid more than 1 hour prior to the onset of labor) were consecutively included in the study based on predefined enrolment criteria. Clinical ChAm is defined by findings such as leukocytosis [WBC count, >15,000/µL, fetal tachycardia, maternal fever (temperature, >100.4°F), fundal or uterine tenderness, or foul-smelling amniotic fluid]. A CRP value of > 10 mg/L was considered as raised or positive CRP. The risk of developing clinical ChAm in patients with raised CRP was then estimated by computing the Odds ratio. Result: The mean age of the women with PROM was 23.9 years. The patients presented with fundal or uterine tenderness (10%), raised maternal temperature (8.9%), foetal tachycardia (10%), maternal tachycardia (13.3%), foul smelling amniotic fluid (6.7%). Over half (52.2%) of the patients were preterm PROM and the rest were term PROM. Positive CRP was found in 16.7% cases. Raised WBC count and raised ESR were found in 11.1 and 33.3% cases respectively. Over two-thirds (70%) who developed clinical chorioamnionitis had raised CRP as opposed to 10% of those who did not develop the condition. The risk of having raised CRP in patients who developed clinical chorioamnionitis was > 20-fold (4.5 - 97.7) higher than those who did not develop the condition (p < 0.001). The sensitivity and specificity of CRP in diagnosing and ruling out chorioamnionitis respectively in cases of PROM were 70% and 90% respectively. The positive and negative predictive values of the test are 46.7% and 96% respectively. Conclusion: The study concluded that a substantial proportion of the PROM cases with clinical chorioamnionitis is manifested with raised CRP compared to PROM cases without chorioamnionitis. However, CRP is moderately sensitive to diagnose chorioamnionitis and highly specific to rule out the condition in cases with PROM. Ibrahim Cardiac Med J 2014; 4(2): 26-31

Sign in / Sign up

Export Citation Format

Share Document